DE60305443D1 - Pharmazeutische zusammnesetzung zur verbesserten in-vivo genübertragung - Google Patents
Pharmazeutische zusammnesetzung zur verbesserten in-vivo genübertragungInfo
- Publication number
- DE60305443D1 DE60305443D1 DE60305443T DE60305443T DE60305443D1 DE 60305443 D1 DE60305443 D1 DE 60305443D1 DE 60305443 T DE60305443 T DE 60305443T DE 60305443 T DE60305443 T DE 60305443T DE 60305443 D1 DE60305443 D1 DE 60305443D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical composition
- improved
- general transmission
- vivo general
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000005540 biological transmission Effects 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 229920001577 copolymer Polymers 0.000 abstract 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 108091006629 SLC13A2 Proteins 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0201584A FR2835749B1 (fr) | 2002-02-08 | 2002-02-08 | Composition pharmaceutique ameliorant le transfert de gene in vivo |
FR0201584 | 2002-02-08 | ||
PCT/FR2003/000407 WO2003066104A2 (fr) | 2002-02-08 | 2003-02-07 | Composition pharmaceutique ameliorant le transfert de gene in vivo |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60305443D1 true DE60305443D1 (de) | 2006-06-29 |
DE60305443T2 DE60305443T2 (de) | 2007-05-10 |
Family
ID=27620039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60305443T Expired - Lifetime DE60305443T2 (de) | 2002-02-08 | 2003-02-07 | Pharmazeutische zusammnesetzung zur verbesserten in-vivo genübertragung |
Country Status (10)
Country | Link |
---|---|
US (2) | US7709452B2 (de) |
EP (1) | EP1471944B1 (de) |
JP (1) | JP4613011B2 (de) |
AT (1) | ATE326986T1 (de) |
AU (1) | AU2003222896A1 (de) |
CA (1) | CA2473212C (de) |
DE (1) | DE60305443T2 (de) |
ES (1) | ES2265569T3 (de) |
FR (1) | FR2835749B1 (de) |
WO (1) | WO2003066104A2 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2868953B1 (fr) * | 2004-04-16 | 2006-06-30 | Inst Nat Sante Rech Med | Composition pour le transfert intracellulaire d'un acide nucleique. |
MX2009002856A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Conjugados polimericos que contienen porciones cargadas positivamente. |
DE102006051623A1 (de) | 2006-11-02 | 2008-07-31 | Horn, Peter A. | Verfahren und Stoffgemisch zur Verbesserung eines in vivo Genfransfers |
WO2010026537A1 (en) | 2008-09-05 | 2010-03-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel multimodular assembly useful for intracellular delivery |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP4015005A1 (de) | 2011-10-03 | 2022-06-22 | ModernaTX, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und ihre verwendungen |
SG11201402666WA (en) | 2011-12-16 | 2014-10-30 | Moderna Therapeutics Inc | Modified nucleoside, nucleotide, and nucleic acid compositions |
WO2013106558A1 (en) | 2012-01-10 | 2013-07-18 | Merial Limited | Lipid based adjuvants for dna - plasmid vaccines |
WO2013128424A1 (en) | 2012-03-02 | 2013-09-06 | Institut National De La Sante Et De La Recherche Medicale | Vaccine for prophylaxis or treatment of an allergen-driven and/or a chronic airways disease |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
AU2013243955B2 (en) | 2012-04-02 | 2018-02-22 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US20150182620A1 (en) | 2012-06-15 | 2015-07-02 | Inserm (Institut De La Sante Et De La Recherche Medicale) | Polypeptides for use in the Prophylactic Treatment of Allergic Asthma |
PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
CN105980401A (zh) | 2013-10-03 | 2016-09-28 | 现代治疗公司 | 编码低密度脂蛋白受体的多核苷酸 |
ES2759243T3 (es) | 2014-04-01 | 2020-05-08 | Inst Nat Sante Rech Med | Moléculas de ARN protegidas y no protegidas y copolímeros de bloques para la administración intracelular de ARN |
EP3225246A1 (de) | 2016-03-31 | 2017-10-04 | Klinikum der Universität München | Synthetische verbindung zur verbesserung der effizienz der transfektion |
US20210000917A1 (en) | 2018-03-05 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and composition for the treatment of allergic asthma |
WO2020182901A1 (en) * | 2019-03-11 | 2020-09-17 | Evaxion Biotech Aps | Nucleic acid vaccination using neo-epitope encoding constructs |
AU2021202658A1 (en) | 2021-04-28 | 2022-11-17 | Fondazione Telethon | Gene therapy |
GB202206346D0 (en) | 2022-04-29 | 2022-06-15 | Ospedale San Raffaele Srl | Gene therapy |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5470568A (en) * | 1992-02-13 | 1995-11-28 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for cell repair |
GB9216082D0 (en) * | 1992-07-28 | 1992-09-09 | Univ Nottingham | Lymphatic delivery composition |
US6359054B1 (en) * | 1994-11-18 | 2002-03-19 | Supratek Pharma Inc. | Polynucleotide compositions for intramuscular administration |
US6221959B1 (en) | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
US6040295A (en) | 1995-01-13 | 2000-03-21 | Genemedicine, Inc. | Formulated nucleic acid compositions and methods of administering the same for gene therapy |
CA2315256A1 (en) * | 1997-12-16 | 1999-06-24 | Valentis, Inc. | Needle-free injection of formulated nucleic acid molecules |
GB9904627D0 (en) * | 1999-03-02 | 1999-04-21 | Danbiosyst Uk | Polymer compositions for polynucleotide delivery |
AU4898699A (en) | 1999-07-16 | 2001-02-05 | Reatech | Phosphor addition in gasification |
AU6389000A (en) * | 1999-07-28 | 2001-02-19 | Valentis, Inc. | Sonoporation of tumors |
WO2001060415A1 (en) | 2000-02-18 | 2001-08-23 | The Immune Response Corporation | Methods and compositions for gene delivery |
AU2001241958A1 (en) * | 2000-03-03 | 2001-09-17 | Valentis, Inc. | Improved poloxamer and poloxamine compositions for nucleic acid delivery |
WO2002061040A2 (en) | 2000-10-20 | 2002-08-08 | Valentis, Inc. | Gene delivery formulations and methods for treatment of ischemic conditions |
-
2002
- 2002-02-08 FR FR0201584A patent/FR2835749B1/fr not_active Expired - Lifetime
-
2003
- 2003-02-07 CA CA2473212A patent/CA2473212C/fr not_active Expired - Lifetime
- 2003-02-07 WO PCT/FR2003/000407 patent/WO2003066104A2/fr active IP Right Grant
- 2003-02-07 JP JP2003565527A patent/JP4613011B2/ja not_active Expired - Lifetime
- 2003-02-07 AU AU2003222896A patent/AU2003222896A1/en not_active Abandoned
- 2003-02-07 DE DE60305443T patent/DE60305443T2/de not_active Expired - Lifetime
- 2003-02-07 EP EP03718854A patent/EP1471944B1/de not_active Expired - Lifetime
- 2003-02-07 AT AT03718854T patent/ATE326986T1/de not_active IP Right Cessation
- 2003-02-07 ES ES03718854T patent/ES2265569T3/es not_active Expired - Lifetime
- 2003-02-07 US US10/502,973 patent/US7709452B2/en not_active Expired - Lifetime
-
2010
- 2010-03-15 US US12/659,618 patent/US8367631B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1471944A2 (de) | 2004-11-03 |
AU2003222896A8 (en) | 2003-09-02 |
DE60305443T2 (de) | 2007-05-10 |
WO2003066104A2 (fr) | 2003-08-14 |
JP4613011B2 (ja) | 2011-01-12 |
JP2005522433A (ja) | 2005-07-28 |
US7709452B2 (en) | 2010-05-04 |
CA2473212A1 (fr) | 2003-08-14 |
EP1471944B1 (de) | 2006-05-24 |
FR2835749A1 (fr) | 2003-08-15 |
AU2003222896A1 (en) | 2003-09-02 |
WO2003066104A3 (fr) | 2004-03-25 |
ATE326986T1 (de) | 2006-06-15 |
US20100179212A1 (en) | 2010-07-15 |
US20050152870A1 (en) | 2005-07-14 |
CA2473212C (fr) | 2013-04-23 |
US8367631B2 (en) | 2013-02-05 |
ES2265569T3 (es) | 2007-02-16 |
FR2835749B1 (fr) | 2006-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |