DE60239606D1 - Antigene zur immunisierung - Google Patents

Antigene zur immunisierung

Info

Publication number
DE60239606D1
DE60239606D1 DE60239606T DE60239606T DE60239606D1 DE 60239606 D1 DE60239606 D1 DE 60239606D1 DE 60239606 T DE60239606 T DE 60239606T DE 60239606 T DE60239606 T DE 60239606T DE 60239606 D1 DE60239606 D1 DE 60239606D1
Authority
DE
Germany
Prior art keywords
catalytic
animals
animal
producing
inventive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60239606T
Other languages
English (en)
Inventor
Alexandr Gabibovich Gabibov
Alexandr Vladimirovic Kolesnikov
Natalya Alexandrovna Ponomarenko
Elena Sergeevna Alexandrova
Ivan Ivanovich Vorobiev
Alexandr Viktorovich Demin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FDS PHARMA ASS
Original Assignee
FDS PHARMA ASS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FDS PHARMA ASS filed Critical FDS PHARMA ASS
Application granted granted Critical
Publication of DE60239606D1 publication Critical patent/DE60239606D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Rehabilitation Therapy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60239606T 2001-04-24 2002-04-18 Antigene zur immunisierung Expired - Lifetime DE60239606D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2001110759/13A RU2221873C2 (ru) 2001-04-24 2001-04-24 Способ получения каталитических антител (варианты), антигены для иммунизации и нуклеотидная последовательность
PCT/RU2002/000177 WO2002086058A2 (en) 2001-04-24 2002-04-18 Method for producing catalytic antibodies (variants), antigens for immunisation and nucleotide sequence

Publications (1)

Publication Number Publication Date
DE60239606D1 true DE60239606D1 (de) 2011-05-12

Family

ID=20248733

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60239606T Expired - Lifetime DE60239606D1 (de) 2001-04-24 2002-04-18 Antigene zur immunisierung

Country Status (9)

Country Link
US (1) US20040265975A1 (de)
EP (2) EP2295082B1 (de)
JP (1) JP2004527248A (de)
AT (1) ATE503497T1 (de)
AU (1) AU2002313135A1 (de)
DE (1) DE60239606D1 (de)
ES (1) ES2440369T3 (de)
RU (1) RU2221873C2 (de)
WO (1) WO2002086058A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560529B2 (en) * 2001-04-24 2009-07-14 FDS Pharma Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434713B1 (de) * 1988-09-13 1994-10-12 Chiron Corporation Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.
US5817629A (en) * 1991-10-22 1998-10-06 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US5961973A (en) * 1992-03-06 1999-10-05 Crea; Roberto Pathogen-targeted biocatalysts
SK116294A3 (en) * 1992-04-01 1996-11-06 Merck & Co Inc Recombinant human hiv-antibodies, cassette for expression, host cell and pharmaceutical agent against hiv
AU5360796A (en) * 1995-03-09 1996-10-02 Neurocrine Biosciences, Inc. Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
ES2283005T3 (es) * 1995-07-21 2007-10-16 University Of Nebraska Board Of Regents Composiciones y procedimientos para catalizar la hidrolisis de gp 120 de hiv.
US5948658A (en) 1996-06-25 1999-09-07 The Trustees Of Columbia University In The City Of New York Anti-cocaine catalytic antibody
US6140091A (en) * 1997-06-20 2000-10-31 Boston Biomedical Research Institute Anti-idiotype vaccines to elicit catalytic antibodies
US6235714B1 (en) * 1998-03-23 2001-05-22 Sudhir Paul Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses

Also Published As

Publication number Publication date
JP2004527248A (ja) 2004-09-09
ATE503497T1 (de) 2011-04-15
EP1394261A2 (de) 2004-03-03
US20040265975A1 (en) 2004-12-30
EP2295082B1 (de) 2013-09-18
EP2295082A1 (de) 2011-03-16
RU2221873C2 (ru) 2004-01-20
EP1394261B1 (de) 2011-03-30
EP1394261A4 (de) 2008-04-09
AU2002313135A1 (en) 2002-11-05
WO2002086058A9 (fr) 2003-11-27
WO2002086058A3 (en) 2003-01-23
WO2002086058A2 (en) 2002-10-31
ES2440369T3 (es) 2014-01-28

Similar Documents

Publication Publication Date Title
Trier et al. Peptides, antibodies, peptide antibodies and more
Burton Phage display
ES2236605T3 (es) Tecnologia de anticuerpos dirigida.
Kehoe et al. Filamentous phage display in the new millennium
ATE170558T1 (de) Verfahren zur herstellung von immunogenen oder diagnostischen reagentien und ebensolche
HUP0303171A2 (hu) Csökkentett immunogenitású mesterséges fehérjék
Barelle et al. VNARs: an ancient and unique repertoire of molecules that deliver small, soluble, stable and high affinity binders of proteins
WO2000073430A3 (de) Vakzine gegen konformationsabhängige antigene sowie gegen antigene, die keine oder nicht ausschliesslich proteine oder peptide sind
US20220403012A1 (en) Peptide-hinge-free flexible antibody-like molecule
Corradin et al. Protein structure based strategies for antigen discovery and vaccine development against malaria and other pathogens
Ch'ng et al. Application of phage display for T-cell receptor discovery
CN107207581A (zh) 用于制备优化的治疗分子的方法
Jemmerson Multiple overlapping epitopes in the three antigenic regions of horse cytochrome c1.
WO2005111081A2 (en) Immunoglobulin-like variable chain binding polypeptides and methods of use
Dudler et al. Antigenic surface of the bee venom allergen phospholipase A2. Structural functional analysis of human IgG4 antibodies reveals potential role in protection.
CN108350450A (zh) 人血清来源的IgG 多克隆抗体的分离剂、以及使用其的人血清来源的IgG 多克隆抗体的分离方法
CN106188279A (zh) 一种免疫库来源的特异性识别免疫球蛋白Fc段的纳米抗体
CN106117350A (zh) 一种免疫库来源的结合免疫球蛋白Fc段的纳米抗体
DE60239606D1 (de) Antigene zur immunisierung
ATE332380T1 (de) Materialen und verfahren mit bezug auf immunantworten gegen fusionsproteine
CN102597771B (zh) 用于重定向抗体特异性的高亲和力衔接分子
Barbas et al. Filamentous phage display
WO2008078177A3 (en) Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence
Ståhl et al. Strategies for gene fusions
CN103275222B (zh) 一种阻断白介素12 p40功能的单克隆抗体及其编码基因和应用