DE60234703D1 - Neue prodrugs von n-h-bindung enthaltenden verbindungen und verfahren zu ihrer herstellung - Google Patents

Neue prodrugs von n-h-bindung enthaltenden verbindungen und verfahren zu ihrer herstellung

Info

Publication number
DE60234703D1
DE60234703D1 DE60234703T DE60234703T DE60234703D1 DE 60234703 D1 DE60234703 D1 DE 60234703D1 DE 60234703 T DE60234703 T DE 60234703T DE 60234703 T DE60234703 T DE 60234703T DE 60234703 D1 DE60234703 D1 DE 60234703D1
Authority
DE
Germany
Prior art keywords
prodrugs
bond
pharmaceutical
bonds
pharmaceutical compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60234703T
Other languages
English (en)
Inventor
Victor R Guarino
Veranja Karunaratne
Valentino J Stella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Original Assignee
University of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kansas filed Critical University of Kansas
Application granted granted Critical
Publication of DE60234703D1 publication Critical patent/DE60234703D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/08—Sulfenic acids; Derivatives thereof
    • C07C313/10—Sulfenic acids; Esters thereof
    • C07C313/12—Sulfenic acids; Esters thereof having sulfur atoms of sulfenic groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/08—Sulfenic acids; Derivatives thereof
    • C07C313/18—Sulfenamides
    • C07C313/20—Sulfenamides having sulfur atoms of sulfenamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/08—Sulfenic acids; Derivatives thereof
    • C07C313/18—Sulfenamides
    • C07C313/26—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C313/28—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE60234703T 2001-10-16 2002-10-16 Neue prodrugs von n-h-bindung enthaltenden verbindungen und verfahren zu ihrer herstellung Expired - Lifetime DE60234703D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32986801P 2001-10-16 2001-10-16
PCT/US2002/032957 WO2003032908A2 (en) 2001-10-16 2002-10-16 Novel prodrugs of n-h bond-containing compounds and methods of making thereof

Publications (1)

Publication Number Publication Date
DE60234703D1 true DE60234703D1 (de) 2010-01-21

Family

ID=23287352

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60234703T Expired - Lifetime DE60234703D1 (de) 2001-10-16 2002-10-16 Neue prodrugs von n-h-bindung enthaltenden verbindungen und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US20030119814A1 (de)
EP (1) EP1435964B1 (de)
AT (1) ATE451105T1 (de)
AU (1) AU2002337861B2 (de)
CA (1) CA2461557A1 (de)
DE (1) DE60234703D1 (de)
NZ (1) NZ531851A (de)
WO (1) WO2003032908A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20095208A0 (fi) * 2009-03-03 2009-03-03 Kuopion Yliopisto Metformiinin uudet aihiolääkkeet
WO2012047993A2 (en) * 2010-10-05 2012-04-12 Regents Of The University Of Minnesota N-hydroxypyrimidine-2,4-diones as inhibitors of hiv and hcv
WO2016044433A2 (en) * 2014-09-16 2016-03-24 Biopharma Works Metformin derivatives

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL282477A (de) * 1961-08-26
AR204232A1 (es) * 1971-03-18 1975-12-10 Lepetit Spa Procedimiento para preparar derivados 1,3,4,5-tetrahidro-2,3-benzoxazepinicos
DE2135543A1 (de) * 1971-07-16 1973-01-25 Boehringer Mannheim Gmbh Benzthiazolderivate enthaltende arzneimittel
US4130554A (en) * 1975-04-08 1978-12-19 Merck & Co., Inc. Process for preparing somatostatin analog
US3980787A (en) * 1975-08-25 1976-09-14 American Hoechst Corporation 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives
JPS54128578A (en) * 1978-03-25 1979-10-05 Sankyo Co Ltd Pyridine sulfenic acid amide and ester, their preparation, and carcinostatic action improver
JPS54160392A (en) * 1978-06-02 1979-12-19 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
US4469874A (en) * 1980-05-22 1984-09-04 Monsanto Company Fragrant prevulcanization inhibitors
US4358591A (en) * 1980-07-21 1982-11-09 Zoecon Corporation 1-Phenyl-3-polyhaloalkyl(vinyl)sulfenyl uracils
DE3118126A1 (de) * 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Sulfenamide zur verwendung in arzneimitteln
ZA835661B (en) * 1982-09-16 1984-04-25 Shell Res Ltd Pesticidal benzoylurea compounds
DE3336410A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Sulfenamidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5089634A (en) * 1984-08-20 1992-02-18 Georgia Tech Research Corporation Isocoumarins with cationic substituents
US5538988A (en) * 1994-04-26 1996-07-23 Martinez; Gregory R. Benzocycloalkylazolethione derivatives
US5821263A (en) * 1996-08-26 1998-10-13 Bristol-Myers Squibb Company Sulfenamide taxane derivatives
AU5620598A (en) * 1996-12-31 1998-07-31 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
ES2198145T3 (es) * 1998-08-17 2004-01-16 Bayer Cropscience Ag Amidas del acido metoximinofenilacetico.
US6194458B1 (en) * 1998-10-30 2001-02-27 Merck & Co., Inc. Benzamide potassium channel inhibitors
US6204265B1 (en) * 1998-12-23 2001-03-20 Schering Corporation Substituted oximes and hydrazones as neurokinin antagonists
JP3268448B2 (ja) * 1999-07-08 2002-03-25 独立行政法人産業技術総合研究所 新規な１，２−ベンゾイソチアゾリン−３−オン化合物誘導体およびその製造方法

Also Published As

Publication number Publication date
AU2002337861B2 (en) 2009-04-02
CA2461557A1 (en) 2003-04-24
EP1435964A4 (de) 2005-01-19
ATE451105T1 (de) 2009-12-15
WO2003032908A2 (en) 2003-04-24
EP1435964A2 (de) 2004-07-14
US20030119814A1 (en) 2003-06-26
EP1435964B1 (de) 2009-12-09
NZ531851A (en) 2008-01-31
WO2003032908A3 (en) 2003-07-10

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