DE60226038D1 - Verfahren zur synthese von aminen wie ephedrin und zwischenprodukten - Google Patents

Verfahren zur synthese von aminen wie ephedrin und zwischenprodukten

Info

Publication number
DE60226038D1
DE60226038D1 DE60226038T DE60226038T DE60226038D1 DE 60226038 D1 DE60226038 D1 DE 60226038D1 DE 60226038 T DE60226038 T DE 60226038T DE 60226038 T DE60226038 T DE 60226038T DE 60226038 D1 DE60226038 D1 DE 60226038D1
Authority
DE
Germany
Prior art keywords
sub
optionally substituted
alkyl
formula
ephedrine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60226038T
Other languages
English (en)
Other versions
DE60226038T2 (de
Inventor
Andrew John Smallridge
Maurice Arthur Trewhella
Kylie Anne Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VICTORIA UNIVERSITY FOOTSCRAY
VICTORIA UNIVERSITY FOOTSCRAY
Original Assignee
VICTORIA UNIVERSITY FOOTSCRAY
VICTORIA UNIVERSITY FOOTSCRAY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VICTORIA UNIVERSITY FOOTSCRAY, VICTORIA UNIVERSITY FOOTSCRAY filed Critical VICTORIA UNIVERSITY FOOTSCRAY
Publication of DE60226038D1 publication Critical patent/DE60226038D1/de
Application granted granted Critical
Publication of DE60226038T2 publication Critical patent/DE60226038T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/26—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
DE60226038T 2001-08-28 2002-08-26 Verfahren zur synthese von aminen wie ephedrin und zwischenprodukten Expired - Lifetime DE60226038T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPR732601 2001-08-28
AUPR7326A AUPR732601A0 (en) 2001-08-28 2001-08-28 Methods for the synthesis of amines such as ephedrine and inter mediates
PCT/AU2002/001148 WO2003018531A1 (en) 2001-08-28 2002-08-26 Methods for the synthesis of amines such as ephedrine and intermediates

Publications (2)

Publication Number Publication Date
DE60226038D1 true DE60226038D1 (de) 2008-05-21
DE60226038T2 DE60226038T2 (de) 2009-05-14

Family

ID=3831278

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60226038T Expired - Lifetime DE60226038T2 (de) 2001-08-28 2002-08-26 Verfahren zur synthese von aminen wie ephedrin und zwischenprodukten

Country Status (7)

Country Link
US (1) US7176332B2 (de)
EP (1) EP1421055B1 (de)
JP (1) JP2005500399A (de)
AT (1) ATE391707T1 (de)
AU (2) AUPR732601A0 (de)
DE (1) DE60226038T2 (de)
WO (1) WO2003018531A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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GB0406125D0 (en) 2004-03-18 2004-04-21 Univ Cambridge Tech Methods of amination
DE602005015091D1 (de) * 2004-04-15 2009-08-06 Emmellen Biotech Pharmaceutica Herstellungsverfahren von optisch aktivem 1-erythro-2-amino-1-phenyl-1-propanol
EP2143707B1 (de) 2005-03-28 2018-04-11 Line-X LLC Sekundäres Diamin
US8076518B2 (en) 2005-03-28 2011-12-13 Albemarle Corporation Chain extenders
US7964695B2 (en) 2005-03-28 2011-06-21 Albemarle Corporation Chain extenders
WO2007077140A1 (de) * 2006-01-06 2007-07-12 Basf Aktiengesellschaft Hydroxy-norephedrin-derivate und verfahren zu ihrer herstellung
GB0607911D0 (en) * 2006-04-21 2006-05-31 Ineos Fluor Holdings Ltd Process
CA2670041A1 (en) 2007-01-10 2008-07-17 Albemarle Corporation Formulations for reaction injection molding and for spray systems
US8654740B2 (en) 2009-03-03 2014-02-18 Intel Corporation Polar cap reset method for differential codebook for wireless communications
CN103113239B (zh) * 2013-03-11 2014-04-30 苏州立新制药有限公司 盐酸利托君的制备方法
CN103113237B (zh) * 2013-03-11 2014-04-30 苏州立新制药有限公司 一种盐酸利托君的制备方法
CN103113238B (zh) * 2013-03-11 2014-04-30 苏州立新制药有限公司 一种利托君的制备方法
NZ730560A (en) 2014-09-29 2020-05-29 Zogenix International Ltd Control system for control of distribution of medication
IL286391B (en) * 2015-12-22 2022-08-01 Zogenix International Ltd Penfluramine preparations and methods for their preparation
US20170174614A1 (en) 2015-12-22 2017-06-22 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
EP4201427A1 (de) 2016-08-24 2023-06-28 Zogenix International Limited Formulierung zur hemmung der bildung von 5-ht2b-agonisten und verfahren zur verwendung davon
CN107311875A (zh) * 2017-06-30 2017-11-03 暨明医药科技（苏州）有限公司 重酒石酸间羟胺的合成方法
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
EP3790537A1 (de) 2018-05-11 2021-03-17 Zogenix International Limited Zusammensetzungen und verfahren zur behandlung von plötzlichem tod infolge eines krampfanfalls
FR3102480B1 (fr) * 2019-10-29 2022-02-04 Commissariat Energie Atomique Matériaux spécifiques utilisables pour la détection d’au moins un élément alcalin
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1956950A (en) 1930-04-08 1934-05-01 Bilhuber Inc E Manufacture of laevo-1-phenyl-2-methylaminopropanol-1
EP0099416B1 (de) 1982-07-20 1987-03-11 Union Carbide Corporation Kontinuierliches Verfahren zur Herstellung von Alkanolaminen
KR19990063939A (ko) * 1995-10-04 1999-07-26 그레이스 스티븐 에스. 아민 캡핑된 폴리에테르 및 이의 제조방법
GB9607917D0 (en) * 1996-04-17 1996-06-19 Swan Thomas & Co Ltd Supercritical hydrogenation
AU1798200A (en) 1998-12-24 2000-07-31 Nagase & Company, Ltd. Process for producing l-erythro-(1r,2s)-2-amino-1-phenylpropan-1-ol
AU769421B2 (en) * 1999-12-13 2004-01-29 Victoria University Yeast-based process for production of L-pac
AUPQ462599A0 (en) 1999-12-13 2000-01-13 Polychip Pharmaceuticals Pty Ltd Yeast-based process for production of l-pac

Also Published As

Publication number Publication date
EP1421055A1 (de) 2004-05-26
ATE391707T1 (de) 2008-04-15
US7176332B2 (en) 2007-02-13
WO2003018531A1 (en) 2003-03-06
AU2002328659B2 (en) 2009-07-30
US20040249212A1 (en) 2004-12-09
EP1421055B1 (de) 2008-04-09
EP1421055A4 (de) 2005-01-19
DE60226038T2 (de) 2009-05-14
AUPR732601A0 (en) 2001-09-20
JP2005500399A (ja) 2005-01-06

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Legal Events

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