DE60224276D1 - Krebsmetastasen-hemmer mit carbacyclischen phosphatidinsäurederivaten - Google Patents

Krebsmetastasen-hemmer mit carbacyclischen phosphatidinsäurederivaten

Info

Publication number
DE60224276D1
DE60224276D1 DE60224276T DE60224276T DE60224276D1 DE 60224276 D1 DE60224276 D1 DE 60224276D1 DE 60224276 T DE60224276 T DE 60224276T DE 60224276 T DE60224276 T DE 60224276T DE 60224276 D1 DE60224276 D1 DE 60224276D1
Authority
DE
Germany
Prior art keywords
carbacyclic
cancer metastasis
hemmer
acid derivatives
phosphatidic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60224276T
Other languages
English (en)
Other versions
DE60224276T2 (de
Inventor
Mutsuko Mukai
Susumu Kobayashi
Hiromu Murofushi
Kimiko Murofushi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE60224276D1 publication Critical patent/DE60224276D1/de
Application granted granted Critical
Publication of DE60224276T2 publication Critical patent/DE60224276T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
DE60224276T 2001-05-21 2002-05-20 Krebsmetastasen-hemmer mit carbacyclischen phosphatidinsäurederivaten Expired - Lifetime DE60224276T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001150685 2001-05-21
JP2001150685 2001-05-21
PCT/JP2002/004839 WO2002094286A1 (fr) 2001-05-21 2002-05-20 Inhibiteurs de metastases cancereuses contenant des derives d'acide phosphatidique carbacycliques

Publications (2)

Publication Number Publication Date
DE60224276D1 true DE60224276D1 (de) 2008-02-07
DE60224276T2 DE60224276T2 (de) 2008-12-18

Family

ID=18995665

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60224276T Expired - Lifetime DE60224276T2 (de) 2001-05-21 2002-05-20 Krebsmetastasen-hemmer mit carbacyclischen phosphatidinsäurederivaten

Country Status (6)

Country Link
US (1) US20040214799A1 (de)
EP (1) EP1402894B1 (de)
JP (1) JP4163007B2 (de)
AT (1) ATE381934T1 (de)
DE (1) DE60224276T2 (de)
WO (1) WO2002094286A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4815063B2 (ja) * 2001-04-13 2011-11-16 きみ子 室伏 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤
JP4836345B2 (ja) * 2001-04-13 2011-12-14 きみ子 室伏 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤
JP4162927B2 (ja) * 2002-06-11 2008-10-08 きみ子 室伏 カルバ環状ホスファチジン酸誘導体
CA2672534A1 (en) * 2006-12-28 2008-07-10 Ochanomizu University Analgesic agent comprising cyclic phosphatidic acid derivative
US8816110B2 (en) 2007-02-15 2014-08-26 Scf Pharma Inc. Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof
ES2561482T3 (es) * 2007-02-15 2016-02-26 Centre De Recherche Sur Les Biotechnologies Marine Monoglicéridos de ácido graso poliinsaturado, derivados, y sus usos
AU2008229604B2 (en) * 2007-03-20 2013-05-30 Scf Pharma Inc. Compositions comprising polyunsaturated fatty acid monoglycerides or derivatives thereof and uses thereof
KR101953181B1 (ko) * 2011-11-11 2019-02-28 산쇼가부시키가이샤 관절증 치료제
US10413559B2 (en) 2013-01-28 2019-09-17 Ochanomizu University Method for treating demyelinating disease
US9447020B2 (en) 2013-10-31 2016-09-20 Scf Pharma Inc. Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof
US9908909B2 (en) 2014-08-12 2018-03-06 Otsuka Chemical Co., Ltd. Crystal of cyclic phosphonic acid sodium salt and method for manufacturing same
AU2019217673A1 (en) 2018-02-07 2020-09-24 Scf Pharma Inc. Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof
CA3054203C (en) 2018-05-03 2021-01-05 Scf Pharma Inc. Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof
JP6727596B1 (ja) 2019-11-22 2020-07-22 国立大学法人お茶の水女子大学 カルバリゾホスファチジン酸
EP4252756A1 (de) 2020-11-26 2023-10-04 Sansho Co., Ltd. Therapeutikum für lungenfibrose

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US811786A (en) * 1904-03-15 1906-02-06 Franklin P Miller Tool-holder.
US936793A (en) * 1908-12-22 1909-10-12 Charles R Middleton Cutting-tool for planers, lathes, &c.
US2799079A (en) * 1955-04-29 1957-07-16 Modern Corp Cutting tools
US3124864A (en) * 1960-10-05 1964-03-17 frommelt etal
US3500522A (en) * 1967-03-01 1970-03-17 Carmet Co Cutoff tool holder
US3534457A (en) * 1968-05-02 1970-10-20 Willey S Carbide Tool Co Cutting insert mounting assembly
US3646649A (en) * 1969-09-05 1972-03-07 Kennametal Inc Grooving and cutoff tool
US3693224A (en) * 1971-03-08 1972-09-26 Fansteel Inc Grooving tool
US3959861A (en) * 1972-04-28 1976-06-01 Wlajko Mihic Clamping arrangement for a cutting tool
SE393759B (sv) * 1974-04-08 1977-05-23 Wlajko M Anordning vid skerhallare
SE392409B (sv) * 1974-10-16 1977-03-28 Seco Tools Ab Skerverktyg
FR2332090A1 (fr) * 1975-11-21 1977-06-17 Plansee Metallwerk Porte-outil, notamment pour tours a copier
IL58378A (en) * 1979-10-03 1981-10-30 Iscar Ltd Tool holder for a single cutting insert
US4321846A (en) * 1980-04-18 1982-03-30 The Gillette Company Tool holder
US4552491A (en) * 1980-06-23 1985-11-12 United Technologies Corporation Cutting tool having cylindrical ceramic insert
IL61368A (en) * 1980-10-29 1984-05-31 Iscar Ltd Holder assembly for tools such as apertured cutting inserts
DE3201508C1 (de) * 1982-01-20 1988-07-07 Mapal Fabrik für Präzisionswerkzeuge Dr.Kress KG, 7080 Aalen Einmesser-Reibahle
JP2701514B2 (ja) * 1989-06-15 1998-01-21 三菱マテリアル株式会社 スローアウエイチップのクランプ機構
JPH06228169A (ja) * 1993-02-05 1994-08-16 Sagami Chem Res Center １−ｏ−アシルグリセロール２，３−ホスフェートの製造法
DE9317533U1 (de) * 1993-11-16 1994-02-10 Krupp Widia Gmbh Halter für spanabhebende Werkzeugeinsätze
SE509362C2 (sv) * 1994-03-18 1999-01-18 Sandvik Ab Diamantbelagd kropp
JPH07258278A (ja) * 1994-03-18 1995-10-09 Sagami Chem Res Center １−Ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするＤＮＡポリメラーゼαの阻害剤
SE508666C2 (sv) * 1994-05-27 1998-10-26 Sandvik Ab Skärhållare för vändskärsplattor
JPH0925235A (ja) * 1995-07-13 1997-01-28 Sagami Chem Res Center １−ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするがん転移抑制剤
SE513952C2 (sv) * 1998-05-29 2000-12-04 Seco Tools Ab Verktyg för skärande bearbetning
US6150345A (en) * 1998-08-10 2000-11-21 Regents Of The University Of California Methods for promoting survival of myelin producing cells
SE519123C2 (sv) * 1998-12-22 2003-01-14 Seco Tools Ab Skär och verktyg för skärande bearbetning samt metod för montering av skär i detta
IL129179A0 (en) * 1999-03-25 2000-02-17 Yeda Res & Dev Cyclic glycerophosphates and analogs thereof

Also Published As

Publication number Publication date
JP4163007B2 (ja) 2008-10-08
EP1402894A1 (de) 2004-03-31
US20040214799A1 (en) 2004-10-28
EP1402894A4 (de) 2005-07-27
JPWO2002094286A1 (ja) 2004-09-02
WO2002094286A1 (fr) 2002-11-28
DE60224276T2 (de) 2008-12-18
ATE381934T1 (de) 2008-01-15
EP1402894B1 (de) 2007-12-26

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