DE60219646T2 - Poröse keramische komposit-knochenimplantate - Google Patents
Poröse keramische komposit-knochenimplantate Download PDFInfo
- Publication number
- DE60219646T2 DE60219646T2 DE60219646T DE60219646T DE60219646T2 DE 60219646 T2 DE60219646 T2 DE 60219646T2 DE 60219646 T DE60219646 T DE 60219646T DE 60219646 T DE60219646 T DE 60219646T DE 60219646 T2 DE60219646 T2 DE 60219646T2
- Authority
- DE
- Germany
- Prior art keywords
- implant
- porous
- biodegradable polymer
- slurry
- ceramic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000919 ceramic Substances 0.000 title claims abstract description 136
- 239000007943 implant Substances 0.000 title claims abstract description 68
- 239000002131 composite material Substances 0.000 title claims abstract description 26
- 210000000988 bone and bone Anatomy 0.000 title description 29
- 239000011159 matrix material Substances 0.000 claims abstract description 49
- 229920002988 biodegradable polymer Polymers 0.000 claims abstract description 47
- 239000004621 biodegradable polymer Substances 0.000 claims abstract description 47
- 210000001519 tissue Anatomy 0.000 claims abstract description 16
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 93
- 229920000642 polymer Polymers 0.000 claims description 65
- 239000006260 foam Substances 0.000 claims description 63
- 238000000576 coating method Methods 0.000 claims description 60
- 239000002002 slurry Substances 0.000 claims description 55
- 239000011248 coating agent Substances 0.000 claims description 54
- 239000002245 particle Substances 0.000 claims description 35
- 230000008569 process Effects 0.000 claims description 34
- 239000007787 solid Substances 0.000 claims description 33
- 239000000463 material Substances 0.000 claims description 27
- 210000004027 cell Anatomy 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 20
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 20
- 239000001506 calcium phosphate Substances 0.000 claims description 19
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 18
- 235000011010 calcium phosphates Nutrition 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 18
- 229920001610 polycaprolactone Polymers 0.000 claims description 14
- 239000004632 polycaprolactone Substances 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000011230 binding agent Substances 0.000 claims description 9
- 239000011575 calcium Substances 0.000 claims description 9
- 239000008177 pharmaceutical agent Substances 0.000 claims description 9
- -1 skelite TM Chemical compound 0.000 claims description 9
- 239000002270 dispersing agent Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000005245 sintering Methods 0.000 claims description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 6
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 5
- 239000002518 antifoaming agent Substances 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 239000000080 wetting agent Substances 0.000 claims description 5
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 4
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 4
- 238000005524 ceramic coating Methods 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 229910052698 phosphorus Inorganic materials 0.000 claims description 4
- 239000011574 phosphorus Substances 0.000 claims description 4
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 4
- 210000002435 tendon Anatomy 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 3
- 229920002732 Polyanhydride Polymers 0.000 claims description 3
- 229920000954 Polyglycolide Polymers 0.000 claims description 3
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 229910052586 apatite Inorganic materials 0.000 claims description 3
- 210000002449 bone cell Anatomy 0.000 claims description 3
- 238000005266 casting Methods 0.000 claims description 3
- 229910052587 fluorapatite Inorganic materials 0.000 claims description 3
- 229940077441 fluorapatite Drugs 0.000 claims description 3
- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims description 3
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 3
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims description 3
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 229940122361 Bisphosphonate Drugs 0.000 claims description 2
- 102000008138 Bone Morphogenetic Protein 3 Human genes 0.000 claims description 2
- 108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 claims description 2
- 102000055006 Calcitonin Human genes 0.000 claims description 2
- 108060001064 Calcitonin Proteins 0.000 claims description 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 2
- 102400001368 Epidermal growth factor Human genes 0.000 claims description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 2
- 229920001710 Polyorthoester Polymers 0.000 claims description 2
- 239000004115 Sodium Silicate Substances 0.000 claims description 2
- 102000013275 Somatomedins Human genes 0.000 claims description 2
- 229930003448 Vitamin K Natural products 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 150000004663 bisphosphonates Chemical class 0.000 claims description 2
- 229960004015 calcitonin Drugs 0.000 claims description 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229960003563 calcium carbonate Drugs 0.000 claims description 2
- 210000003321 cartilage cell Anatomy 0.000 claims description 2
- 229940116977 epidermal growth factor Drugs 0.000 claims description 2
- 229940011871 estrogen Drugs 0.000 claims description 2
- 239000000262 estrogen Substances 0.000 claims description 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 2
- 238000005470 impregnation Methods 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims description 2
- 239000000199 parathyroid hormone Substances 0.000 claims description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 150000003180 prostaglandins Chemical class 0.000 claims description 2
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 2
- 239000011775 sodium fluoride Substances 0.000 claims description 2
- 235000013024 sodium fluoride Nutrition 0.000 claims description 2
- 229960000414 sodium fluoride Drugs 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 2
- 239000001433 sodium tartrate Substances 0.000 claims description 2
- 229960002167 sodium tartrate Drugs 0.000 claims description 2
- 235000011004 sodium tartrates Nutrition 0.000 claims description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 2
- 239000011712 vitamin K Substances 0.000 claims description 2
- 235000019168 vitamin K Nutrition 0.000 claims description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 2
- 229940046010 vitamin k Drugs 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 2
- 230000001427 coherent effect Effects 0.000 claims 2
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 1
- 102000004058 Leukemia inhibitory factor Human genes 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 210000004523 ligament cell Anatomy 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 235000017550 sodium carbonate Nutrition 0.000 claims 1
- 235000011083 sodium citrates Nutrition 0.000 claims 1
- 235000019794 sodium silicate Nutrition 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000000316 bone substitute Substances 0.000 abstract description 13
- 230000000399 orthopedic effect Effects 0.000 abstract description 10
- 238000001727 in vivo Methods 0.000 abstract description 5
- 210000002808 connective tissue Anatomy 0.000 abstract description 3
- 239000011148 porous material Substances 0.000 description 55
- 238000004519 manufacturing process Methods 0.000 description 20
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- 229920005830 Polyurethane Foam Polymers 0.000 description 13
- 239000011496 polyurethane foam Substances 0.000 description 13
- 230000002138 osteoinductive effect Effects 0.000 description 11
- 230000010076 replication Effects 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 239000010802 sludge Substances 0.000 description 8
- 239000012620 biological material Substances 0.000 description 7
- 230000000278 osteoconductive effect Effects 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 229910010293 ceramic material Inorganic materials 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 239000003102 growth factor Substances 0.000 description 6
- 210000003041 ligament Anatomy 0.000 description 6
- 230000009974 thixotropic effect Effects 0.000 description 6
- 235000014653 Carica parviflora Nutrition 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000011068 loading method Methods 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 230000008439 repair process Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 230000008468 bone growth Effects 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 238000013508 migration Methods 0.000 description 4
- 230000005012 migration Effects 0.000 description 4
- 229920002635 polyurethane Polymers 0.000 description 4
- 239000004814 polyurethane Substances 0.000 description 4
- 229910052715 tantalum Inorganic materials 0.000 description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 4
- 241000242757 Anthozoa Species 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229920006237 degradable polymer Polymers 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000013467 fragmentation Methods 0.000 description 3
- 238000006062 fragmentation reaction Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 3
- 238000000197 pyrolysis Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000243321 Cnidaria Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 229920001247 Reticulated foam Polymers 0.000 description 2
- 102000009618 Transforming Growth Factors Human genes 0.000 description 2
- 108010009583 Transforming Growth Factors Proteins 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 230000010478 bone regeneration Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000002659 cell therapy Methods 0.000 description 2
- 238000005229 chemical vapour deposition Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000003362 replicative effect Effects 0.000 description 2
- 238000007669 thermal treatment Methods 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000036829 Device dislocation Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000003076 Osteolysis Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 210000000678 band cell Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000006261 foam material Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000006262 metallic foam Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000011226 reinforced ceramic Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000007569 slipcasting Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249967—Inorganic matrix in void-containing component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249978—Voids specified as micro
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249978—Voids specified as micro
- Y10T428/249979—Specified thickness of void-containing component [absolute or relative] or numerical cell dimension
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249981—Plural void-containing components
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Prostheses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32406801P | 2001-09-24 | 2001-09-24 | |
| US324068P | 2001-09-24 | ||
| PCT/CA2002/001450 WO2003026714A1 (en) | 2001-09-24 | 2002-09-24 | Porous ceramic composite bone grafts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60219646D1 DE60219646D1 (de) | 2007-05-31 |
| DE60219646T2 true DE60219646T2 (de) | 2007-12-27 |
Family
ID=23261920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60219646T Expired - Lifetime DE60219646T2 (de) | 2001-09-24 | 2002-09-24 | Poröse keramische komposit-knochenimplantate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7875342B2 (enExample) |
| EP (1) | EP1429817B8 (enExample) |
| JP (1) | JP4691322B2 (enExample) |
| AT (1) | ATE359836T1 (enExample) |
| AU (1) | AU2002325762B2 (enExample) |
| CA (1) | CA2460026C (enExample) |
| DE (1) | DE60219646T2 (enExample) |
| WO (1) | WO2003026714A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7524335B2 (en) | 1997-05-30 | 2009-04-28 | Smith & Nephew, Inc. | Fiber-reinforced, porous, biodegradable implant device |
| US20050158535A1 (en) * | 2003-05-15 | 2005-07-21 | Miqin Zhang | Methods for making porous ceramic structures |
| GB0311221D0 (en) | 2003-05-15 | 2003-06-18 | Orthogem Ltd | Biomaterial |
| GB0318901D0 (en) * | 2003-08-12 | 2003-09-17 | Univ Bath | Improvements in or relating to bone substitute material |
| DE102004012990A1 (de) * | 2004-04-30 | 2005-11-24 | Girlich, Dieter, Dr. | Verbundwerkstoff, Verfahren zur Herstellung eines derartigen Verbundwerkstoffes sowie dessen Verwendung |
| DE102004027657A1 (de) * | 2004-06-07 | 2006-02-02 | Zow Ag | Gekammerter Werkstoff als Implantat, Knochenersatz und allgemein als Werkstoff |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US7531190B2 (en) | 2005-05-25 | 2009-05-12 | Biomet Manufacturing Corp. | Porous ceramic structure containing biologics |
| BRPI0520465B1 (pt) * | 2005-08-10 | 2017-05-09 | Synthes Gmb | implante poroso |
| DE102005049886A1 (de) * | 2005-10-17 | 2007-04-19 | Sirona Dental Systems Gmbh | Verfahren zur Herstellung eines Zahnersatzteils |
| NL1030364C2 (nl) * | 2005-11-07 | 2007-05-08 | Ft Innovations Fti B V | Implantaat en werkwijze voor het vervaardigen van een dergelijk implantaat. |
| KR20080084808A (ko) | 2005-11-17 | 2008-09-19 | 바이오미메틱 세라퓨틱스, 인크. | ｒｈＰＤＧＦ-ＢＢ 및 생체적합성 매트릭스를 사용하는상악안면골 보강 |
| US20070116734A1 (en) * | 2005-11-18 | 2007-05-24 | Akash Akash | Porous, load-bearing, ceramic or metal implant |
| EP1991284A4 (en) * | 2006-02-01 | 2012-07-04 | Jake Barralet | BIOIMPLANTS FOR USE IN TISSUE GROWTH |
| EP2311505B1 (en) | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| EP2007317A2 (en) * | 2006-04-05 | 2008-12-31 | University Of Nebraska | Bioresorbable polymer reconstituted bone and methods of formation thereof |
| WO2007130648A2 (en) * | 2006-05-05 | 2007-11-15 | Ceramatec, Inc. | Fully or partially bioresorbable orthopedic implant |
| GB0610333D0 (en) * | 2006-05-24 | 2006-07-05 | Orthogem Ltd | Bone repair or augmentation device |
| EP3381463A1 (en) | 2006-06-30 | 2018-10-03 | BioMimetic Therapeutics, LLC | Pdgf-biomatrix compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| CA2660141A1 (en) * | 2006-08-07 | 2008-02-14 | Francois Cardarelli | Composite metallic materials, uses thereof and process for making same |
| JP5326164B2 (ja) * | 2006-09-26 | 2013-10-30 | 独立行政法人産業技術総合研究所 | 生体材料及びその作製方法と用途 |
| US7923020B2 (en) * | 2006-09-29 | 2011-04-12 | Depuy Products, Inc. | Composite for implantation in the body of an animal and method for making the same |
| CA2668189C (en) | 2006-11-03 | 2016-01-26 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures comprising a solution of platelet derived growth factor (pdgf) incorporated in a biocompatible matrix |
| CA2689675A1 (en) * | 2007-02-07 | 2008-08-14 | Mcgill University | Bioceramic implants having bioactive substance |
| US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
| US20090149569A1 (en) * | 2007-07-19 | 2009-06-11 | Shastri V Prasad | Surface engineering of tissue graft materials for enhanced porosity and cell adhesion |
| EP2214736B1 (en) * | 2007-10-29 | 2014-03-05 | Zimmer, Inc. | Medical implants and methods for delivering biologically active agents |
| CN102014977B (zh) | 2008-02-07 | 2015-09-02 | 生物模拟治疗有限责任公司 | 用于牵引成骨术的组合物和方法 |
| EP2123618A1 (en) * | 2008-05-13 | 2009-11-25 | L'AIR LIQUIDE, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Ceramic foam with gradient of porosity in heterogeneous catalysis |
| ES2329329B1 (es) | 2008-05-23 | 2010-09-17 | Institut Quimic De Sarria Cets, Fundacio Privada | Pasta termoplastica para la reparacion tejidos vivos. |
| US20090304775A1 (en) * | 2008-06-04 | 2009-12-10 | Joshi Ashok V | Drug-Exuding Orthopedic Implant |
| JP5538380B2 (ja) * | 2008-06-26 | 2014-07-02 | ケーシーアイ ライセンシング インコーポレイテッド | 減圧治療及び軟骨細胞を用いた軟骨形成の刺激 |
| US20100042213A1 (en) | 2008-08-13 | 2010-02-18 | Nebosky Paul S | Drug delivery implants |
| US8475505B2 (en) | 2008-08-13 | 2013-07-02 | Smed-Ta/Td, Llc | Orthopaedic screws |
| US9616205B2 (en) | 2008-08-13 | 2017-04-11 | Smed-Ta/Td, Llc | Drug delivery implants |
| EP2341852B1 (en) | 2008-08-29 | 2018-08-15 | SMed-TA/TD, LLC | Orthopaedic implant |
| CN102231992B (zh) | 2008-09-09 | 2015-05-20 | 生物模拟治疗公司 | 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法 |
| KR100915899B1 (ko) | 2009-02-03 | 2009-09-07 | 주식회사 디오 | 치아 및 임플란트 처치용 소결재와 그의 제조방법 및 사용방법 |
| US20100226959A1 (en) * | 2009-03-04 | 2010-09-09 | Warsaw Orthopedic, Inc. | Matrix that prolongs growth factor release |
| US20100256758A1 (en) * | 2009-04-02 | 2010-10-07 | Synvasive Technology, Inc. | Monolithic orthopedic implant with an articular finished surface |
| US8556972B2 (en) * | 2009-04-02 | 2013-10-15 | Sevika Holding AG | Monolithic orthopedic implant with an articular finished surface |
| EP2266635A1 (en) | 2009-06-26 | 2010-12-29 | Aarhus Universitet | Three-dimensional nanostructured hybrid scaffold and manufacture thereof |
| EP2456473B1 (en) * | 2009-07-23 | 2016-02-17 | Didier Nimal | Biomedical device, method for manufacturing the same and use thereof |
| US9889012B2 (en) | 2009-07-23 | 2018-02-13 | Didier NIMAL | Biomedical device, method for manufacturing the same and use thereof |
| US9399086B2 (en) * | 2009-07-24 | 2016-07-26 | Warsaw Orthopedic, Inc | Implantable medical devices |
| US8529933B2 (en) | 2009-07-27 | 2013-09-10 | Warsaw Orthopedic, Inc. | Biphasic calcium phosphate cement for drug delivery |
| US9950096B2 (en) * | 2010-01-12 | 2018-04-24 | Vanderbilt University | Particle/polyurethane composites and methods thereof |
| JP2011152490A (ja) * | 2010-01-26 | 2011-08-11 | Panasonic Electric Works Co Ltd | 濾過材およびその濾過材を用いた水処理装置ならびにその濾過材の製造方法 |
| NZ601559A (en) | 2010-02-22 | 2014-10-31 | Biomimetic Therapeutics Llc | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
| US8465582B2 (en) * | 2010-03-16 | 2013-06-18 | Taipei Medical University | Process for producing inorganic interconnected 3D open cell bone substitutes |
| WO2011123110A1 (en) * | 2010-03-30 | 2011-10-06 | Daniel Sunho Oh | Method of preparing ceramic/polymer composite scaffolds with bioactive molecules for hard tissue regeneration |
| KR101281724B1 (ko) * | 2010-04-09 | 2013-07-04 | 서울대학교산학협력단 | 생체활성인자가 포함된 유무기 혼성 코팅층을 가지는 다공성 세라믹 지지체 및 이의 제조방법 |
| MX2012012001A (es) | 2010-04-16 | 2013-05-01 | Apatech Ltd | Biomaterial. |
| EP2450066A1 (en) * | 2010-10-19 | 2012-05-09 | Protip Sas | New hybrid implant |
| WO2012094708A1 (en) * | 2011-01-12 | 2012-07-19 | The University Of Queensland | Bone graft biomaterial |
| ES2404733B2 (es) * | 2011-10-05 | 2013-09-17 | Universidad De Extremadura | Andamiaje híbrido bioactivo, método de fabricación y uso para ingeniería de tejido óseo. |
| CN103520779B (zh) * | 2012-07-02 | 2014-12-24 | 李亚屏 | 含多种活性离子的多孔复合生物材料及制备方法 |
| US20140067082A1 (en) | 2012-09-06 | 2014-03-06 | Xinyin Liu | Bioresorbable ceramic composition for forming a three dimensional scaffold |
| US9681966B2 (en) | 2013-03-15 | 2017-06-20 | Smed-Ta/Td, Llc | Method of manufacturing a tubular medical implant |
| US9724203B2 (en) | 2013-03-15 | 2017-08-08 | Smed-Ta/Td, Llc | Porous tissue ingrowth structure |
| US9408699B2 (en) | 2013-03-15 | 2016-08-09 | Smed-Ta/Td, Llc | Removable augment for medical implant |
| EP3013542A1 (de) * | 2013-06-27 | 2016-05-04 | CeramTec GmbH | Knochenersatz-material und verfahren zur herstellung von knochenersatz-material |
| BR102014003817B1 (pt) * | 2014-02-19 | 2023-09-26 | Fundação Universidade Federal De São Carlos | Processo de recobrimento descontínuo utilizando um biomaterial bioabsorvível e bioativo aplicado sobre substratos sólidos, recobrimento descontínuo e seu uso |
| JP2015228906A (ja) * | 2014-06-03 | 2015-12-21 | オリンパス株式会社 | 骨接合用インプラント |
| HUE045060T2 (hu) * | 2014-09-24 | 2019-12-30 | Matthias Rath | Eljárás habkerámia elõállítására |
| US10035174B2 (en) | 2015-02-09 | 2018-07-31 | United Technologies Corporation | Open-cell reticulated foam |
| CN105012995B (zh) * | 2015-06-04 | 2018-03-09 | 武汉维斯第医用科技股份有限公司 | 一种含促骨愈合药物的胶原蛋白海绵及其制备方法 |
| US11331191B2 (en) | 2015-08-12 | 2022-05-17 | Howmedica Osteonics Corp. | Bioactive soft tissue implant and methods of manufacture and use thereof |
| US10751909B2 (en) | 2017-08-16 | 2020-08-25 | University Of Iowa Research Foundation | Support-free additive manufacturing of ceramics |
| US20200367477A1 (en) * | 2019-05-24 | 2020-11-26 | Alexander SCHOFIELD | Artificial coral articles and preparation methods thereof |
| WO2021034958A2 (en) * | 2019-08-20 | 2021-02-25 | Theradaptive, Inc. | Materials for delivery of tetherable proteins in bone implants |
| US11751997B2 (en) * | 2019-10-15 | 2023-09-12 | b-ONE Medical (Suzhou) Co., Ltd. | Implant and a method of making the implant and a method of calculating porosity of a porous material |
| CN111346260B (zh) * | 2020-03-11 | 2021-09-14 | 四川大学 | 力学适应性的生物活性陶瓷盔甲及其制备方法 |
| FR3118602B1 (fr) * | 2021-01-07 | 2024-04-26 | Univ De Lorraine | Materiau composite a matrice homogene ou a gradient, son procede de preparation et ses utilisations |
| JP2024509814A (ja) | 2021-03-05 | 2024-03-05 | サンーゴバン アブレイシブズ，インコーポレイティド | 研磨物品及びそれを形成するための方法 |
| CN118591435A (zh) | 2021-12-30 | 2024-09-03 | 圣戈班磨料磨具有限公司 | 磨料制品及其形成方法 |
| WO2023130082A1 (en) | 2021-12-30 | 2023-07-06 | Saint-Gobain Abrasives, Inc. | Abrasive articles and methods for forming same |
| CN114712525B (zh) * | 2022-04-20 | 2024-05-31 | 中国医学科学院生物医学工程研究所 | 一种具有抗原双捕获功能的聚合物囊泡及其制备方法和应用 |
| CN119100766B (zh) * | 2024-09-13 | 2025-04-11 | 北矿新材科技有限公司 | 一种填充浆料、耐腐蚀高寿命匣钵及其制备方法和应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3946039A (en) | 1967-10-30 | 1976-03-23 | Energy Research & Generation, Inc. | Reticulated foam structure |
| BE793983A (fr) | 1972-01-14 | 1973-05-02 | Foseco Int | Fabrication de nouveaux produits ceramiques poreux |
| BE793984A (fr) | 1972-01-14 | 1973-05-02 | Foseco Int | Nouvelle fabrication de produits ceramiques poreux |
| DE2242867C3 (de) | 1972-08-31 | 1975-09-25 | Battelle-Institut E.V., 6000 Frankfurt | Verfahren zur Herstellung implantierbarer, keramischer Knochenersatz-, Knochenverbund- oder Prothesenverankerung swerkstoffe |
| US3929971A (en) | 1973-03-30 | 1975-12-30 | Research Corp | Porous biomaterials and method of making same |
| US3947363A (en) | 1974-01-02 | 1976-03-30 | Swiss Aluminium Limited | Ceramic foam filter |
| US3962081A (en) | 1975-03-28 | 1976-06-08 | Swiss Aluminium Ltd. | Ceramic foam filter |
| US4164794A (en) * | 1977-04-14 | 1979-08-21 | Union Carbide Corporation | Prosthetic devices having coatings of selected porous bioengineering thermoplastics |
| JPS577856A (en) | 1980-06-13 | 1982-01-16 | Mitsubishi Mining & Cement Co | Manufacture of calcium phosphate porous body |
| DK154260C (da) * | 1981-02-20 | 1989-05-22 | Mundipharma Gmbh | Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur. |
| US4654314A (en) | 1983-07-09 | 1987-03-31 | Sumitomo Cement Co., Ltd. | Porous ceramic material and processes for preparing same |
| US4568595A (en) | 1984-04-26 | 1986-02-04 | Morris Jeffrey R | Coated ceramic structure and method of making same |
| US4629464A (en) | 1984-09-25 | 1986-12-16 | Tdk Corporation | Porous hydroxyapatite material for artificial bone substitute |
| US4737411A (en) | 1986-11-25 | 1988-04-12 | University Of Dayton | Controlled pore size ceramics particularly for orthopaedic and dental applications |
| JP2567595B2 (ja) * | 1987-01-23 | 1996-12-25 | 京セラ株式会社 | 骨補綴部材 |
| DE4120325A1 (de) * | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | Implantatwerkstoff |
| EP0523926A3 (en) * | 1991-07-15 | 1993-12-01 | Smith & Nephew Richards Inc | Prosthetic implants with bioabsorbable coating |
| US5282861A (en) | 1992-03-11 | 1994-02-01 | Ultramet | Open cell tantalum structures for cancellous bone implants and cell and tissue receptors |
| JPH06298639A (ja) * | 1993-04-15 | 1994-10-25 | Olympus Optical Co Ltd | 薬物徐放製剤 |
| US5626861A (en) * | 1994-04-01 | 1997-05-06 | Massachusetts Institute Of Technology | Polymeric-hydroxyapatite bone composite |
| US5947893A (en) * | 1994-04-27 | 1999-09-07 | Board Of Regents, The University Of Texas System | Method of making a porous prothesis with biodegradable coatings |
| US5456833A (en) | 1994-05-02 | 1995-10-10 | Selee Corporation | Ceramic foam filter having a protective sleeve |
| GB2302656B (en) | 1994-05-24 | 1998-03-18 | Implico Bv | A biomaterial and bone implant for bone repair and replacement |
| US6376573B1 (en) | 1994-12-21 | 2002-04-23 | Interpore International | Porous biomaterials and methods for their manufacture |
| CA2230057C (en) * | 1995-09-01 | 2008-10-21 | Millenium Biologix, Inc. | An artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity |
| US5863984A (en) | 1995-12-01 | 1999-01-26 | Universite Laval, Cite Universitaire | Biostable porous material comprising composite biopolymers |
| US5964807A (en) | 1996-08-08 | 1999-10-12 | Trustees Of The University Of Pennsylvania | Compositions and methods for intervertebral disc reformation |
| US6296667B1 (en) | 1997-10-01 | 2001-10-02 | Phillips-Origen Ceramic Technology, Llc | Bone substitutes |
| US6136029A (en) | 1997-10-01 | 2000-10-24 | Phillips-Origen Ceramic Technology, Llc | Bone substitute materials |
| US6417247B1 (en) | 1997-10-14 | 2002-07-09 | Beth L. Armstrong | Polymer/ceramic composites |
| CN100569301C (zh) * | 1998-01-29 | 2009-12-16 | 沃萨乌整形外科公司 | 一种人造生物材料化合物 |
| US20030114936A1 (en) * | 1998-10-12 | 2003-06-19 | Therics, Inc. | Complex three-dimensional composite scaffold resistant to delimination |
| AU5025000A (en) | 1999-05-20 | 2000-12-12 | Boston University | Polymer re-inforced anatomically accurate bioactive prostheses |
| US6458162B1 (en) * | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
| JP3897220B2 (ja) | 2000-01-19 | 2007-03-22 | 独立行政法人物質・材料研究機構 | リン酸カルシウム系多孔質焼結体とその製造方法 |
| US6596442B1 (en) | 2000-03-23 | 2003-07-22 | International Business Machines Corporation | Asymmetric halftone biasing for sub-grid pattern adjustment |
| US6518328B2 (en) * | 2000-12-15 | 2003-02-11 | Biomet, Inc. | Coated resorbable polymer and method of making the same |
| JP2004531292A (ja) * | 2001-01-02 | 2004-10-14 | アドヴァンスト セラミックス リサーチ インコーポレイテッド | 生物医学的に適用される組成物及び方法 |
| EP1379287A1 (en) | 2001-04-12 | 2004-01-14 | Therics, Inc. | Method and apparatus for engineered regenerative biostructures |
| US6626950B2 (en) * | 2001-06-28 | 2003-09-30 | Ethicon, Inc. | Composite scaffold with post anchor for the repair and regeneration of tissue |
-
2002
- 2002-09-24 DE DE60219646T patent/DE60219646T2/de not_active Expired - Lifetime
- 2002-09-24 WO PCT/CA2002/001450 patent/WO2003026714A1/en not_active Ceased
- 2002-09-24 JP JP2003530346A patent/JP4691322B2/ja not_active Expired - Fee Related
- 2002-09-24 EP EP02760018A patent/EP1429817B8/en not_active Expired - Lifetime
- 2002-09-24 AT AT02760018T patent/ATE359836T1/de not_active IP Right Cessation
- 2002-09-24 AU AU2002325762A patent/AU2002325762B2/en not_active Ceased
- 2002-09-24 CA CA2460026A patent/CA2460026C/en not_active Expired - Fee Related
- 2002-09-24 US US10/490,492 patent/US7875342B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE359836T1 (de) | 2007-05-15 |
| WO2003026714A1 (en) | 2003-04-03 |
| JP2005512614A (ja) | 2005-05-12 |
| DE60219646D1 (de) | 2007-05-31 |
| US20060198939A1 (en) | 2006-09-07 |
| JP4691322B2 (ja) | 2011-06-01 |
| US7875342B2 (en) | 2011-01-25 |
| CA2460026C (en) | 2011-06-28 |
| EP1429817A1 (en) | 2004-06-23 |
| CA2460026A1 (en) | 2003-04-03 |
| EP1429817B8 (en) | 2007-09-12 |
| EP1429817B1 (en) | 2007-04-18 |
| AU2002325762B2 (en) | 2008-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60219646T2 (de) | Poröse keramische komposit-knochenimplantate | |
| DE69824876T2 (de) | Knochenersatzmaterialien | |
| DE60302224T2 (de) | Poröses und bioabbaubares implantatmaterial und verfahren zu seiner herstellung | |
| DE69825911T2 (de) | Knochersatzmaterial | |
| DE60116103T2 (de) | Poröse synthetische knochenimplantate und verfahren zu deren herstellung | |
| EP0743898B1 (de) | Verfahren zur herstellung eines werkstoffes | |
| JP5972788B2 (ja) | セラミックおよびポリマー性充填剤に基づく多孔性複合性移植物 | |
| EP1206292B1 (de) | Resorbierbares knochenersatz- und knochenaufbaumaterial | |
| EP1227851B1 (de) | Resorbierbares knochen-implantatmaterial sowie verfahren zur herstellung desselben | |
| AU2002325762A1 (en) | Porous ceramic composite bone grafts | |
| EP0519293B1 (de) | Implantatwerkstoff | |
| JP2013500085A5 (enExample) | ||
| KR20180003110A (ko) | 다공성 골 이식재 및 이의 제조 방법 | |
| CN102596271A (zh) | 具有设计的孔隙率的动态生物活性骨移植物材料 | |
| CN111803715B (zh) | 具有核壳结构的可降解人工骨颗粒及其制备方法 | |
| JP2023517843A (ja) | 生物活性の埋め込み可能な装置、並びに複合生体材料及びその製造方法 | |
| JPH0359703B2 (enExample) | ||
| DE10063119B4 (de) | Verfahren zur Herstellung eines synthetischen Füllmaterials und temporärer Knochendefektfüller | |
| DE4033291A1 (de) | Werkstoff und verfahren zu seiner herstellung | |
| DE102006026000A1 (de) | Bindersystem zum Verbinden von Calciumphosphatpartikeln, patientenindividuelles Knochenaufbaumittel und Verfahren zu seiner Herstellung | |
| JPS6040298B2 (ja) | 骨欠損部及び空隙部充てん材 | |
| DE102012211390B4 (de) | Synthetisches knochenersatzmaterial und verfahren zu seiner herstellung | |
| DE112016001386T5 (de) | Kohlenstoffpartikel und Komposite derselben für die Regeneration von Skelettmuskelgewebe und Weichgewebe | |
| WO2007118848A2 (de) | Verfahren zum herstellen eines biokompatiblen gerüstes, insbesondere zur herstellung eines implantates | |
| Tan et al. | Characterisation of calcium phosphate cement-derived hydroxyapatite scaffolds with a PLGA-bioactive glass composite coating |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MILLENIUM BIOLOGIX TECHNOLOGIES INC., KINGSTON, CA |
|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: WARSAW ORTHOPEDIC, INC., MINNEAPOLIS, MINN., US |