DE60214155D1 - Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür - Google Patents

Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür

Info

Publication number
DE60214155D1
DE60214155D1 DE60214155T DE60214155T DE60214155D1 DE 60214155 D1 DE60214155 D1 DE 60214155D1 DE 60214155 T DE60214155 T DE 60214155T DE 60214155 T DE60214155 T DE 60214155T DE 60214155 D1 DE60214155 D1 DE 60214155D1
Authority
DE
Germany
Prior art keywords
binding
substrate
shear
field generating
target molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60214155T
Other languages
English (en)
Other versions
DE60214155T2 (de
Inventor
Gert Desmet
Gino Baron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vrije Universiteit Brussel VUB
Universite Libre de Bruxelles ULB
Original Assignee
Vrije Universiteit Brussel VUB
Universite Libre de Bruxelles ULB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vrije Universiteit Brussel VUB, Universite Libre de Bruxelles ULB filed Critical Vrije Universiteit Brussel VUB
Publication of DE60214155D1 publication Critical patent/DE60214155D1/de
Application granted granted Critical
Publication of DE60214155T2 publication Critical patent/DE60214155T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/29—Mixing by periodically deforming flexible tubular members through which the material is flowing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • B01F31/311—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted the motion being a linear movement to one part of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/92—Construction of the plate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/43197—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
    • B01F25/431971—Mounted on the wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0812—Bands; Tapes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Discharge Heating (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60214155T 2001-04-26 2002-04-11 Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür Expired - Fee Related DE60214155T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01870091 2001-04-26
EP01870091 2001-04-26
PCT/EP2002/004034 WO2002087761A1 (en) 2001-04-26 2002-04-11 Method for accelaration and intensification of target-receptor binding and devices therefor

Publications (2)

Publication Number Publication Date
DE60214155D1 true DE60214155D1 (de) 2006-10-05
DE60214155T2 DE60214155T2 (de) 2007-07-19

Family

ID=8184962

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60214155T Expired - Fee Related DE60214155T2 (de) 2001-04-26 2002-04-11 Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür

Country Status (10)

Country Link
US (2) US20040171002A1 (de)
EP (2) EP1627686A1 (de)
JP (1) JP2004536694A (de)
AT (1) ATE337094T1 (de)
CY (1) CY1105742T1 (de)
DE (1) DE60214155T2 (de)
DK (1) DK1383603T3 (de)
ES (1) ES2271256T3 (de)
PT (1) PT1383603E (de)
WO (1) WO2002087761A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1383603E (pt) * 2001-04-26 2007-01-31 Univ Bruxelles Processo para a aceleração e intesificação da ligação receptor- alvo e dispositivo para este fim
JP2004357698A (ja) * 2003-05-09 2004-12-24 Aloka Co Ltd 処理装置
JP5016638B2 (ja) * 2003-05-09 2012-09-05 日立アロカメディカル株式会社 処理装置
EP1671101A1 (de) * 2003-10-03 2006-06-21 Vrije Universiteit Brussel Verfahren und vorrichtung zur trennung von in einer flüssigkeit vorhandenen partikeln nach grösse
WO2005046859A2 (en) * 2003-11-12 2005-05-26 Bio-Rad Haifa Ltd. System and method for carrying out multiple binding reactions in an array format
DE10354806A1 (de) * 2003-11-21 2005-06-02 Boehringer Ingelheim Microparts Gmbh Probenträger
JP4441599B2 (ja) * 2005-01-12 2010-03-31 多摩川精機株式会社 蛋白質スクリーニング装置
WO2007072373A2 (en) * 2005-12-21 2007-06-28 Koninklijke Philips Electronics N.V. A sensor for biomolecules and a method of analysis using said sensor
JP2009530601A (ja) * 2006-03-15 2009-08-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 参照物質の放出の制御が可能なマイクロエレクトロニクス素子
WO2008055096A2 (en) 2006-10-30 2008-05-08 Ventana Medical Systems, Inc. Thin film apparatus and method
EP1944080A1 (de) * 2007-01-11 2008-07-16 F.Hoffmann-La Roche Ag Vorrichtung und Verfahren zum Bewegen einer Flüssigkeit in einer Kavität
DE102008010436A1 (de) * 2008-02-21 2009-09-03 Berthold Technologies Gmbh & Co. Kg Vorrichtung und Verfahren zur Messung von Lumineszenz und Fluoreszenz von transfizierten Zellen oder Organteilen
JP5539958B2 (ja) 2008-04-02 2014-07-02 アボット ポイント オブ ケア インコーポレイテッド 薄膜状体液試料において実施される血清学的凝集イムノアッセイ及び他のイムノアッセイのための方法
US20100075863A1 (en) * 2008-09-25 2010-03-25 Northrop Grumman Systems Corporation Rotary array module for multiplexing spot-based optical readouts
WO2014150853A1 (en) * 2013-03-15 2014-09-25 Inanovate, Inc. Analyte measurement using longitudinal assay
KR101817122B1 (ko) * 2015-12-14 2018-01-10 경희대학교 산학협력단 분자 통신 시스템, 분자 통신 방법, 분자 송신기 및 분자 수신기
US20210354126A1 (en) * 2018-12-07 2021-11-18 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US11118223B2 (en) 2019-03-14 2021-09-14 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587885T2 (de) * 1984-03-21 1994-11-03 Mclaughlin William F Filtration einer flüssigen Suspension.
US4874507A (en) * 1986-06-06 1989-10-17 Whitlock David R Separating constituents of a mixture of particles
DE4108820A1 (de) * 1991-03-18 1992-09-24 Karl Dr Reuter Kontinuierliche chromatographie
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
IL106330A (en) * 1993-07-14 1998-01-04 Univ Ramot Method and instrument for determining the activity of their plaques in the initial coagulation system
EP0670489A3 (de) * 1994-03-03 1996-03-06 Ciba Geigy Ag Vorrichtung und Verfahren zur Trennung fluider Substanzen.
EP0882982A1 (de) * 1997-06-04 1998-12-09 Vrije Universiteit Brussel Verfahren und Vorrichtung zur Trennung eines Fluids
ES2247820T3 (es) * 1998-05-25 2006-03-01 Jennissen, Herbert P. Analizador de cizallamiento de circulacion para moleculas biologicas activas en capas de liquidos en superficies, procedimiento para los analisis de un liquido y procedimiento para determinar un espesor de una capa de liquido ultrafina.
PT1383603E (pt) * 2001-04-26 2007-01-31 Univ Bruxelles Processo para a aceleração e intesificação da ligação receptor- alvo e dispositivo para este fim

Also Published As

Publication number Publication date
ATE337094T1 (de) 2006-09-15
US20060078934A1 (en) 2006-04-13
PT1383603E (pt) 2007-01-31
DK1383603T3 (da) 2007-01-02
WO2002087761A1 (en) 2002-11-07
EP1383603A1 (de) 2004-01-28
ES2271256T3 (es) 2007-04-16
EP1627686A1 (de) 2006-02-22
JP2004536694A (ja) 2004-12-09
EP1383603B1 (de) 2006-08-23
DE60214155T2 (de) 2007-07-19
CY1105742T1 (el) 2010-12-22
US20040171002A1 (en) 2004-09-02

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