DE60211917T2 - Alle somatostatinrezeptorsubtypen-bindende somatostatinanaloge und deren verwendung - Google Patents

Alle somatostatinrezeptorsubtypen-bindende somatostatinanaloge und deren verwendung Download PDF

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Publication number
DE60211917T2
DE60211917T2 DE60211917T DE60211917T DE60211917T2 DE 60211917 T2 DE60211917 T2 DE 60211917T2 DE 60211917 T DE60211917 T DE 60211917T DE 60211917 T DE60211917 T DE 60211917T DE 60211917 T2 DE60211917 T2 DE 60211917T2
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DE
Germany
Prior art keywords
somatostatin
somatostatin analogues
analogues according
group
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60211917T
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German (de)
English (en)
Other versions
DE60211917D1 (de
Inventor
Robert Helmut MAECKE
Claude Jean REUBI
Hans Rink
Klaus-Peter Eisenwiener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Bern
Universitaetsspital Basel USB
Original Assignee
Universitaet Bern
Universitaetsspital Basel USB
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Filing date
Publication date
Application filed by Universitaet Bern, Universitaetsspital Basel USB filed Critical Universitaet Bern
Publication of DE60211917D1 publication Critical patent/DE60211917D1/de
Application granted granted Critical
Publication of DE60211917T2 publication Critical patent/DE60211917T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60211917T 2001-08-10 2002-08-07 Alle somatostatinrezeptorsubtypen-bindende somatostatinanaloge und deren verwendung Expired - Lifetime DE60211917T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203033A EP1283216A1 (en) 2001-08-10 2001-08-10 Somatostatin analogues binding to all somatostatin receptor subtypes and their use
EP01203033 2001-08-10
PCT/EP2002/009004 WO2003014158A1 (en) 2001-08-10 2002-08-07 Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use

Publications (2)

Publication Number Publication Date
DE60211917D1 DE60211917D1 (de) 2006-07-06
DE60211917T2 true DE60211917T2 (de) 2007-01-18

Family

ID=8180776

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60211917T Expired - Lifetime DE60211917T2 (de) 2001-08-10 2002-08-07 Alle somatostatinrezeptorsubtypen-bindende somatostatinanaloge und deren verwendung

Country Status (12)

Country Link
US (2) US7192570B2 (https=)
EP (2) EP1283216A1 (https=)
JP (1) JP2005508886A (https=)
AT (1) ATE328005T1 (https=)
AU (1) AU2002333396B2 (https=)
CA (1) CA2456881A1 (https=)
CY (1) CY1105177T1 (https=)
DE (1) DE60211917T2 (https=)
DK (1) DK1419178T3 (https=)
ES (1) ES2266616T3 (https=)
PT (1) PT1419178E (https=)
WO (1) WO2003014158A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283216A1 (en) * 2001-08-10 2003-02-12 Mallinckrodt Inc. Somatostatin analogues binding to all somatostatin receptor subtypes and their use
NZ542371A (en) * 2003-03-19 2008-10-31 Universitatsspital Basel Radiolabeled conjugates based on substance P and the uses thereof
DE602006014980D1 (de) * 2005-10-14 2010-07-29 Stichting Katholieke Univ Durch ein oder mehrere standortspezifisch konjugierte hydrazin-nikotin-amid(hynic)-teile markiertes interleukin-8 und seine verwendung zur diagnostizierung von infektionen und entzündungen
US8691761B2 (en) * 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
EP2383289B1 (en) 2006-10-16 2014-10-08 The Salk Institute for Biological Studies Receptor (SSTR2)-selective somatostatin antagonists
US8535639B2 (en) 2007-07-17 2013-09-17 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
GB0903496D0 (en) * 2009-02-27 2009-04-08 Cambridge Entpr Ltd Methods for identification
ES2351569B8 (es) * 2009-05-07 2012-06-20 Bcn Peptides S.A. Ligandos peptídicos de receptores de somatostatina.
GB0922369D0 (en) * 2009-12-22 2010-02-03 Hammersmith Imanet Ltd Labelled biotin conjugates
EP2914276A4 (en) 2012-11-01 2016-07-13 Ipsen Pharma Sas SOMATOSTATIN ANALOGA AND DIMERE OUT
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
JP6410339B2 (ja) * 2013-03-25 2018-10-24 国立大学法人千葉大学 放射性核種標識オクトレオチド誘導体
KR20250158818A (ko) 2016-02-09 2025-11-06 씨디알디 벤쳐스 인코포레이티드 소마토스타틴 수용체 길항제 화합물 및 이의 이용 방법
HRP20231458T1 (hr) 2017-01-12 2024-05-10 Radiomedix Inc. Liječenje stanica raka koje prekomjerno eksprimiraju receptore za somatostatin primjenom derivata oktreotida keliranih sa radioizotopima
CN108440664A (zh) * 2018-03-27 2018-08-24 上海欣科医药有限公司 一种用于癌症检测的生长抑素类似物及其制备方法和应用
CN112538103B (zh) * 2020-12-28 2022-10-25 合肥科生景肽生物科技有限公司 制备生长激素释放抑制素的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5819669B2 (ja) * 1978-10-28 1983-04-19 白井松新薬株式会社 新規生理活性ペプチド化合物及びその製造法
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6180082B1 (en) * 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6358491B1 (en) * 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
CA2316767A1 (en) * 1999-09-01 2001-03-01 Bridget Mccarthy Cole Somatostatin antagonists and agonists that act at the sst subtype 2 receptor
EP1283216A1 (en) 2001-08-10 2003-02-12 Mallinckrodt Inc. Somatostatin analogues binding to all somatostatin receptor subtypes and their use

Also Published As

Publication number Publication date
CY1105177T1 (el) 2010-03-03
PT1419178E (pt) 2006-09-29
EP1419178A1 (en) 2004-05-19
US20040242842A1 (en) 2004-12-02
ATE328005T1 (de) 2006-06-15
DK1419178T3 (da) 2006-10-02
EP1283216A1 (en) 2003-02-12
DE60211917D1 (de) 2006-07-06
JP2005508886A (ja) 2005-04-07
AU2002333396B2 (en) 2008-05-22
WO2003014158A1 (en) 2003-02-20
US7541018B2 (en) 2009-06-02
EP1419178B1 (en) 2006-05-31
US20070154392A1 (en) 2007-07-05
CA2456881A1 (en) 2003-02-20
ES2266616T3 (es) 2007-03-01
US7192570B2 (en) 2007-03-20

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