DE60204669D1 - Verfahren und vorrichtung zur gel-freien qualitativen proteomanalyse und deren verwendungen - Google Patents

Verfahren und vorrichtung zur gel-freien qualitativen proteomanalyse und deren verwendungen

Info

Publication number
DE60204669D1
DE60204669D1 DE60204669T DE60204669T DE60204669D1 DE 60204669 D1 DE60204669 D1 DE 60204669D1 DE 60204669 T DE60204669 T DE 60204669T DE 60204669 T DE60204669 T DE 60204669T DE 60204669 D1 DE60204669 D1 DE 60204669D1
Authority
DE
Germany
Prior art keywords
peptides
proteomanalysis
gel
qualitative
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60204669T
Other languages
English (en)
Other versions
DE60204669T2 (de
Inventor
Joel Vandekerckhove
Kris Gevaert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pronota NV
Original Assignee
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Instituut voor Biotechnologie VIB filed Critical Vlaams Instituut voor Biotechnologie VIB
Application granted granted Critical
Publication of DE60204669D1 publication Critical patent/DE60204669D1/de
Publication of DE60204669T2 publication Critical patent/DE60204669T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8411—Intermediate storage of effluent, including condensation on surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G01N30/467—Flow patterns using more than one column with separation columns in parallel all columns being identical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
DE60204669T 2001-03-22 2002-03-22 Verfahren und vorrichtung zur gel-freien qualitativen proteomanalyse und deren verwendungen Expired - Lifetime DE60204669T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US27817101P 2001-03-22 2001-03-22
US278171P 2001-03-22
US31874901P 2001-09-12 2001-09-12
US318749P 2001-09-12
US32399901P 2001-09-20 2001-09-20
US323999P 2001-09-20
PCT/EP2002/003368 WO2002077016A2 (en) 2001-03-22 2002-03-22 Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore

Publications (2)

Publication Number Publication Date
DE60204669D1 true DE60204669D1 (de) 2005-07-21
DE60204669T2 DE60204669T2 (de) 2006-05-04

Family

ID=27402974

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60204669T Expired - Lifetime DE60204669T2 (de) 2001-03-22 2002-03-22 Verfahren und vorrichtung zur gel-freien qualitativen proteomanalyse und deren verwendungen

Country Status (11)

Country Link
US (2) US6908740B2 (de)
EP (1) EP1370571B1 (de)
JP (1) JP4300029B2 (de)
AT (1) ATE297944T1 (de)
AU (2) AU2002310985B2 (de)
CA (2) CA2504413A1 (de)
DE (1) DE60204669T2 (de)
DK (1) DK1370571T3 (de)
ES (1) ES2242864T3 (de)
PT (1) PT1370571E (de)
WO (1) WO2002077016A2 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078375B1 (en) * 1996-10-25 2006-07-18 Peter Mose Larsen Diabetes-mediating proteins and therapeutic uses thereof
DE60204669T2 (de) * 2001-03-22 2006-05-04 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Verfahren und vorrichtung zur gel-freien qualitativen proteomanalyse und deren verwendungen
CA2349265A1 (en) * 2001-05-30 2002-11-30 Andrew Emili Protein expression profile database
CA2393726A1 (en) * 2002-07-16 2004-01-16 Steven J. Locke Quantitative proteomics via isotopically differentiated derivatization
US7846748B2 (en) 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
US7041472B2 (en) * 2002-12-25 2006-05-09 Shimadzu Corporation Method for selectively collecting N-terminal peptide fragment of protein
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
EP1634083A2 (de) * 2003-06-17 2006-03-15 VIB vzw Peptide-zusammenstellungen und deren anwendungen
DE10340521B4 (de) * 2003-09-03 2012-01-05 Bruker Daltonik Gmbh Verfahren selektiver Kapillarelektrophorese
JP4576972B2 (ja) * 2003-10-16 2010-11-10 株式会社島津製作所 タンパク質又はペプチドのスルホン酸誘導体化されたｎ末端ペプチドフラグメントを質量分析する方法
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
US7553625B2 (en) * 2003-12-22 2009-06-30 John Wayne Cancer Institute Method and apparatus for in vivo collection of circulating biological components
CA2556187A1 (en) * 2004-02-12 2005-09-01 John A. Mclean Advanced optics for rapidly patterned laser profiles in analytical spectrometry
DE602004019180D1 (de) * 2004-03-16 2009-03-12 Centre Nat Rech Scient Methode zur Identifizierung von unbekannten Proteinen mittels zwei-dimensionaler Auftrennung und Verwendung von Markern
GB0414233D0 (en) * 2004-06-25 2004-07-28 Bioinvent Int Ab Analysis method
US7024800B2 (en) * 2004-07-19 2006-04-11 Earthrenew, Inc. Process and system for drying and heat treating materials
US20070084077A1 (en) * 2004-07-19 2007-04-19 Gorbell Brian N Control system for gas turbine in material treatment unit
US7685737B2 (en) * 2004-07-19 2010-03-30 Earthrenew, Inc. Process and system for drying and heat treating materials
US7024796B2 (en) * 2004-07-19 2006-04-11 Earthrenew, Inc. Process and apparatus for manufacture of fertilizer products from manure and sewage
ES2473587T3 (es) * 2004-08-03 2014-07-07 Transtech Pharma, Inc. Proteínas de fusión de RAGE y métodos de uso
US7576323B2 (en) * 2004-09-27 2009-08-18 Johns Hopkins University Point-of-care mass spectrometer system
JP4563764B2 (ja) * 2004-10-01 2010-10-13 丸善製薬株式会社 ペプチドの定量方法
EP1815007A4 (de) 2004-11-15 2011-10-19 Univ North Dakota Verfahren zum einbau eines einzelnen sauerstoffatoms in verdaute peptide unter verwendung von peptidasen
US7417223B2 (en) * 2005-10-28 2008-08-26 Mds Inc. Method, system and computer software product for specific identification of reaction pairs associated by specific neutral differences
US20070163316A1 (en) * 2006-01-18 2007-07-19 Earthrenew Organics Ltd. High organic matter products and related systems for restoring organic matter and nutrients in soil
US7610692B2 (en) * 2006-01-18 2009-11-03 Earthrenew, Inc. Systems for prevention of HAP emissions and for efficient drying/dehydration processes
US20080319678A1 (en) * 2006-02-15 2008-12-25 University Of Virginia Patent Foundation Mass Tagging for Quantitative Analysis of Biomolecules using 13C Labeled Phenylisocyanate
PL2005185T3 (pl) 2006-03-22 2011-05-31 Viral Logic Systems Tech Corp Sposoby identyfikowania celów polipeptydowych
JP4609370B2 (ja) * 2006-04-24 2011-01-12 株式会社島津製作所 硫黄含有ペプチドの処理法及び硫黄原子含有ペプチドの解析法
US8580534B2 (en) * 2006-06-30 2013-11-12 The University Of North Dakota Method for incorporation of two oxygen atoms into digested peptides using peptidases
US20100044560A1 (en) * 2006-07-06 2010-02-25 Franco Basile Method and Apparatus for Pyrolysis-Induced Cleavage in Peptides and Proteins
US8637325B2 (en) * 2009-02-16 2014-01-28 University Of Wyoming Method and apparatus for pyrolysis-induced cleavage in peptides and proteins
WO2008138916A1 (en) * 2007-05-10 2008-11-20 Pronota N.V. Isolation of peptides and proteomics platform
WO2009003952A2 (en) * 2007-06-29 2009-01-08 Pronota N.V. Column and method for preparing a biological sample for protein profiling
US20100311114A1 (en) * 2007-10-19 2010-12-09 Pronota N.V. Preparation of samples for proteome analysis
JP4998230B2 (ja) * 2007-11-26 2012-08-15 株式会社島津製作所 タンパク質試料中のメチオニン残基の酸化状態を解析する方法
EP2062911A1 (de) * 2007-11-26 2009-05-27 Koninklijke Philips Electronics N.V. Selektive Anreicherung von posttranslational-modifizierten Proteinen
EP2062910A1 (de) * 2007-11-26 2009-05-27 Koninklijke Philips Electronics N.V. Selektive Anreicherung von posttranslational modifizierten Proteinen und/oder Peptiden aus komplexen Proben
CN103630640B (zh) 2007-12-05 2016-08-17 全技术联合公司 用于分析样本和收集样本流份的方法和装置
EP2108654A1 (de) * 2008-04-07 2009-10-14 Koninklijke Philips Electronics N.V. Selektive Anreicherung von N-terminal modifizierten Peptiden aus komplexen Proben
JP5181908B2 (ja) * 2008-08-04 2013-04-10 株式会社島津製作所 質量分析データ解析装置
JP5653930B2 (ja) 2008-12-04 2015-01-14 オールテック・アソシエイツ・インコーポレーテッド 流体のアリコットサンプルを移動させるための方法および装置
SG172032A1 (en) 2008-12-10 2011-07-28 Alltech Associates Inc Chromatography systems and system components
WO2010086384A1 (en) 2009-01-30 2010-08-05 Pronota N.V. Target for treatment of acute heart failure
WO2010086382A1 (en) 2009-01-30 2010-08-05 Pronota N.V. Target for treatment of acute heart failure
US20110275536A1 (en) 2009-01-30 2011-11-10 Pronota N.V. Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof
US8305582B2 (en) 2009-09-01 2012-11-06 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
CN103038645B (zh) 2010-04-13 2016-05-04 迈卡蒂斯股份有限公司 用于妊娠的高血压疾病的生物标志物
FR2982367B1 (fr) * 2011-11-08 2013-12-27 Biomerieux Sa Procede de detection de l'hemolysine delta de staphylococcus aureus par spectrometrie de masse directement a partir d'une population bacterienne
US9145764B2 (en) 2011-11-22 2015-09-29 International Strategic Alliance, Lc Pass-through bulkhead connection switch for a perforating gun
EP2956768B1 (de) 2013-02-13 2023-10-18 Promega Corporation Verfahren zur bewertung der leistung eines instruments mit funktionalitäten der flüssigkeitschromatographie und der massenspektrometrie
US20170370813A1 (en) * 2015-01-09 2017-12-28 Children's Medical Center Corporation Methods of membrane-based proteomic sample preparation
EP3387430A4 (de) * 2015-12-11 2019-08-14 Expression Pathology, Inc. Srm/mrm-tests
EP3411718B1 (de) * 2016-02-02 2020-03-25 Sandoz AG Empfindliche erkennung von proteinheterogenität unter verwendung von enzymkaskaden
SG10202012275PA (en) 2016-06-09 2021-01-28 Haimachek Inc Collector for detection and reversible capturing of cells from body fluids in vivo
US10429364B2 (en) * 2017-01-31 2019-10-01 Thermo Finnigan Llc Detecting low level LCMS components by chromatographic reconstruction
GB201701986D0 (en) * 2017-02-07 2017-03-22 Thermo Fisher Scient (Bremen) Gmbh n
EP3829733A1 (de) * 2018-07-27 2021-06-09 Waters Technologies Corporation Flüssigchromatografische/massenspektrometrische verfahren zur analyse polarer moleküle
EP3910329A1 (de) * 2020-05-14 2021-11-17 LG Chem, Ltd. Online-system zur verbesserung der nachweisempfindlichkeit von analyten durch flüssigkeitschromatographie und analyseverfahren damit
JP2023011436A (ja) * 2021-07-12 2023-01-24 株式会社日立ハイテク 質量分析システム、処理装置及び異常検出方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
EP1006362A1 (de) * 1998-12-02 2000-06-07 Michael Dr. Cahill Methode und Apparat für die Abtrennung von Komponenten aus einem biologischen Material
US6818454B2 (en) * 2001-02-16 2004-11-16 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
DE60204669T2 (de) * 2001-03-22 2006-05-04 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Verfahren und vorrichtung zur gel-freien qualitativen proteomanalyse und deren verwendungen

Also Published As

Publication number Publication date
AU2006201455A1 (en) 2006-04-27
WO2002077016A3 (en) 2003-10-09
EP1370571B1 (de) 2005-06-15
DE60204669T2 (de) 2006-05-04
AU2002310985B2 (en) 2006-05-11
JP4300029B2 (ja) 2009-07-22
JP2005500990A (ja) 2005-01-13
EP1370571A2 (de) 2003-12-17
WO2002077016A2 (en) 2002-10-03
CA2419492C (en) 2005-07-05
PT1370571E (pt) 2005-09-30
CA2419492A1 (en) 2002-10-03
DK1370571T3 (da) 2005-10-17
ES2242864T3 (es) 2005-11-16
US20050196823A1 (en) 2005-09-08
ATE297944T1 (de) 2005-07-15
CA2504413A1 (en) 2002-10-03
AU2006201455B2 (en) 2008-10-09
US6908740B2 (en) 2005-06-21
US20040005633A1 (en) 2004-01-08

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PAEKADILLY NV, ZWIJNAARDE, BE

8327 Change in the person/name/address of the patent owner

Owner name: PRONOTA NV, ZWIJNAARDE, BE