DE60203944D1 - Verbesserte herstellung von ceftiofur zwischenprodkten - Google Patents

Verbesserte herstellung von ceftiofur zwischenprodkten

Info

Publication number
DE60203944D1
DE60203944D1 DE60203944T DE60203944T DE60203944D1 DE 60203944 D1 DE60203944 D1 DE 60203944D1 DE 60203944 T DE60203944 T DE 60203944T DE 60203944 T DE60203944 T DE 60203944T DE 60203944 D1 DE60203944 D1 DE 60203944D1
Authority
DE
Germany
Prior art keywords
intermediate products
improved manufacture
ceftiofur
ceftiofur intermediate
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60203944T
Other languages
English (en)
Other versions
DE60203944T2 (de
Inventor
Narayan Deshpande
Pandharinath Khadangale
Senthil Kumar
Kumar Das
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Pharma Ltd
Original Assignee
Orchid Chemicals and Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals and Pharmaceuticals Ltd filed Critical Orchid Chemicals and Pharmaceuticals Ltd
Application granted granted Critical
Publication of DE60203944D1 publication Critical patent/DE60203944D1/de
Publication of DE60203944T2 publication Critical patent/DE60203944T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
DE60203944T 2002-01-04 2002-08-13 Verbesserte herstellung von ceftiofur zwischenprodkten Expired - Lifetime DE60203944T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35178 2002-01-04
US10/035,178 US20030135041A1 (en) 2002-01-04 2002-01-04 Synthesis of ceftiofur intermediate
PCT/IB2002/003268 WO2003055893A1 (en) 2002-01-04 2002-08-13 An improved synthesis of ceftiofur intermediate

Publications (2)

Publication Number Publication Date
DE60203944D1 true DE60203944D1 (de) 2005-06-02
DE60203944T2 DE60203944T2 (de) 2006-02-23

Family

ID=21881126

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60203944T Expired - Lifetime DE60203944T2 (de) 2002-01-04 2002-08-13 Verbesserte herstellung von ceftiofur zwischenprodkten

Country Status (12)

Country Link
US (2) US20030135041A1 (de)
EP (1) EP1463734B1 (de)
KR (1) KR100847339B1 (de)
CN (1) CN1310923C (de)
AT (1) ATE294183T1 (de)
AU (1) AU2002367103A1 (de)
BR (1) BR0215473A (de)
CA (1) CA2471310C (de)
DE (1) DE60203944T2 (de)
ES (1) ES2242044T3 (de)
MX (1) MXPA04006587A (de)
WO (1) WO2003055893A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100502390B1 (ko) * 2001-09-07 2005-07-19 주식회사 엘지생명과학 세팔로스포린산 유도체의 제조방법
DE60316459T2 (de) * 2002-10-29 2008-06-19 Lupin Ltd., Mumbai Verfahren zur herstellung von ceftiofur
US8470809B2 (en) * 2005-10-12 2013-06-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
BRPI0617561A2 (pt) * 2005-10-12 2011-08-23 Orchid Chemicals & Pharm Ltd sal de sódio cristalino antibiótico de cefalosporina
US8431562B2 (en) * 2008-08-22 2013-04-30 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
CN102234289B (zh) * 2010-05-02 2013-07-10 青岛科技大学 一种头孢噻呋中间体新的制备方法
CN103804394A (zh) * 2014-01-24 2014-05-21 瑞普（天津）生物药业有限公司 一种头孢噻呋中间体的制备方法
CN108623617B (zh) * 2017-03-22 2021-04-02 蒋辉 一种头孢噻呋中间体的制备方法
CN112645965B (zh) * 2020-12-22 2022-03-25 浙江华尔成生物药业股份有限公司 一种真空冻干注射用头孢噻呋钠的制备工艺
CN114409676A (zh) * 2021-12-24 2022-04-29 河南立诺制药有限公司 一种7-acf的制备方法
CN116535421A (zh) * 2023-07-04 2023-08-04 齐鲁晟华制药有限公司 头孢噻呋钠的合成方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565941A (en) * 1977-02-08 1980-04-23 Toyama Chemical Co Ltd Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids
US4144391A (en) * 1977-03-07 1979-03-13 Eli Lilly And Company Cephalosporin displacement reaction
US4115645A (en) * 1977-05-10 1978-09-19 Eli Lilly And Company Decolorizing process for 7-amino-3-(((2-methyl-1,3,4-thiadiazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid
FR2472574A1 (fr) 1979-12-24 1981-07-03 Ici Pharma Derives de cephalosporine et composition pharmaceutique les contenant
FR2479229B1 (fr) 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
US4472574A (en) * 1981-05-22 1984-09-18 Hoffman-La Roche Inc. Process for the manufacture of a cephem carboxylic acid derivative
AT384222B (de) * 1985-06-03 1987-10-12 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren
WO1987001117A2 (en) 1985-08-12 1987-02-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
GB9115287D0 (en) 1991-07-15 1991-08-28 Antibioticos Spa Process for the preparation of cephalosporins intermediates
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
IN184690B (de) * 1996-03-18 2000-09-23 Ranbaxy Lab Ltd
KR0176013B1 (ko) * 1996-07-19 1999-03-20 성재갑 세펨유도체의 제조방법
IN189046B (de) * 1998-03-30 2002-12-14 Ranbaxy Lab Ltd
IN189047B (de) * 1998-06-01 2002-12-14 Ranbaxy Lab Ltd
US6384213B1 (en) * 1998-10-23 2002-05-07 Ranbaxy Laboratories Limited Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
US6191123B1 (en) * 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
BR0012864A (pt) 1999-07-30 2002-06-04 Ranbaxy Lab Ltd Forma aperfeiçoada de forma i do hidrocloreto de celiprolol
IN190849B (de) 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
US6458949B1 (en) * 2000-08-14 2002-10-01 Aurobindo Pharma Limited Ceftiofur, its intermediate and a process for the preparation of the same
US6476220B2 (en) 2000-11-27 2002-11-05 Aurobindo Pharma Limited Process for the preparation of furaca
SK722003A3 (en) 2001-05-18 2003-12-02 Aurobindo Pharma Ltd Process for the crystallization of losartan potassium

Also Published As

Publication number Publication date
WO2003055893A1 (en) 2003-07-10
US6803461B2 (en) 2004-10-12
AU2002367103A1 (en) 2003-07-15
MXPA04006587A (es) 2005-07-13
KR20040098628A (ko) 2004-11-20
CA2471310A1 (en) 2003-07-10
US20030130502A1 (en) 2003-07-10
ES2242044T3 (es) 2005-11-01
US20030135041A1 (en) 2003-07-17
BR0215473A (pt) 2004-11-30
DE60203944T2 (de) 2006-02-23
EP1463734B1 (de) 2005-04-27
KR100847339B1 (ko) 2008-07-21
ATE294183T1 (de) 2005-05-15
CN1310923C (zh) 2007-04-18
CA2471310C (en) 2011-02-22
CN1639169A (zh) 2005-07-13
EP1463734A1 (de) 2004-10-06

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