ATE294183T1 - Verbesserte herstellung von ceftiofur zwischenprodkten - Google Patents

Verbesserte herstellung von ceftiofur zwischenprodkten

Info

Publication number
ATE294183T1
ATE294183T1 AT02751578T AT02751578T ATE294183T1 AT E294183 T1 ATE294183 T1 AT E294183T1 AT 02751578 T AT02751578 T AT 02751578T AT 02751578 T AT02751578 T AT 02751578T AT E294183 T1 ATE294183 T1 AT E294183T1
Authority
AT
Austria
Prior art keywords
intermediate products
improved production
ceftiofur
ceftiofur intermediate
carbonylthiol
Prior art date
Application number
AT02751578T
Other languages
English (en)
Inventor
Pramod Narayan Deshpande
C Kalakshetra
Bhausaheb Pandharin Khadangale
Road Malaviya Avenue Ramanujam
Surulichamy Senthil Kumar
Gautam Kumar Das
Original Assignee
Orchid Chemicals & Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd filed Critical Orchid Chemicals & Pharm Ltd
Application granted granted Critical
Publication of ATE294183T1 publication Critical patent/ATE294183T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
AT02751578T 2002-01-04 2002-08-13 Verbesserte herstellung von ceftiofur zwischenprodkten ATE294183T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/035,178 US20030135041A1 (en) 2002-01-04 2002-01-04 Synthesis of ceftiofur intermediate
PCT/IB2002/003268 WO2003055893A1 (en) 2002-01-04 2002-08-13 An improved synthesis of ceftiofur intermediate

Publications (1)

Publication Number Publication Date
ATE294183T1 true ATE294183T1 (de) 2005-05-15

Family

ID=21881126

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02751578T ATE294183T1 (de) 2002-01-04 2002-08-13 Verbesserte herstellung von ceftiofur zwischenprodkten

Country Status (12)

Country Link
US (2) US20030135041A1 (de)
EP (1) EP1463734B1 (de)
KR (1) KR100847339B1 (de)
CN (1) CN1310923C (de)
AT (1) ATE294183T1 (de)
AU (1) AU2002367103A1 (de)
BR (1) BR0215473A (de)
CA (1) CA2471310C (de)
DE (1) DE60203944T2 (de)
ES (1) ES2242044T3 (de)
MX (1) MXPA04006587A (de)
WO (1) WO2003055893A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100502390B1 (ko) * 2001-09-07 2005-07-19 주식회사 엘지생명과학 세팔로스포린산 유도체의 제조방법
CA2503885A1 (en) * 2002-10-29 2004-05-13 Lupin Limited A method for manufacture of ceftiofur
US8470809B2 (en) * 2005-10-12 2013-06-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
EP1934231A4 (de) * 2005-10-12 2011-10-26 Orchid Chemicals & Pharm Ltd Kristallines natriumsalz des antibiotikums cephalosporin
WO2010020871A2 (en) * 2008-08-22 2010-02-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
CN102234289B (zh) * 2010-05-02 2013-07-10 青岛科技大学 一种头孢噻呋中间体新的制备方法
CN103804394A (zh) * 2014-01-24 2014-05-21 瑞普（天津）生物药业有限公司 一种头孢噻呋中间体的制备方法
CN108623617B (zh) * 2017-03-22 2021-04-02 蒋辉 一种头孢噻呋中间体的制备方法
CN112645965B (zh) * 2020-12-22 2022-03-25 浙江华尔成生物药业股份有限公司 一种真空冻干注射用头孢噻呋钠的制备工艺
CN114409676A (zh) * 2021-12-24 2022-04-29 河南立诺制药有限公司 一种7-acf的制备方法
CN116535421A (zh) * 2023-07-04 2023-08-04 齐鲁晟华制药有限公司 头孢噻呋钠的合成方法
CN117964641A (zh) * 2023-12-07 2024-05-03 河北和煜药业科技有限公司 一种头孢噻呋中间体7-acf的制备方法
CN118561869B (zh) * 2024-08-05 2024-10-08 齐鲁晟华制药有限公司 一种头孢噻呋钠的合成方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565941A (en) * 1977-02-08 1980-04-23 Toyama Chemical Co Ltd Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids
US4144391A (en) * 1977-03-07 1979-03-13 Eli Lilly And Company Cephalosporin displacement reaction
US4115645A (en) * 1977-05-10 1978-09-19 Eli Lilly And Company Decolorizing process for 7-amino-3-(((2-methyl-1,3,4-thiadiazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid
FR2472574A1 (fr) 1979-12-24 1981-07-03 Ici Pharma Derives de cephalosporine et composition pharmaceutique les contenant
FR2479229B1 (fr) 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
US4472574A (en) * 1981-05-22 1984-09-18 Hoffman-La Roche Inc. Process for the manufacture of a cephem carboxylic acid derivative
AT384222B (de) * 1985-06-03 1987-10-12 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren
DE3650526T2 (de) 1985-08-12 1996-10-31 Upjohn Co Umwandlung des cephalosporin-hydrohalid-salzes zu einem alkalimetallsalz
GB9115287D0 (en) 1991-07-15 1991-08-28 Antibioticos Spa Process for the preparation of cephalosporins intermediates
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
IN184690B (de) * 1996-03-18 2000-09-23 Ranbaxy Lab Ltd
KR0176013B1 (ko) * 1996-07-19 1999-03-20 성재갑 세펨유도체의 제조방법
IN189046B (de) * 1998-03-30 2002-12-14 Ranbaxy Lab Ltd
IN189047B (de) * 1998-06-01 2002-12-14 Ranbaxy Lab Ltd
US6384213B1 (en) * 1998-10-23 2002-05-07 Ranbaxy Laboratories Limited Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
US6191123B1 (en) * 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
JP2003505485A (ja) 1999-07-30 2003-02-12 ランバクシー ラボラトリーズ リミテッド フォームｉセリプロロールヒドロクロリドの改良形態
IN190849B (de) 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
US6458949B1 (en) * 2000-08-14 2002-10-01 Aurobindo Pharma Limited Ceftiofur, its intermediate and a process for the preparation of the same
US6476220B2 (en) 2000-11-27 2002-11-05 Aurobindo Pharma Limited Process for the preparation of furaca
WO2002094816A1 (en) 2001-05-18 2002-11-28 Aurobindo Pharma Limited Process for the crystallization of losartan potassium

Also Published As

Publication number Publication date
US20030130502A1 (en) 2003-07-10
CA2471310C (en) 2011-02-22
CN1310923C (zh) 2007-04-18
US6803461B2 (en) 2004-10-12
ES2242044T3 (es) 2005-11-01
CN1639169A (zh) 2005-07-13
EP1463734A1 (de) 2004-10-06
AU2002367103A1 (en) 2003-07-15
KR20040098628A (ko) 2004-11-20
MXPA04006587A (es) 2005-07-13
DE60203944T2 (de) 2006-02-23
DE60203944D1 (de) 2005-06-02
US20030135041A1 (en) 2003-07-17
KR100847339B1 (ko) 2008-07-21
BR0215473A (pt) 2004-11-30
CA2471310A1 (en) 2003-07-10
WO2003055893A1 (en) 2003-07-10
EP1463734B1 (de) 2005-04-27

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