DE602008005326D1 - Pyridonamidderivate als fokale adhäsionskinase (fak)-inhibitoren und ihre verwendung zur behandlung von krebs - Google Patents
Pyridonamidderivate als fokale adhäsionskinase (fak)-inhibitoren und ihre verwendung zur behandlung von krebsInfo
- Publication number
- DE602008005326D1 DE602008005326D1 DE602008005326T DE602008005326T DE602008005326D1 DE 602008005326 D1 DE602008005326 D1 DE 602008005326D1 DE 602008005326 T DE602008005326 T DE 602008005326T DE 602008005326 T DE602008005326 T DE 602008005326T DE 602008005326 D1 DE602008005326 D1 DE 602008005326D1
- Authority
- DE
- Germany
- Prior art keywords
- cancer
- pyridonamide
- fak
- inhibitors
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07016399A EP2065380A1 (de) | 2007-08-22 | 2007-08-22 | Pyridonamid-Derivate als Focal-Adhesion-Kinase (FAK) Hemmer und deren Verwendung zur Behandlung von Krebs |
| PCT/EP2008/006834 WO2009024332A1 (en) | 2007-08-22 | 2008-08-20 | Pyridoneamide derivatives as focal adhesion kinase (fak) inhibitors and their use for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602008005326D1 true DE602008005326D1 (de) | 2011-04-14 |
Family
ID=38924813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602008005326T Active DE602008005326D1 (de) | 2007-08-22 | 2008-08-20 | Pyridonamidderivate als fokale adhäsionskinase (fak)-inhibitoren und ihre verwendung zur behandlung von krebs |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110218199A1 (de) |
| EP (2) | EP2065380A1 (de) |
| JP (1) | JP2010536813A (de) |
| CN (1) | CN101784538A (de) |
| AT (1) | ATE500245T1 (de) |
| CA (1) | CA2696197A1 (de) |
| DE (1) | DE602008005326D1 (de) |
| ES (1) | ES2360162T3 (de) |
| WO (1) | WO2009024332A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101150530B1 (ko) | 2009-06-01 | 2012-06-01 | 연세대학교 산학협력단 | 신규한 피리돈 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 암 치료용 약학 조성물 |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| DK2675794T3 (da) | 2011-02-17 | 2019-05-06 | Cancer Therapeutics Crc Pty Ltd | Selektive fak-inhibitorer |
| ES2691673T3 (es) | 2011-02-17 | 2018-11-28 | Cancer Therapeutics Crc Pty Limited | Inhibidores de Fak |
| WO2015054477A1 (en) | 2013-10-09 | 2015-04-16 | The General Hospital Corporation | Methods of diagnosing and treating b cell acute lymphoblastic leukemia |
| SI3077374T1 (sl) | 2013-12-03 | 2020-07-31 | Fmc Corporation | Pirolidinoni kot herbicidi |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| AU2015284280C1 (en) | 2014-07-02 | 2020-02-13 | Fmc Corporation | Piperidinone herbicides |
| BR112017009701B1 (pt) | 2014-12-08 | 2021-09-08 | Fmc Corporation | Composto e métodos de preparação de compostos |
| BR112017017945B1 (pt) | 2015-04-10 | 2021-06-08 | Fmc Corporation | composto, composições herbicidas, mistura herbicida e método de controle do crescimento de vegetação indesejada |
| WO2016176082A1 (en) | 2015-04-27 | 2016-11-03 | E I Du Pont De Nemours And Company | Butyrolactones as herbicides |
| CN107592862B (zh) | 2015-05-12 | 2021-06-15 | Fmc公司 | 作为除草剂的芳基取代的双环化合物 |
| US10906873B2 (en) | 2015-05-29 | 2021-02-02 | Fmc Corporation | Substituted cyclic amides as herbicides |
| EP3303321A1 (de) | 2015-06-02 | 2018-04-11 | E. I. du Pont de Nemours and Company | Substituierte cyclische amide und deren verwendung als herbizide |
| AU2016296878B2 (en) | 2015-07-21 | 2020-12-17 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles and uses thereof |
| AU2016303209B2 (en) | 2015-07-31 | 2021-04-01 | Fmc Corporation | Cyclic N-carboxamide compounds useful as herbicides |
| BR112019012910B1 (pt) | 2016-12-21 | 2023-10-17 | Fmc Corporation | Composto, composição herbicida, mistura herbicida e método para controlar o crescimento de vegetação indesejável |
| BR112019019605B1 (pt) | 2017-03-21 | 2023-03-07 | Fmc Corporation | Compostos e processo para preparar um composto de fórmula ii-a |
| CA3057300A1 (en) | 2017-03-21 | 2018-09-27 | Fmc Corporation | Herbicidal mixture, composition and method |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| WO2024105363A1 (en) | 2022-11-15 | 2024-05-23 | Curadev Pharma Ltd | Pyridone and pyrimidinone inhibitors of hematopoietic progenitor kinase 1 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0002320D0 (sv) * | 1999-10-25 | 2000-06-21 | Active Biotech Ab | Malignant tumors |
| RU2003131693A (ru) * | 2001-03-28 | 2005-05-10 | Бристол-Маерс Сквибб Компани (Us) | Новые ингибиторы тирозин киназ |
| WO2004063151A2 (en) * | 2003-01-03 | 2004-07-29 | Bristol-Myers Squibb Company | Novel tyrosine kinase inhibitors |
-
2007
- 2007-08-22 EP EP07016399A patent/EP2065380A1/de not_active Ceased
-
2008
- 2008-08-20 DE DE602008005326T patent/DE602008005326D1/de active Active
- 2008-08-20 JP JP2010521355A patent/JP2010536813A/ja active Pending
- 2008-08-20 ES ES08785643T patent/ES2360162T3/es active Active
- 2008-08-20 CN CN200880103731A patent/CN101784538A/zh active Pending
- 2008-08-20 CA CA2696197A patent/CA2696197A1/en not_active Abandoned
- 2008-08-20 US US12/672,332 patent/US20110218199A1/en not_active Abandoned
- 2008-08-20 AT AT08785643T patent/ATE500245T1/de not_active IP Right Cessation
- 2008-08-20 WO PCT/EP2008/006834 patent/WO2009024332A1/en active Application Filing
- 2008-08-20 EP EP08785643A patent/EP2190834B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010536813A (ja) | 2010-12-02 |
| ATE500245T1 (de) | 2011-03-15 |
| WO2009024332A1 (en) | 2009-02-26 |
| EP2190834B1 (de) | 2011-03-02 |
| ES2360162T3 (es) | 2011-06-01 |
| EP2065380A1 (de) | 2009-06-03 |
| EP2190834A1 (de) | 2010-06-02 |
| CN101784538A (zh) | 2010-07-21 |
| CA2696197A1 (en) | 2009-02-26 |
| US20110218199A1 (en) | 2011-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602008005326D1 (de) | Pyridonamidderivate als fokale adhäsionskinase (fak)-inhibitoren und ihre verwendung zur behandlung von krebs | |
| MX2009002010A (es) | Derivados de heteroarilo como inhibidores de la proteina cinasa. | |
| ATE499372T1 (de) | Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel | |
| MX2007003104A (es) | Nuevos derivados de ftalazinona, como inhibidores de cinasa aurora-a. | |
| DE602004011199D1 (de) | 5-phenylthiazolderivate und deren verwendung als p13-kinase-inhibitoren | |
| WO2006066913A3 (en) | Benzamide substituted imidazo- and pyrolo-pyridines as protein kinase inhibitors | |
| WO2006066914A3 (en) | Carbamate substituted imidazo- and pyrrolo-pyridines as protein kinase inhibitors | |
| TW200730502A (en) | Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents | |
| ATE400570T1 (de) | 2,4,6-trisubstituierte pyrimidine als inhibitoren von phosphatidylinosit-(pi-)3-kinase und deren verwendung bei der behandlung von krebs | |
| MX2007004248A (es) | Derivados heterociclicos de bisarilurea sustituidos como inhibidores de cinasa. | |
| NO20080675L (no) | P38-Map kinaseinhibitorer og metoder for deres anvendelse | |
| EA201200174A1 (ru) | Производные оксазина и их применение в качестве ингибиторов bace для лечения неврологических нарушений | |
| EA200970447A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
| IL196543A (en) | Pyridazinone derivatives, pharmaceutical preparations containing them for use in the treatment of disorders | |
| DK1519724T3 (da) | Fredericamycin-derivater som lægemidler til behandling af tumorer | |
| WO2009121535A3 (en) | Antiproliferative compounds and therapeutic uses thereof | |
| TW200531688A (en) | Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents | |
| ATE439361T1 (de) | 7h-pyridoä3,4-düpyrimidin-8-one, ihre herstellung und ihre verwendung als proteinkinaseinhibitoren | |
| TW200719899A (en) | Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents | |
| ATE485280T1 (de) | Pyrimidylderivate als proteinkinaseinhibitoren | |
| MX2008011769A (es) | Derivados de ftalazinona pirazol, su fabricacion y uso como agentes farmaceuticos. | |
| TW200736220A (en) | Pyridylsulfonamide derivatives, their manufacture and use as pharmaceutical agents | |
| TW200720239A (en) | Styrylsulfonamides, their manufacture and use as pharmaceutical agents | |
| TW200612914A (en) | Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents | |
| MX2008001412A (es) | Derivados de fenilpiridina, su obtencion y su utilizacion como agentes farmaceuticos. |