DE602007012303D1 - Auf einem modifizierten alphahelikalen bereich von ubiquitin beruhende künstliche bindungsproteine - Google Patents
Auf einem modifizierten alphahelikalen bereich von ubiquitin beruhende künstliche bindungsproteineInfo
- Publication number
- DE602007012303D1 DE602007012303D1 DE602007012303T DE602007012303T DE602007012303D1 DE 602007012303 D1 DE602007012303 D1 DE 602007012303D1 DE 602007012303 T DE602007012303 T DE 602007012303T DE 602007012303 T DE602007012303 T DE 602007012303T DE 602007012303 D1 DE602007012303 D1 DE 602007012303D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- ubiquitin
- alphahelical
- cultural
- tie
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Inorganic Insulating Materials (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06124137A EP1925664A1 (de) | 2006-11-15 | 2006-11-15 | Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin |
| PCT/EP2007/062375 WO2008059011A1 (en) | 2006-11-15 | 2007-11-15 | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007012303D1 true DE602007012303D1 (de) | 2011-03-10 |
Family
ID=38024317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007012303T Active DE602007012303D1 (de) | 2006-11-15 | 2007-11-15 | Auf einem modifizierten alphahelikalen bereich von ubiquitin beruhende künstliche bindungsproteine |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8592179B2 (de) |
| EP (2) | EP1925664A1 (de) |
| CN (1) | CN101563456A (de) |
| AT (1) | ATE496999T1 (de) |
| DE (1) | DE602007012303D1 (de) |
| DK (1) | DK2094845T3 (de) |
| ES (1) | ES2358856T3 (de) |
| WO (1) | WO2008059011A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| US6639684B1 (en) * | 2000-09-13 | 2003-10-28 | Nextengine, Inc. | Digitizer using intensity gradient to image features of three-dimensional objects |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| EP1925664A1 (de) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin |
| AU2010332932B2 (en) * | 2009-12-14 | 2013-01-17 | Navigo Proteins Gmbh | Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin |
| EP2719707A3 (de) | 2010-08-10 | 2014-09-10 | The Governing Council Of The University Of Toronto | Spezifische Hemmer des aktiven Zentrums von Enzymen oder substratbindenden Partnern sowie Herstellungsverfahren dafür |
| CA2837804C (en) * | 2011-06-15 | 2018-03-20 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
| US10373702B2 (en) * | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
| US10858405B2 (en) | 2015-02-06 | 2020-12-08 | Navigo Proteins Gmbh | EGFR binding proteins |
| GB201505393D0 (en) * | 2015-03-30 | 2015-05-13 | Secr Defence | Antimicrobal peptide formulations |
| US10808042B2 (en) | 2015-07-16 | 2020-10-20 | Navigo Proteins Gmbh | Immunoglobulin-binding proteins and their use in affinity purification |
| US10584152B2 (en) | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
| WO2017191252A1 (en) | 2016-05-04 | 2017-11-09 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CA3030208A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| EP3706804B1 (de) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusionsproteine mit spezifität für ed-b und langer serumhalbwertszeit für diagnose oder behandlung von krebs |
| CN110025766B (zh) * | 2019-04-22 | 2022-03-08 | 南京医科大学 | 丝束蛋白t的医药用途 |
| CN111733162A (zh) * | 2020-07-01 | 2020-10-02 | 江苏莱森生物科技研究院有限公司 | 一种经基因修饰的cd47蛋白及其单克隆抗体和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| AU7142796A (en) | 1995-10-02 | 1997-04-28 | Erasmus University Rotterdam | Diagnosis method and reagents |
| WO1997016556A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
| US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| FR2761688A1 (fr) | 1997-04-02 | 1998-10-09 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| WO1998054312A1 (en) | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
| DK0985039T3 (da) | 1997-06-12 | 2008-06-09 | Novartis Int Pharm Ltd | Kunstige antistof-polypeptider |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| WO2001062298A2 (en) | 2000-02-24 | 2001-08-30 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| CA2400622A1 (en) | 2000-02-24 | 2001-08-30 | Eidgenossische Technische Hochschule Zurich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| US6799121B2 (en) | 2000-03-30 | 2004-09-28 | York University | Sequencing of peptides by mass spectrometry |
| US20110179531A1 (en) | 2000-05-09 | 2011-07-21 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US20040043386A1 (en) | 2002-08-30 | 2004-03-04 | Todd Pray | Methods and compositions for functional ubiquitin assays |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| GB2422836A (en) * | 2003-11-04 | 2006-08-09 | Univ Yale | Protein binding miniature proteins |
| WO2005059131A2 (en) * | 2003-12-11 | 2005-06-30 | Yale University | Protein binding miniature proteins and uses thereof |
| DE102004049479A1 (de) | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| ES2341126T3 (es) | 2005-05-11 | 2010-06-15 | Philogen S.P.A. | Proteina de fusion del anticuerpo l19 contra fibronectina ed-b e interleucina 12. |
| EP1945767B1 (de) | 2005-11-09 | 2010-04-07 | MorphoSys AG | Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern |
| EP1842553A1 (de) | 2006-04-07 | 2007-10-10 | Bayer Schering Pharma Aktiengesellschaft | Kombination von einem Anti-EDb Fibronektin Domäne Antikörper/ IL2 Fusionsprotein und einem kleinen Molekül |
| AU2007247380B2 (en) | 2006-05-08 | 2011-03-10 | Philogen Spa | Antibody-targeted cytokines for therapy |
| EP1892248A1 (de) | 2006-08-21 | 2008-02-27 | Eidgenössische Technische Hochschule Zürich | Bindeproteine mit spezifischer und hoher Affinität enthaltend modifizierte SH3-Domänen von FYN-Kinasen |
| EP1925664A1 (de) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin |
| EP1955712A1 (de) | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeres Konjugat |
| AU2010332932B2 (en) | 2009-12-14 | 2013-01-17 | Navigo Proteins Gmbh | Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin |
-
2006
- 2006-11-15 EP EP06124137A patent/EP1925664A1/de not_active Withdrawn
-
2007
- 2007-11-15 US US12/514,550 patent/US8592179B2/en active Active
- 2007-11-15 ES ES07847173T patent/ES2358856T3/es active Active
- 2007-11-15 EP EP07847173A patent/EP2094845B1/de active Active
- 2007-11-15 DK DK07847173.7T patent/DK2094845T3/da active
- 2007-11-15 CN CNA2007800471328A patent/CN101563456A/zh active Pending
- 2007-11-15 DE DE602007012303T patent/DE602007012303D1/de active Active
- 2007-11-15 WO PCT/EP2007/062375 patent/WO2008059011A1/en active Application Filing
- 2007-11-15 AT AT07847173T patent/ATE496999T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2358856T3 (es) | 2011-05-16 |
| US8592179B2 (en) | 2013-11-26 |
| ATE496999T1 (de) | 2011-02-15 |
| US20100130720A1 (en) | 2010-05-27 |
| EP2094845B1 (de) | 2011-01-26 |
| EP2094845A1 (de) | 2009-09-02 |
| CN101563456A (zh) | 2009-10-21 |
| DK2094845T3 (da) | 2011-03-21 |
| EP1925664A1 (de) | 2008-05-28 |
| WO2008059011A1 (en) | 2008-05-22 |
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