DE602006020407D1 - Peptide mit neuropeptide-2 rezeptor agonist aktivität - Google Patents

Peptide mit neuropeptide-2 rezeptor agonist aktivität

Info

Publication number
DE602006020407D1
DE602006020407D1 DE602006020407T DE602006020407T DE602006020407D1 DE 602006020407 D1 DE602006020407 D1 DE 602006020407D1 DE 602006020407 T DE602006020407 T DE 602006020407T DE 602006020407 T DE602006020407 T DE 602006020407T DE 602006020407 D1 DE602006020407 D1 DE 602006020407D1
Authority
DE
Germany
Prior art keywords
neuropeptide
peptides
receptor agonist
agonist activity
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006020407T
Other languages
English (en)
Inventor
Waleed Danho
George Ehrlich
David C Fry
Wajiha Khan
Joseph Swistok
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602006020407D1 publication Critical patent/DE602006020407D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602006020407T 2005-01-18 2006-01-11 Peptide mit neuropeptide-2 rezeptor agonist aktivität Active DE602006020407D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64484005P 2005-01-18 2005-01-18
PCT/EP2006/000161 WO2006077035A1 (en) 2005-01-18 2006-01-11 Peptides with neuropeptide-2 receptor (y2r) agonist activity

Publications (1)

Publication Number Publication Date
DE602006020407D1 true DE602006020407D1 (de) 2011-04-14

Family

ID=36118121

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006020407T Active DE602006020407D1 (de) 2005-01-18 2006-01-11 Peptide mit neuropeptide-2 rezeptor agonist aktivität

Country Status (22)

Country Link
US (1) US7410949B2 (de)
EP (1) EP1844070B1 (de)
JP (1) JP4633804B2 (de)
KR (1) KR100905380B1 (de)
CN (1) CN101107266A (de)
AR (1) AR051904A1 (de)
AT (1) ATE500268T1 (de)
AU (1) AU2006207659B2 (de)
BR (1) BRPI0606675A2 (de)
CA (1) CA2594423A1 (de)
DE (1) DE602006020407D1 (de)
DK (1) DK1844070T3 (de)
ES (1) ES2359850T3 (de)
IL (1) IL184428A0 (de)
MX (1) MX2007008614A (de)
NO (1) NO20073664L (de)
PL (1) PL1844070T3 (de)
PT (1) PT1844070E (de)
RU (1) RU2383553C2 (de)
TW (1) TWI309653B (de)
WO (1) WO2006077035A1 (de)
ZA (1) ZA200705674B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE549350T1 (de) * 2005-12-07 2012-03-15 Hoffmann La Roche Neuropeptid-2-rezeptor-agonisten
US8299023B2 (en) * 2008-09-17 2012-10-30 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists
CA2741921A1 (en) * 2008-11-05 2010-05-14 F. Hoffmann-La Roche Ag Neuropeptide-2-receptor (y-2r) agonists and uses thereof
US9260500B2 (en) 2009-07-02 2016-02-16 Takeda Pharmaceutical Company Limited Peptide and use thereof
EP2477643A1 (de) * 2009-09-18 2012-07-25 Novo Nordisk A/S V2-rezeptoragonisten mit langzeitwirkung
WO2011045232A2 (en) * 2009-10-13 2011-04-21 F. Hoffmann-La Roche Ag Neuropeptide-2 receptor (y-2r) agonists
MX345501B (es) 2010-12-16 2017-02-02 Novo Nordisk As Composiciones solidas que comprenden agonista de glp-1 y sal del acido n-(8-(2-hidroxibenzoil)amino)caprilico.
MY171146A (en) 2012-03-22 2019-09-27 Novo Nordisk As Compositions of glp-1 peptides and preparation thereof
TWI633087B (zh) 2012-06-13 2018-08-21 赫孚孟拉羅股份公司 新穎二氮雜螺環烷及氮雜螺環烷
SI2900669T1 (sl) 2012-09-25 2019-12-31 F. Hoffmann-La Roche Ag Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
US10246497B2 (en) 2013-11-15 2019-04-02 Novo Nordisk A/S Selective PYY compounds and uses thereof
CN105764919B (zh) 2013-11-15 2021-04-27 诺和诺德股份有限公司 在位置35具有β-高精氨酸置换的hPYY(1-36)
SI3074400T1 (en) 2013-11-26 2018-03-30 F. Hoffmann-La Roche Ag Octahydro-cyclobut (1,2-c, 3,4-cy) dipyrrole derivatives as autoantaxine inhibitors
AU2015238541B2 (en) 2014-03-26 2019-09-19 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
AU2015238537B2 (en) 2014-03-26 2019-08-01 F. Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
MA41898A (fr) * 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CA2988500A1 (en) 2015-06-12 2016-12-15 Novo Nordisk A/S Selective pyy compounds and uses thereof
PE20180479A1 (es) 2015-09-04 2018-03-07 Hoffmann La Roche Nuevos derivados de fenoximetilo
RU2018114289A (ru) 2015-09-24 2019-10-24 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов аутотаксина (atx)
MA42919A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
PE20180552A1 (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca
WO2018167001A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as dual atx/ca inhibitors
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
EP3717508A1 (de) 2017-12-01 2020-10-07 The University of Copenhagen Peptidhormon mit einem oder mehreren o-glykanen
KR102647171B1 (ko) 2018-02-02 2024-03-15 노보 노르디스크 에이/에스 Glp-1 작용제 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형 조성물
EP3800195A1 (de) * 2019-10-03 2021-04-07 Universitat de Barcelona Peptidverbindungen zur reduzierung der nebenwirkungen von cb1-rezeptoragonisten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
NZ265452A (en) 1993-03-29 1997-09-22 Univ Cincinnati Analogues of peptide yy, dimers and pharmaceutical compositions
US6017879A (en) * 1998-04-03 2000-01-25 B.M.R.A. Corporation B.V. Template associated NPY Y2-receptor agonists
EP1583549A4 (de) * 2003-01-17 2006-10-04 Sod Conseils Rech Applic Yy-peptid-analoga
WO2005053726A1 (en) * 2003-11-25 2005-06-16 Bayer Pharmaceuticals Corporation Selective neuropeptide y2 receptor agonists
EP1789440A4 (de) * 2004-02-11 2008-03-12 Amylin Pharmaceuticals Inc Pankreas-polypeptidfamilienmotive und diese enthaltende polypeptide

Also Published As

Publication number Publication date
KR20070095422A (ko) 2007-09-28
CN101107266A (zh) 2008-01-16
US20060160742A1 (en) 2006-07-20
MX2007008614A (es) 2007-09-11
ES2359850T3 (es) 2011-05-27
AU2006207659B2 (en) 2009-10-29
ZA200705674B (en) 2009-08-26
PL1844070T3 (pl) 2011-07-29
RU2007131504A (ru) 2009-02-27
IL184428A0 (en) 2007-10-31
ATE500268T1 (de) 2011-03-15
CA2594423A1 (en) 2006-07-27
TW200637874A (en) 2006-11-01
JP4633804B2 (ja) 2011-02-16
EP1844070A1 (de) 2007-10-17
JP2008527017A (ja) 2008-07-24
AR051904A1 (es) 2007-02-14
WO2006077035A9 (en) 2006-10-26
AU2006207659A1 (en) 2006-07-27
DK1844070T3 (da) 2011-06-14
EP1844070B1 (de) 2011-03-02
US7410949B2 (en) 2008-08-12
PT1844070E (pt) 2011-05-04
RU2383553C2 (ru) 2010-03-10
BRPI0606675A2 (pt) 2009-07-07
NO20073664L (no) 2007-09-28
TWI309653B (en) 2009-05-11
KR100905380B1 (ko) 2009-06-30
WO2006077035A1 (en) 2006-07-27

Similar Documents

Publication Publication Date Title
ATE500268T1 (de) Peptide mit neuropeptide-2 rezeptor agonist aktivität
FR22C1054I2 (fr) Amides peptidiques synthetiques
FIC20230027I1 (fi) Tremelimumabi
ATE480555T1 (de) Antimykotische polypeptide
DK1776133T3 (da) Peptid-vasopressin-receptor-agonister
DE602005015131D1 (de) Interleukin-15-antagonistisches peptid
CU23872B1 (es) Anticuerpos antagonistas dirigidos contra el péptido relacionado con el gen de calcitonina
BRPI0818288A2 (pt) Proteínas conjugadas e peptídeos.
DK1973886T3 (da) Prokineticin-1-receptor-antagonister
DE602006007563D1 (de) Agonisten
DK2035447T3 (da) Polypeptid
GB2429976B (en) Repeatable protein arrays
DK1711465T3 (da) Hydroisoindolin-tachykinikreceptorantagonister
ATE482281T1 (de) Plastiden transit peptide
ATE549350T1 (de) Neuropeptid-2-rezeptor-agonisten
DK2160221T3 (da) Cykliske peptid-CXCR4-antagonister
IS8482A (is) Kalsítóníngen-skyldir peptíðviðtaka antagónistar
IL184284A0 (en) Modified beta thymosin peptides
IL189922A0 (en) Selective vpac2 receptor peptide agonists
DE602006006428D1 (de) Material mit trennbarer struktur
DK2468292T3 (da) Nyt peptid med antisekretorisk aktivitet
ATE397618T1 (de) Peptidcyclisierung
DK1809660T3 (da) Thymus-specifikt protein
DK2207790T3 (da) Biologisk aktive C-terminalt argininholdige peptider
DK1968623T3 (da) Bacteriocin-inducer-peptider