DE602006017797D1 - - Google Patents
Info
- Publication number
- DE602006017797D1 DE602006017797D1 DE602006017797T DE602006017797T DE602006017797D1 DE 602006017797 D1 DE602006017797 D1 DE 602006017797D1 DE 602006017797 T DE602006017797 T DE 602006017797T DE 602006017797 T DE602006017797 T DE 602006017797T DE 602006017797 D1 DE602006017797 D1 DE 602006017797D1
- Authority
- DE
- Germany
- Prior art keywords
- maytansinoid
- anion
- ester
- maytansinol
- disulfide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64498405P | 2005-01-21 | 2005-01-21 | |
| PCT/US2006/001885 WO2006078809A2 (en) | 2005-01-21 | 2006-01-20 | Method for the preparation of maytansinoid esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006017797D1 true DE602006017797D1 (de) | 2010-12-09 |
Family
ID=36692868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006017797T Active DE602006017797D1 (de) | 2005-01-21 | 2006-01-20 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7301019B2 (de) |
| EP (1) | EP1838715B1 (de) |
| JP (2) | JP5425402B2 (de) |
| AT (1) | ATE486077T1 (de) |
| AU (1) | AU2006206421B2 (de) |
| CA (1) | CA2601670C (de) |
| CY (1) | CY1111157T1 (de) |
| DE (1) | DE602006017797D1 (de) |
| DK (1) | DK1838715T3 (de) |
| ES (1) | ES2355153T3 (de) |
| PL (1) | PL1838715T3 (de) |
| PT (1) | PT1838715E (de) |
| SI (1) | SI1838715T1 (de) |
| WO (1) | WO2006078809A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7589180B2 (en) | 2001-05-11 | 2009-09-15 | Abbott Laboratories Inc. | Specific binding proteins and uses thereof |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| AU2006280146B2 (en) * | 2005-08-09 | 2012-06-28 | Immunogen, Inc. | Method of acylating maytansinol with chiral amino acids |
| WO2008091701A2 (en) | 2007-01-25 | 2008-07-31 | Dana-Farber Cancer Institute | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
| WO2008115404A1 (en) | 2007-03-15 | 2008-09-25 | Ludwing Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| CN101802013B (zh) | 2007-07-16 | 2014-07-02 | 健泰科生物技术公司 | 人源化抗cd79b抗体和免疫偶联物及使用方法 |
| NZ583367A (en) | 2007-07-16 | 2012-10-26 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
| CA2696360C (en) | 2007-08-14 | 2018-11-20 | Ludwig Institute For Cancer Research | Monoclonal antibody targeting the egfr receptor and uses thereof |
| MX2010008437A (es) | 2008-01-31 | 2010-11-25 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados y metodos de uso. |
| WO2010120561A1 (en) | 2009-04-01 | 2010-10-21 | Genentech, Inc. | Anti-fcrh5 antibodies and immunoconjugates and methods of use |
| KR20120080611A (ko) | 2009-10-06 | 2012-07-17 | 이뮤노젠 아이엔씨 | 효능 있는 접합체 및 친수성 링커 |
| RU2573994C2 (ru) | 2010-02-10 | 2016-01-27 | Иммьюноджен, Инк | Антитела против cd20 и их применение |
| JP5889912B2 (ja) | 2010-11-17 | 2016-03-22 | ジェネンテック， インコーポレイテッド | アラニニルメイタンシノール抗体コンジュゲート |
| CA2824864C (en) | 2011-02-15 | 2019-04-09 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| US9289512B2 (en) | 2011-06-21 | 2016-03-22 | Immunogen, Inc. | Maytansinoid derivatives with peptide linker and conjugates thereof |
| EA027900B1 (ru) | 2011-09-22 | 2017-09-29 | Эмджен Инк. | Связывающие антиген cd27l белки |
| CN102731526B (zh) * | 2012-05-14 | 2014-09-10 | 福建省微生物研究所 | 安丝菌素类化合物及其制备方法 |
| UY34813A (es) | 2012-05-18 | 2013-11-29 | Amgen Inc | Proteínas de unión a antígeno dirigidas contra el receptor st2 |
| NZ739573A (en) * | 2012-09-26 | 2019-11-29 | Immunogen Inc | Improved methods for the acylation of maytansinol |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Ｂｃｍａ抗原結合蛋白質 |
| CN103333246B (zh) | 2012-12-21 | 2015-09-16 | 百奥泰生物科技(广州)有限公司 | 一种抗egfr受体的肿瘤生长抑制剂及其制备方法和用途 |
| CN104530235A (zh) | 2012-12-21 | 2015-04-22 | 百奥泰生物科技(广州)有限公司 | 一种抑制肿瘤生长的抗体药物衍生物及其制备方法和用途 |
| CN104688740A (zh) | 2012-12-21 | 2015-06-10 | 百奥泰生物科技(广州)有限公司 | 类美登素衍生物及其制备方法和用途 |
| CN103254213B (zh) | 2012-12-21 | 2015-02-25 | 百奥泰生物科技(广州)有限公司 | 类美登素酯的制备方法及用于所述方法的组合物 |
| ES2728936T3 (es) | 2013-01-25 | 2019-10-29 | Amgen Inc | Anticuerpos dirigidos contra CDH19 para melanoma |
| EP2961434A2 (de) | 2013-02-28 | 2016-01-06 | ImmunoGen, Inc. | Konjugate mit zellbindenden mitteln und zytostatika |
| PL3004167T3 (pl) | 2013-05-30 | 2019-01-31 | Kiniksa Pharmaceuticals, Ltd. | Białka wiążące antygen receptora onkostatyny m |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| ES2960619T3 (es) | 2014-02-28 | 2024-03-05 | Hangzhou Dac Biotech Co Ltd | Enlazadores cargados y sus usos para la conjugación |
| KR20170129769A (ko) * | 2015-03-17 | 2017-11-27 | 리제너론 파아마슈티컬스, 인크. | 아미노산 아실화 시약 및 이의 사용 방법 |
| TW201711702A (zh) | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法 |
| WO2015151081A2 (en) | 2015-07-12 | 2015-10-08 | Suzhou M-Conj Biotech Co., Ltd | Bridge linkers for conjugation of a cell-binding molecule |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| CN107417701A (zh) * | 2016-03-03 | 2017-12-01 | 凯惠科技发展(上海)有限公司 | 一种美登素酯的制备方法及其中间体 |
| KR102459468B1 (ko) | 2016-11-14 | 2022-10-26 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
| EP3956332B1 (de) | 2019-04-18 | 2023-02-22 | Indena S.p.A. | Diasteroselektives verfahren zur herstellung von thiol- oder disulfidhaltigen maytansinoidestern und zwischenprodukten davon |
| WO2021007435A1 (en) | 2019-07-10 | 2021-01-14 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
| CN114302744A (zh) | 2019-07-10 | 2022-04-08 | 赛博克萨3公司 | 作为治疗剂的微管靶向剂的肽缀合物 |
| US20230256114A1 (en) | 2020-07-07 | 2023-08-17 | Bionecure Therapeutics, Inc. | Novel maytansinoids as adc payloads and their use for the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55164685A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) * | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US6020507A (en) * | 1998-03-02 | 2000-02-01 | Bristol-Myers Squibb Company | Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile |
| US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
-
2006
- 2006-01-19 US US11/334,478 patent/US7301019B2/en active Active
- 2006-01-20 DE DE602006017797T patent/DE602006017797D1/de active Active
- 2006-01-20 DK DK06718890.4T patent/DK1838715T3/da active
- 2006-01-20 EP EP06718890A patent/EP1838715B1/de active Active
- 2006-01-20 SI SI200630900T patent/SI1838715T1/sl unknown
- 2006-01-20 ES ES06718890T patent/ES2355153T3/es active Active
- 2006-01-20 AU AU2006206421A patent/AU2006206421B2/en active Active
- 2006-01-20 WO PCT/US2006/001885 patent/WO2006078809A2/en active Application Filing
- 2006-01-20 JP JP2007552258A patent/JP5425402B2/ja active Active
- 2006-01-20 AT AT06718890T patent/ATE486077T1/de active
- 2006-01-20 PT PT06718890T patent/PT1838715E/pt unknown
- 2006-01-20 CA CA2601670A patent/CA2601670C/en active Active
- 2006-01-20 PL PL06718890T patent/PL1838715T3/pl unknown
-
2011
- 2011-01-27 CY CY20111100094T patent/CY1111157T1/el unknown
-
2013
- 2013-08-21 JP JP2013171071A patent/JP2014012693A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CY1111157T1 (el) | 2015-06-11 |
| US7301019B2 (en) | 2007-11-27 |
| SI1838715T1 (sl) | 2011-02-28 |
| PL1838715T3 (pl) | 2011-04-29 |
| EP1838715A2 (de) | 2007-10-03 |
| EP1838715A4 (de) | 2009-06-03 |
| JP2014012693A (ja) | 2014-01-23 |
| CA2601670C (en) | 2013-04-02 |
| CA2601670A1 (en) | 2006-07-27 |
| JP5425402B2 (ja) | 2014-02-26 |
| US20060167245A1 (en) | 2006-07-27 |
| AU2006206421B2 (en) | 2010-12-16 |
| EP1838715B1 (de) | 2010-10-27 |
| PT1838715E (pt) | 2011-01-27 |
| WO2006078809A3 (en) | 2007-07-12 |
| JP2008528493A (ja) | 2008-07-31 |
| DK1838715T3 (da) | 2011-02-14 |
| AU2006206421A1 (en) | 2006-07-27 |
| ATE486077T1 (de) | 2010-11-15 |
| WO2006078809A2 (en) | 2006-07-27 |
| ES2355153T3 (es) | 2011-03-23 |
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