DE602006010522D1 - Verfahren zur identifizierung des zielproteins eines wirkstoffs und verfahren zum screening eines therapeutischen wirkstoffs gegen diabetes mittels des zielproteins - Google Patents

Verfahren zur identifizierung des zielproteins eines wirkstoffs und verfahren zum screening eines therapeutischen wirkstoffs gegen diabetes mittels des zielproteins

Info

Publication number
DE602006010522D1
DE602006010522D1 DE602006010522T DE602006010522T DE602006010522D1 DE 602006010522 D1 DE602006010522 D1 DE 602006010522D1 DE 602006010522 T DE602006010522 T DE 602006010522T DE 602006010522 T DE602006010522 T DE 602006010522T DE 602006010522 D1 DE602006010522 D1 DE 602006010522D1
Authority
DE
Germany
Prior art keywords
target protein
screening
identifying
active substance
against diabetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006010522T
Other languages
English (en)
Inventor
Hideki Endoh
Hiroyuki Yokota
Masahiko Hayakawa
Shinji Soga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of DE602006010522D1 publication Critical patent/DE602006010522D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE602006010522T 2005-08-12 2006-08-09 Verfahren zur identifizierung des zielproteins eines wirkstoffs und verfahren zum screening eines therapeutischen wirkstoffs gegen diabetes mittels des zielproteins Active DE602006010522D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005234673 2005-08-12
JP2005279582 2005-09-27
PCT/JP2006/315745 WO2007020853A1 (ja) 2005-08-12 2006-08-09 薬剤の標的蛋白質を同定する方法及び標的蛋白質を用いた糖尿病治療薬のスクリーニング方法

Publications (1)

Publication Number Publication Date
DE602006010522D1 true DE602006010522D1 (de) 2009-12-31

Family

ID=37757515

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006010522T Active DE602006010522D1 (de) 2005-08-12 2006-08-09 Verfahren zur identifizierung des zielproteins eines wirkstoffs und verfahren zum screening eines therapeutischen wirkstoffs gegen diabetes mittels des zielproteins

Country Status (7)

Country Link
US (1) US8003331B2 (de)
EP (2) EP2124062A1 (de)
JP (1) JP4992716B2 (de)
CA (1) CA2601869A1 (de)
DE (1) DE602006010522D1 (de)
ES (1) ES2336605T3 (de)
WO (1) WO2007020853A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2157092A4 (de) * 2007-04-11 2011-04-13 Ajinomoto Kk Mittel zur behandlung von diabetes
JP5303209B2 (ja) * 2007-08-06 2013-10-02 株式会社ゲノム創薬研究所 血糖値を降下させる物質の評価方法、スクリーニング方法及び製造方法
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CA2830787C (en) * 2011-03-24 2019-11-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Dominant negative hsp110 mutant and its use in prognosing and treating cancers
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8430455D0 (en) 1984-12-03 1985-01-09 Fujisawa Pharmaceutical Co Fr-900506 substance
EP0346427B1 (de) 1987-12-09 1995-03-29 FISONS plc Makrozyklische verbindungen
JP2759504B2 (ja) 1989-06-16 1998-05-28 日立マクセル株式会社 無機非水電解液電池
JPH0387768A (ja) 1989-08-31 1991-04-12 Canon Inc 画像形成装置
US5679582A (en) 1993-06-21 1997-10-21 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5585277A (en) 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US20020055123A1 (en) 1993-06-21 2002-05-09 Anadys Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
CA2184195C (en) 1995-10-25 2002-04-16 Andrew Pakula Screening method for identifying ligands for target proteins
US6716575B2 (en) * 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US6790958B2 (en) 1996-08-02 2004-09-14 Robert T. Lum Purine inhibitors of cyclin dependent kinase 2 & IKBA
US7244577B2 (en) * 1997-04-15 2007-07-17 Merck & Co., Inc. Method of screening for modulator of LRP5 activity
WO1999035147A1 (fr) * 1998-01-05 1999-07-15 Eisai Co., Ltd. Derives de purine et antagonistes du recepteur a2 d'adenosine utiles comme moyens de prevention/traitement du diabete
UA74142C2 (uk) * 1999-02-01 2005-11-15 Сіві Серапьютікс, Інк. ПУРИНОВІ ІНГІБІТОРИ ЦИКЛІНОЗАЛЕЖНОЇ КІНАЗИ 2 ТА Ik-<font face="Symbol">a</font>
WO2001034785A1 (fr) 1999-11-11 2001-05-17 Yamanouchi Pharmaceutical Co., Ltd. Nouvelle metalloprotease presentant une activite aggrecanase
US7470542B2 (en) * 2001-09-05 2008-12-30 Pride Proteomics A/S Proteins in type 2 diabetes
WO2003087768A2 (en) 2002-04-12 2003-10-23 Mitokor Targets for therapeutic intervention identified in the mitochondrial proteome
US20040072368A1 (en) 2002-09-12 2004-04-15 Laurent Martinez Lipoprotein receptor
WO2005090992A2 (en) 2004-03-12 2005-09-29 Exelisis, Inc. Mptens as modifiers of the pten pathway and methods of use
JP4882748B2 (ja) * 2004-09-16 2012-02-22 アステラス製薬株式会社 トリアゾール誘導体またはその塩

Also Published As

Publication number Publication date
US8003331B2 (en) 2011-08-23
US20090041754A1 (en) 2009-02-12
ES2336605T3 (es) 2010-04-14
JPWO2007020853A1 (ja) 2009-02-26
CA2601869A1 (en) 2007-02-22
EP2124062A1 (de) 2009-11-25
JP4992716B2 (ja) 2012-08-08
EP1860438B1 (de) 2009-11-18
WO2007020853A1 (ja) 2007-02-22
EP1860438A4 (de) 2008-11-12
EP1860438A1 (de) 2007-11-28

Similar Documents

Publication Publication Date Title
DE602005025974D1 (de) Vorrichtung und Verfahren zur Bereitstellung von Lösungsmitteln mit Korrektur der Kolbenbewegung
GB0506880D0 (en) Method and apparatus for the detection of biological molecules
DE602007003872D1 (de) Vorrichtung zur Gewebekoagulation unter Verwendung eines Inertgases
EP1938096A4 (de) Verfahren und vorrichtung zur beurteilung der blutkonzentration eines flüchtigen bestandteils
DE602005001367D1 (de) Vorrichtung und Verfahren zur Vermessung biologischen Materials
DE502005000527D1 (de) Verfahren und Vorrichtung zum Bestimmen eines Wendezeitpunktes eines Gargutes
DE602006021335D1 (de) Methode zur rekombinanten expression eines polyeptids
DE602006001836D1 (de) Apparat zur Bestimmung des Ortes des Femurkopfes
DE602007009552D1 (de) Vorrichtung zur bestimmung der position eines aktuators
DE602005005550D1 (de) Verfahren und Vorrichtung zur Ermüdungsprüfung
EP2040790A4 (de) Vorrichtung und verfahren zur stimulation von biologischem gewebe
DE112007001026A5 (de) Vorrichtung zur Ermittlung von Abmessungen menschlicher Körperteile
EP1960000A4 (de) Verfahren und gerät unter verwendung von tieren zum nachweis von target-substanzen
DE602006001724D1 (de) Apparat und Methode zur Messung von Bewegung von Körperorganen
DE602006010522D1 (de) Verfahren zur identifizierung des zielproteins eines wirkstoffs und verfahren zum screening eines therapeutischen wirkstoffs gegen diabetes mittels des zielproteins
DE602004028773D1 (de) Vorrichtung zur Materialuntersuchung mittels Elektronenstrahl
DE602005021851D1 (de) Vorrichtung und Verfahren zur Kompressorregelung
DE502005004321D1 (de) Verfahren und vorrichtung zum steuern eines injektors
DE602006003991D1 (de) Vorrichtung zur Einführung eines Arzneimittels mit Hilfe von Ultraschall
DE602006021243D1 (de) Verfahren und Vorrichtung zur Minimierung der Handoff-Zeit mittels Knoteninformation
DE602007005665D1 (de) Gerät zur entnahme von biologischen gewebeproben zur identifizierung von tieren
DE502005005519D1 (de) Verfahren und Vorrichtung zum Kalibrieren eines medizinischen Instrumentes
DE602006015761D1 (de) Vorrichtung und Verfahren zum Anzeigen eines Ultraschallbildes
DE602007007676D1 (de) Vorrichtung und Programm zum Erwerb von Geräteinformation
DE502007000050D1 (de) Verfahren und vorrichtung zum überwachten transport von blechen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition