DE602006007219D1 - Pyroglutamatsalze und deren verwendung bei der optischen trennung von zwischenprodukten für die synthese von dextrocetirizin und levocetirizin - Google Patents

Pyroglutamatsalze und deren verwendung bei der optischen trennung von zwischenprodukten für die synthese von dextrocetirizin und levocetirizin

Info

Publication number
DE602006007219D1
DE602006007219D1 DE602006007219T DE602006007219T DE602006007219D1 DE 602006007219 D1 DE602006007219 D1 DE 602006007219D1 DE 602006007219 T DE602006007219 T DE 602006007219T DE 602006007219 T DE602006007219 T DE 602006007219T DE 602006007219 D1 DE602006007219 D1 DE 602006007219D1
Authority
DE
Germany
Prior art keywords
chlorobenzhydryl
piperazin
dextrocetirizine
synthesis
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006007219T
Other languages
English (en)
Inventor
Magali Palacio
Celal Ates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Farchim SA
Original Assignee
UCB Farchim SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Farchim SA filed Critical UCB Farchim SA
Publication of DE602006007219D1 publication Critical patent/DE602006007219D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
DE602006007219T 2005-03-03 2006-02-23 Pyroglutamatsalze und deren verwendung bei der optischen trennung von zwischenprodukten für die synthese von dextrocetirizin und levocetirizin Active DE602006007219D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05004653 2005-03-03
PCT/EP2006/001676 WO2006094648A1 (en) 2005-03-03 2006-02-23 Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine

Publications (1)

Publication Number Publication Date
DE602006007219D1 true DE602006007219D1 (de) 2009-07-23

Family

ID=34934038

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006007219T Active DE602006007219D1 (de) 2005-03-03 2006-02-23 Pyroglutamatsalze und deren verwendung bei der optischen trennung von zwischenprodukten für die synthese von dextrocetirizin und levocetirizin

Country Status (16)

Country Link
US (1) US7619085B2 (de)
EP (1) EP1858866B1 (de)
JP (2) JP2008531620A (de)
KR (1) KR101239795B1 (de)
CN (1) CN101128446B (de)
AT (1) ATE433444T1 (de)
AU (1) AU2006222298B2 (de)
CA (1) CA2599498C (de)
DE (1) DE602006007219D1 (de)
EA (2) EA012575B1 (de)
ES (1) ES2326689T3 (de)
IL (1) IL184518A (de)
MX (1) MX2007010455A (de)
NZ (1) NZ556580A (de)
PL (1) PL1858866T3 (de)
WO (1) WO2006094648A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2167479B1 (de) 2007-06-15 2013-09-11 Symed Labs Limited Verfahren zur herstellung von weitgehend optisch reinen levorotatorischen und dextrorotatorischen enantiomeren von cetirizin mittels neuer zwischenprodukte
KR100954755B1 (ko) * 2007-12-17 2010-04-27 한미약품 주식회사 (ｒ)-(-)-1-[(4-클로로페닐)페닐메틸]피페라진의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
JP2995704B2 (ja) * 1989-02-17 1999-12-27 東京化成工業株式会社 光学活性な１ｈ−３−アミノピロリジン化合物の製造法
ATE170749T1 (de) * 1992-09-24 1998-09-15 Sepracor Inc Verwendung von (-) cetirizin zur behandlung allergischer rhinitis und und asthma
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
AU2004205494B2 (en) * 2003-01-23 2009-04-30 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (ko) * 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
US7989623B2 (en) * 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines

Also Published As

Publication number Publication date
CA2599498C (en) 2011-06-21
EA014248B1 (ru) 2010-10-29
MX2007010455A (es) 2007-11-08
ES2326689T3 (es) 2009-10-16
JP2013032380A (ja) 2013-02-14
CN101128446A (zh) 2008-02-20
AU2006222298A1 (en) 2006-09-14
US20080269489A1 (en) 2008-10-30
JP2008531620A (ja) 2008-08-14
EP1858866A1 (de) 2007-11-28
US7619085B2 (en) 2009-11-17
PL1858866T3 (pl) 2009-11-30
ATE433444T1 (de) 2009-06-15
EA200900359A1 (ru) 2009-06-30
KR20070113272A (ko) 2007-11-28
NZ556580A (en) 2009-08-28
EA200701818A1 (ru) 2008-02-28
IL184518A0 (en) 2007-10-31
KR101239795B1 (ko) 2013-03-06
EP1858866B1 (de) 2009-06-10
AU2006222298B2 (en) 2011-02-24
EA012575B1 (ru) 2009-10-30
CA2599498A1 (en) 2006-09-14
IL184518A (en) 2010-11-30
CN101128446B (zh) 2010-12-08
WO2006094648A1 (en) 2006-09-14

Similar Documents

Publication Publication Date Title
EA200701756A1 (ru) Соль производного пролина, её сольват и способ её получения
ES2527794T3 (es) Procedimiento para preparar compuestos de benzazepina o sus sales
Edraki et al. Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors of β-secretase (BACE1)
CY1119076T1 (el) Αλατα πιπεραζινης ως ανταγωνιστες των d3/d2
ATE381559T1 (de) Adamantan- und azabicyclooctan- und - nonanderivate, verfahren zu deren herstellung und deren verwendung als dpp-iv-inhibitoren
ATE361924T1 (de) Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
ATE525351T1 (de) Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung
ATE449090T1 (de) Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
DE602004030334D1 (de) Synthese von 5-substituierten 7-azaindolen und 7-azaindolinen
ATE496022T1 (de) Anthranilsäure-derivat als antikrebswirkstoff und verfahren zur herstellung davon
ATE525350T1 (de) Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung
NZ606700A (en) Process for manufacturing dihydropteridinones and intermediates thereof
ATE398121T1 (de) Neue synthese von irbesartan
ES2370748T3 (es) PIRIMIDIL-PIPERAZINAS ÚTILES COMO LIGANDOS DEL RECEPTOR D3/D2 DE LA DOPAMINA.
ATE449767T1 (de) Industrielles verfahren zur herstellung von 5- bis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophencarbonsäure- etraestern und verwendung zur synthese von zweiwertigen ranetansäuresalzen und deren hydraten
DE602006007219D1 (de) Pyroglutamatsalze und deren verwendung bei der optischen trennung von zwischenprodukten für die synthese von dextrocetirizin und levocetirizin
Donnier-Marechal et al. Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands
EA200600061A1 (ru) Бензамиды 4-(аминометил) пиперидина как 5нт-антагонисты
Lovell et al. N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats
BR0312593A (pt) Aciluréias substituìdas por uréia e uretano, processo para a sua produção e sua aplicação
Hu et al. Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists
HU0501138D0 (en) Process for the production of a pharmaceutical intermediate
BRPI0414107A (pt) produtos intermediários para a preparação de hìbridos de oxazolidinon-quinolona
DE602005005218D1 (de) Kristalline form von cefdinir-ammoniumsalz als zwischenprodukt für die herstellung von reinem cefdinir
Manka et al. Octahydropyrrolo [3, 4-c] pyrrole negative allosteric modulators of mGlu1

Legal Events

Date Code Title Description
8364 No opposition during term of opposition