DE602005023260D1 - Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyse - Google Patents
Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyseInfo
- Publication number
- DE602005023260D1 DE602005023260D1 DE602005023260T DE602005023260T DE602005023260D1 DE 602005023260 D1 DE602005023260 D1 DE 602005023260D1 DE 602005023260 T DE602005023260 T DE 602005023260T DE 602005023260 T DE602005023260 T DE 602005023260T DE 602005023260 D1 DE602005023260 D1 DE 602005023260D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- including mixtures
- analysis
- fragmentions
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/751,388 US7307169B2 (en) | 2004-01-05 | 2004-01-05 | Isotopically enriched N-substituted piperazines and methods for the preparation thereof |
US10/751,354 US20050148771A1 (en) | 2004-01-05 | 2004-01-05 | Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof |
US10/751,353 US20050147982A1 (en) | 2004-01-05 | 2004-01-05 | Mixtures of isobarically labeled analytes and fragments ions derived therefrom |
US10/751,387 US7355045B2 (en) | 2004-01-05 | 2004-01-05 | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
US10/822,639 US20050147985A1 (en) | 2004-01-05 | 2004-04-12 | Mixtures of isobarically labeled analytes and fragments ions derived therefrom |
US10/852,730 US20050148087A1 (en) | 2004-01-05 | 2004-05-24 | Isobarically labeled analytes and fragment ions derived therefrom |
PCT/US2005/000223 WO2005068446A1 (en) | 2004-01-05 | 2005-01-05 | Labeling reagents, labeled analytes, including mixtures thereof, and fragment ions derived therefrom and methods for the analysis thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005023260D1 true DE602005023260D1 (de) | 2010-10-14 |
Family
ID=34799954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005023260T Active DE602005023260D1 (de) | 2004-01-05 | 2005-01-05 | Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyse |
Country Status (7)
Country | Link |
---|---|
US (4) | US20050148771A1 (de) |
EP (2) | EP1701945B1 (de) |
AT (1) | ATE479669T1 (de) |
AU (1) | AU2005205522A1 (de) |
CA (1) | CA2552304C (de) |
DE (1) | DE602005023260D1 (de) |
WO (1) | WO2005068446A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799576B2 (en) * | 2003-01-30 | 2010-09-21 | Dh Technologies Development Pte. Ltd. | Isobaric labels for mass spectrometric analysis of peptides and method thereof |
EP1916527A1 (de) * | 2003-11-26 | 2008-04-30 | Applera Corporation | Analyse von Massenspektraldaten in ruhigen Bereichen |
JP4838725B2 (ja) * | 2003-11-26 | 2011-12-14 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | クワイエットゾーン中の質量スペクトルデータの分析 |
US20050148087A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
US20050148771A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation. | Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof |
WO2005085869A2 (en) | 2004-03-01 | 2005-09-15 | Applera Corporation | Determination of analyte characteristics based upon binding properties |
US20070054345A1 (en) * | 2004-05-19 | 2007-03-08 | Hunter Christie L | Expression quantification using mass spectrometry |
US20080206737A1 (en) * | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
US20060078960A1 (en) * | 2004-05-19 | 2006-04-13 | Hunter Christie L | Expression quantification using mass spectrometry |
US20070048752A1 (en) * | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
EP1776588A1 (de) * | 2004-07-12 | 2007-04-25 | Applera Corporation | Massen-tags für quantitative analysen |
US20060183238A1 (en) | 2005-02-09 | 2006-08-17 | Applera Corporation | Amine-containing compound analysis methods |
US20070037286A1 (en) * | 2005-02-09 | 2007-02-15 | Subhasish Purkayastha | Thyroxine-containing compound analysis methods |
US8975404B2 (en) * | 2006-01-24 | 2015-03-10 | Dh Technologies Development Pte. Ltd. | Labeling reagents for analyte determination and methods and compounds used in making the same |
CN101454488A (zh) | 2006-05-26 | 2009-06-10 | 阿普里拉股份有限公司 | 用于羟基化化合物的标签试剂和方法 |
US7906341B2 (en) | 2006-06-30 | 2011-03-15 | Dh Technologies Development Pte, Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
US8362242B2 (en) | 2006-06-30 | 2013-01-29 | Dh Technologies Development Pte. Ltd. | Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label |
KR101081053B1 (ko) | 2008-07-18 | 2011-11-07 | 포항공과대학교 산학협력단 | 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법 |
US20110003395A1 (en) | 2009-05-31 | 2011-01-06 | Dh Technologies Development Pte. Ltd. | Specific analysis of analytes using reagent compounds, labeling strategies, and mass spectrometry workflow |
US9678083B2 (en) * | 2009-10-14 | 2017-06-13 | Dana-Farber Cancer Institute, Inc. | Protected amine labels and use in detecting analytes |
JP2013514537A (ja) * | 2009-12-15 | 2013-04-25 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | タグ付け試薬およびlc−msワークフローを用いた、アミノ酸およびアミン含有化合物の分析 |
EP2610243A4 (de) | 2010-08-23 | 2014-04-02 | Postech Acad Ind Found | Markierungsmittel und aminosäuresequenz damit sowie verfahren zur durchführung simultaner quantitativer analysen mehrerer proteine |
KR101229704B1 (ko) | 2010-08-23 | 2013-02-05 | 포항공과대학교 산학협력단 | 동중체로 표지된 단백질 및 펩티드를 큰 질량의 y-타입 이온을 이용하여 정량분석하는 방법 |
US8492163B2 (en) | 2011-01-31 | 2013-07-23 | Dh Technologies Development Pte. Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
US20120329661A1 (en) * | 2011-05-18 | 2012-12-27 | Guo Zengkui | Isotope Labeling-Assisted Quantification (iLAQ) of Biological Compounds |
US9835629B2 (en) | 2012-05-18 | 2017-12-05 | Pierce Biotechnology, Inc. | Methods and reagents for biomolecule labeling, enrichment and gentle elution |
JP6272834B2 (ja) | 2012-05-18 | 2018-01-31 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | サイト特異的誘導とlc/ms/msワークフローとを使用した脳腱黄色腫症バイオマーカーのパネルの解析 |
GB201521903D0 (en) * | 2015-12-11 | 2016-01-27 | Electrophoretics Ltd | Isorbaric mass labels |
CN113514531B (zh) * | 2021-04-27 | 2022-10-25 | 清华大学 | 一种化合物的碎片离子预测方法及应用 |
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DE1932995A1 (de) * | 1969-06-28 | 1971-01-07 | Bosch Gmbh Robert | Steuereinrichtung zum Steuern eines ersten Druckmittelstromes in Abhaengigkeit eines zweiten Druckmittelstromes |
US3860581A (en) | 1972-12-27 | 1975-01-14 | American Home Prod | Preparation of 1,4-benzodiazepines |
DE2851953A1 (de) * | 1978-12-01 | 1980-06-19 | Thomae Gmbh Dr K | Neue spectinomycylamine, verfahren zu ihrer herstellung und diese enthaltenden arzneimittel |
AU5940186A (en) | 1985-07-05 | 1987-01-08 | Institut Fur Pflanzenschutzforschung | 2, 6 - dimethyl - morpholine quartenary compounds |
US4761415A (en) | 1986-08-28 | 1988-08-02 | Smithkline Beckman Corporation | Dopamine-β-hydroxylase inhibitors |
JPH01125357A (ja) | 1987-11-06 | 1989-05-17 | Dainippon Pharmaceut Co Ltd | トリペプチドの誘導体 |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5252296A (en) * | 1990-05-15 | 1993-10-12 | Chiron Corporation | Method and apparatus for biopolymer synthesis |
EP1130399B1 (de) * | 1992-05-29 | 2009-04-01 | The Rockefeller University | Verfahren zur Bestimmung der Folge von Peptiden unter Verwendung eines Massenspektrometers |
GB9300883D0 (en) | 1993-01-18 | 1993-03-10 | Pfizer Ltd | Antiparasitic agents |
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DE69912444T3 (de) | 1998-08-25 | 2010-05-06 | University Of Washington, Seattle | Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen |
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US6472156B1 (en) * | 1999-08-30 | 2002-10-29 | The University Of Utah | Homogeneous multiplex hybridization analysis by color and Tm |
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US7045296B2 (en) * | 2001-05-08 | 2006-05-16 | Applera Corporation | Process for analyzing protein samples |
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AU2002340490A1 (en) | 2001-11-09 | 2003-05-19 | Bayer Healthcare Ag | Isotopically coded affinity markers 3 |
WO2003077851A2 (en) | 2002-03-11 | 2003-09-25 | Hk Pharmaceuticals, Inc. | Compounds and methods for analyzing the proteome |
US7473535B2 (en) | 2002-08-20 | 2009-01-06 | The Institute For Systems Biology | Chemical reagents and methods for detection and quantification of proteins in complex mixtures |
US7799576B2 (en) | 2003-01-30 | 2010-09-21 | Dh Technologies Development Pte. Ltd. | Isobaric labels for mass spectrometric analysis of peptides and method thereof |
GB0306756D0 (en) | 2003-03-24 | 2003-04-30 | Xzillion Gmbh & Co Kg | Mass labels |
US20050148771A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation. | Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof |
US7355045B2 (en) * | 2004-01-05 | 2008-04-08 | Applera Corporation | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
-
2004
- 2004-01-05 US US10/751,354 patent/US20050148771A1/en not_active Abandoned
- 2004-01-05 US US10/751,388 patent/US7307169B2/en active Active
-
2005
- 2005-01-05 CA CA2552304A patent/CA2552304C/en not_active Expired - Fee Related
- 2005-01-05 WO PCT/US2005/000223 patent/WO2005068446A1/en not_active Application Discontinuation
- 2005-01-05 DE DE602005023260T patent/DE602005023260D1/de active Active
- 2005-01-05 AU AU2005205522A patent/AU2005205522A1/en not_active Abandoned
- 2005-01-05 EP EP05705033A patent/EP1701945B1/de not_active Not-in-force
- 2005-01-05 AT AT05705033T patent/ATE479669T1/de not_active IP Right Cessation
- 2005-01-05 EP EP10008184.3A patent/EP2251334B1/de active Active
-
2007
- 2007-12-11 US US12/001,734 patent/US7932388B2/en active Active
-
2009
- 2009-03-05 US US12/398,920 patent/US8569304B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20050148773A1 (en) | 2005-07-07 |
US7307169B2 (en) | 2007-12-11 |
ATE479669T1 (de) | 2010-09-15 |
EP1701945B1 (de) | 2010-09-01 |
US20080114169A1 (en) | 2008-05-15 |
EP1701945A1 (de) | 2006-09-20 |
EP2251334A1 (de) | 2010-11-17 |
US8569304B2 (en) | 2013-10-29 |
US20090227791A1 (en) | 2009-09-10 |
EP2251334B1 (de) | 2013-08-14 |
US20050148771A1 (en) | 2005-07-07 |
US7932388B2 (en) | 2011-04-26 |
CA2552304A1 (en) | 2005-07-28 |
WO2005068446A1 (en) | 2005-07-28 |
AU2005205522A1 (en) | 2005-07-28 |
CA2552304C (en) | 2012-03-27 |
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