DE602004031734D1 - Triaza- und tetraaza-anthrazendionderivate, ihre herstellung und verwendung als pharmazeutika - Google Patents
Triaza- und tetraaza-anthrazendionderivate, ihre herstellung und verwendung als pharmazeutikaInfo
- Publication number
- DE602004031734D1 DE602004031734D1 DE602004031734T DE602004031734T DE602004031734D1 DE 602004031734 D1 DE602004031734 D1 DE 602004031734D1 DE 602004031734 T DE602004031734 T DE 602004031734T DE 602004031734 T DE602004031734 T DE 602004031734T DE 602004031734 D1 DE602004031734 D1 DE 602004031734D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- phenyl
- triaza
- tetraaza
- pyridinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical class C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- -1 biphenylyl Chemical group 0.000 abstract 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 108010075520 Nitric Oxide Synthase Type III Proteins 0.000 abstract 1
- 108010050276 Protein Kinase C-alpha Proteins 0.000 abstract 1
- 108010078137 Protein Kinase C-epsilon Proteins 0.000 abstract 1
- 102100024924 Protein kinase C alpha type Human genes 0.000 abstract 1
- 102100037339 Protein kinase C epsilon type Human genes 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000003257 anti-anginal effect Effects 0.000 abstract 1
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 230000001966 cerebroprotective effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 230000001553 hepatotropic effect Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20030009286 EP1471066A1 (de) | 2003-04-24 | 2003-04-24 | Triaza- und Tetraaza-anthrazendionderivate, ihre Herstellung und Verwendung als Pharmazeutika |
PCT/EP2004/003851 WO2004094425A1 (en) | 2003-04-24 | 2004-04-13 | Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004031734D1 true DE602004031734D1 (de) | 2011-04-21 |
Family
ID=32946872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004031734T Expired - Lifetime DE602004031734D1 (de) | 2003-04-24 | 2004-04-13 | Triaza- und tetraaza-anthrazendionderivate, ihre herstellung und verwendung als pharmazeutika |
Country Status (13)
Country | Link |
---|---|
EP (2) | EP1471066A1 (de) |
JP (1) | JP4603530B2 (de) |
AT (1) | ATE501144T1 (de) |
AU (1) | AU2004232456B2 (de) |
BR (1) | BRPI0409698A (de) |
CA (1) | CA2523196C (de) |
DE (1) | DE602004031734D1 (de) |
DK (1) | DK1641795T3 (de) |
ES (1) | ES2362658T3 (de) |
IL (1) | IL171500A (de) |
MX (1) | MXPA05011267A (de) |
PT (1) | PT1641795E (de) |
WO (1) | WO2004094425A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7238702B2 (en) | 2005-02-10 | 2007-07-03 | Bristol-Myers Squibb Company | Dihydroquinazolinones as 5HT modulators |
EP1741708A1 (de) | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl substituierte Amide mit ungesättigtem oder zyklischem Linker, und deren Verwendung als Pharmaka |
EP1741709A1 (de) | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl substituierte Amide mit gesättigtem Linker, und deren Verwendung als Pharmaka |
EP1905764A1 (de) | 2006-09-30 | 2008-04-02 | Sanofi-Aventis | Substituierte 2-Phenylbenzimidazole und ihre Verwendung als Pharmazeutika |
EP1923062A1 (de) | 2006-11-16 | 2008-05-21 | sanofi-aventis | Imidazo[2,1-b]thiazole und ihre Verwendung als Pharmazeutika |
EP1942104A1 (de) | 2006-12-20 | 2008-07-09 | sanofi-aventis | Heteroarylcyclopropancarbonsäureamide und deren pharmazeutische Verwendung |
EP1939180A1 (de) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamide und ihre Verwendung als Arzneimittel für die Stimulation der Expression der endothelialen NO-Synthase |
EP1939181A1 (de) | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituierte Carboxamide und deren Verwendung für die Stimulierung der NO Synthase Expression |
EP1964841A1 (de) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine und deren pharmazeutische Verwendung |
EP1964840A1 (de) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]pyridine und deren pharmazeutische Verwendung |
GB2575490A (en) * | 2018-07-12 | 2020-01-15 | Recordati Ind Chimica E Farmaceutica Spa | P2X3 receptor antagonists |
WO2021048364A1 (en) * | 2019-09-11 | 2021-03-18 | Solvay Sa | Process for manufacturing a substituted cyclohexanecarbonitrile |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294517B1 (en) * | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
PE20020856A1 (es) * | 2001-02-13 | 2002-11-11 | Aventis Pharma Gmbh | 1,2,3,4-tetrahidronaftil aminas aciladas |
-
2003
- 2003-04-24 EP EP20030009286 patent/EP1471066A1/de not_active Withdrawn
-
2004
- 2004-04-13 BR BRPI0409698-3A patent/BRPI0409698A/pt not_active IP Right Cessation
- 2004-04-13 AU AU2004232456A patent/AU2004232456B2/en not_active Ceased
- 2004-04-13 PT PT04726960T patent/PT1641795E/pt unknown
- 2004-04-13 ES ES04726960T patent/ES2362658T3/es not_active Expired - Lifetime
- 2004-04-13 MX MXPA05011267A patent/MXPA05011267A/es active IP Right Grant
- 2004-04-13 CA CA2523196A patent/CA2523196C/en not_active Expired - Fee Related
- 2004-04-13 AT AT04726960T patent/ATE501144T1/de active
- 2004-04-13 WO PCT/EP2004/003851 patent/WO2004094425A1/en active Application Filing
- 2004-04-13 DE DE602004031734T patent/DE602004031734D1/de not_active Expired - Lifetime
- 2004-04-13 DK DK04726960.0T patent/DK1641795T3/da active
- 2004-04-13 JP JP2006505091A patent/JP4603530B2/ja not_active Expired - Fee Related
- 2004-04-13 EP EP04726960A patent/EP1641795B1/de not_active Expired - Lifetime
-
2005
- 2005-10-20 IL IL171500A patent/IL171500A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE501144T1 (de) | 2011-03-15 |
JP4603530B2 (ja) | 2010-12-22 |
IL171500A (en) | 2010-06-30 |
PT1641795E (pt) | 2011-05-18 |
CA2523196C (en) | 2012-05-29 |
EP1641795B1 (de) | 2011-03-09 |
MXPA05011267A (es) | 2006-05-25 |
EP1641795A1 (de) | 2006-04-05 |
JP2006524197A (ja) | 2006-10-26 |
WO2004094425A1 (en) | 2004-11-04 |
DK1641795T3 (da) | 2011-06-27 |
ES2362658T3 (es) | 2011-07-11 |
EP1471066A1 (de) | 2004-10-27 |
AU2004232456A1 (en) | 2004-11-04 |
CA2523196A1 (en) | 2004-11-04 |
AU2004232456B2 (en) | 2010-06-17 |
BRPI0409698A (pt) | 2006-04-18 |
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