DE602004020321D1 - Endomannosidasen zur modifzierung der glykoproteine in eukaryoten - Google Patents
Endomannosidasen zur modifzierung der glykoproteine in eukaryotenInfo
- Publication number
- DE602004020321D1 DE602004020321D1 DE602004020321T DE602004020321T DE602004020321D1 DE 602004020321 D1 DE602004020321 D1 DE 602004020321D1 DE 602004020321 T DE602004020321 T DE 602004020321T DE 602004020321 T DE602004020321 T DE 602004020321T DE 602004020321 D1 DE602004020321 D1 DE 602004020321D1
- Authority
- DE
- Germany
- Prior art keywords
- eukaryotes
- endomannosidases
- modifying
- methods
- glycoproteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 3
- 108090000288 Glycoproteins Proteins 0.000 title abstract 3
- 241000206602 Eukaryota Species 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 230000013595 glycosylation Effects 0.000 abstract 2
- 238000006206 glycosylation reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0113—Glycoprotein endo-alpha-1,2-mannosidase (3.2.1.130)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/371,877 US7449308B2 (en) | 2000-06-28 | 2003-02-20 | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
US10/695,243 US7332299B2 (en) | 2003-02-20 | 2003-10-27 | Endomannosidases in the modification of glycoproteins in eukaryotes |
PCT/US2004/005131 WO2004074497A2 (en) | 2003-02-20 | 2004-02-20 | Endomannosidases in the modification of glycoproteins in eukaryotes |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004020321D1 true DE602004020321D1 (de) | 2009-05-14 |
Family
ID=32911944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004020321T Expired - Lifetime DE602004020321D1 (de) | 2003-02-20 | 2004-02-20 | Endomannosidasen zur modifzierung der glykoproteine in eukaryoten |
Country Status (8)
Country | Link |
---|---|
US (3) | US7332299B2 (de) |
EP (1) | EP1597379B3 (de) |
JP (2) | JP4787737B2 (de) |
AT (1) | ATE427360T1 (de) |
AU (1) | AU2004213860B2 (de) |
CA (1) | CA2516527A1 (de) |
DE (1) | DE602004020321D1 (de) |
WO (1) | WO2004074497A2 (de) |
Families Citing this family (45)
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US8697394B2 (en) * | 2000-06-28 | 2014-04-15 | Glycofi, Inc. | Production of modified glycoproteins having multiple antennary structures |
US20060024304A1 (en) * | 2000-06-28 | 2006-02-02 | Gerngross Tillman U | Immunoglobulins comprising predominantly a Man5GlcNAc2 glycoform |
US20060029604A1 (en) * | 2000-06-28 | 2006-02-09 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
US7449308B2 (en) * | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
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WO2008112092A2 (en) * | 2007-03-07 | 2008-09-18 | Glycofi, Inc. | Production of glycoproteins with modified fucosylation |
CA2733362C (en) * | 2008-08-08 | 2016-10-18 | Universiteit Gent | Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof |
CN102333872B (zh) | 2009-02-25 | 2014-07-09 | 默沙东公司 | 在糖工程化的酵母巴斯德毕赤酵母中对半乳糖同化途径的代谢工程化 |
US8637651B2 (en) | 2009-03-16 | 2014-01-28 | Dsm Ip Assets B.V. | Protein production in microorganisms of the phylum labyrinthulomycota |
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EP2519642B1 (de) * | 2009-12-28 | 2017-10-25 | DSM IP Assets B.V. | Auf xylose wachsende rekombinante thraustochytride sowie zusammensetzungen, herstellungsverfahren und verwendungen davon |
EP2519635B1 (de) | 2009-12-28 | 2018-11-21 | Sanofi Vaccine Technologies, S.A.S. | Herstellung heterologer polypeptide in mikroalgen, extrazelluläre algenkörper, zusammensetzungen und verfahren zur herstellung sowie verwendungen davon |
EP2519636B8 (de) * | 2009-12-28 | 2017-08-09 | DSM IP Assets B.V. | Herstellung eines hämagglutinin-neuraminidase-proteins in mikroalgen |
AU2011220878A1 (en) | 2010-02-24 | 2012-08-23 | Merck Sharp & Dohme Corp. | Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris |
KR20140091017A (ko) * | 2011-10-28 | 2014-07-18 | 머크 샤프 앤드 돔 코포레이션 | Alg3 발현이 결핍된 피키아 파스토리스 균주에서 n-글리칸 점유율을 증가시키고 하이브리드 n-글리칸의 생산을 감소시키는 방법 |
US9695454B2 (en) | 2012-05-23 | 2017-07-04 | Glykos Finland Oy | Production of fucosylated glycoproteins |
US20150246118A1 (en) | 2012-10-26 | 2015-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis |
WO2014090948A1 (en) | 2012-12-13 | 2014-06-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serpin spn4a and biologically active derivatives thereof for use in the treatment of cancer |
AU2013373679A1 (en) | 2013-01-16 | 2015-08-13 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | A soluble fibroblast growth factor receptor 3 (FGR3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders |
WO2015044379A1 (en) | 2013-09-27 | 2015-04-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A dyrk1a polypeptide for use in preventing or treating metabolic disorders |
CN108064266A (zh) | 2014-07-21 | 2018-05-22 | 格利科斯芬兰公司 | 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP4309666A1 (de) | 2022-07-21 | 2024-01-24 | Technische Universität Dresden | M-csf zur verwendung bei der prophylaxe und/oder behandlung viraler infektionen bei immunsuppressionszuständen |
WO2024017998A1 (en) | 2022-07-21 | 2024-01-25 | Technische Universität Dresden | M-csf for use in the prophylaxis and/or treatment of viral infections in states of immunosuppression |
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- 2004-02-20 DE DE602004020321T patent/DE602004020321D1/de not_active Expired - Lifetime
- 2004-02-20 WO PCT/US2004/005131 patent/WO2004074497A2/en active Application Filing
- 2004-02-20 AT AT04713369T patent/ATE427360T1/de not_active IP Right Cessation
- 2004-02-20 CA CA002516527A patent/CA2516527A1/en not_active Abandoned
- 2004-02-20 EP EP04713369.9A patent/EP1597379B3/de not_active Expired - Lifetime
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- 2004-02-20 JP JP2006503759A patent/JP4787737B2/ja not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
EP1597379B3 (de) | 2021-06-23 |
US20120064568A1 (en) | 2012-03-15 |
US20090130709A1 (en) | 2009-05-21 |
JP4787737B2 (ja) | 2011-10-05 |
EP1597379A2 (de) | 2005-11-23 |
ATE427360T1 (de) | 2009-04-15 |
WO2004074497A2 (en) | 2004-09-02 |
US7332299B2 (en) | 2008-02-19 |
EP1597379B2 (de) | 2016-08-03 |
AU2004213860B2 (en) | 2009-04-02 |
EP1597379B1 (de) | 2009-04-01 |
WO2004074497A3 (en) | 2004-12-02 |
US20040171826A1 (en) | 2004-09-02 |
JP5280399B2 (ja) | 2013-09-04 |
JP2006518598A (ja) | 2006-08-17 |
JP2010187693A (ja) | 2010-09-02 |
AU2004213860A1 (en) | 2004-09-02 |
US8986949B2 (en) | 2015-03-24 |
CA2516527A1 (en) | 2004-09-02 |
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