DE602004017146D1 - PHARMAZEUTISCHE VERWENDUNG VON 1-AZABICYCLOi 2.2.2 OCTANEN UND VERFAHREN ZUM TESTEN VON VERBINDUNGEN AUF DIE FÄHIGKEIT ZUR AKTIVIERUNG VON INAKTIVEM WT P53 - Google Patents
PHARMAZEUTISCHE VERWENDUNG VON 1-AZABICYCLOi 2.2.2 OCTANEN UND VERFAHREN ZUM TESTEN VON VERBINDUNGEN AUF DIE FÄHIGKEIT ZUR AKTIVIERUNG VON INAKTIVEM WT P53Info
- Publication number
- DE602004017146D1 DE602004017146D1 DE602004017146T DE602004017146T DE602004017146D1 DE 602004017146 D1 DE602004017146 D1 DE 602004017146D1 DE 602004017146 T DE602004017146 T DE 602004017146T DE 602004017146 T DE602004017146 T DE 602004017146T DE 602004017146 D1 DE602004017146 D1 DE 602004017146D1
- Authority
- DE
- Germany
- Prior art keywords
- inactive
- ability
- octaneses
- azabicycloi
- pharmaceutical use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000008584 quinuclidines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45652503P | 2003-03-24 | 2003-03-24 | |
SE0300812A SE0300812D0 (sv) | 2003-03-24 | 2003-03-24 | Use of chemical compounds for preparing pharmaceutical compositions, and method of testing substances for medical effect |
PCT/SE2004/000452 WO2004084893A1 (en) | 2003-03-24 | 2004-03-24 | Pharmaceutical use of 1-azabicyclo[2.2.2]octanes and a method of testing compounds for the ability of activating inactive wt p53 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004017146D1 true DE602004017146D1 (de) | 2008-11-27 |
Family
ID=33100505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004017146T Expired - Lifetime DE602004017146D1 (de) | 2003-03-24 | 2004-03-24 | PHARMAZEUTISCHE VERWENDUNG VON 1-AZABICYCLOi 2.2.2 OCTANEN UND VERFAHREN ZUM TESTEN VON VERBINDUNGEN AUF DIE FÄHIGKEIT ZUR AKTIVIERUNG VON INAKTIVEM WT P53 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1605939B1 (de) |
JP (1) | JP2006521375A (de) |
AT (1) | ATE411020T1 (de) |
AU (1) | AU2004224488B2 (de) |
CA (1) | CA2519795A1 (de) |
DE (1) | DE602004017146D1 (de) |
DK (1) | DK1605939T3 (de) |
ES (1) | ES2315650T3 (de) |
NZ (1) | NZ542212A (de) |
PL (1) | PL1605939T3 (de) |
WO (1) | WO2004084893A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0400708D0 (sv) | 2004-03-22 | 2004-03-22 | Aprea Ab | New compounds and use thereof |
DK2525796T3 (en) | 2010-01-21 | 2016-07-04 | Aprea Ab | An aqueous solution comprising 3-quinuclidinoner for the treatment of hyperproliferative disease, autoimmune disease and heart disease |
CN104860994A (zh) * | 2014-02-20 | 2015-08-26 | 中国药科大学 | 3-奎宁环酮类含磷化合物的制备及其医药用途 |
CN109280056A (zh) * | 2017-07-21 | 2019-01-29 | 上海时莱生物技术有限公司 | 手性3-奎宁环酮类化合物、制备方法及用途 |
CN109280054A (zh) * | 2017-07-21 | 2019-01-29 | 上海时莱生物技术有限公司 | 氘代3-奎宁环酮类化合物、制备方法及用途 |
EP3853227A1 (de) | 2018-09-20 | 2021-07-28 | Aprea Therapeutics AB | Chinuclidin-3-on-derivate und deren verwendung zur krebsbehandlung |
CA3154120A1 (en) | 2019-09-18 | 2021-03-25 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein |
WO2021170772A1 (en) | 2020-02-26 | 2021-09-02 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of cd47 mediated signaling |
WO2021180338A1 (en) | 2020-03-09 | 2021-09-16 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of dna methyltransferase post stem cell transplant |
WO2022175402A1 (en) | 2021-02-18 | 2022-08-25 | Aprea Therapeutics Ab | Quinuclidine-3-one derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001290422B2 (en) * | 2000-09-20 | 2006-06-15 | Aprea Therapeutics Ab | 1-azabicyclo(2.2.2)octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors |
DE60306896T2 (de) * | 2002-02-21 | 2007-02-15 | Aprea Ab | Verwendung von niedermolekularen verbindungen zur herstellung eines medikaments zur behandlung von durch mutation p53-vermittelten erkrankungen |
-
2004
- 2004-03-24 AT AT04723128T patent/ATE411020T1/de active
- 2004-03-24 EP EP04723128A patent/EP1605939B1/de not_active Expired - Lifetime
- 2004-03-24 NZ NZ542212A patent/NZ542212A/en unknown
- 2004-03-24 AU AU2004224488A patent/AU2004224488B2/en not_active Expired
- 2004-03-24 JP JP2006507983A patent/JP2006521375A/ja active Pending
- 2004-03-24 ES ES04723128T patent/ES2315650T3/es not_active Expired - Lifetime
- 2004-03-24 DE DE602004017146T patent/DE602004017146D1/de not_active Expired - Lifetime
- 2004-03-24 DK DK04723128T patent/DK1605939T3/da active
- 2004-03-24 PL PL04723128T patent/PL1605939T3/pl unknown
- 2004-03-24 WO PCT/SE2004/000452 patent/WO2004084893A1/en active Application Filing
- 2004-03-24 CA CA002519795A patent/CA2519795A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2004224488A1 (en) | 2004-10-07 |
CA2519795A1 (en) | 2004-10-07 |
EP1605939A1 (de) | 2005-12-21 |
PL1605939T3 (pl) | 2009-04-30 |
NZ542212A (en) | 2008-04-30 |
EP1605939B1 (de) | 2008-10-15 |
ATE411020T1 (de) | 2008-10-15 |
ES2315650T3 (es) | 2009-04-01 |
DK1605939T3 (da) | 2009-03-09 |
JP2006521375A (ja) | 2006-09-21 |
AU2004224488B2 (en) | 2009-09-10 |
WO2004084893A1 (en) | 2004-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |