DE60137023D1 - 2-thio-4h-3,1-benzoxazin-4-on derivate und ihre verwendung als enzyminhibitoren - Google Patents

2-thio-4h-3,1-benzoxazin-4-on derivate und ihre verwendung als enzyminhibitoren

Info

Publication number
DE60137023D1
DE60137023D1 DE60137023T DE60137023T DE60137023D1 DE 60137023 D1 DE60137023 D1 DE 60137023D1 DE 60137023 T DE60137023 T DE 60137023T DE 60137023 T DE60137023 T DE 60137023T DE 60137023 D1 DE60137023 D1 DE 60137023D1
Authority
DE
Germany
Prior art keywords
reduced
formula
sup
inhibition
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60137023T
Other languages
English (en)
Inventor
Robert Downham
Richard Michael John Palmer
Harold Francis Hodson
Christopher Robert Dunk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norgine BV
Original Assignee
Alizyme Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alizyme Therapeutics Ltd filed Critical Alizyme Therapeutics Ltd
Application granted granted Critical
Publication of DE60137023D1 publication Critical patent/DE60137023D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60137023T 2000-01-24 2001-01-17 2-thio-4h-3,1-benzoxazin-4-on derivate und ihre verwendung als enzyminhibitoren Expired - Lifetime DE60137023D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0001572.7A GB0001572D0 (en) 2000-01-24 2000-01-24 Inhibitors
PCT/GB2001/000171 WO2001053278A1 (en) 2000-01-24 2001-01-17 2-thio-4h-3,1-benzoxazin-4-one derivatives for use as enzyme inhibitors

Publications (1)

Publication Number Publication Date
DE60137023D1 true DE60137023D1 (de) 2009-01-29

Family

ID=9884222

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60137023T Expired - Lifetime DE60137023D1 (de) 2000-01-24 2001-01-17 2-thio-4h-3,1-benzoxazin-4-on derivate und ihre verwendung als enzyminhibitoren

Country Status (9)

Country Link
US (1) US6916808B2 (de)
EP (1) EP1255742B1 (de)
JP (1) JP2003520278A (de)
AT (1) ATE417835T1 (de)
AU (1) AU2001225380A1 (de)
DE (1) DE60137023D1 (de)
ES (1) ES2317887T3 (de)
GB (1) GB0001572D0 (de)
WO (1) WO2001053278A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04001922A (es) * 2001-08-30 2005-03-07 Alizyme Therapeutics Ltd Tieno-(1,3)-oxazin-4-onas con actividad inhibidora de lipasa.
AU2002366810B2 (en) * 2001-12-20 2009-06-11 Osi Pharmaceuticals, Inc. Pancreatic lipase inhibitor compounds, their synthesis and use
US8372430B2 (en) 2002-12-17 2013-02-12 The Procter & Gamble Company Compositions, methods, and kits useful for the alleviation of gastrointestinal effects
WO2006116773A2 (en) * 2005-04-28 2006-11-02 The Regents Of The University Of California Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders
US9039158B2 (en) * 2013-06-13 2015-05-26 Xerox Corporation Ink stick identification system
CN111763164B (zh) * 2019-04-02 2023-03-10 中国医学科学院药物研究所 一类邻位羰基氨基取代苯衍生物的制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022204A1 (es) 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors

Also Published As

Publication number Publication date
ES2317887T3 (es) 2009-05-01
US6916808B2 (en) 2005-07-12
GB0001572D0 (en) 2000-03-15
ATE417835T1 (de) 2009-01-15
WO2001053278A1 (en) 2001-07-26
JP2003520278A (ja) 2003-07-02
US20030176429A1 (en) 2003-09-18
EP1255742A1 (de) 2002-11-13
EP1255742B1 (de) 2008-12-17
AU2001225380A1 (en) 2001-07-31

Similar Documents

Publication Publication Date Title
MY129247A (en) 2-amino-benzoxazinone derivatives for the treatment of obesity
MXPA01006921A (es) Derivados de 2-oxi-benzoxazinona para el tratamiento de la obesidad.
HUT62886A (en) Process for producing new, furyl and thienyl group-substituted taxane derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HUP0400451A2 (hu) Pirrolszármazékok és ezeket tartalmazó gyógyászati készítmények
MY117290A (en) Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
PT870765E (pt) Derivados de aminotiazole drogas contendo os mesmos e intermediarios na producao dos compostos
DK1018511T3 (da) Isochromanforbindelser og fremgangsmåde til deres fremstilling
BR0207846A (pt) Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas
AU7517400A (en) N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
HUP0204347A2 (en) Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them and their use
NO20002125D0 (no) FremgangsmÕter for fremstilling av 7- isoindolinkinolonkarboksylsyre-derivater og mellomprodukter for disse, salter av 7-isoindolinkinolonkarboksylsyrer, hydrater derav, og blanding inneholdende disse som aktiv bestandel
HUP0001957A2 (hu) Gombaellenes hatású, piridingyűrűben karbonsavszármazékokkal helyettesített 2-(metoxi-imino)-2-(piridinil-oxi-metil)-fenil-acetamid-származékok, intermedierjeik, előállításuk és alkalmazásuk
PT900211E (pt) Tiadiazolil(tio)ureias uteis como inibidores de metaloproteases com matriz
DE60137023D1 (de) 2-thio-4h-3,1-benzoxazin-4-on derivate und ihre verwendung als enzyminhibitoren
ATE229526T1 (de) Pyranone, verfahren zu ihrer herstellung und verwendung
NO20010559D0 (no) Fremgangsmåte for syntese av (1H)-benzo[c]kinolizin-3-ones derivater
AU2318600A (en) Chondrongenesis promotors and indolin-2-one derivatives
DE60045821D1 (de) Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
HUP0303760A2 (hu) AZ NF-kB faktort gátló szubsztituált benzoesavszármazékok és ezeket tartalmazó gyógyszerkészítmények
PT852226E (pt) Derivados de pirimidina
IL151167A0 (en) Pyrrolopyridazine derivatives and pharmaceutical compositions containing the same
MY139608A (en) Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity
TW200502204A (en) Oligo acid derivatives
RU94040727A (ru) Ангидриды кислот, способ их получения, таксаны, способ их получения и фармацевтическая композиция
TH59783B (th) ตัวยับยั้ง

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NORGINE B.V., AMSTERDAM, NL