DE60136446D1 - Verfahren zur herstellung von amin-derivaten - Google Patents
Verfahren zur herstellung von amin-derivatenInfo
- Publication number
- DE60136446D1 DE60136446D1 DE60136446T DE60136446T DE60136446D1 DE 60136446 D1 DE60136446 D1 DE 60136446D1 DE 60136446 T DE60136446 T DE 60136446T DE 60136446 T DE60136446 T DE 60136446T DE 60136446 D1 DE60136446 D1 DE 60136446D1
- Authority
- DE
- Germany
- Prior art keywords
- amine derivatives
- secretion
- inhibiting
- accumulation
- action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000105398 | 2000-04-03 | ||
| PCT/JP2001/002845 WO2001074756A1 (fr) | 2000-04-03 | 2001-04-02 | Procede de production de derives d'amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60136446D1 true DE60136446D1 (de) | 2008-12-18 |
Family
ID=18618765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60136446T Expired - Lifetime DE60136446D1 (de) | 2000-04-03 | 2001-04-02 | Verfahren zur herstellung von amin-derivaten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6784314B2 (de) |
| EP (1) | EP1270545B1 (de) |
| KR (1) | KR100769504B1 (de) |
| CN (4) | CN100486957C (de) |
| AT (1) | ATE413379T1 (de) |
| AU (1) | AU2001244700A1 (de) |
| CA (1) | CA2404736C (de) |
| CY (1) | CY1108727T1 (de) |
| DE (1) | DE60136446D1 (de) |
| ES (1) | ES2312423T3 (de) |
| WO (1) | WO2001074756A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2471531A1 (en) * | 2001-12-26 | 2003-07-10 | Takeda Chemical Industries, Ltd. | Agents for treating mild cognitive impairment |
| RU2372344C2 (ru) * | 2004-05-05 | 2009-11-10 | Ф. Хоффманн-Ля Рош Аг | Арилсульфонилбензодиоксаны, применяемые для модуляции 5-нт6 рецептора, 5-нт2a рецептора или и того, и другого |
| EP1760071A4 (de) | 2004-06-23 | 2008-03-05 | Ono Pharmaceutical Co | Verbindung mit s1p-rezeptorbindungsfähigkeit und verwendung dafür |
| AU2005318598B2 (en) * | 2004-12-21 | 2010-08-26 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof as 5-HT antagonists |
| ES2306275T3 (es) * | 2004-12-21 | 2008-11-01 | F. Hoffmann-La Roche Ag | Derivados de cromano y sus usos como ligandos dde receptores 5-ht. |
| BRPI0515830A (pt) | 2004-12-21 | 2008-08-05 | F Hoffmann La Roche | derivados de cromano e usos dos mesmos no tratamento de distúrbios do sistema nervoso central |
| CN101119965B (zh) * | 2004-12-21 | 2012-09-26 | 弗·哈夫曼-拉罗切有限公司 | 萘满和茚满衍生物及其用途 |
| CA2591793A1 (en) * | 2004-12-21 | 2006-06-29 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| DE602006020351D1 (en) * | 2005-11-03 | 2011-04-07 | Hoffmann La Roche | Arylsulfonylchromane als 5-ht6-inhibitoren |
| JP2009541249A (ja) * | 2006-06-20 | 2009-11-26 | エフ．ホフマン−ラ ロシュ アーゲー | アリールスルホニルナフタレン誘導体およびその使用 |
| AU2007263084A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| CA2655524A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffman-La Roche Ag | Arylsulfonamidyl tetralin derivatives and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3630903A1 (de) | 1986-09-11 | 1988-03-24 | Thomae Gmbh Dr K | Neue tetrahydronaphthalin- und indanderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| DE3807813A1 (de) | 1988-03-10 | 1989-09-21 | Thomae Gmbh Dr K | Neue benzocycloheptenderivate, diese verbindungen enthaltende arzneimittel und verfahren zu deren herstellung |
| DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| CA2105067C (en) | 1991-03-01 | 2002-05-14 | Kiyoshi Yoshida | Indan derivative and thromboxane antagonist containing the same |
| WO1995032967A1 (en) | 1994-05-28 | 1995-12-07 | Smithkline Beecham Plc | Amide derivatives having 5ht1d-antagonist activity |
| ES2098186B1 (es) | 1995-02-09 | 1998-02-01 | Consejo Superior Investigacion | Composiciones farmaceuticas a base de aminometilindoles para su aplicacion terapeutica como neuroprotectores en las enfermedades de parkinson y alzheimer. |
| WO1998006691A2 (en) | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | Low molecular weight dendritic compounds as pharmaceutical agents |
| US6048877A (en) | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
| ATE390404T1 (de) * | 1997-02-27 | 2008-04-15 | Takeda Pharmaceutical | Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta |
| JP3868096B2 (ja) * | 1997-02-27 | 2007-01-17 | 武田薬品工業株式会社 | アミン誘導体、その製造法および剤 |
| JP4367982B2 (ja) * | 1997-07-18 | 2009-11-18 | 武田薬品工業株式会社 | 光学異性体の製造法 |
-
2001
- 2001-04-02 WO PCT/JP2001/002845 patent/WO2001074756A1/ja active Application Filing
- 2001-04-02 CN CNB018076440A patent/CN100486957C/zh not_active Expired - Fee Related
- 2001-04-02 CN CN2006100932675A patent/CN101058543B/zh not_active Expired - Fee Related
- 2001-04-02 ES ES01917774T patent/ES2312423T3/es not_active Expired - Lifetime
- 2001-04-02 AU AU2001244700A patent/AU2001244700A1/en not_active Abandoned
- 2001-04-02 KR KR1020027013158A patent/KR100769504B1/ko not_active IP Right Cessation
- 2001-04-02 AT AT01917774T patent/ATE413379T1/de not_active IP Right Cessation
- 2001-04-02 CN CNA2005100591252A patent/CN1680280A/zh active Pending
- 2001-04-02 CN CNB2005100591267A patent/CN100349872C/zh not_active Expired - Fee Related
- 2001-04-02 DE DE60136446T patent/DE60136446D1/de not_active Expired - Lifetime
- 2001-04-02 EP EP01917774A patent/EP1270545B1/de not_active Expired - Lifetime
- 2001-04-02 CA CA2404736A patent/CA2404736C/en not_active Expired - Fee Related
- 2001-04-02 US US10/240,574 patent/US6784314B2/en not_active Expired - Fee Related
-
2009
- 2009-01-27 CY CY20091100099T patent/CY1108727T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2312423T3 (es) | 2009-03-01 |
| EP1270545A1 (de) | 2003-01-02 |
| ATE413379T1 (de) | 2008-11-15 |
| EP1270545A4 (de) | 2005-10-12 |
| CN100486957C (zh) | 2009-05-13 |
| CN1680332A (zh) | 2005-10-12 |
| EP1270545B1 (de) | 2008-11-05 |
| CN100349872C (zh) | 2007-11-21 |
| US20030139602A1 (en) | 2003-07-24 |
| KR20020089424A (ko) | 2002-11-29 |
| CN1422244A (zh) | 2003-06-04 |
| KR100769504B1 (ko) | 2007-10-23 |
| CN1680280A (zh) | 2005-10-12 |
| CY1108727T1 (el) | 2014-04-09 |
| CA2404736C (en) | 2011-12-06 |
| AU2001244700A1 (en) | 2001-10-15 |
| CN101058543A (zh) | 2007-10-24 |
| US6784314B2 (en) | 2004-08-31 |
| CN101058543B (zh) | 2010-05-26 |
| CA2404736A1 (en) | 2002-10-02 |
| WO2001074756A1 (fr) | 2001-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |