DE60128940T2 - C-nitroso verbindungen und deren verwendung - Google Patents
C-nitroso verbindungen und deren verwendung Download PDFInfo
- Publication number
- DE60128940T2 DE60128940T2 DE60128940T DE60128940T DE60128940T2 DE 60128940 T2 DE60128940 T2 DE 60128940T2 DE 60128940 T DE60128940 T DE 60128940T DE 60128940 T DE60128940 T DE 60128940T DE 60128940 T2 DE60128940 T2 DE 60128940T2
- Authority
- DE
- Germany
- Prior art keywords
- nitroso
- group
- compounds
- atoms
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 150000004006 C-nitroso compounds Chemical class 0.000 title claims description 136
- 229910052799 carbon Inorganic materials 0.000 claims description 94
- -1 amino, hydroxyl Chemical group 0.000 claims description 56
- 150000001875 compounds Chemical class 0.000 claims description 52
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 42
- 229920000642 polymer Polymers 0.000 claims description 28
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 21
- 150000001721 carbon Chemical group 0.000 claims description 16
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims description 16
- 125000004429 atom Chemical group 0.000 claims description 15
- 239000000178 monomer Substances 0.000 claims description 14
- 125000001424 substituent group Chemical group 0.000 claims description 12
- XGELWHWQKAMULX-UHFFFAOYSA-N CC(C)CC1=CC=C(C(C=O)(N=O)C(O)=O)C=C1 Chemical compound CC(C)CC1=CC=C(C(C=O)(N=O)C(O)=O)C=C1 XGELWHWQKAMULX-UHFFFAOYSA-N 0.000 claims description 10
- 235000019260 propionic acid Nutrition 0.000 claims description 10
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 10
- 125000004122 cyclic group Chemical group 0.000 claims description 9
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
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- 150000003573 thiols Chemical class 0.000 description 7
- 208000031226 Hyperlipidaemia Diseases 0.000 description 6
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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- 125000000468 ketone group Chemical group 0.000 description 5
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- 208000006820 Arthralgia Diseases 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 4
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- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US695934 | 2000-10-26 | ||
| US09/695,934 US6359182B1 (en) | 2000-10-26 | 2000-10-26 | C-nitroso compounds and use thereof |
| PCT/US2001/027734 WO2002034705A2 (en) | 2000-10-26 | 2001-09-27 | C-nitroso compounds and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60128940D1 DE60128940D1 (de) | 2007-07-26 |
| DE60128940T2 true DE60128940T2 (de) | 2008-02-21 |
Family
ID=24795034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60128940T Expired - Lifetime DE60128940T2 (de) | 2000-10-26 | 2001-09-27 | C-nitroso verbindungen und deren verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6359182B1 (enExample) |
| EP (1) | EP1330425B1 (enExample) |
| JP (1) | JP2004512318A (enExample) |
| AU (1) | AU2001292582A1 (enExample) |
| CA (1) | CA2422787A1 (enExample) |
| DE (1) | DE60128940T2 (enExample) |
| WO (1) | WO2002034705A2 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| CA2425489C (en) | 2000-10-16 | 2011-05-17 | Duke University | Therapeutic use of aerosolized s-nitrosoglutathione in cystic fibrosis |
| US7049308B2 (en) * | 2000-10-26 | 2006-05-23 | Duke University | C-nitroso compounds and use thereof |
| US6359182B1 (en) * | 2000-10-26 | 2002-03-19 | Duke University | C-nitroso compounds and use thereof |
| US6627602B2 (en) | 2001-11-13 | 2003-09-30 | Duke University | Preventing desensitization of receptors |
| WO2003049593A2 (en) * | 2001-12-06 | 2003-06-19 | Duke University | Prevention of flap necrosis in plastic surgery |
| US20030212138A1 (en) * | 2002-01-14 | 2003-11-13 | Pharmacia Corporation | Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor |
| US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
| US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
| WO2004050639A2 (en) * | 2002-12-03 | 2004-06-17 | Epcellon, Inc. | 5-nitroso-6-piperazinyl-pyrimidine derivatives for treating ischemia |
| DE60332387D1 (de) | 2002-12-13 | 2010-06-10 | Warner Lambert Co | Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege |
| WO2004062598A2 (en) * | 2003-01-13 | 2004-07-29 | Beta Pharma, Inc. | Anti-inflammatory and anti-thrombotic compounds and their compositions |
| US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| US20050014729A1 (en) * | 2003-07-16 | 2005-01-20 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
| US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
| US20050113409A1 (en) * | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
| JP2007518788A (ja) | 2004-01-22 | 2007-07-12 | ファイザー・インク | バソプレッシンのアンタゴニスト活性を阻害するトリアゾール誘導体 |
| EP1718603A4 (en) * | 2004-02-09 | 2009-09-23 | Noxilizer Inc | MOLECULES RELEASING NITROGEN MONOXIDE |
| US8110259B2 (en) | 2004-04-02 | 2012-02-07 | Curwood, Inc. | Packaging articles, films and methods that promote or preserve the desirable color of meat |
| US8545950B2 (en) | 2004-04-02 | 2013-10-01 | Curwood, Inc. | Method for distributing a myoglobin-containing food product |
| US8053047B2 (en) | 2004-04-02 | 2011-11-08 | Curwood, Inc. | Packaging method that causes and maintains the preferred red color of fresh meat |
| US7867531B2 (en) | 2005-04-04 | 2011-01-11 | Curwood, Inc. | Myoglobin blooming agent containing shrink films, packages and methods for packaging |
| US8029893B2 (en) | 2004-04-02 | 2011-10-04 | Curwood, Inc. | Myoglobin blooming agent, films, packages and methods for packaging |
| US8470417B2 (en) | 2004-04-02 | 2013-06-25 | Curwood, Inc. | Packaging inserts with myoglobin blooming agents, packages and methods for packaging |
| US8741402B2 (en) | 2004-04-02 | 2014-06-03 | Curwood, Inc. | Webs with synergists that promote or preserve the desirable color of meat |
| US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
| MXPA06012510A (es) * | 2004-04-28 | 2006-12-15 | Pfizer | Derivados de 3-heterociclil-4-fenil-triazol como inhibidores del receptor de vasopresina via. |
| CA2606565C (en) | 2005-05-27 | 2016-05-10 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| EP1968615A4 (en) * | 2005-12-06 | 2010-08-04 | Amulet Pharmaceuticals Inc | POLYMERS RELEASING NITRIC OXIDE |
| US7686448B2 (en) * | 2006-06-16 | 2010-03-30 | Marie Betts-Johnson | Eyeglass frames |
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
| US20080025972A1 (en) * | 2006-07-26 | 2008-01-31 | Duke University | Treating sex steriod responsive disorders |
| PT2125021E (pt) * | 2006-12-22 | 2011-07-26 | Recordati Ireland Ltd | Terapia de combinação de distúrbios do tracto urinário inferior com 2 ligandos e nsaid |
| US7935847B2 (en) * | 2007-04-20 | 2011-05-03 | Duke University | Nitroxyl ion source with second order reaction nitroxyl release |
| WO2008130567A1 (en) * | 2007-04-20 | 2008-10-30 | Duke University | Stable neutral nitric oxide source |
| JP5524209B2 (ja) | 2008-08-15 | 2014-06-18 | エヌサーティー・ファーマシューティカルズ・インコーポレーテッド | Ｓ−ニトロソグルタチオンレダクターゼのピロール阻害剤 |
| AU2009281747B2 (en) | 2008-08-15 | 2015-01-15 | Nivalis Therapeutics, Inc. | Novel pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents |
| EP2334279A4 (en) * | 2008-10-16 | 2013-03-20 | Novan Inc | STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| BR112012003804B1 (pt) | 2009-08-21 | 2019-02-19 | Novan, Inc. | Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento |
| CN102711729B (zh) | 2009-08-21 | 2015-04-01 | 诺万公司 | 局部用凝胶 |
| EP2480086A4 (en) | 2009-09-25 | 2013-03-20 | N30 Pharmaceuticals Inc | NOVEL DIHYDROPYRIMIDINE-2 (1H) -ONES COMPOUNDS AS INHIBITORS OF S-NITROSOGLUTATHION REDUCTASE |
| BR112012008508A2 (pt) * | 2009-10-13 | 2017-06-13 | Novan Inc | revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel |
| EP2512247B1 (en) | 2009-12-16 | 2014-06-04 | N30 Pharmaceuticals, Inc. | Novel thiophene inhibitors of s-nitrosoglutathione reductase |
| HRP20160450T1 (hr) | 2010-02-12 | 2016-05-20 | Nivalis Therapeutics, Inc. | Novi inhibitori reduktaze s-nitrozoglutationa |
| WO2012009227A1 (en) | 2010-07-16 | 2012-01-19 | N30 Pharmaceuticals, Llc | Novel dihydropyridin-2(1h)-one compounds as s-nitrosoglutathione reductase inhibitors and neurokinin-3 receptor antagonists |
| RU2599144C2 (ru) | 2010-10-08 | 2016-10-10 | Нивалис Терапьютикс,Инк. | Новые замещенные хинолиновые соединения как ингибиторы s-нитрозоглутатион-редуктазы |
| EP2468269A1 (en) | 2010-11-26 | 2012-06-27 | Universitätsklinikum Münster | Nitric oxide donors in therapy of nitric oxide deficiency-induced disturbances of cerebral microcirculation |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| AU2011343518B2 (en) | 2010-12-16 | 2016-11-10 | Nivalis Therapeutics, Inc. | Novel substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| EP2731658B1 (en) | 2011-07-12 | 2020-04-01 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into trans-dermal catheter |
| DK3421042T3 (da) | 2012-03-07 | 2024-07-22 | Beyond Air Ltd | Indånding af nitrogenoxid til behandling af luftvejssygdomme |
| WO2015168677A1 (en) | 2014-05-02 | 2015-11-05 | Excelsior Medical Corporation | Strip package for antiseptic cap |
| US11351155B2 (en) | 2014-12-05 | 2022-06-07 | Case Western Reserve University | Compositions and methods of modulating s-nitrosylation |
| JP6822978B2 (ja) | 2015-05-08 | 2021-01-27 | アイシーユー・メディカル・インコーポレーテッド | 治療薬のエミッタを受け入れるように構成された医療用コネクタ |
| CA2997896A1 (en) | 2015-09-09 | 2017-03-16 | Advanced Inhalation Therapies (Ait) Ltd. | Nitric oxide inhalation therapy for infants with bronchiolitis |
| WO2018049014A1 (en) | 2016-09-07 | 2018-03-15 | Trustees Of Tufts College | Dash inhibitors, and uses related thereto |
| AU2017341782B2 (en) | 2016-10-14 | 2023-03-16 | Icu Medical, Inc. | Sanitizing caps for medical connectors |
| WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| JP2022513096A (ja) | 2018-11-21 | 2022-02-07 | アイシーユー・メディカル・インコーポレーテッド | リング及びインサートを有するキャップを備える抗菌装置 |
| CN110396086B (zh) * | 2019-04-23 | 2023-03-24 | 天津国际生物医药联合研究院 | No供体类化合物、组合物、制备方法和及其应用 |
| JP2024500319A (ja) | 2020-12-07 | 2024-01-09 | アイシーユー・メディカル・インコーポレーテッド | 腹膜透析キャップ、システム、及び方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9423868D0 (en) * | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
| GB9424694D0 (en) * | 1994-12-07 | 1995-02-01 | Wellcome Found | Compounds for use in medicine |
| WO2000025776A1 (en) * | 1998-10-30 | 2000-05-11 | Nitromed, Inc. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| US6231894B1 (en) | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
| US7049308B2 (en) * | 2000-10-26 | 2006-05-23 | Duke University | C-nitroso compounds and use thereof |
| US6359182B1 (en) | 2000-10-26 | 2002-03-19 | Duke University | C-nitroso compounds and use thereof |
-
2000
- 2000-10-26 US US09/695,934 patent/US6359182B1/en not_active Expired - Fee Related
-
2001
- 2001-09-27 JP JP2002537699A patent/JP2004512318A/ja not_active Ceased
- 2001-09-27 CA CA002422787A patent/CA2422787A1/en not_active Abandoned
- 2001-09-27 DE DE60128940T patent/DE60128940T2/de not_active Expired - Lifetime
- 2001-09-27 AU AU2001292582A patent/AU2001292582A1/en not_active Abandoned
- 2001-09-27 EP EP01972952A patent/EP1330425B1/en not_active Expired - Lifetime
- 2001-09-27 WO PCT/US2001/027734 patent/WO2002034705A2/en not_active Ceased
- 2001-12-13 US US10/013,491 patent/US6538116B2/en not_active Expired - Fee Related
-
2003
- 2003-01-17 US US10/346,146 patent/US6887994B2/en not_active Expired - Fee Related
-
2005
- 2005-02-09 US US11/052,777 patent/US7030238B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002034705A2 (en) | 2002-05-02 |
| DE60128940D1 (de) | 2007-07-26 |
| JP2004512318A (ja) | 2004-04-22 |
| US6359182B1 (en) | 2002-03-19 |
| WO2002034705A3 (en) | 2002-07-11 |
| US20030176668A1 (en) | 2003-09-18 |
| US6887994B2 (en) | 2005-05-03 |
| AU2001292582A1 (en) | 2002-05-06 |
| US20020077506A1 (en) | 2002-06-20 |
| US6538116B2 (en) | 2003-03-25 |
| EP1330425B1 (en) | 2007-06-13 |
| US20050203295A1 (en) | 2005-09-15 |
| US7030238B2 (en) | 2006-04-18 |
| CA2422787A1 (en) | 2002-05-02 |
| EP1330425A2 (en) | 2003-07-30 |
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| 8364 | No opposition during term of opposition |