DE60128399T2 - Verwendung von thrombomodulinanaloga zur regenerierung von rückenmarkverletzungen - Google Patents

Verwendung von thrombomodulinanaloga zur regenerierung von rückenmarkverletzungen Download PDF

Info

Publication number
DE60128399T2
DE60128399T2 DE60128399T DE60128399T DE60128399T2 DE 60128399 T2 DE60128399 T2 DE 60128399T2 DE 60128399 T DE60128399 T DE 60128399T DE 60128399 T DE60128399 T DE 60128399T DE 60128399 T2 DE60128399 T2 DE 60128399T2
Authority
DE
Germany
Prior art keywords
thrombomodulin
spinal cord
amino acid
injury
native
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60128399T
Other languages
German (de)
English (en)
Other versions
DE60128399D1 (de
Inventor
Barry W. Kansas City FESTOFF
Michael John San Francisco MORSER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paion Deutschland GmbH
Original Assignee
Paion Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Deutschland GmbH filed Critical Paion Deutschland GmbH
Application granted granted Critical
Publication of DE60128399D1 publication Critical patent/DE60128399D1/de
Publication of DE60128399T2 publication Critical patent/DE60128399T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/366Thrombomodulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Ropes Or Cables (AREA)
  • Communication Cables (AREA)
  • Signal Processing Not Specific To The Method Of Recording And Reproducing (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60128399T 2000-08-31 2001-08-31 Verwendung von thrombomodulinanaloga zur regenerierung von rückenmarkverletzungen Expired - Fee Related DE60128399T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22971400P 2000-08-31 2000-08-31
US229714P 2000-08-31
US09/938,405 US20020111296A1 (en) 2000-08-31 2001-08-23 Thrombomodulin analogs for use in recovery of spinal cord injury
US938405 2001-08-23
PCT/US2001/041930 WO2002017953A2 (en) 2000-08-31 2001-08-31 Thrombomodulin analogs for use in recovery of signal cord injury

Publications (2)

Publication Number Publication Date
DE60128399D1 DE60128399D1 (de) 2007-06-21
DE60128399T2 true DE60128399T2 (de) 2008-01-10

Family

ID=26923554

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60128399T Expired - Fee Related DE60128399T2 (de) 2000-08-31 2001-08-31 Verwendung von thrombomodulinanaloga zur regenerierung von rückenmarkverletzungen

Country Status (13)

Country Link
US (3) US20020111296A1 (cg-RX-API-DMAC7.html)
EP (1) EP1365788B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004521076A (cg-RX-API-DMAC7.html)
AT (1) ATE361755T1 (cg-RX-API-DMAC7.html)
AU (2) AU9322901A (cg-RX-API-DMAC7.html)
CA (1) CA2420900A1 (cg-RX-API-DMAC7.html)
DE (1) DE60128399T2 (cg-RX-API-DMAC7.html)
DK (1) DK1365788T3 (cg-RX-API-DMAC7.html)
ES (1) ES2287161T3 (cg-RX-API-DMAC7.html)
IL (2) IL154600A0 (cg-RX-API-DMAC7.html)
NO (1) NO20030919L (cg-RX-API-DMAC7.html)
PT (1) PT1365788E (cg-RX-API-DMAC7.html)
WO (1) WO2002017953A2 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006005362A1 (en) * 2004-07-13 2006-01-19 Paion Deutschland Gmbh Production of mammalian proteins in plant cells
US20060148695A1 (en) * 2005-01-03 2006-07-06 National Cheng Kung University Novel angiogenic composition and use thereof
US8293710B2 (en) * 2005-01-03 2012-10-23 Blue Blood Biotech Corp. Method for treating wounds using an EGF-like domain of thrombomodulin
WO2007018400A1 (en) * 2005-08-11 2007-02-15 Medigenes Co., Ltd Pharmaceutical composition for the treatment of nerve damage comprising blood plasma or serum
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
JP2011527992A (ja) * 2008-07-16 2011-11-10 パイオン ドイチュラント ゲーエムベーハー 放射線傷害の予防および治療
CA2875069C (en) 2012-05-31 2018-01-02 Kinki University Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
CN112839669A (zh) * 2018-09-28 2021-05-25 旭化成制药株式会社 用于减轻由抗恶性肿瘤剂引起的末梢神经障碍的症状和/或抑制其发病的药物
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466668A (en) * 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
JP3789147B2 (ja) * 1995-04-11 2006-06-21 旭化成ファーマ株式会社 脊髄損傷後の神経障害に対する治療剤

Also Published As

Publication number Publication date
US20040002446A1 (en) 2004-01-01
WO2002017953A2 (en) 2002-03-07
HK1062398A1 (en) 2004-11-05
DK1365788T3 (da) 2007-09-17
US20020111296A1 (en) 2002-08-15
EP1365788B1 (en) 2007-05-09
ES2287161T3 (es) 2007-12-16
WO2002017953A3 (en) 2003-10-09
AU9322901A (en) 2002-03-13
IL154600A0 (en) 2003-09-17
DE60128399D1 (de) 2007-06-21
NO20030919L (no) 2003-04-10
US20090143281A1 (en) 2009-06-04
ATE361755T1 (de) 2007-06-15
AU2001293229B2 (en) 2007-04-05
EP1365788A2 (en) 2003-12-03
NO20030919D0 (no) 2003-02-27
CA2420900A1 (en) 2002-03-07
JP2004521076A (ja) 2004-07-15
IL154600A (en) 2009-02-11
PT1365788E (pt) 2007-08-10

Similar Documents

Publication Publication Date Title
DE69432179T2 (de) Eine formulierung des gerinnungsfaktors viii
DE60024268T2 (de) Zusammensetzungen mit stabilem faktor viii
DE69527966T2 (de) Pharmazeutische zubereitung für die subkutane, intramuskuläre oder intradermale verabreichung von faktor viii
DE10234192B4 (de) Verwendung von Erythropoetin
DE69034040T2 (de) Rekombinanter Abkömmling des menschlichen Faktors VIII
DE69428905T2 (de) Aktivierter faktor viii als ein therapeutisches mittel und verfahren zur behandlung eines faktor viii mangels
DE60031999T2 (de) Stabilisierte flüssige polypeptid-haltige pharmazeutische zusammensetzungen
DE3520228C2 (de) Wasserlösliche bioaktive Trockenfeststoffzusammensetzung, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
DE69830582T2 (de) Verwendung von lactoferrin in der behandlung von beschwerden, die von allergenen verursacht sind
DE69433133T2 (de) Lösliches thrombomodulin enthaltende zubereitung
DE68905438T2 (de) Verwendung von Interferon-gamma in pharmazeutischen Zubereitungen zur Behandlung von Gefässstenose.
EP1129186B1 (de) Ein faktor viii-polypeptid mit faktor viii:c-aktivität
EP0784632A1 (de) Verfahren zur gewinnung von hochreinem von willebrand-faktor
EP0705846B1 (de) Hochmolekulare und niedermolekulare Fraktionen des von Willebrand-Faktors
DE68929388T2 (de) Aus Harn isolierte antikoagulierende Verbindung
EP0508194A1 (de) Stabilisierte Faktor VIII-Präparationen
EP0207956A1 (de) Hirudin-pa und dessen derivate, verfahren zu deren herstellung und deren verwendung.
DE60128399T2 (de) Verwendung von thrombomodulinanaloga zur regenerierung von rückenmarkverletzungen
DE69802918T2 (de) Vwf propeptide enthaltendes pharmazeutisches präparat
DE69333491T2 (de) Protease-Resistant Thrombomodulin Analogs
EP0774261A2 (de) Verwendung von von Willebrand-Faktor und pharmazeutische Zubereitung
DE602004005392T2 (de) Biologisch stabile flüssige Zusammensetzung von FVIII, vWF oder FVIII/vWF-Komplex menschlichen Ursprungs
DE69321007T2 (de) Zusammensetzung zur Stabilisierung von Blutplasma im Laufe der Pasteurisation und Pasteurisationsverfahren unter Verwendung dieser Zusammensetzung
EP0271885A2 (de) Arzneimittel enthaltend das Gewebeprotein PP4, Verfahren zur Herstellung von PP4 und zu seiner Pasteurisierung sowie die Verwendung von PP4
EP1405863B1 (de) Konzentrat eines Faktor VIII:C-haltigen von-Willebrand-Faktors und das dazu gehörige Verfahren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee