DE60118370D1 - Leader-anteile zur erhöhung der sekretion von rekombinanten proteine aus einer wirtzelle - Google Patents

Leader-anteile zur erhöhung der sekretion von rekombinanten proteine aus einer wirtzelle

Info

Publication number
DE60118370D1
DE60118370D1 DE60118370T DE60118370T DE60118370D1 DE 60118370 D1 DE60118370 D1 DE 60118370D1 DE 60118370 T DE60118370 T DE 60118370T DE 60118370 T DE60118370 T DE 60118370T DE 60118370 D1 DE60118370 D1 DE 60118370D1
Authority
DE
Germany
Prior art keywords
secretion
host cell
increase
recombinant proteins
leader
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60118370T
Other languages
English (en)
Other versions
DE60118370T2 (de
Inventor
T Chen
Brian Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corixa Corp
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of DE60118370D1 publication Critical patent/DE60118370D1/de
Application granted granted Critical
Publication of DE60118370T2 publication Critical patent/DE60118370T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60118370T 2000-06-05 2001-06-05 Leader-anteile zur erhöhung der sekretion von rekombinanten proteinen aus einer wirtzelle Expired - Lifetime DE60118370T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20951700P 2000-06-05 2000-06-05
US209517P 2000-06-05
PCT/US2001/018222 WO2001094418A2 (en) 2000-06-05 2001-06-05 Leader peptides for enhancing secretion of recombinant protein from a host cell

Publications (2)

Publication Number Publication Date
DE60118370D1 true DE60118370D1 (de) 2006-05-18
DE60118370T2 DE60118370T2 (de) 2006-12-07

Family

ID=22779048

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60118370T Expired - Lifetime DE60118370T2 (de) 2000-06-05 2001-06-05 Leader-anteile zur erhöhung der sekretion von rekombinanten proteinen aus einer wirtzelle

Country Status (9)

Country Link
US (1) US6875590B2 (de)
EP (1) EP1290197B1 (de)
JP (1) JP2004510410A (de)
AT (1) ATE321870T1 (de)
AU (1) AU2001275267A1 (de)
CA (1) CA2412374A1 (de)
DE (1) DE60118370T2 (de)
ES (1) ES2263626T3 (de)
WO (1) WO2001094418A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003243273A1 (en) * 2002-05-22 2003-12-12 Biogen Idec Ma Inc. Detection of secreted polypeptides
EP3101034A1 (de) * 2004-02-12 2016-12-07 Morphotek, Inc. Monoklonale, spezifisch an folatrezeptor-alpha bindende antikörper
DK3540062T3 (da) 2004-11-16 2021-06-28 Humanigen Inc Immunoglobulin-variabel region kassetteudskiftning
US7592426B2 (en) 2005-03-10 2009-09-22 Morphotek, Inc. Anti-mesothelin antibodies
RU2435863C2 (ru) * 2005-05-12 2011-12-10 Адзиномото Ко., Инк. Способ продукции белка
US7393671B2 (en) * 2006-03-30 2008-07-01 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolases
DE102006044841A1 (de) * 2006-09-22 2008-04-03 Wacker Chemie Ag Signalpeptid zur Produktion von rekombinanten Proteinen
AU2009266989B2 (en) * 2008-07-03 2013-05-02 Pfenex, Inc. High throughput screening method and use thereof to identify a production platform for a multifunctional binding protein
AU2009293640A1 (en) * 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of 2G12 -derived domain exchanged antibodies
CN102770555B (zh) * 2009-11-17 2015-01-28 詹森生物科技公司 改善的细菌膜蛋白分泌
JP2014045730A (ja) * 2012-08-31 2014-03-17 Meiji Univ ポリペプチド、遺伝子、発現ベクター、及びタンパク質を小胞体に輸送する方法、並びに、シグナルペプチドの設計方法
WO2016130667A1 (en) 2015-02-10 2016-08-18 Ohio State Innovation Foundation Chlamydia-activated b cell platforms and methods thereof
EP3373961A4 (de) 2015-11-10 2019-07-31 Ohio State Innovation Foundation Verfahren und zusammensetzungen in zusammenhang mit humoraler affinität
WO2018175875A1 (en) * 2017-03-23 2018-09-27 Ohio State Innovation Foundation Recombinant chlamydia-activated b cell platforms and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757013A (en) 1983-07-25 1988-07-12 The Research Foundation Of State University Of New York Cloning vehicles for polypeptide expression in microbial hosts
CA1341235C (en) * 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
FR2636643B1 (fr) * 1988-08-24 1990-12-28 Sanofi Sa Peptide-signal, sequences d'adn codant pour celui-ci, vecteurs d'expression portant l'une de ces sequences et procede de production periplasmique d'un polypeptide
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
EP0626448A3 (de) * 1993-05-26 1998-01-14 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung und Reinigung von alpha-Interferon
US5470719A (en) 1994-03-18 1995-11-28 Meng; Shi-Yuan Modified OmpA signal sequence for enhanced secretion of polypeptides
US5747662A (en) 1995-03-01 1998-05-05 Genentech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
CA2403432A1 (en) 2000-03-22 2001-09-27 Corixa Corporation Immune mediators and related methods
US20020082411A1 (en) * 2001-01-23 2002-06-27 Darrick Carter Immune mediators and related methods

Also Published As

Publication number Publication date
AU2001275267A1 (en) 2001-12-17
EP1290197B1 (de) 2006-03-29
ATE321870T1 (de) 2006-04-15
CA2412374A1 (en) 2001-12-13
ES2263626T3 (es) 2006-12-16
JP2004510410A (ja) 2004-04-08
DE60118370T2 (de) 2006-12-07
WO2001094418A2 (en) 2001-12-13
US20020072093A1 (en) 2002-06-13
WO2001094418A3 (en) 2002-09-26
US6875590B2 (en) 2005-04-05
EP1290197A2 (de) 2003-03-12

Similar Documents

Publication Publication Date Title
ATE321870T1 (de) Leader-anteile zur erhöhung der sekretion von rekombinanten proteine aus einer wirtzelle
NO20033673L (no) Fusjonsprotein for sekresjon av et protein av interesse til supernatanten til en bakteriekultur
TR199900624T2 (xx) Proteinlerin y�ksek seviyede ekspresyonu.
DE69128285D1 (de) Expression rekombinanter polypeptide mit verbesserter möglichkeit zur reinigung
ATE335078T1 (de) Überexpression von säugetier- und virusproteinen
NO960767D0 (no) Protocadherinproteiner og deres anvendelse
ATE80660T1 (de) Verfahren zur herstellung eines polypeptides.
ATE454393T1 (de) Egvii-endoglucanase und dafür codierende nukleinsäuren
DK0792367T3 (da) DNA-konstruktion, der koder YAP3-signalpeptidet
DK0737207T3 (da) Inhibitorer for humant plasmin afledt af Kunitz-domæner
DK1265914T3 (da) WNT-1-relaterede polypeptider og nukleinsyrer, der koder for samme
DE59903410D1 (de) Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung
BR9810701A (pt) Proteìna "swollenina" de trichoderma reesei e seqâências de codificação de dna
UA84666C2 (ru) ВЫДеЛЕНнЫЙ ПОЛИНУКЛЕОТИД, КОДИРУЮЩИЙ СЛИТОЙ ПРОТЕИН С ПЕСТИЦИДНОЙ АКТИВНОСТЬЮ, И ТРАНСГЕННАЯ КЛЕТКА-ХОЗЯИН
DE60114363D1 (de) Oligomere von konformationsbeschränkten, nicht-peptidischen di- oder tripeptid-mimetika, und ihre verwendung zur synthese von künstlichen polypeptiden und proteinen
ATE345381T1 (de) Neue polypeptide aus bienengift und verfahren zu deren verwendung
NO922421D0 (no) Collagenbindende protein, samt fremstilling derav
ATE240349T1 (de) Peptide zur inhibierung von hpv e6-proteinen
FR2692907B1 (fr) Levures kluyveromyces modifiees, preparation et utilisation.
DE60132571D1 (de) Für den menschlichen vanilloid-rezeptor vr3 kodierende dns
PT676413E (pt) Proteina de ligacao a interferoes alfa/beta, sua preparacao e utilizacao
ATE427355T1 (de) Menschliche alpha2-delta4-calciumkanal- untereinheit codierende cdna
DK0938555T3 (da) Konstruktioner og komplekser af cyclin E
DE69838104D1 (de) C-terminale region des "agouti-related-transcript"-proteins (art)
DE60044468D1 (de) Herstellung von sekretierten polypeptiden

Legal Events

Date Code Title Description
8364 No opposition during term of opposition