DE60113248T2 - Vitronektin rezeptor antagonisten - Google Patents
Vitronektin rezeptor antagonisten Download PDFInfo
- Publication number
- DE60113248T2 DE60113248T2 DE60113248T DE60113248T DE60113248T2 DE 60113248 T2 DE60113248 T2 DE 60113248T2 DE 60113248 T DE60113248 T DE 60113248T DE 60113248 T DE60113248 T DE 60113248T DE 60113248 T2 DE60113248 T2 DE 60113248T2
- Authority
- DE
- Germany
- Prior art keywords
- amino
- tetrahydro
- oxo
- pyrimidinyl
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 31
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P19/00—Drugs for skeletal disorders
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0005859 | 2000-05-09 | ||
| FR0005859A FR2808798A1 (fr) | 2000-05-09 | 2000-05-09 | Nouveaux derives antagonistes du recepteur de la vitronectine |
| PCT/FR2001/001357 WO2001085729A1 (fr) | 2000-05-09 | 2001-05-04 | Nouveaux derives antagonistes du recepteur de la vitronectine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60113248D1 DE60113248D1 (de) | 2005-10-13 |
| DE60113248T2 true DE60113248T2 (de) | 2006-06-29 |
Family
ID=8850000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60113248T Expired - Lifetime DE60113248T2 (de) | 2000-05-09 | 2001-05-04 | Vitronektin rezeptor antagonisten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6838453B2 (enExample) |
| EP (1) | EP1282621B1 (enExample) |
| JP (1) | JP5143989B2 (enExample) |
| AT (1) | ATE304012T1 (enExample) |
| AU (1) | AU2001258489A1 (enExample) |
| CA (1) | CA2408293A1 (enExample) |
| DE (1) | DE60113248T2 (enExample) |
| ES (1) | ES2249431T3 (enExample) |
| FR (1) | FR2808798A1 (enExample) |
| IL (1) | IL152613A0 (enExample) |
| MX (1) | MXPA02011043A (enExample) |
| WO (1) | WO2001085729A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3332679B2 (ja) | 1995-08-08 | 2002-10-07 | 昭和電工株式会社 | 押継ぎ押出用ダイス |
| PL371841A1 (pl) | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372332A1 (pl) | 2005-01-19 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| AU2017292754B2 (en) * | 2016-07-05 | 2021-06-17 | Icahn School Of Medicine At Mount Sinai | Tetrahydronaphthyridinepentanamide integrin antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| DE19629817A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| EP0933367A1 (en) * | 1997-12-19 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Novel acylguanidine derivates as inhibitors of bone resorption and as vitronectin receptor antagonists |
| SK10632000A3 (sk) * | 1998-01-23 | 2001-02-12 | Aventis Pharma Deutschland Gmbh | Sulfónamidové deriváty ako inhibítory resorpcie kostí a inhibítory bunkovej adhézie |
| BR9908636A (pt) * | 1998-03-10 | 2002-01-08 | Smithkline Beecham Corp | Antagonistas de receptor vitronectina |
| ATE253061T1 (de) * | 1998-06-29 | 2003-11-15 | Iaf Biochem Int | Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide |
| HK1040076A1 (zh) * | 1998-09-21 | 2002-05-24 | 希雷生物化学有限公司 | 作为整联蛋白抑制剂的喹嗪酮 |
| GB9821061D0 (en) * | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
-
2000
- 2000-05-09 FR FR0005859A patent/FR2808798A1/fr active Pending
-
2001
- 2001-05-04 IL IL15261301A patent/IL152613A0/xx unknown
- 2001-05-04 JP JP2001582330A patent/JP5143989B2/ja not_active Expired - Fee Related
- 2001-05-04 ES ES01931789T patent/ES2249431T3/es not_active Expired - Lifetime
- 2001-05-04 WO PCT/FR2001/001357 patent/WO2001085729A1/fr not_active Ceased
- 2001-05-04 US US10/275,409 patent/US6838453B2/en not_active Expired - Lifetime
- 2001-05-04 DE DE60113248T patent/DE60113248T2/de not_active Expired - Lifetime
- 2001-05-04 MX MXPA02011043A patent/MXPA02011043A/es unknown
- 2001-05-04 AU AU2001258489A patent/AU2001258489A1/en not_active Abandoned
- 2001-05-04 CA CA002408293A patent/CA2408293A1/fr not_active Abandoned
- 2001-05-04 EP EP01931789A patent/EP1282621B1/fr not_active Expired - Lifetime
- 2001-05-04 AT AT01931789T patent/ATE304012T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE304012T1 (de) | 2005-09-15 |
| WO2001085729A1 (fr) | 2001-11-15 |
| FR2808798A1 (fr) | 2001-11-16 |
| ES2249431T3 (es) | 2006-04-01 |
| DE60113248D1 (de) | 2005-10-13 |
| MXPA02011043A (es) | 2003-03-10 |
| AU2001258489A1 (en) | 2001-11-20 |
| CA2408293A1 (fr) | 2001-11-15 |
| US6838453B2 (en) | 2005-01-04 |
| JP5143989B2 (ja) | 2013-02-13 |
| EP1282621A1 (fr) | 2003-02-12 |
| JP2003532732A (ja) | 2003-11-05 |
| US20040225111A1 (en) | 2004-11-11 |
| IL152613A0 (en) | 2003-06-24 |
| EP1282621B1 (fr) | 2005-09-07 |
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| 8364 | No opposition during term of opposition |