FR2808798A1 - Nouveaux derives antagonistes du recepteur de la vitronectine - Google Patents
Nouveaux derives antagonistes du recepteur de la vitronectine Download PDFInfo
- Publication number
- FR2808798A1 FR2808798A1 FR0005859A FR0005859A FR2808798A1 FR 2808798 A1 FR2808798 A1 FR 2808798A1 FR 0005859 A FR0005859 A FR 0005859A FR 0005859 A FR0005859 A FR 0005859A FR 2808798 A1 FR2808798 A1 FR 2808798A1
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- FR
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- Prior art keywords
- amino
- tetrahydro
- oxo
- tyrosine
- pyrimidinyl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0005859A FR2808798A1 (fr) | 2000-05-09 | 2000-05-09 | Nouveaux derives antagonistes du recepteur de la vitronectine |
| AT01931789T ATE304012T1 (de) | 2000-05-09 | 2001-05-04 | Vitronektin rezeptor antagonisten |
| CA002408293A CA2408293A1 (fr) | 2000-05-09 | 2001-05-04 | Nouveaux derives antagonistes du recepteur de la vitronectine |
| PCT/FR2001/001357 WO2001085729A1 (fr) | 2000-05-09 | 2001-05-04 | Nouveaux derives antagonistes du recepteur de la vitronectine |
| DE60113248T DE60113248T2 (de) | 2000-05-09 | 2001-05-04 | Vitronektin rezeptor antagonisten |
| ES01931789T ES2249431T3 (es) | 2000-05-09 | 2001-05-04 | Nuevos derivados antagonistas del receptor de la vitronectina. |
| US10/275,409 US6838453B2 (en) | 2000-05-09 | 2001-05-04 | Antagonist derivatives of the vitronectin receptor |
| JP2001582330A JP5143989B2 (ja) | 2000-05-09 | 2001-05-04 | ビトロネクチン受容体の新規な拮抗薬誘導体 |
| IL15261301A IL152613A0 (en) | 2000-05-09 | 2001-05-04 | Novel vitronectin receptor antagonists |
| AU2001258489A AU2001258489A1 (en) | 2000-05-09 | 2001-05-04 | Novel vitronectin receptor antagonists |
| MXPA02011043A MXPA02011043A (es) | 2000-05-09 | 2001-05-04 | Nuevos derivados antagonistas del receptor de la vitronectina. |
| EP01931789A EP1282621B1 (fr) | 2000-05-09 | 2001-05-04 | derives antagonistes du recepteur de la vitronectine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0005859A FR2808798A1 (fr) | 2000-05-09 | 2000-05-09 | Nouveaux derives antagonistes du recepteur de la vitronectine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2808798A1 true FR2808798A1 (fr) | 2001-11-16 |
Family
ID=8850000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0005859A Pending FR2808798A1 (fr) | 2000-05-09 | 2000-05-09 | Nouveaux derives antagonistes du recepteur de la vitronectine |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6838453B2 (enExample) |
| EP (1) | EP1282621B1 (enExample) |
| JP (1) | JP5143989B2 (enExample) |
| AT (1) | ATE304012T1 (enExample) |
| AU (1) | AU2001258489A1 (enExample) |
| CA (1) | CA2408293A1 (enExample) |
| DE (1) | DE60113248T2 (enExample) |
| ES (1) | ES2249431T3 (enExample) |
| FR (1) | FR2808798A1 (enExample) |
| IL (1) | IL152613A0 (enExample) |
| MX (1) | MXPA02011043A (enExample) |
| WO (1) | WO2001085729A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3332679B2 (ja) | 1995-08-08 | 2002-10-07 | 昭和電工株式会社 | 押継ぎ押出用ダイス |
| PL371841A1 (pl) * | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372332A1 (pl) | 2005-01-19 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| EP3481814B1 (en) | 2016-07-05 | 2022-04-27 | The Rockefeller University | Tetrahydronaphthyridinepentanamide integrin antagonists |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0820991A2 (de) * | 1996-07-24 | 1998-01-28 | Hoechst Aktiengesellschaft | Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| EP0820988A2 (de) * | 1996-07-24 | 1998-01-28 | Hoechst Aktiengesellschaft | Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| WO1999037621A1 (en) * | 1998-01-23 | 1999-07-29 | Aventis Pharma Deutschland Gmbh | Novel sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
| WO2000018759A1 (en) * | 1998-09-28 | 2000-04-06 | Celltech Therapeutics Limited | Phenylalanine derivatives as alpha 4 integrin inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| EP0933367A1 (en) * | 1997-12-19 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Novel acylguanidine derivates as inhibitors of bone resorption and as vitronectin receptor antagonists |
| AR015241A1 (es) * | 1998-03-10 | 2001-04-18 | Smithkline Beecham Corp | Antagonistas del receptor de vitronectina composicion farmaceutica que los contiene, procedimiento para su preparacion y su empleo para la fabricacion deun medicamento. |
| ATE253061T1 (de) * | 1998-06-29 | 2003-11-15 | Iaf Biochem Int | Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide |
| HK1040076A1 (zh) * | 1998-09-21 | 2002-05-24 | 希雷生物化学有限公司 | 作为整联蛋白抑制剂的喹嗪酮 |
-
2000
- 2000-05-09 FR FR0005859A patent/FR2808798A1/fr active Pending
-
2001
- 2001-05-04 CA CA002408293A patent/CA2408293A1/fr not_active Abandoned
- 2001-05-04 JP JP2001582330A patent/JP5143989B2/ja not_active Expired - Fee Related
- 2001-05-04 AU AU2001258489A patent/AU2001258489A1/en not_active Abandoned
- 2001-05-04 WO PCT/FR2001/001357 patent/WO2001085729A1/fr not_active Ceased
- 2001-05-04 AT AT01931789T patent/ATE304012T1/de not_active IP Right Cessation
- 2001-05-04 US US10/275,409 patent/US6838453B2/en not_active Expired - Lifetime
- 2001-05-04 EP EP01931789A patent/EP1282621B1/fr not_active Expired - Lifetime
- 2001-05-04 MX MXPA02011043A patent/MXPA02011043A/es unknown
- 2001-05-04 IL IL15261301A patent/IL152613A0/xx unknown
- 2001-05-04 DE DE60113248T patent/DE60113248T2/de not_active Expired - Lifetime
- 2001-05-04 ES ES01931789T patent/ES2249431T3/es not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0820991A2 (de) * | 1996-07-24 | 1998-01-28 | Hoechst Aktiengesellschaft | Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| EP0820988A2 (de) * | 1996-07-24 | 1998-01-28 | Hoechst Aktiengesellschaft | Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| WO1999037621A1 (en) * | 1998-01-23 | 1999-07-29 | Aventis Pharma Deutschland Gmbh | Novel sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
| WO2000018759A1 (en) * | 1998-09-28 | 2000-04-06 | Celltech Therapeutics Limited | Phenylalanine derivatives as alpha 4 integrin inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1282621A1 (fr) | 2003-02-12 |
| JP2003532732A (ja) | 2003-11-05 |
| ES2249431T3 (es) | 2006-04-01 |
| ATE304012T1 (de) | 2005-09-15 |
| MXPA02011043A (es) | 2003-03-10 |
| DE60113248D1 (de) | 2005-10-13 |
| CA2408293A1 (fr) | 2001-11-15 |
| JP5143989B2 (ja) | 2013-02-13 |
| US20040225111A1 (en) | 2004-11-11 |
| US6838453B2 (en) | 2005-01-04 |
| IL152613A0 (en) | 2003-06-24 |
| AU2001258489A1 (en) | 2001-11-20 |
| DE60113248T2 (de) | 2006-06-29 |
| WO2001085729A1 (fr) | 2001-11-15 |
| EP1282621B1 (fr) | 2005-09-07 |
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