DE60108111T2 - Synthetische immunogene jedoch nicht amyloidogene peptide, die homolog zu amyloid beta sind und deren verwendung zur induktion einer immunantwort gegen amyloid beta und amyloidaggregate - Google Patents

Synthetische immunogene jedoch nicht amyloidogene peptide, die homolog zu amyloid beta sind und deren verwendung zur induktion einer immunantwort gegen amyloid beta und amyloidaggregate Download PDF

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Publication number
DE60108111T2
DE60108111T2 DE60108111T DE60108111T DE60108111T2 DE 60108111 T2 DE60108111 T2 DE 60108111T2 DE 60108111 T DE60108111 T DE 60108111T DE 60108111 T DE60108111 T DE 60108111T DE 60108111 T2 DE60108111 T2 DE 60108111T2
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Prior art keywords
peptide
xaa
amyloid
seq
peptides
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Expired - Lifetime
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DE60108111T
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German (de)
English (en)
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DE60108111D1 (de
Inventor
Blas Frangione
Thomas Wisniewski
M. Einar SIGURDSSON
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New York University NYU
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New York University NYU
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60108111T 2000-05-22 2001-05-22 Synthetische immunogene jedoch nicht amyloidogene peptide, die homolog zu amyloid beta sind und deren verwendung zur induktion einer immunantwort gegen amyloid beta und amyloidaggregate Expired - Lifetime DE60108111T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20557800P 2000-05-22 2000-05-22
US205578P 2000-05-22
PCT/US2001/016322 WO2001090182A2 (en) 2000-05-22 2001-05-22 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits

Publications (2)

Publication Number Publication Date
DE60108111D1 DE60108111D1 (de) 2005-02-03
DE60108111T2 true DE60108111T2 (de) 2005-12-08

Family

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DE60108111T Expired - Lifetime DE60108111T2 (de) 2000-05-22 2001-05-22 Synthetische immunogene jedoch nicht amyloidogene peptide, die homolog zu amyloid beta sind und deren verwendung zur induktion einer immunantwort gegen amyloid beta und amyloidaggregate

Country Status (14)

Country Link
US (3) US6713450B2 (https=)
EP (1) EP1284998B1 (https=)
JP (1) JP2003534351A (https=)
CN (1) CN1249085C (https=)
AT (1) ATE286072T1 (https=)
AU (2) AU2001274873B2 (https=)
CA (1) CA2408925A1 (https=)
DE (1) DE60108111T2 (https=)
ES (1) ES2238049T3 (https=)
IL (2) IL152625A0 (https=)
NZ (1) NZ521939A (https=)
PT (1) PT1284998E (https=)
WO (1) WO2001090182A2 (https=)
ZA (1) ZA200207992B (https=)

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US7179892B2 (en) * 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
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US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
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JP4696079B2 (ja) 2003-12-17 2011-06-08 ヤンセン アルツハイマー イミュノセラピー Ａβ免疫原性ペプチド担体結合物およびそれの製造方法
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Also Published As

Publication number Publication date
EP1284998B1 (en) 2004-12-29
US7427655B2 (en) 2008-09-23
WO2001090182A2 (en) 2001-11-29
NZ521939A (en) 2004-04-30
US20090081204A1 (en) 2009-03-26
ZA200207992B (en) 2003-07-02
DE60108111D1 (de) 2005-02-03
JP2003534351A (ja) 2003-11-18
CN1249085C (zh) 2006-04-05
EP1284998A2 (en) 2003-02-26
IL152625A (en) 2009-12-24
PT1284998E (pt) 2005-06-30
US20020077288A1 (en) 2002-06-20
US7700107B2 (en) 2010-04-20
WO2001090182A3 (en) 2002-05-23
US20040043935A1 (en) 2004-03-04
US6713450B2 (en) 2004-03-30
CN1444598A (zh) 2003-09-24
ES2238049T3 (es) 2005-08-16
IL152625A0 (en) 2003-06-24
ATE286072T1 (de) 2005-01-15
CA2408925A1 (en) 2001-11-29
AU2001274873B2 (en) 2006-10-05
AU7487301A (en) 2001-12-03

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