DE60101091D1 - (2s)-aminoindanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als selektive dopamin-d3-liganden - Google Patents

(2s)-aminoindanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als selektive dopamin-d3-liganden

Info

Publication number
DE60101091D1
DE60101091D1 DE60101091T DE60101091T DE60101091D1 DE 60101091 D1 DE60101091 D1 DE 60101091D1 DE 60101091 T DE60101091 T DE 60101091T DE 60101091 T DE60101091 T DE 60101091T DE 60101091 D1 DE60101091 D1 DE 60101091D1
Authority
DE
Germany
Prior art keywords
aminoin
ligands
derivatives
production
selective dopamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60101091T
Other languages
English (en)
Other versions
DE60101091T2 (de
Inventor
Andrew Runge
Glenn Romero
D Hewitt
A Svensson
Chiu-Hong Lin
Anne Cleek
R Haadsma-Svensson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE60101091D1 publication Critical patent/DE60101091D1/de
Application granted granted Critical
Publication of DE60101091T2 publication Critical patent/DE60101091T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
DE60101091T 2000-02-22 2001-02-14 (2s)-aminoindanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als selektive dopamin-d3-liganden Expired - Fee Related DE60101091T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18402000P 2000-02-22 2000-02-22
US184020P 2000-02-22
PCT/US2001/001231 WO2001062712A1 (en) 2000-02-22 2001-02-14 (2s)-aminoindan derivatives, a process for their preparation and their use as selective dopamine d3 ligands

Publications (2)

Publication Number Publication Date
DE60101091D1 true DE60101091D1 (de) 2003-12-04
DE60101091T2 DE60101091T2 (de) 2004-07-29

Family

ID=22675272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60101091T Expired - Fee Related DE60101091T2 (de) 2000-02-22 2001-02-14 (2s)-aminoindanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als selektive dopamin-d3-liganden

Country Status (13)

Country Link
US (2) US6410787B2 (de)
EP (1) EP1257527B1 (de)
JP (1) JP2003523991A (de)
AR (1) AR030552A1 (de)
AT (1) ATE253040T1 (de)
AU (1) AU2001234453A1 (de)
CO (1) CO5270005A1 (de)
DE (1) DE60101091T2 (de)
DK (1) DK1257527T3 (de)
ES (1) ES2210128T3 (de)
PT (1) PT1257527E (de)
TR (1) TR200302026T4 (de)
WO (1) WO2001062712A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009081148A1 (en) * 2007-12-24 2009-07-02 Cipla Limited Process for the synthesis of propargylated aminoindan derivatives
JP5295613B2 (ja) * 2008-04-07 2013-09-18 日宝化学株式会社 ヨウ素化芳香族化合物の製造方法
CN103664816B (zh) * 2011-01-06 2016-03-02 中国科学院上海有机化学研究所 Hiv逆转录酶抑制剂依法韦伦类化合物的一锅法不对称合成工艺
CN104418775B (zh) * 2013-09-05 2017-01-18 中国科学院大连化学物理研究所 一种钯催化氨基醇的不对称氢解合成手性胺的方法
CN107056630B (zh) * 2017-01-23 2020-01-17 合肥工业大学 一种茚满类衍生物及其合成方法和在医药上的用途
CN113401961B (zh) * 2021-05-20 2023-06-23 陈鹏 一种可光谱调控的水处理用黑色素材料及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5708018A (en) 1993-08-06 1998-01-13 Pharmacia & Upjohn Company 2-aminoindans as selective dopamine D3 ligands
WO1997045403A1 (en) 1996-05-31 1997-12-04 Pharmacia & Upjohn Company Aryl substituted cyclic amines as selective dopamine d3 ligands

Also Published As

Publication number Publication date
EP1257527B1 (de) 2003-10-29
TR200302026T4 (tr) 2004-01-21
US20020151596A1 (en) 2002-10-17
WO2001062712A1 (en) 2001-08-30
AU2001234453A1 (en) 2001-09-03
US6870070B2 (en) 2005-03-22
US6410787B2 (en) 2002-06-25
US20010044471A1 (en) 2001-11-22
EP1257527A1 (de) 2002-11-20
CO5270005A1 (es) 2003-04-30
ATE253040T1 (de) 2003-11-15
DK1257527T3 (da) 2004-01-12
AR030552A1 (es) 2003-08-27
ES2210128T3 (es) 2004-07-01
PT1257527E (pt) 2004-03-31
JP2003523991A (ja) 2003-08-12
DE60101091T2 (de) 2004-07-29

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