ATE272634T1 - Benzothiophenderivate, verhahren zu ihrer herstellung und ihre verwendung - Google Patents

Benzothiophenderivate, verhahren zu ihrer herstellung und ihre verwendung

Info

Publication number
ATE272634T1
ATE272634T1 AT01983737T AT01983737T ATE272634T1 AT E272634 T1 ATE272634 T1 AT E272634T1 AT 01983737 T AT01983737 T AT 01983737T AT 01983737 T AT01983737 T AT 01983737T AT E272634 T1 ATE272634 T1 AT E272634T1
Authority
AT
Austria
Prior art keywords
production
benzothiophene derivatives
benzothiophene
derivatives
Prior art date
Application number
AT01983737T
Other languages
English (en)
Inventor
Castillo Nieto Juan Carlos Del
Aldaz Berta Esperanza Lasheras
Vega Antonio Monge
Mancini Marisabel Mourelle
Rio Zambrana Joaquin Del
Original Assignee
Vita Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Lab filed Critical Vita Lab
Application granted granted Critical
Publication of ATE272634T1 publication Critical patent/ATE272634T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
AT01983737T 2000-11-29 2001-11-19 Benzothiophenderivate, verhahren zu ihrer herstellung und ihre verwendung ATE272634T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200002914A ES2188344B1 (es) 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
PCT/IB2001/002211 WO2002044170A2 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof

Publications (1)

Publication Number Publication Date
ATE272634T1 true ATE272634T1 (de) 2004-08-15

Family

ID=8495887

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01983737T ATE272634T1 (de) 2000-11-29 2001-11-19 Benzothiophenderivate, verhahren zu ihrer herstellung und ihre verwendung

Country Status (35)

Country Link
US (1) US20040034219A1 (de)
EP (1) EP1337528B1 (de)
JP (1) JP2004514719A (de)
KR (1) KR20030066689A (de)
CN (1) CN1478088A (de)
AP (1) AP2003002801A0 (de)
AR (1) AR034009A1 (de)
AT (1) ATE272634T1 (de)
AU (1) AU2002215157A1 (de)
BG (1) BG107851A (de)
BR (1) BR0115708A (de)
CA (1) CA2429892A1 (de)
CZ (1) CZ20031398A3 (de)
DE (1) DE60104717T2 (de)
EA (1) EA200300519A1 (de)
EE (1) EE200300245A (de)
ES (2) ES2188344B1 (de)
GE (1) GEP20043366B (de)
HR (1) HRP20030407A2 (de)
HU (1) HUP0303568A3 (de)
IL (1) IL155966A0 (de)
IS (1) IS6824A (de)
MA (1) MA26963A1 (de)
MX (1) MXPA03004875A (de)
NO (1) NO20032332D0 (de)
NZ (1) NZ525950A (de)
OA (1) OA12536A (de)
PE (1) PE20020692A1 (de)
PL (1) PL362982A1 (de)
PT (1) PT1337528E (de)
SI (1) SI1337528T1 (de)
SK (1) SK6202003A3 (de)
TR (1) TR200402779T4 (de)
WO (1) WO2002044170A2 (de)
ZA (1) ZA200303858B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2453837C (en) * 2001-07-20 2011-10-04 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder using eltoprazine and related compounds
CA2479786C (en) 2002-03-27 2011-11-29 Glaxo Group Limited Quinoline derivatives and their use as 5-ht6 ligands
DE602004005814T2 (de) 2003-01-13 2008-01-10 Dynogen Pharmaceuticals Inc., Waltham Verfahren zur behandlung von übelkeit, erbrechen, würgereiz oder jede kombination daraus
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
DK1558582T3 (da) 2003-07-22 2006-05-08 Arena Pharm Inc Diaryl og arylheteroarylureaderivater som modulatorer af aktiviteten af 5-HT2A-serotoninreceptoren anvendelige til profylakse eller behandling af forstyrrelser relateret dertil
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
US7881267B2 (en) * 2004-06-04 2011-02-01 Hewlett-Packard Development Company, L.P. Portable computing device for wireless communications and method of operation
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
EP2254564A1 (de) 2007-12-12 2010-12-01 Glaxo Group Limited Kombinationen mit 3-phenylsulfonyl-8-piperazinyl-1yl-chinolin
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
CN101619056B (zh) 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
US10022355B2 (en) 2015-06-12 2018-07-17 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder
RU2018103338A (ru) 2015-07-15 2019-08-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5658909A (en) * 1994-11-17 1997-08-19 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.

Also Published As

Publication number Publication date
AP2003002801A0 (en) 2003-06-30
ES2188344A1 (es) 2003-06-16
CZ20031398A3 (cs) 2004-01-14
EA200300519A1 (ru) 2003-12-25
GEP20043366B (en) 2004-04-13
AR034009A1 (es) 2004-01-21
OA12536A (en) 2006-06-05
EE200300245A (et) 2003-08-15
KR20030066689A (ko) 2003-08-09
EP1337528B1 (de) 2004-08-04
NO20032332L (no) 2003-05-22
HRP20030407A2 (en) 2004-08-31
ZA200303858B (en) 2004-05-19
EP1337528A2 (de) 2003-08-27
BR0115708A (pt) 2004-02-03
PT1337528E (pt) 2004-11-30
PL362982A1 (en) 2004-11-02
CN1478088A (zh) 2004-02-25
IL155966A0 (en) 2003-12-23
WO2002044170A2 (en) 2002-06-06
CA2429892A1 (en) 2002-06-06
MXPA03004875A (es) 2005-02-14
MA26963A1 (fr) 2004-12-20
WO2002044170A3 (en) 2002-09-06
SI1337528T1 (en) 2005-02-28
SK6202003A3 (en) 2004-05-04
TR200402779T4 (tr) 2004-11-22
PE20020692A1 (es) 2002-09-02
AU2002215157A1 (en) 2002-06-11
ES2225623T3 (es) 2005-03-16
DE60104717D1 (de) 2004-09-09
IS6824A (is) 2003-05-22
US20040034219A1 (en) 2004-02-19
HUP0303568A2 (hu) 2004-03-01
JP2004514719A (ja) 2004-05-20
NO20032332D0 (no) 2003-05-22
HUP0303568A3 (en) 2005-02-28
DE60104717T2 (de) 2006-04-06
ES2188344B1 (es) 2004-09-16
NZ525950A (en) 2004-11-26
BG107851A (bg) 2004-06-30

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