DE60100761D1 - Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittel - Google Patents
Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittelInfo
- Publication number
- DE60100761D1 DE60100761D1 DE60100761T DE60100761T DE60100761D1 DE 60100761 D1 DE60100761 D1 DE 60100761D1 DE 60100761 T DE60100761 T DE 60100761T DE 60100761 T DE60100761 T DE 60100761T DE 60100761 D1 DE60100761 D1 DE 60100761D1
- Authority
- DE
- Germany
- Prior art keywords
- perindopril
- tert
- production
- crystalline form
- product containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0008791A FR2811318B1 (fr) | 2000-07-06 | 2000-07-06 | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR0008791 | 2000-07-06 | ||
PCT/FR2001/002169 WO2001083439A2 (fr) | 2000-07-06 | 2001-07-06 | NOUVELLE FORME CRISTALLINE η DU SEL DE TERT-BUTYLAMINE DU PERINDOPRIL, SON PROCEDE DE PREPARATION, ET LES COMPOSITIONS PHARMACEUTIQUES QUI LA CONTIENNENT |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60100761D1 true DE60100761D1 (de) | 2003-10-16 |
DE60100761T2 DE60100761T2 (de) | 2004-07-15 |
Family
ID=8852170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60100761T Expired - Lifetime DE60100761T2 (de) | 2000-07-06 | 2001-07-06 | Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittel |
Country Status (36)
Country | Link |
---|---|
US (2) | US20030158121A1 (de) |
EP (1) | EP1296948B1 (de) |
JP (2) | JP3592296B2 (de) |
KR (1) | KR100513572B1 (de) |
CN (1) | CN1328258C (de) |
AP (1) | AP1452A (de) |
AR (1) | AR029570A1 (de) |
AT (1) | ATE249435T1 (de) |
AU (2) | AU2001276420B2 (de) |
BG (1) | BG66239B1 (de) |
BR (1) | BR0112211A (de) |
CA (1) | CA2415447C (de) |
CZ (1) | CZ302022B6 (de) |
DE (1) | DE60100761T2 (de) |
DK (1) | DK1296948T3 (de) |
EA (1) | EA004275B1 (de) |
EE (1) | EE05286B1 (de) |
ES (1) | ES2206423T3 (de) |
FR (1) | FR2811318B1 (de) |
GE (1) | GEP20043362B (de) |
HK (1) | HK1058199A1 (de) |
HR (1) | HRP20030078B1 (de) |
HU (1) | HU228115B1 (de) |
ME (1) | ME01367B (de) |
MX (1) | MXPA02012904A (de) |
NO (1) | NO323445B1 (de) |
NZ (1) | NZ523311A (de) |
OA (1) | OA12306A (de) |
PL (1) | PL348491A1 (de) |
PT (1) | PT1296948E (de) |
RS (1) | RS51621B (de) |
SI (1) | SI1296948T1 (de) |
SK (1) | SK287452B6 (de) |
UA (1) | UA57187C2 (de) |
WO (1) | WO2001083439A2 (de) |
ZA (1) | ZA200300025B (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2811319B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2834893B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de perindopril |
GB2395195A (en) * | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
EA008603B1 (ru) * | 2003-06-24 | 2007-06-29 | Ле Лаборатуар Сервье | Новые кристаллические формы периндоприл эрбумина |
AU2003263584A1 (en) * | 2003-08-21 | 2005-03-10 | Hetero Drugs Limited | Process for pure perindopril tert-butylamine salt |
JP4677611B2 (ja) | 2003-10-21 | 2011-04-27 | レ ラボラトワール セルヴィエ | 結晶ペリンドプリルエルブミンの新規な調製方法 |
SI21704A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
SI21703A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia |
LT1729739T (lt) * | 2004-03-29 | 2016-11-10 | Les Laboratoires Servier | Kietos farmacinės kompozicijos gamybos būdas |
SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
SG125976A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
SG125975A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
JP2006290825A (ja) * | 2005-04-13 | 2006-10-26 | Shiono Chemical Co Ltd | アルファ型ペリンドプリルエルブミンの製造法 |
WO2007017894A2 (en) * | 2005-05-05 | 2007-02-15 | Arch Pharmalabs Limited | PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE |
WO2007020012A1 (en) * | 2005-08-12 | 2007-02-22 | Lek Pharmaceuticals D.D. | A process for the preparation of perindopril erbumine |
WO2007020009A1 (en) * | 2005-08-12 | 2007-02-22 | Sandoz Ag | New crystalline form of perindopril erbumine |
EP1815857A1 (de) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | Pharmazeutische Zusammensetzung enthaltend Perindopril |
WO2007092758A2 (en) * | 2006-02-03 | 2007-08-16 | Dr. Reddy's Laboratories Ltd. | Crystalline forms of perindopril erbumine |
FR2897865B1 (fr) * | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2897866B1 (fr) | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
WO2008114270A1 (en) * | 2007-03-22 | 2008-09-25 | Aarti Healthcare Limited | Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof |
WO2008120241A2 (en) * | 2007-03-29 | 2008-10-09 | Ipca Laboratories Limited | Novel alcohol solvates of perindopril erbumine |
SI22543A (sl) | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
EP2318365B1 (de) * | 2008-06-24 | 2015-08-12 | Mylan Laboratories Limited | Neue polymorphe formen von perindopril (l)-arginin und verfahren zu deren herstellung |
KR200453510Y1 (ko) * | 2009-02-09 | 2011-05-11 | 윤유원 | 튀김유 정제기 |
KR101041878B1 (ko) * | 2009-03-26 | 2011-06-15 | 신준호 | 튀김장치용 찌꺼기 제거장치 |
SI23149A (sl) | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
PT105315B (pt) | 2010-09-29 | 2013-01-16 | Inst Superior Tecnico | Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas |
EP3842035A1 (de) | 2019-12-23 | 2021-06-30 | KRKA, d.d., Novo mesto | Zusammensetzung zur herstellung von perindopril-arginin-granulaten, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung damit |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR2620703B1 (fr) * | 1987-09-17 | 1991-10-04 | Adir | Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
FR2771010B1 (fr) * | 1997-11-19 | 2003-08-15 | Adir | Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires |
FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811319B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
-
2000
- 2000-07-06 FR FR0008791A patent/FR2811318B1/fr not_active Expired - Fee Related
-
2001
- 2001-06-07 UA UA2003021019A patent/UA57187C2/uk unknown
- 2001-07-05 HU HU0102814A patent/HU228115B1/hu not_active IP Right Cessation
- 2001-07-06 WO PCT/FR2001/002169 patent/WO2001083439A2/fr active IP Right Grant
- 2001-07-06 KR KR10-2003-7000117A patent/KR100513572B1/ko not_active IP Right Cessation
- 2001-07-06 ME MEP-2008-672A patent/ME01367B/me unknown
- 2001-07-06 NZ NZ523311A patent/NZ523311A/en not_active IP Right Cessation
- 2001-07-06 CN CNB018123538A patent/CN1328258C/zh not_active Expired - Fee Related
- 2001-07-06 PT PT01954060T patent/PT1296948E/pt unknown
- 2001-07-06 AU AU2001276420A patent/AU2001276420B2/en not_active Ceased
- 2001-07-06 SK SK150-2003A patent/SK287452B6/sk not_active IP Right Cessation
- 2001-07-06 OA OA1200200399A patent/OA12306A/en unknown
- 2001-07-06 BR BR0112211-8A patent/BR0112211A/pt not_active Application Discontinuation
- 2001-07-06 ES ES01954060T patent/ES2206423T3/es not_active Expired - Lifetime
- 2001-07-06 EA EA200300104A patent/EA004275B1/ru not_active IP Right Cessation
- 2001-07-06 GE GE5074A patent/GEP20043362B/en unknown
- 2001-07-06 AT AT01954060T patent/ATE249435T1/de active
- 2001-07-06 AU AU7642001A patent/AU7642001A/xx active Pending
- 2001-07-06 AR ARP010103224A patent/AR029570A1/es not_active Application Discontinuation
- 2001-07-06 CA CA002415447A patent/CA2415447C/fr not_active Expired - Fee Related
- 2001-07-06 EE EEP200300003A patent/EE05286B1/xx not_active IP Right Cessation
- 2001-07-06 US US10/312,903 patent/US20030158121A1/en not_active Abandoned
- 2001-07-06 EP EP01954060A patent/EP1296948B1/de not_active Expired - Lifetime
- 2001-07-06 PL PL01348491A patent/PL348491A1/xx not_active Application Discontinuation
- 2001-07-06 DE DE60100761T patent/DE60100761T2/de not_active Expired - Lifetime
- 2001-07-06 RS YU100302A patent/RS51621B/sr unknown
- 2001-07-06 SI SI200130029T patent/SI1296948T1/xx unknown
- 2001-07-06 MX MXPA02012904A patent/MXPA02012904A/es active IP Right Grant
- 2001-07-06 JP JP2001580868A patent/JP3592296B2/ja not_active Expired - Fee Related
- 2001-07-06 DK DK01954060T patent/DK1296948T3/da active
- 2001-07-06 CZ CZ20030358A patent/CZ302022B6/cs not_active IP Right Cessation
- 2001-07-06 AP APAP/P/2002/002709A patent/AP1452A/en active
-
2003
- 2003-01-02 ZA ZA200300025A patent/ZA200300025B/en unknown
- 2003-01-06 NO NO20030051A patent/NO323445B1/no not_active IP Right Cessation
- 2003-02-05 BG BG107534A patent/BG66239B1/bg unknown
- 2003-02-06 HR HR20030078A patent/HRP20030078B1/xx not_active IP Right Cessation
-
2004
- 2004-02-12 HK HK04100948A patent/HK1058199A1/xx not_active IP Right Cessation
- 2004-03-29 US US10/811,727 patent/US20040248817A1/en not_active Abandoned
- 2004-07-13 JP JP2004206157A patent/JP5016184B2/ja not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8365 | Fully valid after opposition proceedings |