DE60044241D1 - Xylo-lna analoge - Google Patents

Xylo-lna analoge

Info

Publication number
DE60044241D1
DE60044241D1 DE60044241T DE60044241T DE60044241D1 DE 60044241 D1 DE60044241 D1 DE 60044241D1 DE 60044241 T DE60044241 T DE 60044241T DE 60044241 T DE60044241 T DE 60044241T DE 60044241 D1 DE60044241 D1 DE 60044241D1
Authority
DE
Germany
Prior art keywords
oligonucleotides
useful
xylo
lnas
configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044241T
Other languages
English (en)
Inventor
Jesper Wengel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exiqon AS
Original Assignee
Exiqon AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exiqon AS filed Critical Exiqon AS
Application granted granted Critical
Publication of DE60044241D1 publication Critical patent/DE60044241D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60044241T 1999-03-18 2000-03-17 Xylo-lna analoge Expired - Lifetime DE60044241D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900382 1999-03-18
DKPA199901224 1999-09-01
PCT/DK2000/000125 WO2000056748A1 (en) 1999-03-18 2000-03-17 Xylo-lna analogues

Publications (1)

Publication Number Publication Date
DE60044241D1 true DE60044241D1 (de) 2010-06-02

Family

ID=26063889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60044241T Expired - Lifetime DE60044241D1 (de) 1999-03-18 2000-03-17 Xylo-lna analoge

Country Status (11)

Country Link
EP (1) EP1161439B1 (de)
JP (1) JP2002540118A (de)
KR (1) KR20020013513A (de)
CN (1) CN1350542A (de)
AT (1) ATE465168T1 (de)
AU (1) AU777049B2 (de)
CA (1) CA2368135C (de)
DE (1) DE60044241D1 (de)
HK (1) HK1048639A1 (de)
IL (1) IL145495A0 (de)
WO (1) WO2000056748A1 (de)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
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US6936467B2 (en) 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
AP2002002638A0 (en) 2000-03-27 2002-09-30 Univ Delaware Targeted chromosomal genomic alternations with modified single stranded oligonucleotides.
EP1414840A4 (de) 2001-03-27 2005-04-13 Univ Delaware Genomics-anwendungen für modifizierte oligonukleotide
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AU2002334307A1 (en) 2001-09-04 2003-03-18 Exiqon A/S Novel lna compositions and uses thereof
EP1446503A2 (de) 2001-09-27 2004-08-18 University Of Delaware Zusammensetzung und verfahren zur verbesserung der oligonukleotidgesteuerten veränderung von nukleinsäuresequenzen
US7468244B2 (en) 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
WO2003039523A2 (en) * 2001-11-05 2003-05-15 Exiqon A/S OLIGONUCLEOTIDES MODIFIED WITH NOVEL α-L-RNA ANALOGUES
JP2005518817A (ja) 2002-03-07 2005-06-30 ユニバーシティー、オブ、デラウェア ヒストン・デアセチラーゼ・インヒビタ、ラムダファージベータ蛋白、またはヒドロキシウレアを含む組成物を使用してオリゴヌクレオチド媒介性核酸配列改変を高める方法、組成物およびキット
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DE60327775D1 (de) * 2002-06-24 2009-07-09 Exiqon As Methoden und systeme zur detektion und isolation von nucleinsäuresequenzen
US20040219565A1 (en) 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
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UND VORRICHTUNG ZUR DURCHFÜHRUNG DES VERFAHRENS
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CN1273476C (zh) * 1997-09-12 2006-09-06 埃克西康有限公司 寡核苷酸类似物

Also Published As

Publication number Publication date
JP2002540118A (ja) 2002-11-26
CA2368135C (en) 2010-06-08
KR20020013513A (ko) 2002-02-20
WO2000056748A1 (en) 2000-09-28
CA2368135A1 (en) 2000-09-28
ATE465168T1 (de) 2010-05-15
CN1350542A (zh) 2002-05-22
IL145495A0 (en) 2002-06-30
AU3274300A (en) 2000-10-09
AU777049B2 (en) 2004-09-30
EP1161439B1 (de) 2010-04-21
HK1048639A1 (zh) 2003-04-11
EP1161439A1 (de) 2001-12-12

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