DE60036861D1 - Verkapselung biologisch aktiver komplexe in liposomen - Google Patents

Verkapselung biologisch aktiver komplexe in liposomen

Info

Publication number
DE60036861D1
DE60036861D1 DE60036861T DE60036861T DE60036861D1 DE 60036861 D1 DE60036861 D1 DE 60036861D1 DE 60036861 T DE60036861 T DE 60036861T DE 60036861 T DE60036861 T DE 60036861T DE 60036861 D1 DE60036861 D1 DE 60036861D1
Authority
DE
Germany
Prior art keywords
liposomes
encapsulation
biologically active
active complexes
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60036861T
Other languages
English (en)
Other versions
DE60036861T2 (de
Inventor
Paul Meers
Tong Shangguan
Donna Cabral-Lilly
Andrew Janoff
Patrick Ahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transave LLC
Original Assignee
Transave LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transave LLC filed Critical Transave LLC
Publication of DE60036861D1 publication Critical patent/DE60036861D1/de
Application granted granted Critical
Publication of DE60036861T2 publication Critical patent/DE60036861T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE60036861T 1999-03-02 2000-03-01 Verkapselung biologisch aktiver komplexe in liposomen Expired - Fee Related DE60036861T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12236599P 1999-03-02 1999-03-02
US122365P 1999-03-02
PCT/US2000/005395 WO2000051565A1 (en) 1999-03-02 2000-03-01 Encapsulation of bioactive complexes in liposomes

Publications (2)

Publication Number Publication Date
DE60036861D1 true DE60036861D1 (de) 2007-12-06
DE60036861T2 DE60036861T2 (de) 2008-07-24

Family

ID=22402271

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036861T Expired - Fee Related DE60036861T2 (de) 1999-03-02 2000-03-01 Verkapselung biologisch aktiver komplexe in liposomen

Country Status (20)

Country Link
US (2) US7491409B1 (de)
EP (1) EP1156783B1 (de)
JP (1) JP2002538096A (de)
KR (1) KR20010112301A (de)
CN (1) CN1349402A (de)
AT (1) ATE376413T1 (de)
AU (1) AU3715900A (de)
BR (1) BR0008711A (de)
CA (1) CA2362485A1 (de)
CZ (1) CZ20013103A3 (de)
DE (1) DE60036861T2 (de)
EA (1) EA200100856A1 (de)
ES (1) ES2295018T3 (de)
HU (1) HUP0200114A2 (de)
IL (1) IL145117A0 (de)
NO (1) NO20014231L (de)
NZ (1) NZ513829A (de)
PL (1) PL351487A1 (de)
WO (1) WO2000051565A1 (de)
ZA (1) ZA200107205B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1349402A (zh) * 1999-03-02 2002-05-15 利普索姆公司 生物活性络合物于脂质体中囊封工艺
ES2336766T3 (es) * 2000-10-04 2010-04-16 Kyowa Hakko Kirin Co., Ltd. Procedimiento de recubrimiento de particulas finas con pelicula lipidica.
US7713942B2 (en) 2001-04-04 2010-05-11 Nordic Vaccine Technology A/S Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
DK1377320T3 (da) * 2001-04-04 2009-02-09 Nordic Vaccine Technology As Polynukleotidbindingskomplekser omfattende steroler og saponiner
JP4370451B2 (ja) * 2001-09-28 2009-11-25 大塚製薬株式会社 医薬組成物
EP1474107A4 (de) * 2002-01-09 2010-01-20 Transave Inc Wirkungsvolle liposomen-verkapselung unter milden bedingungen
US20060058249A1 (en) * 2002-01-09 2006-03-16 Shangguan Tong Efficient nucleic acid encapsulation into medium sized liposomes
CA2478479A1 (en) 2002-03-07 2003-09-18 University Of Delaware Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phagebeta protein, or hydroxyurea
EP1513538A4 (de) * 2002-06-14 2007-08-22 Mirus Bio Corp Neuartige verfahren zum einbringen von polynukleotiden in zellen
ES2640060T3 (es) * 2005-01-28 2017-10-31 Kyowa Hakko Kirin Co., Ltd. Proceso para producir una partícula fina revestida
WO2006101201A1 (ja) * 2005-03-24 2006-09-28 National University Corporation Hokkaido University 目的物質を効率的に核内に送達可能なリポソーム
EP1930436B1 (de) * 2005-09-30 2011-04-27 National University Corporation Hokkaido University Vektor zur zuführung einer zielsubstanz in den zellkern oder die zelle
JP2010528615A (ja) * 2007-05-31 2010-08-26 サノフィ−アベンティス ＮＡＰＥ−ＰＬＤ又はＡｂｈ４の活性を修飾する薬剤を同定するためのアッセイ方法
US8784659B2 (en) 2007-08-08 2014-07-22 General Electric Company Method for controlling microbial biofilm in aqueous systems
PT2279254T (pt) 2008-04-15 2017-09-04 Protiva Biotherapeutics Inc Novas formulações lipídicas para entrega de ácido nucleico
WO2010054401A1 (en) 2008-11-10 2010-05-14 Alnylam Pharmaceuticals, Inc. Novel lipids and compositions for the delivery of therapeutics
WO2011000107A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
US20110177147A1 (en) * 2010-01-21 2011-07-21 General Electric Company Stable biocidal delivery systems
KR101102834B1 (ko) * 2010-02-24 2012-01-05 충남대학교산학협력단 신규한 리포좀 제조 방법 및 장치
KR101198715B1 (ko) * 2010-05-14 2012-11-13 한국생명공학연구원 핵산 및 친수성 음이온 화합물의 고효율 포획을 위한 비대칭 리포솜 및 이의 제조방법
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
FR2964569B1 (fr) * 2010-09-10 2012-10-19 Ct De Cooperation Internationale En Rech Agronomique Pour Le Dev Cirad Nouveaux liposomes de vaccination genique
KR20140026396A (ko) * 2011-03-08 2014-03-05 어섹스 팔마큐티칼스 인코포레이티드 생물학적 막을 가로질러 활성물질의 전달을 위한 표적화된 나노담체 시스템
US9758395B2 (en) 2011-04-28 2017-09-12 Aquero Company, Llc Lysine-based polymer coagulants for use in clarification of process waters
KR102194648B1 (ko) 2013-05-17 2020-12-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 반응 혼합물, 다공성 입자 및 제조 방법
WO2014186336A1 (en) 2013-05-17 2014-11-20 3M Innovative Properties Company Release of biologically active agents from polymeric composite particles
EP3823634A4 (de) * 2018-07-21 2022-08-03 University of Tennessee Research Foundation Neutrale liposomen, die biologische wirkstoffe enthalten
JP2022527638A (ja) * 2019-03-29 2022-06-02 グライコミン， インコーポレイテッド リポソーム製剤、ならびにリポソーム製剤を使用および調製する方法
EP3739321B1 (de) * 2019-05-17 2023-03-08 Xtal Concepts GmbH Qualifizierungsverfahren für kryoelektronenmikroskopie-proben sowie dazugehöriger probenhalter
WO2022045009A1 (ja) * 2020-08-24 2022-03-03 国立大学法人山口大学 流体を追跡するための組成物及び流体の追跡方法
EP4314327A1 (de) 2021-03-22 2024-02-07 Illumina Cambridge Limited Verfahren zur verbesserung der klonalität von nukleinsäureclustern
CN113785975B (zh) * 2021-09-09 2023-08-29 天津医科大学 精胺、亚精胺脂质体在抗氧化、抗衰老中的应用
DE102022134188B3 (de) 2022-12-20 2024-03-28 Universität Augsburg - Körperschaft des öffentlichen Rechts Verfahren zur in-situ Erfassung von Änderungen eines Lipidsystems bei dessen Lagerung bei einer Lagertemperatur unterhalb von -60 °C

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723147A (en) * 1987-02-23 1998-03-03 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5286634A (en) * 1989-09-28 1994-02-15 Stadler Joan K Synergistic method for host cell transformation
DK0695169T3 (da) * 1993-04-22 2003-03-17 Skyepharma Inc Multivesikulære liposomer med indkapslet cyclodextrin og farmakologisk aktive forbindelser samt fremgangsmåder til anvendelse af disse
US5795587A (en) * 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
ES2392246T3 (es) * 1996-11-12 2012-12-07 The Regents Of The University Of California Preparación de formulaciones estables de complejos de lípido-ácido nucleico para el suministro eficaz in vivo
CN1349402A (zh) * 1999-03-02 2002-05-15 利普索姆公司 生物活性络合物于脂质体中囊封工艺

Also Published As

Publication number Publication date
NZ513829A (en) 2001-09-28
NO20014231L (no) 2001-10-03
CN1349402A (zh) 2002-05-15
PL351487A1 (en) 2003-04-22
AU3715900A (en) 2000-09-21
EP1156783A4 (de) 2003-05-21
ATE376413T1 (de) 2007-11-15
NO20014231D0 (no) 2001-08-31
US7491409B1 (en) 2009-02-17
KR20010112301A (ko) 2001-12-20
BR0008711A (pt) 2002-10-01
IL145117A0 (en) 2002-06-30
WO2000051565A1 (en) 2000-09-08
EA200100856A1 (ru) 2002-02-28
EP1156783A1 (de) 2001-11-28
JP2002538096A (ja) 2002-11-12
ES2295018T3 (es) 2008-04-16
DE60036861T2 (de) 2008-07-24
CZ20013103A3 (cs) 2002-01-16
ZA200107205B (en) 2002-12-02
EP1156783B1 (de) 2007-10-24
WO2000051565A9 (en) 2002-02-14
US20090068256A1 (en) 2009-03-12
HUP0200114A2 (hu) 2002-05-29
CA2362485A1 (en) 2000-09-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee