DE600365C - Process for the production of an effective preparation from dioxyphenylisatin or its substitution products and derivatives - Google Patents

Process for the production of an effective preparation from dioxyphenylisatin or its substitution products and derivatives

Info

Publication number
DE600365C
DE600365C DEC45831D DEC0045831D DE600365C DE 600365 C DE600365 C DE 600365C DE C45831 D DEC45831 D DE C45831D DE C0045831 D DEC0045831 D DE C0045831D DE 600365 C DE600365 C DE 600365C
Authority
DE
Germany
Prior art keywords
dioxyphenylisatin
derivatives
substitution products
production
effective preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEC45831D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMISCHE FABRIKEN DR JOACHIM
Original Assignee
CHEMISCHE FABRIKEN DR JOACHIM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMISCHE FABRIKEN DR JOACHIM filed Critical CHEMISCHE FABRIKEN DR JOACHIM
Priority to DEC45831D priority Critical patent/DE600365C/en
Application granted granted Critical
Publication of DE600365C publication Critical patent/DE600365C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung eines wirksamen Präparates aus Dioxyphenylisatin bzw. dessen Substitutionsprodukten und Derivaten In dem Patent 573 034 ist ein Verfahren zur Herstellung wasserlöslicher Präparate aus DioxypheDylisatin und dessen Substitutionsprodukten geschützt, welches auf der Behandlung dieser Substanzen mit gallensauren Salzen beruht.Process for the production of an effective preparation from dioxyphenylisatin or its substitution products and derivatives. Patent 573 034 is a process for the production of water-soluble preparations from DioxypheDylisatin and its substitution products protected, which is based on the treatment of these substances with bile salts is based.

Es wurde gefunden, daß sich ein Fortschritt von allgemeiner Bedeutung erzielen läßt, wenn man das Dioxyphenylisatin bzw. dessen Substitutionsprodukte oder Derivate bei Gegenwart oder Abwesenheit von sonstigen Lösungsmitteln mit anderen Substanzen, welche als Wasserlöslichmachungsmittelwirken, behandelt. Als solche Mittel kommen beispielsweise Urethane oder Dialkylamide von Fettsäuren in Betracht.It has been found that there is an advance of general importance can be achieved if the dioxyphenylisatin or its substitution products or derivatives in the presence or absence of other solvents with others Substances that act as water solubilizers treated. As such Agents are, for example, urethanes or dialkylamides of fatty acids.

Es ist zwar bekannt, daß gewisse Körperklassen die Eigenschaft besitzen, an sich wasserunlösliche Stoffe in Lösung zu bringen. Es zeigte sich aber überraschenderweise, daß durch die bessere Löslichmachung von Dioxyphenylisatin besonders wirksame Präparate erhalten wurden, die dem wasserunlöslichen Diphenolisatin insofern überlegen sind, als sie in viel kleineren Dosen ohne Beeinträchtigung des allgemeinen Zustandes wirksam sind.It is known that certain body classes have the property to bring water-insoluble substances into solution. But surprisingly it turned out that the better solubilization of dioxyphenylisatin particularly effective preparations which are superior to the water-insoluble diphenolisatin, than they are in much smaller doses without affecting the general condition are effective.

Die nach der Erfindung hergestellten Präparate sind auf Grund ihrer Wasserlöslichkeit dazu geeignet, für therapeutische Zwecke, und zwar auch für Injektionen verwendet zu werden. Die Indikation entspricht derjenigen des Hauptpatentes. Beispiel i i Teil Dioxyphenylisatin wird mit 2o Teilen Carbaminsäureäthylester und 3o Teilen Wasser behandelt. Man erhält eine bei Zimmertemperatur klare Lösung, die sich beispielsweise mit weiteren 3o Teilen Wasser verdünnen läßt, ohne daß eine Ausscheidung eintritt.The preparations produced according to the invention are due to their Water solubility suitable for therapeutic purposes, including injections to be used. The indication corresponds to that of the main patent. example i i part of dioxyphenylisatin is mixed with 2o parts of ethyl carbamate and 3o parts Treated water. A clear solution is obtained at room temperature, for example can be diluted with a further 30 parts of water without precipitation occurring.

Beispiel 2 i Teil Dioxyphenylisatin wird in 2o Teilen Essigsäurediäthylamid in Lösung gebracht. Die Lösung bleibt bei Zimmertemperatur auch nach Zusatz von 3o Teilen Wasser klar.Example 2 1 part of dioxyphenylisatin is added to 2o parts of acetic acid diethylamide brought into solution. The solution remains at room temperature even after adding 3o parts of clear water.

Claims (1)

PATENTANSPRUCH: Abänderung des Verfahrens zur Herstellung eines wirksamen Präparates aus Dioxyphenylisatin bzw. dessen Substitutionsprodukten und Derivaten gemäß Patent 573 034, dadurch gekennzeichnet, daß hier diese Substanzen bei Gegenwart oder Abwesenheit von sonstigen Lösungsmitteln mit Wasserlöslichmachungsmitteln, und zwar insbesondere Dialkylamiden von Fettsäuren oder Urethanen, behandelt werden.PATENT CLAIM: Modification of the process for producing an effective Preparation made from dioxyphenylisatin or its substitution products and derivatives according to patent 573 034, characterized in that these substances are present here or absence of other solvents with water-solubilizing agents, and in particular dialkylamides of fatty acids or urethanes.
DEC45831D 1931-12-31 1931-12-31 Process for the production of an effective preparation from dioxyphenylisatin or its substitution products and derivatives Expired DE600365C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEC45831D DE600365C (en) 1931-12-31 1931-12-31 Process for the production of an effective preparation from dioxyphenylisatin or its substitution products and derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC45831D DE600365C (en) 1931-12-31 1931-12-31 Process for the production of an effective preparation from dioxyphenylisatin or its substitution products and derivatives

Publications (1)

Publication Number Publication Date
DE600365C true DE600365C (en) 1934-07-21

Family

ID=7026200

Family Applications (1)

Application Number Title Priority Date Filing Date
DEC45831D Expired DE600365C (en) 1931-12-31 1931-12-31 Process for the production of an effective preparation from dioxyphenylisatin or its substitution products and derivatives

Country Status (1)

Country Link
DE (1) DE600365C (en)

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