DE60033835D1 - Heterologe herstellung von polyketiden - Google Patents

Heterologe herstellung von polyketiden

Info

Publication number
DE60033835D1
DE60033835D1 DE60033835T DE60033835T DE60033835D1 DE 60033835 D1 DE60033835 D1 DE 60033835D1 DE 60033835 T DE60033835 T DE 60033835T DE 60033835 T DE60033835 T DE 60033835T DE 60033835 D1 DE60033835 D1 DE 60033835D1
Authority
DE
Germany
Prior art keywords
polycetides
heterologist
preparation
host cells
coli host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60033835T
Other languages
English (en)
Other versions
DE60033835T2 (de
Inventor
Daniel Santi
Larry Peck
Linda Dayem
James Kealey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of DE60033835D1 publication Critical patent/DE60033835D1/de
Application granted granted Critical
Publication of DE60033835T2 publication Critical patent/DE60033835T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
DE60033835T 1999-10-27 2000-10-27 Heterologe herstellung von polyketiden Expired - Lifetime DE60033835T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16170399P 1999-10-27 1999-10-27
US161703P 1999-10-27
PCT/US2000/029775 WO2001031035A2 (en) 1999-10-27 2000-10-27 Heterologous production of polyketides

Publications (2)

Publication Number Publication Date
DE60033835D1 true DE60033835D1 (de) 2007-04-19
DE60033835T2 DE60033835T2 (de) 2007-11-15

Family

ID=22582342

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60033835T Expired - Lifetime DE60033835T2 (de) 1999-10-27 2000-10-27 Heterologe herstellung von polyketiden

Country Status (12)

Country Link
US (4) US7011959B1 (de)
EP (1) EP1224300B9 (de)
JP (1) JP2003512073A (de)
AT (1) ATE356216T1 (de)
AU (1) AU1105201A (de)
CA (1) CA2388422A1 (de)
DE (1) DE60033835T2 (de)
ES (1) ES2283323T3 (de)
IL (1) IL148934A0 (de)
MX (1) MXPA02004153A (de)
NZ (1) NZ518259A (de)
WO (1) WO2001031035A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6790605B1 (en) 1995-12-07 2004-09-14 Diversa Corporation Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US6939691B1 (en) * 1999-10-13 2005-09-06 Board Of Trustees Of The Leland Stanford Junior University E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
DE60026563D1 (de) 1999-10-25 2006-05-04 Kosan Biosciences Inc Herstellung von polyketiden
EP1381672A4 (de) * 2001-02-28 2006-01-25 Trustees Of Board Of Biosynthese von polyketidsynthasesubstraten
WO2004007688A2 (en) 2002-07-15 2004-01-22 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
JP2006500928A (ja) * 2002-07-31 2006-01-12 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 大腸菌におけるグリコシル化マクロライドの産生
CN100363359C (zh) 2002-08-29 2008-01-23 菲塞股份有限公司 运动内酯化合物
AU2003291534A1 (en) 2002-11-12 2004-06-03 Kosan Biosciences, Inc. Method for producing polyketides
WO2007024997A2 (en) * 2005-08-22 2007-03-01 Fermalogic, Inc. Methods of increasing production of secondary metabolites
DE102006025821A1 (de) * 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
BRPI0605166A (pt) * 2006-11-03 2008-07-01 Inst Fleury método de determinação de ácido metilmalÈnico baseado na extração alquilativa associada à cromatografia lìquida acoplada à espectrometria de massas
EP2486129B1 (de) 2009-10-08 2016-04-13 The Regents of The University of California Lov-D-MUTANTEN MIT VERBESSERTEN EIGENSCHAFTEN IN BEZUG AUF SIMVASTATIN-SYNTHESE
BR112013003003A2 (pt) 2010-08-06 2016-06-14 Mascoma Corp produção de produtos malonil-coa derivados através de rotas anaeróbicas
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
CN103060248B (zh) * 2011-10-19 2017-05-17 中国科学院上海有机化学研究所 一种构建基因工程fk506高产菌株的方法和筑波链霉菌高产菌株
US10119145B2 (en) 2013-03-15 2018-11-06 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) Engineered organisms for production of novel lipids
DE102013112501A1 (de) 2013-11-13 2015-05-13 Bergische Universität Wuppertal Verfahren zur Herstellung chiraler Verbindungen
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN112410274B (zh) * 2019-08-23 2023-01-24 上海医药工业研究院 一种生产子囊霉素的基因工程菌及其制备方法和用途
CN114874931B (zh) * 2021-12-22 2023-06-27 河北省科学院生物研究所 一种复合微生物菌剂及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
JP4709333B2 (ja) 1995-10-13 2011-06-22 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ ホスホパンテテイニルトランスフェラーゼおよびその使用
US6033883A (en) * 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
AU744751C (en) 1997-07-10 2005-11-24 Kosan Biosciences, Inc. Production of polyketides in plants
EP1029076A4 (de) * 1997-10-15 2002-03-06 Diversa Inc Screening für neue verbindungen, die biologische interaktionen regulieren
WO2000020601A2 (en) * 1998-10-02 2000-04-13 Kosan Biosciences, Inc. Polyketide synthase enzymes and recombinant dna constructs therefor
KR100851418B1 (ko) * 1998-11-20 2008-08-08 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
JP5142435B2 (ja) 1999-10-13 2013-02-13 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ ポリケチド合成基質の生合成

Also Published As

Publication number Publication date
IL148934A0 (en) 2002-09-12
ES2283323T3 (es) 2007-11-01
EP1224300B1 (de) 2007-03-07
MXPA02004153A (es) 2002-10-17
US7291486B2 (en) 2007-11-06
US7011959B1 (en) 2006-03-14
AU1105201A (en) 2001-05-08
US20040185541A1 (en) 2004-09-23
NZ518259A (en) 2004-03-26
ATE356216T1 (de) 2007-03-15
WO2001031035A2 (en) 2001-05-03
EP1224300A2 (de) 2002-07-24
US20020142401A1 (en) 2002-10-03
EP1224300B9 (de) 2007-09-26
JP2003512073A (ja) 2003-04-02
DE60033835T2 (de) 2007-11-15
US20090098615A1 (en) 2009-04-16
WO2001031035A3 (en) 2001-11-22
CA2388422A1 (en) 2001-05-03

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