ATE356216T1 - Heterologe herstellung von polyketiden - Google Patents
Heterologe herstellung von polyketidenInfo
- Publication number
- ATE356216T1 ATE356216T1 AT00972384T AT00972384T ATE356216T1 AT E356216 T1 ATE356216 T1 AT E356216T1 AT 00972384 T AT00972384 T AT 00972384T AT 00972384 T AT00972384 T AT 00972384T AT E356216 T1 ATE356216 T1 AT E356216T1
- Authority
- AT
- Austria
- Prior art keywords
- polyketides
- production
- heterologue
- host cells
- coli host
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16170399P | 1999-10-27 | 1999-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE356216T1 true ATE356216T1 (de) | 2007-03-15 |
Family
ID=22582342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00972384T ATE356216T1 (de) | 1999-10-27 | 2000-10-27 | Heterologe herstellung von polyketiden |
Country Status (12)
Country | Link |
---|---|
US (4) | US7011959B1 (de) |
EP (1) | EP1224300B9 (de) |
JP (1) | JP2003512073A (de) |
AT (1) | ATE356216T1 (de) |
AU (1) | AU1105201A (de) |
CA (1) | CA2388422A1 (de) |
DE (1) | DE60033835T2 (de) |
ES (1) | ES2283323T3 (de) |
IL (1) | IL148934A0 (de) |
MX (1) | MXPA02004153A (de) |
NZ (1) | NZ518259A (de) |
WO (1) | WO2001031035A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6939689B2 (en) | 1995-12-07 | 2005-09-06 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
US6790605B1 (en) | 1995-12-07 | 2004-09-14 | Diversa Corporation | Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source |
US5830696A (en) | 1996-12-05 | 1998-11-03 | Diversa Corporation | Directed evolution of thermophilic enzymes |
US6713279B1 (en) | 1995-12-07 | 2004-03-30 | Diversa Corporation | Non-stochastic generation of genetic vaccines and enzymes |
US6939691B1 (en) * | 1999-10-13 | 2005-09-06 | Board Of Trustees Of The Leland Stanford Junior University | E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production |
AU1231701A (en) | 1999-10-25 | 2001-05-08 | Kosan Biosciences, Inc. | Production of polyketides |
CA2438798A1 (en) * | 2001-02-28 | 2002-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Biosynthesis of polyketide synthase substrates |
AU2003253949A1 (en) | 2002-07-15 | 2004-02-02 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
US20040214276A1 (en) * | 2002-07-31 | 2004-10-28 | Chaitan Khosla | Production of glycosylated macrolides in E. coli |
CA2492846C (en) | 2002-08-29 | 2012-09-25 | Kosan Biosciences, Inc. | Motilide compounds |
WO2004044180A2 (en) | 2002-11-12 | 2004-05-27 | Kosan Biosciences, Inc. | Method for producing polyketides |
US20070122885A1 (en) * | 2005-08-22 | 2007-05-31 | Fermalogic, Inc. | Methods of increasing production of secondary metabolites by manipulating metabolic pathways that include methylmalonyl-coa |
DE102006025821A1 (de) * | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
BRPI0605166A (pt) * | 2006-11-03 | 2008-07-01 | Inst Fleury | método de determinação de ácido metilmalÈnico baseado na extração alquilativa associada à cromatografia lìquida acoplada à espectrometria de massas |
EP2486129B1 (de) | 2009-10-08 | 2016-04-13 | The Regents of The University of California | Lov-D-MUTANTEN MIT VERBESSERTEN EIGENSCHAFTEN IN BEZUG AUF SIMVASTATIN-SYNTHESE |
WO2012019175A2 (en) | 2010-08-06 | 2012-02-09 | Mascoma Corporation | Production of malonyl-coa drived products via anaerobic pathways |
US8852902B2 (en) | 2010-11-22 | 2014-10-07 | The Regents Of The University Of California | Producing a trimethylpentanoic acid using hybrid polyketide synthases |
CN103060248B (zh) * | 2011-10-19 | 2017-05-17 | 中国科学院上海有机化学研究所 | 一种构建基因工程fk506高产菌株的方法和筑波链霉菌高产菌株 |
US10119145B2 (en) | 2013-03-15 | 2018-11-06 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) | Engineered organisms for production of novel lipids |
DE102013112501A1 (de) | 2013-11-13 | 2015-05-13 | Bergische Universität Wuppertal | Verfahren zur Herstellung chiraler Verbindungen |
US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
CN112410274B (zh) * | 2019-08-23 | 2023-01-24 | 上海医药工业研究院 | 一种生产子囊霉素的基因工程菌及其制备方法和用途 |
CN114874931B (zh) * | 2021-12-22 | 2023-06-27 | 河北省科学院生物研究所 | 一种复合微生物菌剂及其制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
JP4709333B2 (ja) | 1995-10-13 | 2011-06-22 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | ホスホパンテテイニルトランスフェラーゼおよびその使用 |
US6033883A (en) | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
CA2288030A1 (en) | 1997-04-30 | 1998-11-05 | Kosan Biosciences, Inc. | Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold |
CA2294616A1 (en) * | 1997-07-10 | 1999-01-21 | Kosan Biosciences, Inc. | Production of polyketides in plants |
CA2315819A1 (en) * | 1997-10-15 | 1999-04-22 | Diversa Corporation | Screening for novel compounds which regulate biological interactions |
NZ510819A (en) * | 1998-10-02 | 2004-03-26 | Kosan Biosciences Inc | Polyketide synthase enzymes and recombinant DNA constructs therefor |
JP4662635B2 (ja) * | 1998-11-20 | 2011-03-30 | コーサン バイオサイエンシーズ, インコーポレイテッド | エポチロンおよびエポチロン誘導体を生成するための組換え方法および材料 |
ES2335385T3 (es) | 1999-10-13 | 2010-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | Biosintesis de sustratos de policetido sintasa. |
-
2000
- 2000-10-27 US US09/699,136 patent/US7011959B1/en not_active Expired - Lifetime
- 2000-10-27 MX MXPA02004153A patent/MXPA02004153A/es unknown
- 2000-10-27 ES ES00972384T patent/ES2283323T3/es not_active Expired - Lifetime
- 2000-10-27 CA CA002388422A patent/CA2388422A1/en not_active Abandoned
- 2000-10-27 NZ NZ518259A patent/NZ518259A/en unknown
- 2000-10-27 AT AT00972384T patent/ATE356216T1/de not_active IP Right Cessation
- 2000-10-27 JP JP2001533170A patent/JP2003512073A/ja active Pending
- 2000-10-27 AU AU11052/01A patent/AU1105201A/en not_active Abandoned
- 2000-10-27 WO PCT/US2000/029775 patent/WO2001031035A2/en active IP Right Grant
- 2000-10-27 EP EP00972384A patent/EP1224300B9/de not_active Expired - Lifetime
- 2000-10-27 IL IL14893400A patent/IL148934A0/xx unknown
- 2000-10-27 DE DE60033835T patent/DE60033835T2/de not_active Expired - Lifetime
-
2001
- 2001-08-29 US US09/942,407 patent/US20020142401A1/en not_active Abandoned
-
2004
- 2004-04-21 US US10/829,897 patent/US7291486B2/en not_active Expired - Fee Related
-
2007
- 2007-11-05 US US11/935,351 patent/US20090098615A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7011959B1 (en) | 2006-03-14 |
JP2003512073A (ja) | 2003-04-02 |
DE60033835T2 (de) | 2007-11-15 |
US7291486B2 (en) | 2007-11-06 |
MXPA02004153A (es) | 2002-10-17 |
US20090098615A1 (en) | 2009-04-16 |
WO2001031035A2 (en) | 2001-05-03 |
EP1224300A2 (de) | 2002-07-24 |
US20040185541A1 (en) | 2004-09-23 |
DE60033835D1 (de) | 2007-04-19 |
AU1105201A (en) | 2001-05-08 |
IL148934A0 (en) | 2002-09-12 |
NZ518259A (en) | 2004-03-26 |
EP1224300B9 (de) | 2007-09-26 |
US20020142401A1 (en) | 2002-10-03 |
CA2388422A1 (en) | 2001-05-03 |
EP1224300B1 (de) | 2007-03-07 |
ES2283323T3 (es) | 2007-11-01 |
WO2001031035A3 (en) | 2001-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE356216T1 (de) | Heterologe herstellung von polyketiden | |
Goto et al. | Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights | |
Caliskan et al. | Conditional switch between frameshifting regimes upon translation of dnaX mRNA | |
WO2004007688A3 (en) | Metabolic pathways for starter units in polyketide biosynthesis | |
DK0698105T3 (da) | Nukleotidsekvenser til styring af ekspressionen af DNAsekvenser i en værtscelle | |
WO2000026349A3 (en) | Recombinant oleandolide polyketide synthase | |
EP1829892A3 (de) | proteine und nukleinsäuren von staphylococcus aureus | |
EP1824977A4 (de) | Aus bakterien der gattung corynebacterium stammende neue promotornukleinsäure, den promotor umfassende expressionskassette und die kassette umfassender vektor, den vektor umfassende wirtszelle sowie verfahren zur expression eines gens unter verwendung der zelle | |
WO1998049315A3 (en) | Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold | |
AU2002314738A1 (en) | Methods for the production of products in host cells | |
EP1576160B8 (de) | Borrelidin-derivate und ihre medizinische anwendung | |
ATE319848T1 (de) | Herstellung von polyketiden | |
Yim et al. | Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster | |
Nedal et al. | Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 | |
WO2005058945A3 (de) | Genvarianten die für proteine aus dem stoffwechselweg von feinchemikalien kodieren | |
WO2001027284A3 (en) | Recombinant megalomicin biosynthetic genes and uses thereof | |
Kim et al. | One-pot combinatorial biosynthesis of glycosylated anthracyclines by cocultivation of Streptomyces strains producing aglycones and nucleotide deoxysugars | |
WO2000004051A3 (en) | Growth differentiation factor promoter and uses therefor | |
AU5437390A (en) | Methods and nucleic acid sequences for the expression of the cellulose synthase operon | |
BR9609102A (pt) | Construção de dna recombinante e vetor útil para produzir transformantes de células de hospedeiro bacteriano | |
CA2394616A1 (en) | Gene cluster for ramoplanin biosynthesis | |
WO2000037656A3 (en) | Flavonoid biosynthetic enzymes | |
AU2002355157A1 (en) | Genes and proteins for the biosynthesis of rosaramicin | |
WO2005026327A3 (en) | Biosynthetic gene cluster for leptomycins | |
ATE312177T1 (de) | Proteinproduktion in gram-positiven mikroorganismen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |