DE60031244D1 - Reinigung von biologischen substanzen - Google Patents

Reinigung von biologischen substanzen

Info

Publication number
DE60031244D1
DE60031244D1 DE60031244T DE60031244T DE60031244D1 DE 60031244 D1 DE60031244 D1 DE 60031244D1 DE 60031244 T DE60031244 T DE 60031244T DE 60031244 T DE60031244 T DE 60031244T DE 60031244 D1 DE60031244 D1 DE 60031244D1
Authority
DE
Germany
Prior art keywords
cleaning
biological substances
purifying
employing
types
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60031244T
Other languages
English (en)
Other versions
DE60031244T2 (de
Inventor
Henry Kopf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NCSRT Inc
Original Assignee
NCSRT Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/255,186 external-priority patent/US6214221B1/en
Application filed by NCSRT Inc filed Critical NCSRT Inc
Application granted granted Critical
Publication of DE60031244D1 publication Critical patent/DE60031244D1/de
Publication of DE60031244T2 publication Critical patent/DE60031244T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Jellies, Jams, And Syrups (AREA)
DE60031244T 1999-02-22 2000-02-22 Reinigung von biologischen substanzen Expired - Lifetime DE60031244T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US255186 1994-06-07
US09/255,186 US6214221B1 (en) 1999-02-22 1999-02-22 Method and apparatus for purification of biological substances
US09/300,891 US6139746A (en) 1999-02-22 1999-04-28 Method and apparatus for purification of biological substances
PCT/US2000/040035 WO2000048703A1 (en) 1999-02-22 2000-02-22 Purification of biological substances
US300891 2002-11-21

Publications (2)

Publication Number Publication Date
DE60031244D1 true DE60031244D1 (de) 2006-11-23
DE60031244T2 DE60031244T2 (de) 2007-05-24

Family

ID=26944506

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031244T Expired - Lifetime DE60031244T2 (de) 1999-02-22 2000-02-22 Reinigung von biologischen substanzen

Country Status (10)

Country Link
US (1) US6383380B1 (de)
EP (1) EP1154827B1 (de)
AT (1) ATE342112T1 (de)
AU (1) AU756832B2 (de)
CA (1) CA2361545C (de)
DE (1) DE60031244T2 (de)
DK (1) DK1154827T3 (de)
IL (1) IL144421A (de)
NZ (1) NZ513242A (de)
WO (1) WO2000048703A1 (de)

Families Citing this family (52)

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US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
NO20002828D0 (no) * 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
WO2003095632A1 (fr) * 2002-05-07 2003-11-20 Asahi Kasei Kabushiki Kaisha Procede et systeme permettant d'obtenir des cellules d'un type specifique a partir d'un materiau biologique
KR100473703B1 (ko) * 2002-08-23 2005-03-10 한미약품 주식회사 형질전환 동물의 젖으로부터 재조합 펩타이드 또는단백질의 정제 방법
RU2005129745A (ru) * 2003-02-24 2006-03-20 Джитиси Байотерапьютикс, Инк. (Us) Способы и устройство проточной фильтрации вдоль потока
US8152999B2 (en) * 2004-05-21 2012-04-10 Wisconsin Alumni Research Foundation Membrane cascade-based separation
DK1786273T3 (en) * 2004-08-20 2019-02-18 Prometic Biosciences Ltd SEQUENTIAL PROTEIN INSULATION AND PURIFICATION PLANS WITH AFFINITY CHROMATOGRAPHY
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
US7531632B2 (en) 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
EP3827841B1 (de) 2006-10-09 2024-04-03 Neurofluidics, Inc. System zur reinigung von liquor
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
CN101497649B (zh) * 2008-01-31 2011-06-08 上海依科赛生物制品有限公司 高融合率无噬菌体新生牛血清的生产工艺
FR2931838B1 (fr) * 2008-06-02 2010-06-11 Millipore Corp Installation pour traiter un liquide biologique.
FR2940145B1 (fr) 2008-12-24 2011-03-25 Millipore Corp Chariot et installation de traitement d'un liquide biologique
US8795530B2 (en) 2009-01-21 2014-08-05 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
FR2941385B1 (fr) 2009-01-23 2011-04-01 Millipore Corp Procede pour fournir un circuit pour liquide biologique et circuit obtenu.
US7988859B2 (en) * 2009-02-05 2011-08-02 Chromatan Inc. Countercurrent tangential chromatography methods, systems, and apparatus
KR20100102926A (ko) * 2009-03-12 2010-09-27 삼성전자주식회사 표적물질 정제를 위한 필터유닛 및 이를 채용한 미세유동장치
KR20100111097A (ko) * 2009-04-06 2010-10-14 삼성전자주식회사 표적물질 분리를 위한 미세유동장치 및 그 정제방법
WO2011066498A2 (en) 2009-11-28 2011-06-03 Smartflow Technologies, Inc. Portable filtration unit
FR2955119B1 (fr) 2010-01-13 2012-12-28 Millipore Corp Circuit pour liquide biologique
FR2960794B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960795B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960796B1 (fr) 2010-06-08 2014-01-24 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2961711B1 (fr) 2010-06-23 2012-08-17 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
FR2961713B1 (fr) 2010-06-23 2012-08-10 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
FR2963573B1 (fr) 2010-08-03 2012-08-31 Millipore Corp Chariot de pompage pour une installation de traitement de liquide biologique
JP5860887B2 (ja) * 2010-10-15 2016-02-16 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 大容量使い捨て限外濾過システム及び方法
US8919385B2 (en) 2010-11-24 2014-12-30 Pall Corporation Manifold plates and fluid treatment arrangements including manifold plates
US10005697B1 (en) 2011-02-21 2018-06-26 Smartflow Technologies, Inc. Method and systems for isolation and/or separation of target products from animal produced waste streams
WO2012115932A2 (en) 2011-02-21 2012-08-30 Smartflow Technologies, Inc. Method and systems for isolation and/or separation of products from production processes
DE112012001444T5 (de) * 2011-03-25 2014-04-10 Receptors Llc Faser mit Mikrobenentfernungs- oder Mikrobizidwirkungsvermögen oder Vermögen zur Bewirkung von statischem Wachstum
FR2973396B1 (fr) 2011-03-28 2013-05-10 Millipore Corp Installation de traitement de liquide biologique
US9284346B2 (en) * 2011-09-07 2016-03-15 Therapeutic Proteins International, LLC Preparative chromatography column and methods
US9670429B2 (en) 2012-02-16 2017-06-06 Smartflow Technologies, Inc. Separation systems for dewatering of fog and biodiesel fuel production
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
FR2993572B1 (fr) 2012-07-23 2016-04-15 Emd Millipore Corp Circuit pour liquide biologique comportant une vanne a pincement
US10786784B2 (en) 2012-09-06 2020-09-29 Smartflow Technologies, Inc. Permeate channel alterations for counter current filtration for use in cross-flow filtration modules useful in osmotic systems
US10611826B2 (en) 2013-07-05 2020-04-07 Laboratoire Français Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
US10324070B2 (en) 2014-04-23 2019-06-18 Chromatan Inc. High efficiency continuous countercurrent tangential chromatography
WO2015195452A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Single-pass filtration systems and processes
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
ES2742704T3 (es) 2014-06-25 2020-02-17 Emd Millipore Corp Elementos, módulos y sistemas de filtro compactos, enrollados en espiral
WO2016033546A1 (en) 2014-08-29 2016-03-03 Emd Millipore Corporation Single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
EP3010626B1 (de) 2014-08-29 2022-12-14 EMD Millipore Corporation Verfahren zum filtrieren von flüssigkeiten mit querstromfilterungssystemen mit einzelnen durchgängen sowie querstromfilterungssysteme mit retentatrückführung
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
WO2017096228A1 (en) 2015-12-04 2017-06-08 Minnetronix, Inc. Systems and methods for the conditioning of cerebrospinal fluid
CN109564198A (zh) 2016-08-26 2019-04-02 纯化迪发有限公司 层析系统
CA3097042A1 (en) 2018-04-17 2019-10-24 Smartflow Technologies, Inc. Filter cassette article, and filter comprising same
US11028124B2 (en) 2018-05-07 2021-06-08 Repligen Corporation Methods, devices and systems for 3-stage filtration
JP2021535221A (ja) 2018-08-29 2021-12-16 メルク バイオディベロップメント ソシエテ パ アクシオンス シンプリフィエ 新規精製方法

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US5077391A (en) 1989-12-01 1991-12-31 Raison Robert L Purification of immunoglobulin M
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Also Published As

Publication number Publication date
DE60031244T2 (de) 2007-05-24
EP1154827A1 (de) 2001-11-21
EP1154827A4 (de) 2002-08-28
EP1154827B1 (de) 2006-10-11
IL144421A (en) 2004-12-15
US6383380B1 (en) 2002-05-07
WO2000048703A1 (en) 2000-08-24
DK1154827T3 (da) 2007-02-19
WO2000048703B1 (en) 2000-12-07
IL144421A0 (en) 2002-05-23
CA2361545A1 (en) 2000-08-24
CA2361545C (en) 2009-01-27
AU3008300A (en) 2000-09-04
ATE342112T1 (de) 2006-11-15
NZ513242A (en) 2003-10-31
WO2000048703A9 (en) 2002-08-08
AU756832B2 (en) 2003-01-23

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