DE60028192T2 - Vorrichtung und Verfahren zum Nachweis der Zellaktivität - Google Patents
Vorrichtung und Verfahren zum Nachweis der Zellaktivität Download PDFInfo
- Publication number
- DE60028192T2 DE60028192T2 DE60028192T DE60028192T DE60028192T2 DE 60028192 T2 DE60028192 T2 DE 60028192T2 DE 60028192 T DE60028192 T DE 60028192T DE 60028192 T DE60028192 T DE 60028192T DE 60028192 T2 DE60028192 T2 DE 60028192T2
- Authority
- DE
- Germany
- Prior art keywords
- membrane
- cells
- electromagnetic radiation
- film
- pores
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US271765 | 1999-03-18 | ||
| US09/271,765 US6329164B1 (en) | 1999-03-18 | 1999-03-18 | Method for using a cell activity assay apparatus |
| PCT/US2000/005760 WO2000055298A1 (en) | 1999-03-18 | 2000-03-06 | Cell activity assay apparatus and methods for making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60028192D1 DE60028192D1 (de) | 2006-06-29 |
| DE60028192T2 true DE60028192T2 (de) | 2006-11-02 |
Family
ID=23036978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60028192T Expired - Lifetime DE60028192T2 (de) | 1999-03-18 | 2000-03-06 | Vorrichtung und Verfahren zum Nachweis der Zellaktivität |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6329164B1 (enExample) |
| EP (1) | EP1165745B1 (enExample) |
| JP (1) | JP4558949B2 (enExample) |
| AT (1) | ATE327315T1 (enExample) |
| AU (1) | AU3725400A (enExample) |
| DE (1) | DE60028192T2 (enExample) |
| WO (1) | WO2000055298A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329164B1 (en) * | 1999-03-18 | 2001-12-11 | Neuro Probe, Incorporated | Method for using a cell activity assay apparatus |
| US6864065B2 (en) * | 2000-11-08 | 2005-03-08 | Surface Logix, Inc. | Assays for monitoring cell motility in real-time |
| US6844184B2 (en) * | 2000-11-08 | 2005-01-18 | Surface Logix, Inc. | Device for arraying biomolecules and for monitoring cell motility in real-time |
| US7326563B2 (en) | 2000-11-08 | 2008-02-05 | Surface Logix, Inc. | Device and method for monitoring leukocyte migration |
| US6699665B1 (en) * | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
| US6893851B2 (en) | 2000-11-08 | 2005-05-17 | Surface Logix, Inc. | Method for arraying biomolecules and for monitoring cell motility in real-time |
| US7033819B2 (en) | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | System for monitoring cell motility in real-time |
| US7374906B2 (en) | 2000-11-08 | 2008-05-20 | Surface Logix, Inc. | Biological assays using gradients formed in microfluidic systems |
| US7033821B2 (en) * | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | Device for monitoring cell motility in real-time |
| US7123764B2 (en) * | 2000-11-08 | 2006-10-17 | Surface Logix Inc. | Image processing method for use in analyzing data of a chemotaxis or haptotaxis assay |
| TWI241343B (en) | 2000-12-07 | 2005-10-11 | Effector Cell Inst Inc | Well unit for detecting cell chemotaxis and separating chemotactic cells |
| JP3738899B2 (ja) * | 2000-12-07 | 2006-01-25 | 株式会社 エフェクター細胞研究所 | 微量試料処理装置 |
| US6923939B1 (en) * | 2001-07-05 | 2005-08-02 | Uop Llc | Heat activated membrane introduction apparatus and method for screening materials |
| US20030082632A1 (en) * | 2001-10-25 | 2003-05-01 | Cytoprint, Inc. | Assay method and apparatus |
| EP1490520A4 (en) * | 2002-03-12 | 2006-06-07 | Surface Logix Inc | TEST APPARATUS ANALYZING THE ABSORPTION, METABOLISM, PERMEABILITY AND / OR TOXICITY OF A CANDIDATE COMPOUND |
| TW200506364A (en) * | 2003-04-09 | 2005-02-16 | Effector Cell Inst Inc | Apparatus for detecting cell chemo-taxis |
| US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
| US6901945B2 (en) * | 2003-09-30 | 2005-06-07 | Nalco Company | System for feeding solid materials to a pressurized pipeline |
| US6972184B2 (en) * | 2003-12-23 | 2005-12-06 | Millipore Corporation | Cell motility assay |
| US20050202052A1 (en) * | 2004-03-15 | 2005-09-15 | Lee Clemie M. | Flavored medicaments to deter or attract and kill microorganisms |
| US7547525B2 (en) * | 2004-08-12 | 2009-06-16 | Neuro Probe Incorporated | Point source diffusion cell activity assay |
| US8673628B2 (en) | 2011-06-10 | 2014-03-18 | Essen Instruments, Inc. | Methods and apparatus for improving in vitro measurements using boyden chambers |
| US9644177B2 (en) * | 2012-07-12 | 2017-05-09 | Board Of Regents, The University Of Texas System | Extracellular matrix films and methods of making and using same |
| US10384207B2 (en) | 2015-07-21 | 2019-08-20 | Neuro Probe Incorporated | Assay apparatus and methods |
| WO2022187684A1 (en) * | 2021-03-05 | 2022-09-09 | Enumerix, Inc. | Systems and methods for generating droplets and performing digital analyses |
| CN117241878A (zh) | 2021-03-05 | 2023-12-15 | 伊努梅里斯公司 | 用于生成微滴和执行数字分析的系统和方法 |
| US12252745B2 (en) | 2021-09-02 | 2025-03-18 | Enumerix, Inc. | Detection and digital quantitation of multiple targets |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888770A (en) | 1971-10-21 | 1975-06-10 | Shlomo Avital | Plural-sample filter device |
| US3929583A (en) | 1975-08-14 | 1975-12-30 | Canadian Patents Dev | Apparatus for enumerating microorganisms |
| US4317726A (en) | 1981-02-12 | 1982-03-02 | The United States Of America As Represented By The Secretary Of The Army | Microbial filter assembly |
| US4514495A (en) | 1982-05-18 | 1985-04-30 | Spiral Systems Instruments, Inc. | Method for testing microbial interaction with growth affecting substances |
| US4493815A (en) | 1983-07-28 | 1985-01-15 | Bio-Rad Laboratories, Inc. | Supporting and filtering biochemical test plate assembly |
| US4714674A (en) | 1985-02-28 | 1987-12-22 | Genentech, Inc. | Chemotactic assay for immunogenicity |
| US5137023A (en) * | 1990-04-19 | 1992-08-11 | Worcester Polytechnic Institute | Method and apparatus for monitoring blood analytes noninvasively by pulsatile photoplethysmography |
| US4912057A (en) | 1989-06-13 | 1990-03-27 | Cancer Diagnostics, Inc. | Cell chamber for chemotaxis assay |
| DE69129121T2 (de) * | 1990-12-21 | 1998-11-19 | Curative Technologies, Inc., Setauket, N.Y. | Angiogene peptide |
| US5210021A (en) | 1991-03-20 | 1993-05-11 | Neuro Probe, Inc. | Multiple-site chemotactic test apparatus and method |
| US5284753A (en) | 1991-03-20 | 1994-02-08 | Neuro Probe, Inc. | Multiple-site chemotactic test apparatus and method |
| GB2264169B (en) * | 1992-02-07 | 1995-08-02 | Alan John Hayes | Fluid monitoring |
| US5302515A (en) | 1992-08-20 | 1994-04-12 | Neuro Probe, Inc. | Chemotactic test apparatus and method |
| US5601997A (en) * | 1995-02-03 | 1997-02-11 | Tchao; Ruy | Chemotaxis assay procedure |
| US6329164B1 (en) * | 1999-03-18 | 2001-12-11 | Neuro Probe, Incorporated | Method for using a cell activity assay apparatus |
-
1999
- 1999-03-18 US US09/271,765 patent/US6329164B1/en not_active Expired - Lifetime
-
2000
- 2000-03-06 WO PCT/US2000/005760 patent/WO2000055298A1/en not_active Ceased
- 2000-03-06 DE DE60028192T patent/DE60028192T2/de not_active Expired - Lifetime
- 2000-03-06 EP EP00916095A patent/EP1165745B1/en not_active Expired - Lifetime
- 2000-03-06 AT AT00916095T patent/ATE327315T1/de not_active IP Right Cessation
- 2000-03-06 AU AU37254/00A patent/AU3725400A/en not_active Abandoned
- 2000-03-06 JP JP2000605716A patent/JP4558949B2/ja not_active Expired - Lifetime
-
2001
- 2001-09-28 US US09/964,391 patent/US6468786B2/en not_active Expired - Lifetime
- 2001-09-28 US US09/964,686 patent/US6395505B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1165745A1 (en) | 2002-01-02 |
| EP1165745A4 (en) | 2004-10-06 |
| US20020019024A1 (en) | 2002-02-14 |
| ATE327315T1 (de) | 2006-06-15 |
| WO2000055298A1 (en) | 2000-09-21 |
| EP1165745B1 (en) | 2006-05-24 |
| JP2002538816A (ja) | 2002-11-19 |
| AU3725400A (en) | 2000-10-04 |
| US6329164B1 (en) | 2001-12-11 |
| DE60028192D1 (de) | 2006-06-29 |
| US6395505B2 (en) | 2002-05-28 |
| US6468786B2 (en) | 2002-10-22 |
| US20020009796A1 (en) | 2002-01-24 |
| JP4558949B2 (ja) | 2010-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NEURO PROBE, INC., GAITHERSBURG, MD., US |
|
| 8364 | No opposition during term of opposition |