DE60014881D1 - para-BORONOPHENYLALANINKOMPLEXE MIT FRUKTOSE UND AHNLICHEN KOHLENHYDRATEN UND POLYOLEN - Google Patents

para-BORONOPHENYLALANINKOMPLEXE MIT FRUKTOSE UND AHNLICHEN KOHLENHYDRATEN UND POLYOLEN

Info

Publication number
DE60014881D1
DE60014881D1 DE2000614881 DE60014881T DE60014881D1 DE 60014881 D1 DE60014881 D1 DE 60014881D1 DE 2000614881 DE2000614881 DE 2000614881 DE 60014881 T DE60014881 T DE 60014881T DE 60014881 D1 DE60014881 D1 DE 60014881D1
Authority
DE
Germany
Prior art keywords
boronophenylalanine
fruktose
polyols
para
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2000614881
Other languages
English (en)
Inventor
Brian Shull
David Spielvogel
Gerald Head
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycosyn Pharmaceuticals Inc
Original Assignee
Glycosyn Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycosyn Pharmaceuticals Inc filed Critical Glycosyn Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60014881D1 publication Critical patent/DE60014881D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
DE2000614881 1999-03-31 2000-03-24 para-BORONOPHENYLALANINKOMPLEXE MIT FRUKTOSE UND AHNLICHEN KOHLENHYDRATEN UND POLYOLEN Expired - Lifetime DE60014881D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/282,847 US6169076B1 (en) 1999-03-31 1999-03-31 P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols
PCT/US2000/007833 WO2000057887A1 (en) 1999-03-31 2000-03-24 p-BORONOPHENYLALANINE COMPLEXES WITH FRUCTOSE AND RELATED CARBOHYDRATES AND POLYOLS

Publications (1)

Publication Number Publication Date
DE60014881D1 true DE60014881D1 (de) 2004-11-18

Family

ID=23083384

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2000614881 Expired - Lifetime DE60014881D1 (de) 1999-03-31 2000-03-24 para-BORONOPHENYLALANINKOMPLEXE MIT FRUKTOSE UND AHNLICHEN KOHLENHYDRATEN UND POLYOLEN

Country Status (8)

Country Link
US (1) US6169076B1 (de)
EP (1) EP1173184B1 (de)
JP (1) JP4643017B2 (de)
AT (1) ATE279201T1 (de)
AU (1) AU3917000A (de)
CA (1) CA2368634C (de)
DE (1) DE60014881D1 (de)
WO (1) WO2000057887A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2435146C (en) * 2001-01-25 2011-03-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Formulation of boronic acid compounds
GB0222945D0 (en) * 2002-10-03 2002-11-13 Psimei Pharmaceuticals Plc Therapeutic compositions
US20070104648A1 (en) * 2005-11-09 2007-05-10 Glyconix Corporation Compositions, methods of preparing amino acids, and nuclear magnetic resonance spectroscopy
US20080050309A1 (en) * 2006-08-25 2008-02-28 Hadron Systems Compositions of pharmaceuticals for use in low energy neutron therapy
JP5150084B2 (ja) * 2006-10-17 2013-02-20 日本ケミカルリサーチ株式会社 高水溶性ｐ−ボロノフェニルアラニン含有組成物
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
JP5345771B2 (ja) * 2007-08-27 2013-11-20 公立大学法人大阪府立大学 ｐ−ボロノフェニルアラニンとソルビトールとを含有する液状組成物
EP2730580A1 (de) 2008-06-17 2014-05-14 Millennium Pharmaceuticals, Inc. Boronatesterverbindungen und pharmazeutische Zusammensetzungen davon
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
EP2552216B1 (de) 2010-03-31 2018-01-24 Millennium Pharmaceuticals, Inc. Derivate von 1-amino-2-cyclopropylethylboronsäure
US8921533B2 (en) 2011-07-25 2014-12-30 Chromatin Technologies Glycosylated valproic acid analogs and uses thereof
US9327025B2 (en) * 2012-10-11 2016-05-03 Hanif Kazerooni Enriched 10-boron composition for cancer therapy and a method of synthesizing the same
EP3145526A1 (de) 2014-05-20 2017-03-29 Millennium Pharmaceuticals, Inc. Borhaltige proteasom-hemmer zur verwendung nach der primären krebstherapie
JP7219925B2 (ja) * 2018-02-20 2023-02-10 国立大学法人東京工業大学 ｐ－ボロノフェニルアラニン誘導体及びそれを含む組成物、並びにそれらを製造するためのキット
KR102562968B1 (ko) * 2018-11-01 2023-08-04 주식회사 셀비온 붕소 중성자 포획 치료용 파라-보로노페닐알라닌 조성물 및 이의 제조방법
EP3960204A4 (de) * 2019-04-26 2022-07-06 Neuboron Medtech Ltd. Lyophilisiertes bpa-präparat und verfahren zu seiner herstellung
EP4029505A4 (de) 2019-09-12 2023-10-11 Stella Pharma Corporation P-boronophenylalanin enthaltende injektion
KR20220062368A (ko) 2019-09-12 2022-05-16 스텔라파머 가부시키가이샤 p-보로노페닐알라닌을 함유하는 주사액제의 석출 방지 방법
CA3236955A1 (en) * 2021-12-13 2023-06-22 Tenboron Oy Pharmaceutical composition comprising p-boronophenylalanine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492900A (en) 1993-09-10 1996-02-20 Neutron Technology Corporation Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA)
JP2979139B2 (ja) * 1998-03-11 1999-11-15 東北大学長 Ｌ−パラボロノフェニルアラニンの製造方法

Also Published As

Publication number Publication date
WO2000057887A1 (en) 2000-10-05
CA2368634C (en) 2007-06-26
JP2002540159A (ja) 2002-11-26
JP4643017B2 (ja) 2011-03-02
CA2368634A1 (en) 2000-10-05
EP1173184A1 (de) 2002-01-23
AU3917000A (en) 2000-10-16
ATE279201T1 (de) 2004-10-15
EP1173184B1 (de) 2004-10-13
EP1173184A4 (de) 2003-05-02
US6169076B1 (en) 2001-01-02

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Legal Events

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8332 No legal effect for de