ATE279201T1 - Para-boronophenylalaninkomplexe mit fruktose und ahnlichen kohlenhydraten und polyolen - Google Patents

Para-boronophenylalaninkomplexe mit fruktose und ahnlichen kohlenhydraten und polyolen

Info

Publication number
ATE279201T1
ATE279201T1 AT00918342T AT00918342T ATE279201T1 AT E279201 T1 ATE279201 T1 AT E279201T1 AT 00918342 T AT00918342 T AT 00918342T AT 00918342 T AT00918342 T AT 00918342T AT E279201 T1 ATE279201 T1 AT E279201T1
Authority
AT
Austria
Prior art keywords
boronophenylalanine
fructose
polyols
para
complexes
Prior art date
Application number
AT00918342T
Other languages
English (en)
Inventor
Brian Shull
David Spielvogel
Gerald Head
Original Assignee
Glycosyn Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycosyn Pharmaceuticals Inc filed Critical Glycosyn Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE279201T1 publication Critical patent/ATE279201T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
AT00918342T 1999-03-31 2000-03-24 Para-boronophenylalaninkomplexe mit fruktose und ahnlichen kohlenhydraten und polyolen ATE279201T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/282,847 US6169076B1 (en) 1999-03-31 1999-03-31 P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols
PCT/US2000/007833 WO2000057887A1 (en) 1999-03-31 2000-03-24 p-BORONOPHENYLALANINE COMPLEXES WITH FRUCTOSE AND RELATED CARBOHYDRATES AND POLYOLS

Publications (1)

Publication Number Publication Date
ATE279201T1 true ATE279201T1 (de) 2004-10-15

Family

ID=23083384

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00918342T ATE279201T1 (de) 1999-03-31 2000-03-24 Para-boronophenylalaninkomplexe mit fruktose und ahnlichen kohlenhydraten und polyolen

Country Status (8)

Country Link
US (1) US6169076B1 (de)
EP (1) EP1173184B1 (de)
JP (1) JP4643017B2 (de)
AT (1) ATE279201T1 (de)
AU (1) AU3917000A (de)
CA (1) CA2368634C (de)
DE (1) DE60014881D1 (de)
WO (1) WO2000057887A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2435146C (en) 2001-01-25 2011-03-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Formulation of boronic acid compounds
GB0222945D0 (en) * 2002-10-03 2002-11-13 Psimei Pharmaceuticals Plc Therapeutic compositions
US20070104648A1 (en) * 2005-11-09 2007-05-10 Glyconix Corporation Compositions, methods of preparing amino acids, and nuclear magnetic resonance spectroscopy
US20080050309A1 (en) * 2006-08-25 2008-02-28 Hadron Systems Compositions of pharmaceuticals for use in low energy neutron therapy
JP5150084B2 (ja) * 2006-10-17 2013-02-20 日本ケミカルリサーチ株式会社 高水溶性ｐ−ボロノフェニルアラニン含有組成物
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
JP5345771B2 (ja) * 2007-08-27 2013-11-20 公立大学法人大阪府立大学 ｐ−ボロノフェニルアラニンとソルビトールとを含有する液状組成物
SI2318419T2 (sl) 2008-06-17 2025-10-30 Takeda Pharmaceutical Company Limited Spojine boronat estra in njihovi farmacevtski sestavki
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
AU2011235227B2 (en) 2010-03-31 2016-09-08 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclopropylethylboronic acid
US8921533B2 (en) 2011-07-25 2014-12-30 Chromatin Technologies Glycosylated valproic acid analogs and uses thereof
US9327025B2 (en) * 2012-10-11 2016-05-03 Hanif Kazerooni Enriched 10-boron composition for cancer therapy and a method of synthesizing the same
UA121389C2 (uk) 2014-05-20 2020-05-25 Мілленніум Фармасьютікалз, Інк. Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії
JP7219925B2 (ja) * 2018-02-20 2023-02-10 国立大学法人東京工業大学 ｐ－ボロノフェニルアラニン誘導体及びそれを含む組成物、並びにそれらを製造するためのキット
KR102562968B1 (ko) * 2018-11-01 2023-08-04 주식회사 셀비온 붕소 중성자 포획 치료용 파라-보로노페닐알라닌 조성물 및 이의 제조방법
EP3960204A4 (de) * 2019-04-26 2022-07-06 Neuboron Medtech Ltd. Lyophilisiertes bpa-präparat und verfahren zu seiner herstellung
CA3151009A1 (en) 2019-09-12 2021-03-18 Yoshiya IGUCHI Injection containing p-boronophenylalanine
AU2020345320B2 (en) 2019-09-12 2025-09-04 Stella Pharma Corporation Method for preventing precipitation of injectable solution containing p-boronophenylalanine
JP2024546071A (ja) * 2021-12-13 2024-12-17 テンボロン オーワイ ｐ－ホウ素化フェニルアラニンを含む医薬組成物
JP2024132863A (ja) * 2023-03-14 2024-10-01 禾榮科技股▲フン▼有限公司 ホウ素錯体含有凍結乾燥粉末及びその形成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492900A (en) 1993-09-10 1996-02-20 Neutron Technology Corporation Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA)
JP2979139B2 (ja) * 1998-03-11 1999-11-15 東北大学長 Ｌ−パラボロノフェニルアラニンの製造方法

Also Published As

Publication number Publication date
EP1173184B1 (de) 2004-10-13
CA2368634C (en) 2007-06-26
DE60014881D1 (de) 2004-11-18
JP2002540159A (ja) 2002-11-26
AU3917000A (en) 2000-10-16
EP1173184A1 (de) 2002-01-23
JP4643017B2 (ja) 2011-03-02
US6169076B1 (en) 2001-01-02
CA2368634A1 (en) 2000-10-05
EP1173184A4 (de) 2003-05-02
WO2000057887A1 (en) 2000-10-05

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