DE60011430T2 - Stickstoff enthaltende heterobicyclen als factor xa inhibitoren - Google Patents

Stickstoff enthaltende heterobicyclen als factor xa inhibitoren Download PDF

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Publication number
DE60011430T2
DE60011430T2 DE60011430T DE60011430T DE60011430T2 DE 60011430 T2 DE60011430 T2 DE 60011430T2 DE 60011430 T DE60011430 T DE 60011430T DE 60011430 T DE60011430 T DE 60011430T DE 60011430 T2 DE60011430 T2 DE 60011430T2
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DE
Germany
Prior art keywords
phenyl
radical
trifluoromethyl
pyrazol
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60011430T
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German (de)
English (en)
Other versions
DE60011430D1 (de
Inventor
C. Irina JACOBSON
L. Mimi QUAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of DE60011430D1 publication Critical patent/DE60011430D1/de
Publication of DE60011430T2 publication Critical patent/DE60011430T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60011430T 1999-07-16 2000-07-12 Stickstoff enthaltende heterobicyclen als factor xa inhibitoren Expired - Lifetime DE60011430T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14434499P 1999-07-16 1999-07-16
US144344P 1999-07-16
PCT/US2000/018903 WO2001005784A1 (fr) 1999-07-16 2000-07-12 Composes heterobicycliques contenant de l'azote et utilises en tant qu'inhibiteurs du facteur xa

Publications (2)

Publication Number Publication Date
DE60011430D1 DE60011430D1 (de) 2004-07-15
DE60011430T2 true DE60011430T2 (de) 2005-07-07

Family

ID=22508178

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60011430T Expired - Lifetime DE60011430T2 (de) 1999-07-16 2000-07-12 Stickstoff enthaltende heterobicyclen als factor xa inhibitoren

Country Status (18)

Country Link
US (2) US6429205B1 (fr)
EP (1) EP1196412B1 (fr)
JP (1) JP2004507439A (fr)
KR (1) KR20030011268A (fr)
CN (1) CN1454211A (fr)
AT (1) ATE268766T1 (fr)
AU (1) AU2481501A (fr)
BR (1) BR0013200A (fr)
CA (1) CA2380727A1 (fr)
DE (1) DE60011430T2 (fr)
ES (1) ES2222257T3 (fr)
HK (1) HK1045502B (fr)
IL (1) IL147317A0 (fr)
MX (1) MXPA02000537A (fr)
NO (1) NO20020217L (fr)
PL (1) PL357108A1 (fr)
WO (1) WO2001005784A1 (fr)
ZA (1) ZA200200094B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
DE60022508T2 (de) 1999-06-14 2006-06-08 Eli Lilly And Co., Indianapolis Inhibitoren von serin proteasen
AU2001234690A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
EP1255743A1 (fr) * 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINES UTILISEES COMME INHIBITEURS DU FACTEUR Xa
US7229986B2 (en) * 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
EP1296982B1 (fr) 2000-06-23 2007-09-19 Bristol-Myers Squibb Pharma Company Derives de pyrazole condenses par 1 - (heteroaryl-phenyl) utilises comme inhibiteurs du facteur xa
US6599926B2 (en) 2000-06-23 2003-07-29 Bristol-Myers Squibb Company Heteroaryl-phenyl substituted factor Xa inhibitors
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CH1427415H1 (de) 2001-09-21 2023-12-21 Bristol Myers Squibb Holdings Ireland Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
WO2003048081A2 (fr) 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides en tant qu'inhibiteurs du facteur xa
US7241767B2 (en) * 2002-01-22 2007-07-10 E. I. Du Pont De Nemours And Company Quinazoline(di)ones for invertebrate pest control
MXPA04009329A (es) 2002-03-26 2005-01-25 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y usos de los mismos.
AU2003273179A1 (en) 2002-05-10 2003-12-12 Bristol-Myers Squibb Company 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors
AU2003259747A1 (en) * 2002-08-21 2004-03-11 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
EP1479678A1 (fr) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Derivés du pyrazole en tant qu'inhibiteurs du facteur Xa
AU2003292218A1 (en) * 2002-12-23 2004-07-14 Sanofi-Aventis Deutschland Gmbh PYRAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US7122557B2 (en) 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US20050124664A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Urea thiadiazole inhibitors of plasminogen activator inhibior-1
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
CN101087609B (zh) * 2004-10-26 2012-11-14 詹森药业有限公司 因子Xa化合物
US7741361B2 (en) 2004-12-27 2010-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
DE102005038947A1 (de) 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
WO2008070507A2 (fr) 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Substances mimétiques de glucocorticoïde, procédés de préparation de celles-ci, compositions pharmaceutiques et utilisations de celles-ci
WO2008141081A1 (fr) * 2007-05-10 2008-11-20 Amr Technology, Inc. Tétrahydrobenzo-l,4-diazépines substituées par un aryle ou un hétéroaryle et utilisation desdites dans le blocage de la réassimilation de la norépinéphrine, de la dopamine et de la sérotonine
AU2009256289A1 (en) 2008-06-06 2009-12-10 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP2865671B1 (fr) * 2012-06-22 2017-11-01 Sumitomo Chemical Company, Ltd Composé hétérocyclique fusionné
JP7017524B2 (ja) * 2016-05-23 2022-02-15 ザ ロックフェラー ユニバーシティー 自己免疫疾患を治療するためのアミノアシルインダゾール免疫調節薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0874629B1 (fr) 1995-12-21 2004-05-19 Bristol-Myers Squibb Pharma Company ISOXAZOLINE, ISOTHIAZOLINE ET PYRAZOLINE INHIBITEURS DU FACTEUR Xa
EA003056B1 (ru) * 1996-12-23 2002-12-26 Дюпон Фармасьютикалз Компани АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ
WO1998028282A2 (fr) 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company OXYGENE OU SOUFRE CONTANANT DES HETERO-AROMATIQUES UTILISES COMME INHIBITEURS DU FACTEUR Xa
ES2239806T3 (es) 1997-06-19 2005-10-01 Bristol-Myers Squibb Pharma Company Inhibidores del factor xa con un grupo de especificidad neutro p1.
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
BR9813835A (pt) 1997-12-22 2000-10-10 Du Pont Pharm Co Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromboembólica

Also Published As

Publication number Publication date
JP2004507439A (ja) 2004-03-11
HK1045502B (zh) 2004-12-10
CN1454211A (zh) 2003-11-05
IL147317A0 (en) 2002-08-14
US6429205B1 (en) 2002-08-06
ES2222257T3 (es) 2005-02-01
BR0013200A (pt) 2002-05-07
CA2380727A1 (fr) 2001-01-25
NO20020217D0 (no) 2002-01-15
HK1045502A1 (en) 2002-11-29
ATE268766T1 (de) 2004-06-15
US20030096820A1 (en) 2003-05-22
NO20020217L (no) 2002-03-15
ZA200200094B (en) 2003-04-30
PL357108A1 (en) 2004-07-12
EP1196412B1 (fr) 2004-06-09
MXPA02000537A (es) 2004-09-10
KR20030011268A (ko) 2003-02-07
WO2001005784A1 (fr) 2001-01-25
DE60011430D1 (de) 2004-07-15
EP1196412A1 (fr) 2002-04-17
US6716841B2 (en) 2004-04-06
AU2481501A (en) 2001-02-05

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