DE60008579D1 - Verfahren zur untersuchung von zellproben durch bildherstellung und analysen - Google Patents

Verfahren zur untersuchung von zellproben durch bildherstellung und analysen

Info

Publication number
DE60008579D1
DE60008579D1 DE60008579T DE60008579T DE60008579D1 DE 60008579 D1 DE60008579 D1 DE 60008579D1 DE 60008579 T DE60008579 T DE 60008579T DE 60008579 T DE60008579 T DE 60008579T DE 60008579 D1 DE60008579 D1 DE 60008579D1
Authority
DE
Germany
Prior art keywords
cell extract
markers
image
mixture
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60008579T
Other languages
English (en)
Other versions
DE60008579T2 (de
Inventor
Erik Sloge
Tobias Soederman
Lennart Bjoerkesten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Amersham Bioscience AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20417599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60008579(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amersham Bioscience AB filed Critical Amersham Bioscience AB
Application granted granted Critical
Publication of DE60008579D1 publication Critical patent/DE60008579D1/de
Publication of DE60008579T2 publication Critical patent/DE60008579T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Quality & Reliability (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Multimedia (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60008579T 1999-11-03 2000-10-31 Verfahren zur untersuchung von zellproben durch bildherstellung und analysen Expired - Lifetime DE60008579T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9903988A SE9903988D0 (sv) 1999-11-03 1999-11-03 Method of analysis
SE9903988 1999-11-03
PCT/SE2000/002124 WO2001033573A1 (en) 1999-11-03 2000-10-31 Method of analysing cell samples, by creating and analysing a resultant image

Publications (2)

Publication Number Publication Date
DE60008579D1 true DE60008579D1 (de) 2004-04-01
DE60008579T2 DE60008579T2 (de) 2004-12-23

Family

ID=20417599

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60008579T Expired - Lifetime DE60008579T2 (de) 1999-11-03 2000-10-31 Verfahren zur untersuchung von zellproben durch bildherstellung und analysen

Country Status (9)

Country Link
US (2) US7155050B1 (de)
EP (2) EP1389770A2 (de)
JP (2) JP5329014B2 (de)
AT (1) ATE260496T1 (de)
AU (1) AU1563901A (de)
DE (1) DE60008579T2 (de)
ES (1) ES2215759T3 (de)
SE (1) SE9903988D0 (de)
WO (1) WO2001033573A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903988D0 (sv) * 1999-11-03 1999-11-03 Amersham Pharm Biotech Ab Method of analysis
EP1463934A1 (de) * 2002-01-11 2004-10-06 Ludesi AB Verfahren und computerprogramm zur digitalen bildbearbeitung für zweidimensionale elektrophorese
WO2006062222A1 (ja) * 2004-12-06 2006-06-15 National Institute Of Advanced Industrial Science And Technology タンパク質の分離方法及び染色方法、並びにこれらの方法に用いるタンパク質染色液及びタンパク質染色用キット
MY152857A (en) * 2005-09-01 2014-11-28 Dominant Opto Tech Sdn Bhd Surface mount optoelectronic component with lens
ATE509329T1 (de) 2005-11-10 2011-05-15 Microsoft Corp Entdeckung biologischer merkmale unter verwendung zusammengesetzter bilder
US8321144B2 (en) 2008-10-23 2012-11-27 Microsoft Corporation Non-contiguous regions processing
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US8355544B2 (en) 2011-02-01 2013-01-15 Universidade Da Coruna-Otri Method, apparatus, and system for automatic retinal image analysis
US8897536B2 (en) * 2011-04-24 2014-11-25 Universidade Da Coruna. Otri Molecular block-matching method for gel image analysis
US10732176B2 (en) * 2011-06-29 2020-08-04 Ge Healthcare Bio-Sciences Ab Method for specific identification of target biomolecules
EP2820158B1 (de) 2012-02-27 2018-01-10 Cellular Research, Inc. Zusammensetzungen und kits zur molekularen zählung
JP6189946B2 (ja) 2012-06-22 2017-08-30 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 生検組織試料搬送装置及びその使用方法
ES2832554T3 (es) 2012-06-22 2021-06-10 Leica Biosystems Nussloch Gmbh Recipiente para muestras de tejido
CA2845832C (en) 2013-03-15 2020-09-22 Leica Biosystems Nussloch Gmbh Tissue cassette with biasing element
US9052256B2 (en) 2013-03-15 2015-06-09 Leica Biosystems Nussloch Gmbh Method for processing and embedding tissue
CA2845830C (en) 2013-03-15 2020-10-27 Leica Biosystems Nussloch Gmbh Tissue cassette with retractable member
GB2546833B (en) 2013-08-28 2018-04-18 Cellular Res Inc Microwell for single cell analysis comprising single cell and single bead oligonucleotide capture labels
US9582877B2 (en) * 2013-10-07 2017-02-28 Cellular Research, Inc. Methods and systems for digitally counting features on arrays
WO2016134078A1 (en) 2015-02-19 2016-08-25 Becton, Dickinson And Company High-throughput single-cell analysis combining proteomic and genomic information
CN107208158B (zh) 2015-02-27 2022-01-28 贝克顿迪金森公司 空间上可寻址的分子条形编码
US10304188B1 (en) 2015-03-27 2019-05-28 Caleb J. Kumar Apparatus and method for automated cell analysis
JP7508191B2 (ja) 2015-03-30 2024-07-01 ベクトン・ディキンソン・アンド・カンパニー コンビナトリアルバーコーディングのための方法および組成物
WO2016172373A1 (en) 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
WO2016196229A1 (en) 2015-06-01 2016-12-08 Cellular Research, Inc. Methods for rna quantification
JP6261152B2 (ja) * 2015-06-23 2018-01-17 プロメディコ株式会社 二次元電気泳動画像の解析方法、解析プログラム、及び解析装置
EP3347465B1 (de) 2015-09-11 2019-06-26 Cellular Research, Inc. Verfahren und zusammensetzung zur standardisierung von nukleinsäure bibliothek
US10822643B2 (en) 2016-05-02 2020-11-03 Cellular Research, Inc. Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
WO2017205691A1 (en) 2016-05-26 2017-11-30 Cellular Research, Inc. Molecular label counting adjustment methods
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
CA3034924A1 (en) 2016-09-26 2018-03-29 Cellular Research, Inc. Measurement of protein expression using reagents with barcoded oligonucleotide sequences
WO2018089377A1 (en) 2016-11-08 2018-05-17 Cellular Research, Inc. Methods for cell label classification
EP3539035B1 (de) 2016-11-08 2024-04-17 Becton, Dickinson and Company Verfahren zur klassifizierung von expressionsprofilen
JP7104048B2 (ja) 2017-01-13 2022-07-20 セルラー リサーチ， インコーポレイテッド 流体チャネルの親水性コーティング
WO2018144240A1 (en) 2017-02-01 2018-08-09 Cellular Research, Inc. Selective amplification using blocking oligonucleotides
JPWO2018207361A1 (ja) * 2017-05-12 2020-03-12 オリンパス株式会社 細胞画像取得装置
US10676779B2 (en) 2017-06-05 2020-06-09 Becton, Dickinson And Company Sample indexing for single cells
CN111339822B (zh) * 2017-07-17 2023-06-30 Oppo广东移动通信有限公司 活体检测方法及相关产品
CN111492068A (zh) 2017-12-19 2020-08-04 贝克顿迪金森公司 与寡核苷酸相关联的颗粒
CN112272710A (zh) 2018-05-03 2021-01-26 贝克顿迪金森公司 高通量多组学样品分析
US11365409B2 (en) 2018-05-03 2022-06-21 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
EP3861134B1 (de) 2018-10-01 2024-09-04 Becton, Dickinson and Company Bestimmung von 5'-transkriptsequenzen
US11932849B2 (en) 2018-11-08 2024-03-19 Becton, Dickinson And Company Whole transcriptome analysis of single cells using random priming
EP3894552A1 (de) 2018-12-13 2021-10-20 Becton, Dickinson and Company Selektive verlängerung in der vollständigen transkriptomanalyse von einzelzellen
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
US11661631B2 (en) 2019-01-23 2023-05-30 Becton, Dickinson And Company Oligonucleotides associated with antibodies
CN113454234A (zh) 2019-02-14 2021-09-28 贝克顿迪金森公司 杂合体靶向和全转录物组扩增
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
WO2021016239A1 (en) 2019-07-22 2021-01-28 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
US11773436B2 (en) 2019-11-08 2023-10-03 Becton, Dickinson And Company Using random priming to obtain full-length V(D)J information for immune repertoire sequencing
WO2021146207A1 (en) 2020-01-13 2021-07-22 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and rna
CN111429761B (zh) * 2020-02-28 2022-10-21 中国人民解放军陆军军医大学第二附属医院 一种骨髓细胞形态学人工智能模拟教学系统及其方法
CN115605614A (zh) 2020-05-14 2023-01-13 贝克顿迪金森公司（Us） 用于免疫组库谱分析的引物
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
CN116635533A (zh) 2020-11-20 2023-08-22 贝克顿迪金森公司 高表达的蛋白和低表达的蛋白的谱分析
CN113610700B (zh) * 2021-07-23 2022-03-22 广东国地规划科技股份有限公司 一种全域综合整治的图斑的自动配准方法、装置及系统
WO2024182381A1 (en) * 2023-02-27 2024-09-06 The Regents Of The University Of Colorado, A Body Corporate Parent/progeny isotope discrimination techniques using high-resolution charged particle detectors and medical applications thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0430798A (ja) * 1990-05-28 1992-02-03 Fuji Electric Co Ltd 生菌計数方法およびその装置
US5235522A (en) * 1990-10-10 1993-08-10 Cell Analysis Systems, Inc. Method and apparatus for automated analysis of biological specimens
JPH05322770A (ja) * 1992-05-15 1993-12-07 Toyobo Co Ltd 多標識系電気泳動法
US5694478A (en) 1994-12-15 1997-12-02 Minnesota Mining And Manufacturing Company Method and apparatus for detecting and identifying microbial colonies
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
KR20000052802A (ko) * 1996-10-25 2000-08-25 모세 라르센 페터 생물학적 샘플내의 상승 조절 및 하강 조절된 단백질의 특성화를위한 프로테옴 분석
WO1998019271A1 (en) * 1996-10-25 1998-05-07 Peter Mose Larsen Proteome analysis for characterization of up- and down-regulated proteins in biological samples
US6535624B1 (en) * 1999-09-01 2003-03-18 Large Scale Proteomics Corporation Gel electrophoresis image combining for improved dynamic range
SE9903988D0 (sv) * 1999-11-03 1999-11-03 Amersham Pharm Biotech Ab Method of analysis

Also Published As

Publication number Publication date
WO2001033573A1 (en) 2001-05-10
EP1234280A2 (de) 2002-08-28
ATE260496T1 (de) 2004-03-15
JP2003513292A (ja) 2003-04-08
JP2013033052A (ja) 2013-02-14
AU1563901A (en) 2001-05-14
US7155050B1 (en) 2006-12-26
DE60008579T2 (de) 2004-12-23
SE9903988D0 (sv) 1999-11-03
US20070292044A1 (en) 2007-12-20
EP1389770A2 (de) 2004-02-18
EP1234280B1 (de) 2004-02-25
ES2215759T3 (es) 2004-10-16
US7881517B2 (en) 2011-02-01
JP5329014B2 (ja) 2013-10-30

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Representative=s name: HAMMONDS RECHTSANWAELTE PATENTANWAELTE, 80539 MUENCHEN

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Owner name: GE HEALTHCARE BIO-SCIENCES AB, UPPSALA, SE

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