TWI238250B - Method of automatically detecting a test result of a probe zone of a test strip - Google Patents

Method of automatically detecting a test result of a probe zone of a test strip Download PDF

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TWI238250B
TWI238250B TW92107795A TW92107795A TWI238250B TW I238250 B TWI238250 B TW I238250B TW 92107795 A TW92107795 A TW 92107795A TW 92107795 A TW92107795 A TW 92107795A TW I238250 B TWI238250 B TW I238250B
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test
strip
color
test strip
bar
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TW92107795A
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TW200420881A (en
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Wen-Chao Tseng
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Transpacific Ip Ltd
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Abstract

A method of automatically detecting a test result of a probe zone of a test strip is provided. The present method scans a scanning object including a bar code and a plurality of test strips to read the bar code pattern and the images of the test strips. Decoding the bar code pattern to obtain the information of types of the test strips, and thereby a plurality of mapping tables of setting values versus positions of target lines of one of the test strips. Each of the test strips corresponds to one of the mapping tables based on the type of the test strip. Each of the setting values of the mapping table corresponds to one target line of the test strip. Calculating a color response of one target line of the test strip based on the image of the test strip, and comparing the color response with the setting value from the mapping table corresponding thereto. Thereby, determining whether the target line has a positive test result or a negative test result in response to a specific component in a test liquid detected by the test strip.

Description

1238250 五、發明說明(1) 法 方 測 偵 果 結 測 檢 區 驗 檢 3 片 域試 領種 術一 技於 之關 屬有 所係 明明 發發 t本 檢 片 試 測 偵 以 術 技 0C- ίι /4 取 擷 像 影 合 〇 結法 種方 一之 於果 關結 有測 是檢 別區 特驗 二、【先前技術】 過去數十年來,基於驗孕及各種藥物分析的目的,各 種生物性檢體(b i ο 1 〇 g i c a 1 s p e c i m e η )的分析已有逐漸增 加的趨勢。已有相當多的時間及金錢投入於各種分析系統 及技術的開發,以期獲致更令人信賴及準確的檢測結果。 再者,隨著濫用藥物(drugs of abuse)的不斷、;巳濫, 此些藥物及其代謝物的檢驗及鑑定已變得非常重要,有許 多的濫用藥物檢測方法已被發展出來。 色層層析分析方法(Thin Layer Chromatography)( TLC)係用以檢測尿液中的藥物成份,其需要仔細小心地準 備待測檢體及有技巧地將待測檢體施於靜置在一展開室 (developing chamber)内的一色層層析片上。一旦色層層 析片從展開室中取出及乾燥之後,即以顯色劑喷灑於其上 面。此色層層析片上顯現的顯色區域再與已知的標準品比 較,以得知檢體中的成份物。此種分析方法係一種以定性 分析方法檢測未知檢體樣品中的各種藥物成份’過程冗長 耗時,需要經驗豐富技術熟練的技術人員解釋分析結果。1238250 V. Description of the invention (1) The method of the French test and detection of the fruit test area inspection 3 field trials of seeding techniques is related to the issue of Mingfafat t This test film test and detection techniques 0C- ίι / 4 Take photos and photos. The method of the first method is to test the fruit. The previous test is a special test area. [Previous technology] In the past decades, based on the purpose of pregnancy testing and various drug analysis, various biological The analysis of sexual specimens (bi ο 1 〇gica 1 specime η) has been gradually increasing. Considerable time and money have been invested in the development of various analytical systems and technologies in order to obtain more reliable and accurate test results. Furthermore, with the continuous abuse of drugs of abuse, the testing and identification of these drugs and their metabolites have become very important, and many methods of drug abuse detection have been developed. Thin Layer Chromatography (TLC) is used to detect drug components in urine. It requires careful and careful preparation of test specimens and skillful application of the test specimens to a static test. On a chromatographic slice in a developing chamber. Once the chromatophores are taken out of the expansion chamber and dried, they are sprayed on with a developer. The color-developed regions appearing on this chromatographic slide are compared with known standards to know the components in the specimen. This analysis method is a qualitative analysis method for the detection of various drug components in unknown specimens. The process is lengthy and time-consuming, and requires experienced and skilled technicians to interpret the analysis results.

1238250 五、發明說明(2) 少樣丨生免疫化孥試驗方法(E n z y m e M u 11 i p 1 i e d ImmunaihenMeal Test)(EMiT)係一種檢測生物性液體 Cbiologi^al fluid)中濫用藥物成份的半定量免疫分 法。此種貫驗至檢驗方法需要訓練有素的技術人員來執 ’所需要的設備亦相當昂貴。 幸昌射免疫分析方法(Radio-Immuno-Assay)(RIA>^— 種用以檢測濫用藥物的定量敏感的實驗室分析方法。各種 的免疫化學物質係被標記具放射活性之 心使用此些免疫化學物質及使用後小心丢辛:丄 質”在’亦需要從政府處取得:執;者以= 。午使用此一貫驗室分析方法。氣相液體屛1238250 V. Description of the invention (2) A small sample 丨 bioimmunization test method (E nzyme Mu 11 ip 1 ied Immunaihen Meal Test) (EMiT) is a semi-quantitative method for detecting the abuse of drug components in biological fluid Immunoassay. This pass-through-to-check method requires trained technicians to perform the required equipment and is quite expensive. Xingchang Radio-Immuno-Assay (RIA) ^ —A quantitative and sensitive laboratory analysis method for the detection of drug abuse. Various immunochemical substances are labeled with radioactive hearts using these immunochemical Substance and use carefully after the use of dioxin: the "quality" also needs to be obtained from the government: hold; those with =. Use this conventional laboratory analysis method at noon. Gas phase liquids

Liquid Chromatography ) (GLC)可提供,二刀 ' aS 備,其分析過程亦非常複雜,而需要細 叩貝的儀為设 人員來執行。 文、、工過兩度訓練的技術 上述已知的分析方法皆需要技巧外 巧複雜的儀器設備’因此往往使得此=t的技術人員及精 昂責。 二分析方法花費相當 基於上述原因及隨著藥物濫用趨熱 性液體檢體中檢測藥物殘餘物的新分彳頒升咼,在生物 吓刀析方法的開發已顯得Liquid Chromatography (GLC) is available. The two-tool 'aS device is also very complicated in its analysis process, and requires a detailed instrument to perform it. The techniques of two trainings in text, work, and the above-mentioned known analysis methods all require skillful and complicated instruments and equipment ', so this often makes the technical staff and precision responsible. The cost of the second analysis method is considerable. Based on the above reasons and the new analysis of drug residue detection in the hot liquid specimens of drug abuse, the development of biological scarification analysis methods has appeared.

1238250 五、發明說明(3) 更形重要及需要。一種檢測生物性液體中濫用藥物成份之 濫用藥物檢驗試紙已被發展出來。此種試紙對於檢測液體 中特定成份敏感並且以無顯色反應表示正反應,代表欲檢 測之特定成份存在於檢測液體中,而以顯色反應表示負反 應,代表欲檢測之特定成份不存在於檢測液體中。對於此 種濫用藥物檢驗試紙在各種檢驗情況下所產生的各種顯色 圖案做一介紹如下。首先,參照第一 A圖,係一濫用藥物 檢驗試紙1 0於檢驗收集自一受測對象的一液體樣品之前 的頂視示意圖。此濫用藥物檢驗試紙1 0在檢驗一液體樣 品之前係為空白並無顯色圖案產生。虛線1 1至1 6係分 別代表濫用藥物檢驗試紙1 0上一個別的檢驗區。濫用藥 物檢驗試紙1 0上相應虛線1 1的一頂部檢驗區對於此液 體樣品產生顯色反應,其係用以檢測此液體樣品之取樣量 是否足以使液體樣品藉毛細現象經過濫用藥物檢驗試紙1 0的每一個檢驗區。因此,此一頂部檢驗區經顯色反應產 生的顯色色條通稱做控制色條(c ο n t r ο 1 1 i n e )。濫用藥物 檢驗試紙1 0上相應虛線1 2至1 6所在位置的其它檢驗 區係分別對於此液體樣品中一個別的濫用藥物的存在與否 產生顯色反應。此些檢驗區經顯色反應產生的顯色色條稱 做標的色條(t a r g e t 1 i n e )。 參照第一 B圖,其顯示濫用藥物檢驗試紙1 0相應虛 線1 1的頂部檢驗區不具顯色反應的一種顯色圖案示意圖 ,其係由於受測液體樣品取樣量不足,使其無法經由毛細1238250 V. Description of the invention (3) More important and needed. A substance abuse test strip for the detection of substance abuse in biological fluids has been developed. This kind of test paper is sensitive to the detection of specific components in the liquid and indicates a positive reaction with no color reaction, which indicates that the specific component to be detected is present in the detection liquid, and a color reaction indicates a negative reaction, which indicates that the specific component to be detected does not exist. Detection in liquid. The following is a description of the various color development patterns produced by this kind of drug abuse test strip under various test conditions. First, referring to FIG. 1A, it is a schematic top view of a drug abuse test strip 10 before testing a liquid sample collected from a subject. The drug abuse test strip 10 was blank before a liquid sample was tested and no color development pattern was generated. The dashed lines 1 1 to 16 represent the other test areas on the drug abuse test strip 10 respectively. A top inspection area of the corresponding dotted line 11 on the drug abuse test strip 10 produces a color reaction to the liquid sample, which is used to detect whether the sample amount of the liquid sample is sufficient to allow the liquid sample to pass the capillary phenomenon through the drug abuse test strip 1 0 for each inspection area. Therefore, the color-developing color bar generated by the color-developing reaction at this top inspection area is generally called a control color bar (c ο n t r ο 1 1 i n e). Substances of abuse The other test areas at the corresponding dashed lines 12 to 16 on the test strip 10 have a color response to the presence or absence of another substance of abuse in this liquid sample. The color-developing color bars produced by the color-developing reaction in these inspection areas are called standard color bars (t a r g e t 1 i n e). Referring to the first figure B, a schematic diagram of a color development pattern showing a non-color reaction at the top inspection area corresponding to the dashed line 1 1 of the drug abuse test strip 10 is due to insufficient sampling of the liquid sample to be tested, which prevents it from passing through the capillary.

1238250 五、發明說明(4) 現象達到頂部檢驗區所致,在此情況下,亦無法確認液體 樣品是否有經過濫用藥物檢驗試紙1 0上其它所有的檢驗 區。因此,根據第一 B圖所示由標的色條1 4至1 6組成 之顯色圖案,並無法完全檢測及鑑定出液體樣品中所存在 的濫用藥物成份。參照第一 C圖,其顯示濫用藥物檢驗試 紙1 0上僅有頂部檢驗區產生一控制色條1 1的顯色圖案 示意圖,其代表頂部檢驗區對於液體樣品為正反應( ρ 〇 s i t i v e r e s ρ ο n s e),即液體樣品取樣量足夠使其經毛 細現象經過濫用藥物檢驗試紙1 0上所有檢驗區,而虛線 1 2至1 6相應的其它檢驗區未產生標的色條,係對於液 體樣品皆為正反應,代表相應此些檢驗區所欲檢測的藥物 成份皆存在於液體樣品中。參照第一 D圖,其顯示濫用藥 物檢驗試紙1 0上具有控制色條1 1及標的色條1 2與1 5之顯色圖案示意圖,係代表頂部檢驗區對於液體樣品為 正反應,液體樣品取樣量足夠使其經毛細現象經過濫用藥 物檢驗試紙1 0上所有檢驗區,而標的色條1 2及1 5代 表相應的個別檢驗區對於液體樣品為負反應(n e g a t i v e r e s ρ ο n s e),表示欲檢測之藥物成份並不存在於液體樣品 中。相反地,第一 D圖中虛線1 3 、1 4及1 6相應之檢 驗區對於液體樣品為正反應,此些檢驗區所欲檢測之藥物 成份係存在於液體樣品中。 上述之濫用藥物檢驗試紙1 0之控制色條1 1對於液 體樣品為正反應時,會產生顯色反應。標的色條1 2至11238250 V. Explanation of the invention (4) The phenomenon reached the top inspection area. In this case, it is also impossible to confirm whether the liquid sample has passed all other inspection areas on the drug abuse test strip 10. Therefore, according to the color development pattern composed of the target color bars 14 to 16 shown in the first B figure, it is impossible to completely detect and identify the substance of abuse in the liquid sample. Referring to the first figure C, it shows a schematic diagram of a color development pattern where only the top inspection area on the drug test strip 10 produces a control color bar 11, which represents that the top inspection area is a positive reaction to a liquid sample (ρ 〇sitiveres ρ ο nse), that is, the sample size of the liquid sample is sufficient to pass the capillary phenomenon to all the test areas on the drug abuse test strip 10, and the other test areas corresponding to the dashed lines 12 to 16 do not produce a colored bar. A positive response indicates that the drug components to be detected in these test areas are all present in the liquid sample. Referring to the first figure D, it shows a schematic diagram of the color development pattern of the control test strip 10 with the control color bars 11 and the target color bars 12 and 15 on the test strip for drug abuse. It represents that the top test area is a positive reaction to the liquid sample. The liquid sample The sampling volume is sufficient to pass the capillary phenomenon through all the test areas on the drug abuse test strip 10, and the colored bars 12 and 15 represent the corresponding individual test areas that are negative to the liquid sample (negativeres ρ ο nse), indicating that The medicinal components tested were not present in the liquid sample. Conversely, the test areas corresponding to the dashed lines 1 3, 14 and 16 in the first D figure are positive reactions to the liquid sample. The drug components to be detected in these test areas are present in the liquid sample. When the control color strip 11 of the above-mentioned drug abuse test strip 10 is positive for a liquid sample, a color reaction occurs. Targeted color bars 1 2 to 1

第9頁 1238250 五、發明說明(5) 6分別對液體樣品中欲偵測之一特定成份為正反應時,不 會產生顯色反應,代表液體樣品中此一特定成份的含量相 當高;但為負反應時,則產生顯色反應,根據顯色反應顏 色深淺(顯色反應強弱)可判斷液體樣品中此一特定成份 含量多寡或者並不存在。標的色條1 2至1 6的顯色強度 係與液體樣品中欲檢測的一特定成份的含量成反比關係。 此一特定成份於液體樣品中的含量愈高,其相應標的色條 的顯色反應就愈淡。此種濫用藥物檢驗試紙的顯色反應結 果僅由目判方式來下結論。因此,很難以目判方式決定當 顯色反應達到哪一顯色強度時,即表示欲檢測之特定成份 不存在於檢測液體中。此種檢測方法雖然快速方便,但在 判斷受測對象是否使用藥物上較難令人信服。 據此,亟待提供一種可分析及鑑定出生物液體檢體中 濫用藥物成份之方法,其可克服上述各種習知方法的缺點 三、【發明内容】 本發明之主要目的係提供一種試片檢驗區檢測結果自 動偵測方法,其係藉讀取相應一條狀試片之一條碼圖案, 以取得此條狀試片之每一標的色條的顯色反應閥值( threshold of a color response),及艮據此顯色反應 閥值,以決定標的色條相應受測液體中一特定成份的檢測 結果。Page 9 1238250 V. Description of the invention (5) 6 When a specific component in the liquid sample to be detected is a positive reaction, no color reaction occurs, which represents that the content of this specific component in the liquid sample is quite high; but When the reaction is negative, a color reaction occurs. According to the color depth of the color reaction (the color reaction is strong or weak), it can be judged whether the content of this specific component in the liquid sample is not present or not. The color intensity of the target color bars 12 to 16 is inversely related to the content of a specific component to be detected in the liquid sample. The higher the content of this specific component in the liquid sample, the weaker the color response of the corresponding color bar. The color reaction results of such drug abuse test strips can only be concluded by visual judgment. Therefore, it is difficult to determine visually which color development intensity is reached by the color development reaction, which means that the specific component to be detected does not exist in the detection liquid. Although this detection method is fast and convenient, it is difficult to be convincing in judging whether the test subject is using drugs. Accordingly, there is an urgent need to provide a method that can analyze and identify the substance of drug abuse in biological liquid specimens, which can overcome the shortcomings of the various conventional methods described above. [Abstract] The main purpose of the present invention is to provide a test strip inspection area An automatic detection method for detecting results by reading a bar code pattern of a corresponding strip test strip to obtain a threshold of a color response for each target color bar of the strip test strip, and Based on this, the color reaction threshold is used to determine the detection result of a specific component in the target liquid corresponding to the liquid being tested.

第10頁 1238250 五、發明說明(6) 本發明之另一目的係提供一種試片檢驗區檢測結果自 動偵測方法,其係利用結合一使用者介面的一影像擷取裝 置以擷取一條狀試片顯色圖案影像及讀取相應的一條碼圖 案,藉將此條碼圖案解碼以取得此條狀試片上每一標的色 條的顯色反應閥值,據以決定此標的色條的檢測結果,並 將檢測結果直接顯示於使用者介面上,方便使用者檢視。 本發明之又一目的係提供一種試片檢驗區檢測結果自 動偵測方法,其係利用一影像擷取/處理技術結合一影像 分析程式以自動偵、測一條狀試片上每一標的色條的個別檢 測結果,係可減少人為操做及縮短試片檢測時間。 根據以上所述之目的’本發明提供一種試片檢驗區檢 測結果自動偵測方法。本發明方法係提供一掃描物件,此 掃描物件包括一條碼及複數片條狀試片。條碼係置放於掃 描物件上一預定位置及此些條狀試片係依序排列於掃描物 件上未與條碼重疊的一區域。每一條狀試片具有包括一控 制色條及複數條標的色條的一顯色圖案,控制色條及此些 標的色條係依序排列於條狀試片一端至其另一端,及控制 色條與每一標的色條係分別相應條狀試片上一檢驗區。掃 描此掃描物件,以讀取條碼圖案及擷取此些條狀試片之影 像資料。將條碼圖案解碼,以測得此些條狀試片之個別類 型(r e s p e c t i v e t y p e s),並根據每一條狀試片之個別類Page 10 1238250 V. Description of the invention (6) Another object of the present invention is to provide an automatic detection method for the test result of a test strip inspection area, which uses an image capture device combined with a user interface to capture a strip of Test strip color development pattern image and read the corresponding bar code pattern, decode the bar code pattern to obtain the color rendering reaction threshold of each target color bar on the bar test strip, and then determine the test result of the target color bar And display the test results directly on the user interface for easy viewing by users. Another object of the present invention is to provide an automatic detection method for the test result of a test strip inspection area, which uses an image capture / processing technology combined with an image analysis program to automatically detect and measure the color stripe of each mark on a strip of test strip Individual test results can reduce manual operation and test strip test time. According to the object described above, the present invention provides a method for automatically detecting a test result of a test strip inspection area. The method of the present invention provides a scanning object. The scanning object includes a bar code and a plurality of strip-shaped test strips. The bar code is placed at a predetermined position on the scanned object and these strip-shaped test strips are sequentially arranged in an area on the scanned object that does not overlap with the bar code. Each strip test strip has a color rendering pattern including a control strip and a plurality of color strips. The control strip and the color strips are sequentially arranged from one end to the other end of the strip strip, and the control color. The strips and the color strips of each target are the corresponding test areas on the strip test strips. Scan the scanned object to read the bar code pattern and capture the image data of these strip test strips. The bar code pattern is decoded to determine the individual types of these strip-shaped test strips (r e s p e c t i v e t y p e s), and according to the individual types of each strip-shaped test strip

1238250 五、發明說明(7) 型,以得到相應的一顯色反應閥值對映表,其中對映表( mapping table)中每一顯色反應閥值(a threshold of a c ο 1 o r r e s p ο n s e )係相應此條狀試片上一標的色條位置。 根據此條狀試片之影像資料,計算此條狀試片上一標的色 條的一顯色反應。根據此條狀試片相應的此顯色反應閥值 對映表,比較此標的色條之顯色反應與相應的一顯色反應 閥值,以決定此標的色條的正或負反應。 本發明方法係藉偵測相應一條狀試片之一條碼,以獲 得此條狀試片之類型,並根據此條狀試片之類型取得相應 的一顯色反應閥值對映表,其中此條狀試片之每一標的色 條係相應此對映表中的一顯色反應閥值。再藉由比較每一 標的色條的顯色反應與相應的一顧色反應閥值,以決定此 標的色條的檢測結果。本發明係提供一種自動、快速及準 確的試片檢驗區檢測結果偵測方法。 本發明之目的及諸多優點藉由以下具體實施例之詳細 說明,並參照所附圖式,將趨於明瞭。 _ 四、【實施方式】 本發明提供一種試片檢驗區檢測結果自動偵測方法, 其係利用一影像擷取裝置,例如掃描器,以擷取一條狀試 片上具有一控制色條及複數條標的色條的一顯色圖案影像 ,例如是一濫用藥物檢驗試片之顯色圖案影像,及一相應1238250 V. Description of the invention (7) type to obtain a corresponding color rendering reaction threshold value mapping table, where each color rendering reaction threshold (a threshold of ac ο 1 orresp ο nse) in the mapping table ) Is the position of a color bar on the strip. Based on the image data of the strip test strip, a color rendering reaction of a marked color bar on the strip test strip is calculated. According to the corresponding color rendering reaction threshold mapping table of the strip test strip, compare the color rendering reaction of the target color strip with the corresponding color rendering reaction threshold to determine the positive or negative response of the color strip. The method of the present invention is to detect a bar code of a corresponding strip test strip to obtain the type of the strip test strip, and obtain a corresponding color rendering reaction threshold value mapping table according to the type of the strip test strip. Each color bar of the strip test strip corresponds to a color reaction threshold in the mapping table. Then, by comparing the color reaction of each target color bar with the corresponding color response threshold, the detection result of the target color bar is determined. The invention provides an automatic, fast and accurate detection method for detection results of a test strip inspection area. The purpose and many advantages of the present invention will be made clear by the following detailed description of specific embodiments and with reference to the accompanying drawings. _IV. [Embodiment] The present invention provides an automatic detection method for the test result of a test strip inspection area, which uses an image capture device, such as a scanner, to capture a strip of test strip with a control color bar and a plurality of bars. A color image of the target color bar, for example, a color image of a drug abuse test strip, and a corresponding image

第12頁 1238250 五、發明說明(8) 的條碼圖案。將此條碼圖案解碼以測得此條狀試片之類型 (type),再根據此條狀試片之類型以取得相應的一顯色 反應閥值對映表。本發明中條狀試片之類型係用以代表一 條狀試片可檢測一受測液體中的特定成份種類,而其相應 的對映表中的每一顯色反應閥值係代表相應的一標的色條 對於受測液體中欲檢測之特定成份為正反應的最小顯色反 應值。本發明方法係根據擷取的此條狀試片顯色圖案影像 ,以計算其每一標的色條的顯色反應,及比較此顯色反應 與對映表中相應的顯色反應閥值,以決定此標的色條的檢 測結果。此條狀試片之每一標的色條的檢測結果係直接顯 示於影像擷取裝置的使用者介面。使用者可直接在使用者 介面顯示晝面上檢視各種試片檢測結果。 第二圖係使用於本發明影像擷取裝置之使用者介面示 意圖。一影像預覽視窗2 0係顯示於此使用者介面之右邊 區域。此影像預覽視窗2 0係用以顯示出掃描物件之預覽 影像。第三A圖及第三B圖係本發明之掃描物件頂視示意圖 ,第三A圖之掃描物件3 0包括一條碼(bar code) 3 1 及具有一顯色圖案之一條狀試片3 2 。條狀試片3 2之顯 色圖案包括一控制色條及複數條標的色條,係從條狀試片 3 2 —端依序排列至其另一端。控制色條係對於條狀試片 3 2檢驗之一受測液體相應產生顯色反應,而每一標的色 條代表條狀試片3 2上一檢驗區,係對於受測液體中一特 定成份存在與否產生顯色反應。第三B圖之掃描物件3 3Page 12 1238250 V. Bar code pattern of invention description (8). Decode the bar code pattern to determine the type of the strip test strip, and then obtain a corresponding color rendering response threshold value mapping table according to the type of the strip test strip. The type of strip test strip in the present invention is used to represent that a strip test strip can detect a specific component type in a test liquid, and each color reaction threshold value in its corresponding mapping table represents a corresponding standard. The color bar is the minimum positive color response value for the specific component to be detected in the test liquid. The method of the present invention calculates the color rendering reaction of each target color strip according to the captured color rendering pattern image of the strip test strip, and compares the color rendering reaction with the corresponding color rendering reaction threshold in the mapping table. To determine the detection results of this target color bar. The detection result of each target color bar of this strip test strip is directly displayed on the user interface of the image capture device. The user can directly view the test results of various test strips on the day and time display on the user interface. The second diagram is a schematic diagram of a user interface used in the image capture device of the present invention. An image preview window 20 is displayed in the right area of the user interface. This image preview window 20 is used to display the preview image of the scanned object. Figures A and B are schematic top views of the scanned object of the present invention. The scanned object 3 of Figure A includes a bar code 3 1 and a strip-shaped test piece 3 2 having a color rendering pattern. . The color development pattern of the strip test strip 32 includes a color strip for controlling color bars and a plurality of labels, which are sequentially arranged from the strip test strip 3 2 -end to the other end thereof. Controlled color strips respond to the test liquid corresponding to one of the strip test strips 3 2 test, and each colored strip represents the upper test area of the strip test strip 3 2, which is for a specific component in the test liquid. Presence or absence of color reaction. Scanned Object in Figure 3B 3 3

第13頁 1238250 明說明(9)_ ^ 包括一條碼3 4及複數片條狀試片3 碼3 4係置於掃描物件3 3上一預定、3 6及3 7。條 、3 6及3 7係依序排列於掃描物件^置及條狀試片3 5 重疊之區域。第三A圖及第三B圖所示 3上未與條碼3 4 6及3 7可以是第一圖所示之濫用藥狀試片3 5 、3 測液體可以是收集自一受測對象的生 双驗試紙1 〇 。受 、尿液、汗液及唾液。使用者可直勿,檢體,例如血液 上直接框選欲進行常態掃描之掃描物影像預覽视窗2 0 視窗2 0上同時框選欲進行常態掃描^亦可在影像預覽 些掃描物件之框選次序同時被儲存下來夕個掃描物件,此 一影像分析資料顯示框2 3係顯八 左邊頂部區域,其顯示被框選之至*少、二1此使用者介面之 描影像資料分析結果,係包含一影^:掃描物件之常態掃 每一條狀試片中標的色條影像位置之度相對掃插物件上 強度相對每一條狀試片中標的色條(ϋ圖2 4及一影像 表2 5。在此數據表2 5中具有—掃描影像仇置之數據 1 D co 1 umn),係經由讀取掃描物件上田 件代表螞攔位( 據表2 5亦具有一受測對象名稱攔位的备'喝而得到。數 可供使用者自行鍵入。數據表2 5 Φ仏N&m6 c0 1 umη),Page 13 1238250 Explanation (9) _ ^ Includes a bar code 3 4 and a plurality of strip-shaped test strips 3 code 3 4 is placed on the scanned object 3 3 on a scheduled, 3 6 and 37. Strips, 3 6 and 37 are sequentially arranged in the area where the scanning object is placed and the strip test strips 3 5 overlap. The barcodes 3 and 6 shown in Figures 3A and 3B may be the drug test strips 3 5 and 3 shown in the first figure. The test liquid may be collected from a test subject. Health test paper 10. Affected by urine, sweat, and saliva. The user can directly select the specimen, for example, directly select the scanned object image preview window 2 for normal scanning on the blood, and select the normal scanning on the window 2 0 at the same time. The sequence is stored at the same time, and a scan object is displayed. This image analysis data display box 2 3 displays the top left area of the eighth, which displays the minimum selected by the frame. Contains a shadow ^: The normal position of the scanned object is the degree of the position of the image of the color bar in each strip test piece relative to the intensity of the scanned object relative to the color bar of each strip test piece (ϋFigure 2 4 and an image table 2 5 In this data table 25, there is the data of the scanned image (1 D co 1 umn), which is based on reading the scanned object on the field to represent the ant stop (According to table 25 also has a test object name stop Prepared to get it. The number can be entered by the user. Data table 2 5 Φ 仏 N & m6 c0 1 umη),

尸/y盘音一了 I 一條狀試片之標的色條影像位置係故R77 ^不知描物件上每 給予一編號(I tem number),方便使’、狀甙片排列次序 2 5中同時顯示有每一條狀試片上麵^者辨別。數據表 色條(C)對於受測液體樣品的陰性 ( T)及控制 )或陽性反應(+ )The corpse / y disk sound is I. The position of the color bar image of the strip test strip is R77. ^ I do n’t know that each item is given a number (I tem number), so that the ', glucosides are arranged in the order 2 and 5 at the same time Each of the strips is identified above. Data Sheet Color Bar (C) Negative (T) and Control for Liquid Samples Tested) or Positive Response (+)

*气第14頁 1238250 五、發明說明(10) 之,位(Judgement/Control) ( + /-)。藉由本發明方法經 將2描物件上的條碼圖案解碼,以取得每一標的色條相應 之,色反應閥值(a threshold of a color response )’藉此顯色反應閥值判斷條狀試片上此標的色條顯色反 2之正/或負檢測結果,此一正/或負檢測結果即直接顯示 於使用者介面之數據表2 5中。此外,影像分析資料顯示 框2 3頂部區域顯示有多個選擇鍵(Target 7, 8 , Target 9 , Target 1 〇 , Target 1 1 , Target 1* P.14 1238250 V. Description of Invention (10), Judgement / Control (+ /-). By the method of the present invention, the barcode pattern on the object is decoded to obtain the color bar corresponding to each target, and a threshold of a color response is used to determine the color threshold on the strip test strip. This standard color bar shows a positive / or negative detection result when the color is negative 2. This positive / or negative detection result is directly displayed in the data table 25 of the user interface. In addition, there are multiple selection keys (Target 7, 8, Target 9, Target 1 〇, Target 1 1, Target 1

f ),此些選擇鍵排列次序係相應影像預覽視窗2 〇被框 运之預覽影像之框選次序。使用者可直接點選其中一選擇 、建刀換衫像刀析資料顯示框2 3顯示的掃描物件經常,能 掃描的影像資料分析結果。 、 … 一功能鍵顯示框2 Θ係顯示於使用者介面之影像 貧=顯示框2 3下方,其包括—預覽按鍵(Preview)刀析 :知心按鍵(Scan)、一自動掃描按鍵(Aut〇)、一結果 it (Print Result)^ — iu jL· ^ ^ . ώ ^ ; 報告列印鍵(Pnnt Report)及一報 : = ΡΓΐη〇。預覽按鍵(Pr-iew)係提f), the selection order of these selection keys is the order of selecting the frame of the preview image of the corresponding image preview window 2 0. The user can directly click one of the options, and create a knife and change clothes, as shown in the data analysis box 2 and 3. The scanned objects are often displayed, and the scanned image data can be analyzed. ,… A function key display frame 2 Θ is displayed on the user interface below the image poor = display frame 2 3, which includes-Preview button analysis: Scan button, an automatic scan button (Aut〇) A result it (Print Result) ^ — iu jL · ^ ^. FREE ^; Pnnt Report and one report: = ΡΓΐη〇. Preview button (Pr-iew)

: ?描按係提㈣行被框選之至 少一預覽影像之常態掃描功能,白說 供整I預寶旦;傻$ #〜P 自動知描按鍵(Auto)係提 仏正頁預見〜像之吊恶知描功能,結果列印鍵(hi以 R e s u 11)係提供被框選之至少一臨 ^ ^ 預見景》像常態掃描影傻咨 料分析結果列印功能。報土列ep •吊〜何彻〜像貝 被框選之至少一預覽影像當能播 攸仏 豕H抑^田衫像貢料及其影像資料: The normal scanning function of the at least one preview image selected by the frame-drawing line is to be used for pre-editing. It is silly $ # ~ P The auto-draw button (Auto) is foreseeing the front page of the image ~ The holy evil description function, the result print key (hi to Resu 11) is to provide at least one frame selected by the frame ^ ^ "Foresee the scene" like a normal scan shadow silly information analysis results printing function. Newspaper ep • Hanging ~ He Che ~ Xianbei at least one preview image selected by the frame can be broadcasted

1238250 五、發明說明(π) 分析結果列印功能。報告自動列印鍵(A u t ο P r i n t )係提供 整頁預覽影像之常態掃描影像資料及其等資料分析結果列 印功能。 第四圖係本發明方法的一具體實施例之步驟流程圖。 首先,在步驟4 0 ,提供一掃描物件,此掃描物件包括一 條碼(bar code)及複數片條狀試片。此條碼係置放於此 掃描物件上一預定位置及此些條狀試片係依序排列於此掃 描物件上未與此條碼重疊的一區域。每一條狀試片具有包 括一控制色條及複數條標的色條之一顯色圖案,控制色條 及此些標的色條係依序排列於此條狀試片一端至其另一端 。控制色條相應經此條狀試片檢驗的一受測液體產生一顯 色反應,及每一標的色條代表此條狀試片上一檢驗區,係 相應此受測液體中一特定成份產生顯色反應。本發明之掃 描物件可以是第三A圖及第三B圖所示之掃描物件3 0及3 2。本發明係根據條狀試片可檢測受測液體中特定成份種 類,將條狀試片分類成各種不同類型(v a r i 〇 u s t y p e s )。 本發明條碼可以是一一維條碼(〇 n e - d i m e n s i ο n a 1 b a r code),例如第五圖所示之條碼,係包括一 ”開始n條碼圖 案、一第一組條碼圖案、複數群第二組條碼圖案、一第三 組條碼圖案及一 ”結束”條碼圖案。第一組條碼圖案係相應 掃描物件上此些條狀試片之個別類型,其中第一組條碼圖 案之每一條碼圖案(each bar pat tern)係依序相應一條 狀試片之個別類型(type)。每一第二組條碼圖案係依序1238250 V. Description of invention (π) Analysis result printing function. The report automatic print key (A u t ο Pr n t) provides the normal scan image data of the whole page preview image and the analysis result printing function. The fourth diagram is a flowchart of the steps of a specific embodiment of the method of the present invention. First, in step 40, a scanning object is provided, and the scanning object includes a bar code and a plurality of strip-shaped test pieces. The bar code is placed at a predetermined position on the scanned object and the strip test strips are sequentially arranged in an area on the scanned object that does not overlap with the bar code. Each strip-shaped test piece has a color rendering pattern including a control color bar and a plurality of color bars, and the control color bars and the target color bars are sequentially arranged from one end of the strip-shaped test piece to the other end thereof. Control the color bar to produce a color response corresponding to a test liquid tested by the strip test strip, and each marked color bar represents a test area on the strip test strip, corresponding to a specific component in the test liquid.色 反应。 Color reaction. The scanning objects of the present invention may be the scanning objects 30 and 32 shown in Figures A and B. The present invention classifies strip test strips into various types (v a r i 0 u s t y p e s) based on the strip test strips that can detect specific types of components in the liquid being tested. The bar code of the present invention may be a one-dimensional bar code (〇ne-dimensi ο na 1 bar code), for example, the bar code shown in the fifth figure, which includes a "start n bar code pattern, a first group bar code pattern, a plural group second Set of bar code patterns, a third set of bar code patterns, and an "end" bar code pattern. The first set of bar code patterns are the respective types of these strip-shaped test strips on the scanned object. Each bar code pattern of the first set of bar code patterns each bar pat tern) is the individual type of the corresponding strip of test strips in sequence. Each second set of bar code patterns is in sequence

第16頁 1238250 五、發明說明(12)Page 16 1238250 V. Description of the invention (12)

相應此掃描物件上一條狀試片,及此第- ϋ乐一組條碼圖案之每一條碼圖案係依序相應此條狀試片之一/ ^ , 知的色條的位置。 弟二、,且條碼圖案係相應此掃描物件之—b T , ^ . r . 、 1代表碼( identification Number) 〇 此一維你版 > ^ ^ r , u x 、详九卞石馬之每一條碼圖案 (each bar pattern)具有一固定碼异广 «丄…也,“ ^ V code length)及由複數條條線(bars)與複數條空白綠 。 1卞工白線(spaces)組成 仕步驟4 1 ,以具有一電荷 掃描此掃描物件,以讀取此條碼 之影像資料。本發明影像擷取裝 ^ed)、綠(Green)及藍(Blue)像 何耦合裝置之一頂面上。本發明 )、綠(Green)及藍(Blue)像素通 所組成,每一感測胞代表一像素 亦可使用具單色像素通道之電荷 ,逭之電荷耦合裝置、具綠像素 &像素通道之電荷耦合裝置。 2圖案解碼,卩測得此些條狀試 ::条狀試片之個別類型,以得到 =f此條狀試片上複數條標的測:反應閥值係相應此條 ^ 4寸义成份,並代表此_ Μ 結果為正 ϋ ^不的 反應的琅小頦色反庫值 耦合裝 圖案及 置之電 素通道 中電荷 道係分 位置。 耦合裝 通道之 著,在 片之個 相應的 色條位 狀試片 色條對 。當讀 擷取此些條 荷耦合裝置 互相平行排 耦合裝置的 別由複數個 另一方面, 置,例如具 電荷耦合裝 步驟4 2 , 別類型,並 複數個顯色 置的一對映 上一標的色 於此特定成 取本發明條 取裝置 狀試片 具有紅 列於電 紅(Red 感測胞 本發明 紅像素 置或具 將此條 根據每 反應閥 表,其 條欲檢 份檢測 石馬圖案Corresponding to the strip test strip on the scanned object, and each bar code pattern of the first bar code set, the position of the color bar corresponding to one of the strip test strips is sequentially determined. Brother 2, and the bar code pattern is corresponding to this scanned object — b T, ^. R., 1 representative code (identification number) 〇 this one-dimensional version of you > ^ ^ r, ux, detailed Each bar pattern has a fixed code «广 ... also," ^ V code length "and consists of a plurality of bars and a plurality of blank greens. 1 卞 white lines (spaces) form a step 41, scanning the scanned object with a charge to read the image data of the barcode. The image capture device of the present invention is mounted on one of the top surfaces of one of the coupling devices, such as green, green, and blue. The present invention), green (Green) and blue (Blue) pixel pass, each sensing cell represents a pixel can also use the charge with a single-color pixel channel, the charge-coupled device with 逭, the green pixel & pixel channel Charge-coupled device. 2 Pattern decoding, I have measured these strip tests :: Individual types of strip test strips to get = f. Tests for multiple labels on this strip test strip: The response threshold is corresponding to this strip ^ 4 inch Meaning component, and represent this _ Μ result is positive reaction The coupling channel pattern and the charge channel in the placed electron channel are divided into positions. The writing of the coupling channel, the corresponding color strip on the film is a test strip and the color strip pair. When reading and extracting these strips, the coupling devices are parallel to each other The row coupling device is composed of a plurality of other aspects, such as a step 4 2 with a charge coupling device, of a different type, and a plurality of color-developed pairs that are mapped to a target color. This is specifically taken as the device of the present invention. The red test piece has a red column in the electric red (Red sensor cell, the red pixel of the present invention is provided with a strip, and the strip is based on each reaction valve table.

1238250_ 五、發明說明(13) 而债測到掃描物件上一條狀試片屬於第I類型(type I) 條狀試片時,本發明之影像分析程式會根據此第I類型條 狀試片,取得如下所示一相應的對映表I。1238250_ 5. Description of the invention (13) When the debt test detects that the strip test strip belongs to the type I strip test strip, the image analysis program of the present invention will use this type I strip test strip, A corresponding mapping table I is obtained as shown below.

對映表I 標的色條 位置 1 2 3 4 5 顯色反應 閥值 50 30 60 55 70 對映表I係列示出第I類型條狀試片之所有標的色條在 其上之位置順序與每一標的色條相應的一顯色反應閥值( a threshold of a color response) 〇 例如,第 I類型條 狀試片可檢測受測液體中五種特定成份時,其相應的對映 表I即列示出五條標的色條相應的個別顯色反應閥值。本 發明方法藉讀取掃描物件上的條碼圖案,可偵測出掃描物 件上每一條狀試片的個別類型,本發明之影像分析程式根 據每一條狀試片之個別類型,即可取得此條狀試片相應的 一顯色反應閥值對映表,並根據此一對映表可得到此條狀 試片上每一標的色條的一顯色反應閥值。Position of the colored bars in the mapping table I 1 2 3 4 5 Threshold of color rendering reaction 50 30 60 55 70 The mapping table I series shows the order and position of all marked color bars in the strip test strip of type I on each A threshold of a color response corresponding to a standard color bar. For example, when the type I strip test strip can detect five specific components in the liquid under test, its corresponding mapping table I is The columns show the individual color response thresholds of the five colored bars. The method of the present invention can detect the individual type of each strip test strip on the scanned object by reading the bar code pattern on the scanned object. The image analysis program of the present invention can obtain this strip according to the individual type of each strip test strip. A color rendering reaction threshold mapping table corresponding to the strip test strip, and according to the pair mapping table, a color rendering reaction threshold of each color bar on the strip test strip can be obtained.

第18頁 1238250_ 五、發明說明(14) 接下來,在步驟4 3 ,根據擷取的一條狀試片影像資 料,計算此條狀試片上一標的色條的顯色反應。第六圖係 可置放於本發明掃描物件上的一濫用藥物檢驗試片1 0之 一顯色圖案影像示意圖。此濫用藥物檢驗試片1 0之顯色 圖案包括一控制色條1 1及複數條標的色條1 2至1 6 。 從整個影像上選擇至少一條掃描線L-L’,此掃描線L-L’係 垂直於控制色條1 1及標的色條1 2至1 6之影像。接著 ,根據掃描線L - L ’,建立濫用藥物檢驗試紙1 〇之整個影 像的一像素值相對像素位置的關係圖。第七圖分別顯示出 電荷耦合裝置之紅(Red)、綠(Green)及藍(Blue)通道的個 別的像素值相對像素位置的曲線,分別以紅像素曲線、綠 像素曲線及藍像素曲線簡稱。另一方面,本發明亦可使用 具單色像素通道之電荷耦合裝置,例如具紅像素通道之電 荷耦合裝置、具綠像素通道之電荷耦合裝置或具藍像素通 道之電荷耦合裝置,以擷取濫用藥物檢驗試紙1 0之整個 影像。接著,選擇第七圖所示之像素值相對像素位置的關 係圖中紅像素曲線、綠像素曲線及藍像素曲線中任一條曲 線,或者紅像素曲線、綠像素曲線及藍像素曲線所合成之 一條平均曲線,並根據所選擇的曲線及公式(I )計算每一 標的色條的一顯色反應R : R = { (T-C)/(A-C) } X 100°/〇 ( I), 以選擇藍像素曲線以計算標的色條1 3的顯色反應R為例 ,其中,T係取標的色條1 3相應影像中一像素位置區間 之一像素平均值,C係取控制色條1 1相應影像中一像素Page 18 1238250_ V. Description of the invention (14) Next, in step 4 3, calculate the color rendering reaction of a marked color bar on the strip test strip based on the captured strip test strip image data. The sixth diagram is a schematic diagram of a color-developed pattern image of a drug abuse test strip 10 that can be placed on a scanning object of the present invention. The color development pattern of the drug abuse test strip 10 includes a control color bar 11 and a plurality of labeled color bars 12 to 16. At least one scanning line L-L 'is selected from the entire image. This scanning line L-L' is an image perpendicular to the control color bars 11 and the target color bars 12 to 16. Next, based on the scan lines L-L ', a graph of the relationship between the pixel value and the pixel position of the entire image of the drug abuse test strip 10 is established. The seventh graph shows the individual pixel values versus pixel positions of the red, green, and blue channels of the charge-coupled device. The red pixel curve, green pixel curve, and blue pixel curve are abbreviated respectively. . On the other hand, the present invention can also use a charge-coupled device with a monochrome pixel channel, such as a charge-coupled device with a red pixel channel, a charge-coupled device with a green pixel channel, or a charge-coupled device with a blue pixel channel to capture The entire image of the Drug Abuse Test Strip 10. Next, select any one of the red pixel curve, the green pixel curve, and the blue pixel curve, or a combination of the red pixel curve, the green pixel curve, and the blue pixel curve. Average the curve, and calculate a color rendering reaction R of each target color bar according to the selected curve and formula (I): R = {(TC) / (AC)} X 100 ° / 〇 (I) to select the blue The pixel curve is calculated by calculating the color rendering reaction R of the target color bar 13. Among them, T is the average value of one pixel in a pixel position interval in the corresponding image of the target color bar 1 3, and C is the corresponding image of the control color bar 1 1 One pixel

第19頁 1238250 五、發明說明(15) 位置區間之一像素平均值,及A取標的色條1 3兩旁之濫 用藥物檢驗試紙1 0淺色底面相應影像之一第一像素區間 A及一第二像素區間A & —參考白像素平均值。 接著,在步驟4 4 ,根據此條狀試片相應的一顯色反 應閥值對映表,比較此標的色條之顯色反應與相應的一顯 色反應閥值。在步驟4 5 ,當此標的色條的顯色反應不小 於此顯色反應閥值時,決定此標的色條相應受測液體中之 此特定成份為正反應,代表此特定成份存在於受測液體中 :而當此標的色條的顯色反應小於此顯色反應閥值時,決 定此標的色條相應受測液體中之此特定成份為負反應,代 表此特定成份不存在於受測液體中。此條狀試片上每一標 的色條的檢測結果即直接顯示於第二圖所示之使用者介面 的數據表2 5中。 本發明方法係藉偵測相應一條狀試片之一條碼,以獲 得此條狀試片之類型,並根據此條狀試片之類型取得相應 的一顯色反應閥值對映表,其中此條狀試片之每一標的色 條係相應此對映表中的一顯色反應閥值。再藉由比較每一 標的色條的顯色反應與相應的一顯色反應閥值,以決定此 標的色條的檢測結果。本發明係提供一種自動、快速及準 確的試片檢驗區檢測結果偵測方法。 以上所述僅為本發明之具體實施例而已,並非用以限Page 19 1238250 V. Description of the invention (15) Mean value of one pixel in the location interval, and A take the target color bar 1 3 Drug abuse test strips on both sides 1 0 One of the first pixel interval A and one of the corresponding images on the light-colored bottom surface Two pixel interval A & —Reference white pixel average. Next, in step 44, according to a color rendering reaction threshold value mapping table corresponding to the strip test strip, compare the color rendering response of the target color strip with the corresponding color rendering response threshold. In step 45, when the color rendering reaction of the target color bar is not less than the color rendering reaction threshold, it is determined that the specific component in the liquid to be tested corresponding to the target color bar is a positive reaction, indicating that the specific component is present in the test component. In liquid: and when the color reaction of the target color bar is smaller than the color reaction threshold, it is determined that the specific component in the test liquid corresponding to the target color bar is a negative reaction, which means that the specific component does not exist in the test liquid. in. The test results of each color bar on the strip test strip are directly displayed in the data table 25 of the user interface shown in the second figure. The method of the present invention is to detect a bar code of a corresponding strip test strip to obtain the type of the strip test strip, and obtain a corresponding color rendering reaction threshold value mapping table according to the type of the strip test strip. Each color bar of the strip test strip corresponds to a color reaction threshold in the mapping table. Then, by comparing the color reaction of each target color bar with a corresponding color development reaction threshold, the detection result of the target color bar is determined. The invention provides an automatic, fast and accurate detection method for detection results of a test strip inspection area. The above descriptions are only specific embodiments of the present invention, and are not intended to be limiting.

第20頁 1238250 五、發明說明(16) 定本發明之申請專利範圍;凡其它未脫離本發明所揭示之 精神下所完成之等效改變或修飾,均應包含在下述之申請 專利範圍内。Page 20 1238250 V. Description of the invention (16) The scope of patent application for the present invention is determined; all other equivalent changes or modifications made without departing from the spirit disclosed by the present invention shall be included in the scope of patent application described below.

第21頁 1238250 圖式簡單說明 五、【圖式簡单說明】 第一 A圖至第一 D圖係一種已知的濫用藥物檢驗試紙在 各種檢驗情況下所產生的各種顯色圖案示意圖; 第二圖係使用於本發明之一影像擷取裝置之一使用者 介面示意圖; 第三A圖至第三B圖係本發明掃描物件之頂視示意圖; 第四圖係根據本發明一具體實施例之步驟流程圖; 第五圖係本發明一條碼格式示意圖; 第六圖係本發明具有一顯色圖案之一條狀試片影像示 意圖;及 第七圖係根據從第六圖之條狀試片影像上選擇的一掃 描線所建立的一像素值相對像素位置的關係圖。 主要部份之代表符號: 10 濫用藥物檢驗試紙 11 控制色條 1 2〜1 6 標的色條 2 0 影像預覽視窗1238250 on page 21 Brief description of the drawings 5. [Schematic description of the drawings] Figures A through D are schematic diagrams of various colored patterns produced by a known drug abuse test strip under various test conditions; Figure 2 is a schematic diagram of a user interface used in an image capture device of the present invention; Figures 3A to 3B are schematic top views of a scanning object of the present invention; and Figure 4 is a specific embodiment of the present invention The flowchart of the steps; the fifth diagram is a schematic diagram of the barcode format of the present invention; the sixth diagram is a schematic diagram of the strip test strip of the present invention having a color rendering pattern; and the seventh diagram is based on the strip test strip from the sixth diagram The relationship between a pixel value and a pixel position established by a selected scanning line on the image. Main symbols: 10 Drug abuse test strips 11 Control color bars 1 2 ~ 1 6 Target color bars 2 0 Image preview window

第22頁 1238250 圖式簡單說明 2 3 2 4 2 5 2 6 3 0 3 1 3 2 3 3 3 4 3 5 6 影像分析貧料顯不框 樹狀圖 數據表 功能顯示框 掃描物件 條碼 條狀試片 掃描物件 條碼 3 7 條狀試片Page 22 1238250 Simple description of the diagram 2 3 2 4 2 5 2 6 3 0 3 1 3 2 3 3 3 3 4 3 5 6 Image analysis Scanned object barcode 3 7 strip test strips

第?3項No? 3 items

Claims (1)

1238250 六、申請專利範圍 1. 一種試片檢驗區檢測結果自動偵測方法i其包括: 提供一掃描物件,該掃描物件包括一條碼及複數片條狀試 片,該條碼係置放於該掃描物件上一預定位置及該等條狀 試片係依序排列於該掃描物件上未與該條碼重疊的一區域 ,每一該條狀試片具有包括一控制色條及複數條標的色條 之一顯色圖案,該控制色條及該等標的色條係依序排列於 該條狀試片一端至其另一端,及該控制色條與每一該標的 色條係分別相應該條狀試片上一檢驗區; 掃描該掃描物件,以讀取該條碼圖案及擷取該等條狀 試片之影像資料; 將該條碼圖案解碼,以測得該等條狀試片之個別類型 ,並根據每一該條狀試片之該個別類型,以得到複數個顯 色反應閥值相對該條狀試片上複數條該等標的色條位置的 一對映表; 根據該條狀試片之該影像資料,計算該條狀試片上一 該標的色條的一顯色反應;及 根據該條狀試片相應的該對映表’比較該標的色條之 該顯色反應與相應的一該顯色反應閥值,以決定該標的色 條的正或負反應。 2 .如申請專利範圍第1項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之條狀試片之該標的色條之該顯 色反應係根據以下公式(I )計算而得: R = {(T-C)/(A-C)} X 100% ( I),1238250 6. Scope of patent application 1. A method for automatically detecting the test result of a test strip inspection area i includes: providing a scanned object, the scanned object includes a bar code and a plurality of bar test strips, and the bar code is placed on the scan A predetermined position on the object and the strip test strips are sequentially arranged in an area on the scanned object that does not overlap with the bar code. Each strip test strip has a color bar including a control color bar and a plurality of color bars. A color rendering pattern, the control color bar and the target color bars are sequentially arranged from one end to the other end of the strip test strip, and the control color bar and each of the target color bars are corresponding to the strip test An inspection area on the chip; scan the scanned object to read the bar code pattern and capture the image data of the strip test strips; decode the bar code pattern to measure the individual types of the strip test strips, and according to Each individual type of the strip test strip to obtain a pair of mapping tables of the color rendering reaction thresholds relative to the positions of the plurality of the target color strips on the strip test strip; according to the image of the strip test strip Data, calculation A color development reaction of a target color bar on a strip test strip; and comparing the color development reaction of the target color bar with a corresponding color development reaction threshold value according to the corresponding table of the map of the strip test strip, To determine the positive or negative response of the target color bar. 2. The method for automatically detecting the test result of the test strip inspection area as described in item 1 of the scope of patent application, wherein the color rendering reaction of the target color bar of the strip test strip is calculated according to the following formula (I) : R = {(TC) / (AC)} X 100% (I), 第24頁 1238250 六、申請專利範圍 其中,τ係取該標的色條相應影像中一像素位置區間之一 像素平均值,c係取該條狀試片上該控制色條相應影像中 一像素位置區間之一像素平均值,及A取該標的色條兩旁 之該條狀試片底面相應影像之一第一像素區間及一第二像 素區間之一像素平均值。 3 .如申請專利範圍第1項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之條碼係為一一維條碼,該一維 條碼包括: 一第一組條碼圖案,係相應該等條狀試片之該等個別 類型,該第一組條碼圖案之每一條碼圖案係依序相應該掃 描物件上一該條狀試片之該個別類型; 複數群第二組條碼圖案,每一該第二組條碼圖案係依 序相應該掃描物件上一該條狀試片,及該第二組條碼圖案 之每一條碼圖案係依序相應該條狀試片之一該標的色條的 位置;及 一第三組條碼圖案,係相應該掃描物件之一代表碼。 4.如申請專利範圍第3項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之一維條碼之每一該條碼圖案係 具有一固定的碼長及係由複數條條線與複數條空白線組成 5 .如申請專利範圍第2項所述之試片檢驗區檢測結果Page 24 1238250 6. Scope of patent application Among them, τ is the average of one pixel position interval in the corresponding image of the target color bar, and c is the pixel position interval in the corresponding image of the control color bar on the strip test strip. A pixel average value, and A takes the pixel average value of a first pixel interval and a second pixel interval of the corresponding image on the bottom surface of the strip test strip on both sides of the target color bar. 3. The method for automatically detecting the test result of the test strip inspection area as described in item 1 of the scope of patent application, wherein the above-mentioned barcode is a one-dimensional barcode, and the one-dimensional barcode includes: a first set of barcode patterns, corresponding to the For each of the individual types of bar test strips, each bar code pattern of the first set of bar code patterns corresponds to the individual type of a bar test strip on the scanned object in sequence; a plurality of groups of second bar code patterns, each A second set of bar code patterns sequentially corresponds to a strip test strip on the scanned object, and each bar code pattern of the second set of bar code patterns sequentially corresponds to the target color bar of one of the bar test strips. Position; and a third set of bar code patterns corresponding to one of the representative codes of the scanned object. 4. The automatic detection method for the test result of the test strip inspection area as described in item 3 of the scope of the patent application, wherein each of the barcode patterns of the aforementioned one-dimensional barcode has a fixed code length and is composed of a plurality of lines and Multiple blank lines make up 5. Test result of test strip inspection area as described in item 2 of patent application scope 第25頁 1238250_ 六、申請專利範圍 自動偵測方法,其中上述之條狀試片之該標的色條之該顯 色反應係根據該條狀試片之紅像素影像資料計算而得。 6 .如申請專利範圍第2項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之條狀試片之該標的色條之該顯 色反應係根據該條狀試片之綠像素影像資料計算而得。 7. 如申請專利範圍第2項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之條狀試片之該標的色條之該顯 色反應係根據該條狀試片之藍像素影像資料計算而得。 8. 如申請專利範圍弟2項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之條狀試片之該標的色條之該顯 色反應係根據該條狀試片之紅、綠及藍像素影像資料之經 平均之影像資料計算而得。 9 .如申請專利範圍第1項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之條狀試片之該控制色條係相應 經該條狀試片檢驗的一受測液體產生一顯色反應,及每一 該標的色條係相應該受測液體中一特定成份產生顯色反應 1 0 .如申請專利範圍第9項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之每一顯色反應閥值係相應該條Page 25 1238250_ VI. Patent application automatic detection method, wherein the color response of the target color bar of the strip test strip is calculated based on the red pixel image data of the strip test strip. 6. The method for automatically detecting the test result of the test strip inspection area as described in item 2 of the scope of patent application, wherein the color rendering response of the target color bar of the strip test strip is based on the green pixels of the strip test strip Calculated from image data. 7. The method for automatically detecting the test result of the test strip inspection area as described in item 2 of the scope of patent application, wherein the color rendering response of the target color bar of the strip test strip is based on the blue pixels of the strip test strip. Calculated from image data. 8. The automatic detection method for the test result of the test strip inspection area described in item 2 of the patent application scope, wherein the color reaction of the target color bar of the strip test strip described above is based on the red, Green and blue pixel image data are calculated by averaging the image data. 9. The automatic detection method for the test result of the test strip inspection area described in item 1 of the scope of patent application, wherein the control color bar of the strip test strip is generated by a test liquid corresponding to the test of the strip test strip. A color reaction, and each of the target color bars is a color reaction 10 corresponding to a specific component in the liquid under test. The automatic detection method for the test result of the test strip inspection area described in item 9 of the patent application scope, Each of the above-mentioned color reaction thresholds corresponds to that 第26頁 1238250 六、申請專利範圍 狀試片上一該標的色條欲檢測之一該特定成份。、 1 1.如申請專利範圍第1 0項所述之試片檢驗區檢測結 果自動偵測方法,其中上述之標的色條的該顯色反應不小 於該顯色反應閥值時,決定該標的色條相應該受測液體中 之該特定成份為正反應,代表該特定成份存在於該受測液 體中;而當該標的色條的該顯色反應小於該顯色反應閥值 時〃決定該標的色條相應該受測液體中之該特定成份為負 反應,代表該特定成份不存在於該受測液體中。 1 2 .如申請專利範圍第1項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之條狀試片係包括一濫用藥物檢 驗試片。 1 3 .如申請專利範圍第9項所述之試片檢驗區檢測結果 自動偵測方法,其中上述之受測液體包括收集自一受測對 象的一生物性檢體。 1 4 .如申請專利範圍笫1 3項所述之試片檢驗區檢測結 果自動偵測方法,其中上述之生物性檢體係選自下列任一 者··血液、尿液、汗液及唾液。 1 5 . —種一維條碼圖案,係包括: 一第一組條碼圖案,係相應一組物件之個別類型,該Page 26 1238250 VI. Scope of patent application A color bar of the target on the test strip is to test one of the specific components. 1. 11. The automatic detection method for the test result of the test strip inspection area as described in Item 10 of the scope of patent application, wherein when the color rendering reaction of the above-mentioned target color bar is not less than the color rendering reaction threshold, the target color is determined. The color bar corresponds to the specific component in the test liquid as a positive reaction, indicating that the specific component exists in the test liquid; and when the color reaction of the target color bar is less than the color reaction threshold, it is determined that The marked color bar corresponds to a negative reaction of the specific component in the liquid under test, which indicates that the specific component does not exist in the liquid under test. 12. The method for automatically detecting the test result of the test strip inspection area as described in item 1 of the scope of patent application, wherein the strip test strip includes a test strip for drug abuse. 13. The automatic detection method for detecting results of a test strip inspection area as described in item 9 of the scope of patent application, wherein the liquid to be tested includes a biological specimen collected from a test object. 14. The automatic detection method for the test result of the test strip inspection area according to item 13 of the patent application scope, wherein the above-mentioned biological test system is selected from any of the following: blood, urine, sweat, and saliva. 1 5. — A one-dimensional bar code pattern, including: a first set of bar code patterns, which are the individual types of the corresponding set of objects, the 第27頁 1238250 六、申請專利範圍 第一組條碼圖案之每一條碼圖案係分別相應一該物件之該 個別類型; 複數群第二組條碼圖案,每一該第二組條碼圖案係分 別相應一該物件之一組設定值,該第二組條碼圖案之每一 條碼圖案係相應一該設定值,及該組設定值係根據該物件 之該個別類型而定;及 一第三組條碼圖案’係相應該組物件之一代表碼。 1 6 .如申請專利範圍第1 5項所述之一維條碼圖案,其 中上述之每一條碼圖案係具有一固定碼長及由複數條條線 及複數條空白線組成。Page 27 1238250 VI. Each bar code pattern of the first set of bar code patterns corresponding to the patent application corresponds to the individual type of the object; a plurality of bar code patterns of the second group, each of the second set of bar code patterns corresponds to one A set of set values of the object, each bar code pattern of the second set of bar code patterns is a corresponding set value, and the set of set values is based on the individual type of the object; and a third set of bar code patterns' It is a representative code of the corresponding group of objects. 16. The one-dimensional bar code pattern described in item 15 of the scope of patent application, wherein each of the above bar code patterns has a fixed code length and is composed of a plurality of lines and a plurality of blank lines. 第28頁Page 28
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI398633B (en) * 2008-10-14 2013-06-11 Actherm Inc Detecting strip reading apparatus and the detecting strip used therein

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI398633B (en) * 2008-10-14 2013-06-11 Actherm Inc Detecting strip reading apparatus and the detecting strip used therein

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