DE60003162D1 - Modifizierte trägerpartikel zur verwendung in trockenpulverinhalatoren - Google Patents
Modifizierte trägerpartikel zur verwendung in trockenpulverinhalatorenInfo
- Publication number
- DE60003162D1 DE60003162D1 DE60003162T DE60003162T DE60003162D1 DE 60003162 D1 DE60003162 D1 DE 60003162D1 DE 60003162 T DE60003162 T DE 60003162T DE 60003162 T DE60003162 T DE 60003162T DE 60003162 D1 DE60003162 D1 DE 60003162D1
- Authority
- DE
- Germany
- Prior art keywords
- dry powder
- support particles
- powder inhalers
- modified support
- aerodynamic diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI990455 | 1999-03-05 | ||
IT1999MI000455A IT1309592B1 (it) | 1999-03-05 | 1999-03-05 | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
PCT/EP2000/001773 WO2000053158A1 (en) | 1999-03-05 | 2000-03-02 | Modified carrier particles for use in dry powder inhalers |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60003162D1 true DE60003162D1 (de) | 2003-07-10 |
DE60003162T2 DE60003162T2 (de) | 2004-02-12 |
Family
ID=11382167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60003162T Expired - Lifetime DE60003162T2 (de) | 1999-03-05 | 2000-03-02 | Modifizierte trägerpartikel zur verwendung in trockenpulverinhalatoren |
Country Status (8)
Country | Link |
---|---|
US (3) | US6641844B1 (de) |
EP (2) | EP1312357A3 (de) |
AT (1) | ATE241961T1 (de) |
AU (1) | AU3426400A (de) |
DE (1) | DE60003162T2 (de) |
ES (1) | ES2199793T3 (de) |
IT (1) | IT1309592B1 (de) |
WO (1) | WO2000053158A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
PT1158958E (pt) * | 1999-03-05 | 2007-08-13 | Chiesi Farma Spa | ''composições farmacêuticas em pó, melhoradas, para inalação'' |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
ITMI991582A1 (it) * | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
GB0009469D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
CN100551358C (zh) | 2000-06-27 | 2009-10-21 | 维克多瑞有限公司 | 用于药物组合物的颗粒的制备方法 |
FI20002215A0 (fi) * | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit |
FI20002216A0 (fi) * | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit astman hoitoon |
DK1337240T4 (en) * | 2000-11-30 | 2015-01-05 | Vectura Ltd | A process for the preparation of particles for use in a pharmaceutical composition |
AU2002220857A1 (en) | 2000-11-30 | 2002-06-11 | Vectura Limited | Particles for use in a pharmaceutical composition |
WO2003024396A2 (en) | 2001-09-17 | 2003-03-27 | Glaxo Group Limited | Dry powder medicament formulations |
ITMI20012174A1 (it) * | 2001-10-18 | 2003-04-18 | Univ Parma | Polvere per somministrazione nasale di farmaci |
DE60318938T2 (de) | 2002-03-20 | 2009-01-22 | Mannkind Corp., Valencia | Inhalationsgerät |
GB0219511D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
EA007377B1 (ru) * | 2002-08-21 | 2006-10-27 | Нортон Хелткэа Лтд. | Композиции для ингаляции |
GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
GB0321607D0 (en) * | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
JO3102B1 (ar) * | 2004-03-17 | 2017-09-20 | Chiesi Framaceutici S P A | صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة |
ES2385934T3 (es) | 2004-08-20 | 2012-08-03 | Mannkind Corporation | Catálisis de la síntesis de dicetopiperazina. |
EP2314298B1 (de) | 2004-08-23 | 2015-05-27 | MannKind Corporation | Mikropartikel enthaltend Diketopiperazinsalze zur Arzneimitteldarreichung |
DE102004048389A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
DE102004048390A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pulverinhalativa auf Basis modifizierter Laktosemischungen als Hilfsstoff |
WO2006086270A1 (en) | 2005-02-10 | 2006-08-17 | Glaxo Group Limited | Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom |
KR20160022404A (ko) | 2005-09-14 | 2016-02-29 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
MX2008010721A (es) | 2006-02-22 | 2008-09-01 | Mannkind Corp | Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo. |
CA2647073A1 (en) * | 2006-04-03 | 2007-10-18 | Teva Pharmaceutical Industries Ltd. | Drug microparticles |
DE102006053375A1 (de) | 2006-11-10 | 2008-05-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mischung von Pulvern |
GB0714134D0 (en) * | 2007-07-19 | 2007-08-29 | Norton Healthcare Ltd | Dry-powder medicament |
EP3281663B8 (de) | 2008-06-13 | 2022-09-21 | MannKind Corporation | Atemluftbetriebener trockenpulverinhalator zur verabreichung von medikamenten |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
MX2010014240A (es) | 2008-06-20 | 2011-03-25 | Mankind Corp | Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion. |
TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
PL2400950T3 (pl) | 2009-02-26 | 2019-12-31 | Glaxo Group Limited | Preparaty farmaceutyczne zawierające 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzylo)oksy]etoksy}heksylo)amino]-1-hydroksyetylo}-2-(hydroksymetylo)fenol |
CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
CA2770714A1 (en) | 2009-08-27 | 2011-03-17 | Stc.Unm | Methods and systems for dosing and coating inhalation powders onto carrier particles |
EP2496295A1 (de) | 2009-11-03 | 2012-09-12 | MannKind Corporation | Vorrichtung und verfahren zur simulation von einatmungsanstrengungen |
GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
EP2552424B1 (de) | 2010-04-01 | 2018-05-09 | Chiesi Farmaceutici S.p.A. | Verfahren zur herstellung von trägerteilchen für trockenpulver zur inhalation |
BR112012033060A2 (pt) | 2010-06-21 | 2018-02-27 | Mannkind Corp | métodos de sistema de liberação de fármaco em pó seco |
KR101940832B1 (ko) | 2011-04-01 | 2019-01-21 | 맨카인드 코포레이션 | 의약 카트리지용 블리스터 패키지 |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
EP2776053A1 (de) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Verfahren und zusammensetzungen zur schmerzbehandlung |
BR112014017481A8 (pt) * | 2012-01-25 | 2021-06-15 | Chiesi Farm Spa | formulação em pó seco para uso em um inalador de pó seco, inalador de pó seco e uso de uma formulação |
WO2013114374A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy |
ES2814336T3 (es) | 2012-04-13 | 2021-03-26 | Glaxosmithkline Ip Dev Ltd | Partículas de agregado |
SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
EP2911690A1 (de) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalierbare influenza-impfstoffzusammensetzungen und verfahren |
EP3587404B1 (de) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Mikrokristalline diketopiperazinzusammensetzungen, verfahren zur herstellung und deren verwendung |
GB201305825D0 (en) | 2013-03-28 | 2013-05-15 | Vectura Ltd | New use |
BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
WO2016057693A1 (en) | 2014-10-10 | 2016-04-14 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
KR20220002600A (ko) | 2019-04-29 | 2022-01-06 | 인스메드 인코포레이티드 | 트레프로스티닐 전구약물의 건조 분말 조성물 및 이의 사용 방법 |
WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2107715B (en) * | 1981-10-19 | 1985-11-13 | Glaxo Group Ltd | Micronised beclomethasone dipropionate monohydrate and powder inhalation compositions containing it |
GB9322014D0 (en) * | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
DE4425255A1 (de) * | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
SK284889B6 (sk) * | 1998-11-13 | 2006-02-02 | Jago Research Ag | Použitie stearátu horečnatého v suchých práškových formuláciách na inhaláciu |
PT1158958E (pt) * | 1999-03-05 | 2007-08-13 | Chiesi Farma Spa | ''composições farmacêuticas em pó, melhoradas, para inalação'' |
IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
GB0009469D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
-
1999
- 1999-03-05 IT IT1999MI000455A patent/IT1309592B1/it active
-
2000
- 2000-03-02 EP EP03003987A patent/EP1312357A3/de not_active Withdrawn
- 2000-03-02 ES ES00912534T patent/ES2199793T3/es not_active Expired - Lifetime
- 2000-03-02 AT AT00912534T patent/ATE241961T1/de active
- 2000-03-02 WO PCT/EP2000/001773 patent/WO2000053158A1/en active IP Right Grant
- 2000-03-02 EP EP00912534A patent/EP1158960B1/de not_active Expired - Lifetime
- 2000-03-02 DE DE60003162T patent/DE60003162T2/de not_active Expired - Lifetime
- 2000-03-02 US US09/926,105 patent/US6641844B1/en not_active Expired - Lifetime
- 2000-03-02 AU AU34264/00A patent/AU3426400A/en not_active Abandoned
-
2003
- 2003-04-28 US US10/423,912 patent/US20040009127A1/en not_active Abandoned
- 2003-07-29 US US10/628,453 patent/US7132115B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20040009127A1 (en) | 2004-01-15 |
EP1312357A2 (de) | 2003-05-21 |
IT1309592B1 (it) | 2002-01-24 |
ES2199793T3 (es) | 2004-03-01 |
US6641844B1 (en) | 2003-11-04 |
WO2000053158A1 (en) | 2000-09-14 |
EP1312357A3 (de) | 2004-01-07 |
ITMI990455A1 (it) | 2000-09-05 |
AU3426400A (en) | 2000-09-28 |
DE60003162T2 (de) | 2004-02-12 |
EP1158960A1 (de) | 2001-12-05 |
EP1158960B1 (de) | 2003-06-04 |
US7132115B2 (en) | 2006-11-07 |
US20040096516A1 (en) | 2004-05-20 |
ATE241961T1 (de) | 2003-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |