DE60000590D1 - Nitroimidazolderivate als Empfindlichkeitsverstärker für Chemotherapie und Radiotherapie - Google Patents

Nitroimidazolderivate als Empfindlichkeitsverstärker für Chemotherapie und Radiotherapie

Info

Publication number
DE60000590D1
DE60000590D1 DE60000590T DE60000590T DE60000590D1 DE 60000590 D1 DE60000590 D1 DE 60000590D1 DE 60000590 T DE60000590 T DE 60000590T DE 60000590 T DE60000590 T DE 60000590T DE 60000590 D1 DE60000590 D1 DE 60000590D1
Authority
DE
Germany
Prior art keywords
radiotherapy
chemotherapy
sensitivity enhancers
nitroimidazole derivatives
enhancers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60000590T
Other languages
English (en)
Other versions
DE60000590T2 (de
Inventor
Ruihong Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandong Luye Pharmaceutical Co Ltd
Original Assignee
S & H Pharm Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S & H Pharm Technology Co Ltd filed Critical S & H Pharm Technology Co Ltd
Publication of DE60000590D1 publication Critical patent/DE60000590D1/de
Application granted granted Critical
Publication of DE60000590T2 publication Critical patent/DE60000590T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60000590T 1999-04-08 2000-04-05 Nitroimidazolderivate als Empfindlichkeitsverstärker für Chemotherapie und Radiotherapie Expired - Lifetime DE60000590T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN99116128A CN1270062A (zh) 1999-04-08 1999-04-08 一种放射、化学治疗增效剂—甘氨双唑金属盐及其制法和用途

Publications (2)

Publication Number Publication Date
DE60000590D1 true DE60000590D1 (de) 2002-11-21
DE60000590T2 DE60000590T2 (de) 2003-11-27

Family

ID=5278973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60000590T Expired - Lifetime DE60000590T2 (de) 1999-04-08 2000-04-05 Nitroimidazolderivate als Empfindlichkeitsverstärker für Chemotherapie und Radiotherapie

Country Status (9)

Country Link
US (1) US6271250B1 (de)
EP (1) EP1043316B1 (de)
JP (1) JP4598227B2 (de)
CN (1) CN1270062A (de)
AT (1) ATE226197T1 (de)
DE (1) DE60000590T2 (de)
DK (1) DK1043316T3 (de)
ES (1) ES2184678T3 (de)
PT (1) PT1043316E (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100364529C (zh) * 2001-08-14 2008-01-30 中国人民解放军军事医学科学院放射与辐射医学研究所 含肿瘤放疗增敏剂的透皮吸收组合物
CN100341858C (zh) * 2003-09-29 2007-10-10 山东绿叶制药有限公司 甘氨双唑钠的合成工艺
WO2005041853A2 (en) * 2003-10-28 2005-05-12 Ems S.A. Antibacterial and/or antiprotozoal nitroimidazole derivative compounds with urease inhibitor activity, process for preparing these compounds and use in pharmaceutical compositions and medicines.
CN100560572C (zh) * 2004-12-29 2009-11-18 杨喜鸿 甘氨双唑酸的碱性氨基酸盐及其制备和用途
CN102190626A (zh) * 2010-03-15 2011-09-21 南京莱因医药科技有限公司 一种甘氨双唑钠的合成方法
CN104356070A (zh) * 2014-12-05 2015-02-18 江苏艾凡生物医药有限公司 一种甘氨双唑钠的合成方法
CN105541727B (zh) * 2016-01-15 2018-01-30 徐州医学院 一种具放疗增敏功能的脂质分子、其制备方法及其在肿瘤放射治疗药物中的应用
CN108685859A (zh) * 2017-04-12 2018-10-23 苏州特瑞药业有限公司 一种含甘氨双唑钠制剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614890B1 (fr) * 1987-05-04 1989-08-11 Centre Nat Rech Scient Compose resultant du couplage d'une molecule a structure chimiosensibilisante et d'une molecule a structure cytotoxique, procede de preparation, application a titre de medicament et compositions pharmaceutiques le contenant
DE3854645T2 (de) * 1987-12-04 1996-05-02 British Tech Group Nitro substituierte aromatische und heteroaromatische Verbindungen für Krebsbehandlungen.

Also Published As

Publication number Publication date
ES2184678T3 (es) 2003-04-16
EP1043316A3 (de) 2000-11-02
CN1270062A (zh) 2000-10-18
EP1043316A2 (de) 2000-10-11
US6271250B1 (en) 2001-08-07
PT1043316E (pt) 2003-03-31
JP4598227B2 (ja) 2010-12-15
EP1043316B1 (de) 2002-10-16
JP2000302762A (ja) 2000-10-31
ATE226197T1 (de) 2002-11-15
DE60000590T2 (de) 2003-11-27
DK1043316T3 (da) 2003-02-17

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Legal Events

Date Code Title Description
8332 No legal effect for de
8327 Change in the person/name/address of the patent owner

Owner name: GUANGZHOU LIFETECH PHARMACEUTICALS LTD., CONGHUA,

8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SHANDONG LUYE PHARMACEUTICAL CO., LTD., YANTAI, CN