DE59508973D1 - Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols - Google Patents

Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols

Info

Publication number
DE59508973D1
DE59508973D1 DE59508973T DE59508973T DE59508973D1 DE 59508973 D1 DE59508973 D1 DE 59508973D1 DE 59508973 T DE59508973 T DE 59508973T DE 59508973 T DE59508973 T DE 59508973T DE 59508973 D1 DE59508973 D1 DE 59508973D1
Authority
DE
Germany
Prior art keywords
formula
reacting
lower alkyl
alpha
r1oconhch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59508973T
Other languages
German (de)
English (en)
Inventor
Hans Hilpert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE59508973D1 publication Critical patent/DE59508973D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE59508973T 1994-09-23 1995-09-11 Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols Expired - Lifetime DE59508973D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH290494 1994-09-23
CH373694 1994-12-09

Publications (1)

Publication Number Publication Date
DE59508973D1 true DE59508973D1 (de) 2001-02-22

Family

ID=25691689

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59508973T Expired - Lifetime DE59508973D1 (de) 1994-09-23 1995-09-11 Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols

Country Status (9)

Country Link
US (5) US5591885A (OSRAM)
EP (1) EP0710651B1 (OSRAM)
JP (1) JP3819955B2 (OSRAM)
KR (1) KR100418237B1 (OSRAM)
CN (3) CN1116284C (OSRAM)
AT (1) ATE198740T1 (OSRAM)
DE (1) DE59508973D1 (OSRAM)
DK (1) DK0710651T3 (OSRAM)
ES (1) ES2154310T3 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
KR100411856B1 (ko) * 1995-02-03 2004-05-20 카네카 코포레이션 α-할로케톤,α-할로히드린및에폭사이드의제조법
WO1997028105A1 (fr) * 1996-01-29 1997-08-07 Kaneka Corporation Procede de reduction de composes de carbonyle
DK0847994T3 (da) 1996-12-11 2003-07-28 Hoffmann La Roche Fremgangsmåde til fremstilling af blandede anhydrider
JP4482783B2 (ja) * 1999-01-28 2010-06-16 味の素株式会社 α−アミノケトン類の製造方法
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
JP4143787B2 (ja) * 1999-07-28 2008-09-03 味の素株式会社 α−アミノハロメチルケトン誘導体の製造方法
DE10143742A1 (de) 2001-09-06 2003-03-27 Consortium Elektrochem Ind Verfahren zur Herstellung von alpha-Halogenketonen
US7038553B2 (en) * 2002-10-03 2006-05-02 International Business Machines Corporation Scalable computer system having surface-mounted capacitive couplers for intercommunication
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
BRPI0919257B8 (pt) * 2008-09-24 2021-05-25 Zach System processo de preparação de nebivolol
CN102127061B (zh) * 2010-01-15 2016-02-17 浙江华海药业股份有限公司 一种制备6-氟-3，4-二氢-2h-1-苯并吡喃-2-环氧乙烷的改进方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
JP2551901B2 (ja) * 1991-07-26 1996-11-06 エフ エム シー コーポレーション 接触アルキル化方法
JPH06184069A (ja) * 1991-11-19 1994-07-05 Lonza Ag α−ヒドロキシ−β−アミノカルボン酸の製造方法
US5380849A (en) * 1992-11-09 1995-01-10 Merck & Co., Inc. Process for optically pure decahydroisoqiunolines
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
DE59401846D1 (de) * 1993-07-15 1997-04-03 Hoffmann La Roche Verfahren zur Herstellung eines N-tert.Butylisochinolin-3-carboxamid Derivates und Zwischenprodukte in diesem Verfahren
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols

Also Published As

Publication number Publication date
CN1127251A (zh) 1996-07-24
CN1133620C (zh) 2004-01-07
CN1275563A (zh) 2000-12-06
CN1116284C (zh) 2003-07-30
JPH0899959A (ja) 1996-04-16
US5684176A (en) 1997-11-04
US5591885A (en) 1997-01-07
KR100418237B1 (ko) 2004-07-23
US5965733A (en) 1999-10-12
EP0710651B1 (de) 2001-01-17
US5977388A (en) 1999-11-02
JP3819955B2 (ja) 2006-09-13
KR960010629A (ko) 1996-04-20
DK0710651T3 (da) 2001-05-14
CN1111156C (zh) 2003-06-11
EP0710651A1 (de) 1996-05-08
CN1275562A (zh) 2000-12-06
ATE198740T1 (de) 2001-02-15
ES2154310T3 (es) 2001-04-01
US5847144A (en) 1998-12-08

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