DE4120109A1 - 3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln - Google Patents

3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln

Info

Publication number
DE4120109A1
DE4120109A1 DE4120109A DE4120109A DE4120109A1 DE 4120109 A1 DE4120109 A1 DE 4120109A1 DE 4120109 A DE4120109 A DE 4120109A DE 4120109 A DE4120109 A DE 4120109A DE 4120109 A1 DE4120109 A1 DE 4120109A1
Authority
DE
Germany
Prior art keywords
carboline
methoxymethyl
benzyloxy
alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4120109A
Other languages
German (de)
English (en)
Inventor
Andreas Dr Huth
Dieter Dr Seidelmann
Ralph Dr Schmiechen
Herbert Dr Schneider
Lechoslaw Dr Turski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE4120109A priority Critical patent/DE4120109A1/de
Priority to PCT/DE1992/000497 priority patent/WO1992022549A1/fr
Priority to JP5500741A priority patent/JPH06501956A/ja
Priority to EP92912055A priority patent/EP0543968A1/fr
Priority to CA002089569A priority patent/CA2089569A1/fr
Priority to PT100593A priority patent/PT100593A/pt
Publication of DE4120109A1 publication Critical patent/DE4120109A1/de
Priority to US08/329,051 priority patent/US5543519A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE4120109A 1991-06-15 1991-06-15 3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln Withdrawn DE4120109A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE4120109A DE4120109A1 (de) 1991-06-15 1991-06-15 3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln
PCT/DE1992/000497 WO1992022549A1 (fr) 1991-06-15 1992-06-12 3-ARYL- OU 3-HETARYL-β-CARBOLINES, LEUR FABRICATION ET LEUR UTILISATION DANS DES MEDICAMENTS
JP5500741A JPH06501956A (ja) 1991-06-15 1992-06-12 ３―アリール―または３―ヘテロアリール―β―カルボリン、その製造および薬剤としての使用
EP92912055A EP0543968A1 (fr) 1991-06-15 1992-06-12 3-ARYL- OU 3-HETARYL-$g(b)-CARBOLINES, LEUR FABRICATION ET LEUR UTILISATION DANS DES MEDICAMENTS
CA002089569A CA2089569A1 (fr) 1991-06-15 1992-06-12 3-aryl- ou 3-hetaryl-.beta.-carbolines; preparation et utilisation dans des agents pharmaceutiques
PT100593A PT100593A (pt) 1991-06-15 1992-06-15 3-aril-beta-carbolinas ou 3-heteroaril-beta-carbolinas, processos para a sua preparacao e composicoes farmaceuticas que as contem
US08/329,051 US5543519A (en) 1991-06-15 1994-10-25 3-aryl or 3-hetaryl-β-carbolines, their production and use in pharmaceutical agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4120109A DE4120109A1 (de) 1991-06-15 1991-06-15 3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
DE4120109A1 true DE4120109A1 (de) 1992-12-17

Family

ID=6434220

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4120109A Withdrawn DE4120109A1 (de) 1991-06-15 1991-06-15 3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln

Country Status (6)

Country Link
EP (1) EP0543968A1 (fr)
JP (1) JPH06501956A (fr)
CA (1) CA2089569A1 (fr)
DE (1) DE4120109A1 (fr)
PT (1) PT100593A (fr)
WO (1) WO1992022549A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1134221A1 (fr) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Bêta-carbolines substituées comme inhibiteurs de lkB kinase

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4330175A1 (de) * 1993-08-31 1995-03-02 Schering Ag Alkoxy-substituierte beta-Carboline

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240511A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinderivaten
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
DK240084D0 (da) * 1984-05-15 1984-05-15 Ferrosan As New beta-carboline-3-oxadiazolyl derivatives
DE3540654A1 (de) * 1985-11-13 1987-05-14 Schering Ag Phenoxy-substituierte ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3608089A1 (de) * 1986-03-08 1987-09-10 Schering Ag Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
AU619203B2 (en) * 1987-08-28 1992-01-23 Schering Aktiengesellschaft Isoxazole-beta-carboline derivatives
DE3903753A1 (de) * 1989-02-06 1990-08-23 Schering Ag Verfahren zur herstellung waessriger mischmicelloesungen
DE3943225A1 (de) * 1989-12-23 1991-06-27 Schering Ag Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1134221A1 (fr) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Bêta-carbolines substituées comme inhibiteurs de lkB kinase

Also Published As

Publication number Publication date
PT100593A (pt) 1993-08-31
WO1992022549A1 (fr) 1992-12-23
CA2089569A1 (fr) 1992-12-16
JPH06501956A (ja) 1994-03-03
EP0543968A1 (fr) 1993-06-02

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: SCHERING AG, 13353 BERLIN, DE

8130 Withdrawal