DE4037174A1 - Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten - Google Patents

Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten

Info

Publication number
DE4037174A1
DE4037174A1 DE4037174A DE4037174A DE4037174A1 DE 4037174 A1 DE4037174 A1 DE 4037174A1 DE 4037174 A DE4037174 A DE 4037174A DE 4037174 A DE4037174 A DE 4037174A DE 4037174 A1 DE4037174 A1 DE 4037174A1
Authority
DE
Germany
Prior art keywords
chain
straight
radical
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4037174A
Other languages
German (de)
English (en)
Inventor
Hans Alois Dr Med Dr Re Dresel
Reinhard Dr Rer Nat Heck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE4037174A priority Critical patent/DE4037174A1/de
Priority to TW080108804A priority patent/TW264466B/zh
Priority to NZ240630A priority patent/NZ240630A/en
Priority to PCT/EP1991/002186 priority patent/WO1992009571A1/de
Priority to JP4500024A priority patent/JPH06502632A/ja
Priority to FI932323A priority patent/FI932323L/fi
Priority to DE59104443T priority patent/DE59104443D1/de
Priority to CA002096847A priority patent/CA2096847A1/en
Priority to MX9102127A priority patent/MX9102127A/es
Priority to HU9301498A priority patent/HUT68277A/hu
Priority to EP91920295A priority patent/EP0558569B1/de
Priority to AT91920295T priority patent/ATE117674T1/de
Priority to AU89057/91A priority patent/AU659421B2/en
Priority to PT99572A priority patent/PT99572A/pt
Priority to IL100120A priority patent/IL100120A0/xx
Priority to IE404491A priority patent/IE914044A1/en
Priority to ZA919206A priority patent/ZA919206B/xx
Publication of DE4037174A1 publication Critical patent/DE4037174A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE4037174A 1990-11-22 1990-11-22 Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten Withdrawn DE4037174A1 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE4037174A DE4037174A1 (de) 1990-11-22 1990-11-22 Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
TW080108804A TW264466B (OSRAM) 1990-11-22 1991-11-07
NZ240630A NZ240630A (en) 1990-11-22 1991-11-18 Sulphonamides and pharmaceutical compositions thereof
PCT/EP1991/002186 WO1992009571A1 (de) 1990-11-22 1991-11-19 Sulfonamide enthaltende arzneimittel, neue sulfonamide und verfahren zu ihrer herstellung
JP4500024A JPH06502632A (ja) 1990-11-22 1991-11-19 スルホンアミドを含む医薬組成物、新規なスルホンアミド類およびその製造方法
FI932323A FI932323L (fi) 1990-11-22 1991-11-19 Laekemedel innehaollande sulfonamider, nya sulfonamider och foerfaranden foer deras framstaellning
DE59104443T DE59104443D1 (de) 1990-11-22 1991-11-19 Sulfonamide enthaltende arzneimittel, neue sulfonamide und verfahren zu ihrer herstellung.
CA002096847A CA2096847A1 (en) 1990-11-22 1991-11-19 Pharmaceutical preparations containing sulfonamides novel sulfonamides and processes for their production
MX9102127A MX9102127A (es) 1990-11-22 1991-11-19 Nuevas sulfonamidas,proceso para su produccion y composiciones farmaceuticas que las contienen
HU9301498A HUT68277A (en) 1990-11-22 1991-11-19 Medicaments containing sulphonamides, novel sulphonamides and process for producing them
EP91920295A EP0558569B1 (de) 1990-11-22 1991-11-19 Sulfonamide enthaltende arzneimittel, neue sulfonamide und verfahren zu ihrer herstellung
AT91920295T ATE117674T1 (de) 1990-11-22 1991-11-19 Sulfonamide enthaltende arzneimittel, neue sulfonamide und verfahren zu ihrer herstellung.
AU89057/91A AU659421B2 (en) 1990-11-22 1991-11-19 Medicaments containing sulphonamides, novel sulphonamides and proces for producing them
PT99572A PT99572A (pt) 1990-11-22 1991-11-21 Processo para a preparacao de novas sulfonamidas e de composicoes farmaceuticas que as contem
IL100120A IL100120A0 (en) 1990-11-22 1991-11-21 Pharmaceutical compositions containing sulfonamides,certain sulfonamides and process for their production
IE404491A IE914044A1 (en) 1990-11-22 1991-11-21 Pharmaceutical compositions containing sulfonamides, novel¹sulfonamides and process for their production
ZA919206A ZA919206B (en) 1990-11-22 1991-11-21 Pharmaceutical compositions containing sulfonamides,novel sulfonamides and process for their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4037174A DE4037174A1 (de) 1990-11-22 1990-11-22 Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten

Publications (1)

Publication Number Publication Date
DE4037174A1 true DE4037174A1 (de) 1992-05-27

Family

ID=6418735

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4037174A Withdrawn DE4037174A1 (de) 1990-11-22 1990-11-22 Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE59104443T Expired - Fee Related DE59104443D1 (de) 1990-11-22 1991-11-19 Sulfonamide enthaltende arzneimittel, neue sulfonamide und verfahren zu ihrer herstellung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59104443T Expired - Fee Related DE59104443D1 (de) 1990-11-22 1991-11-19 Sulfonamide enthaltende arzneimittel, neue sulfonamide und verfahren zu ihrer herstellung.

Country Status (16)

Country Link
EP (1) EP0558569B1 (OSRAM)
JP (1) JPH06502632A (OSRAM)
AT (1) ATE117674T1 (OSRAM)
AU (1) AU659421B2 (OSRAM)
CA (1) CA2096847A1 (OSRAM)
DE (2) DE4037174A1 (OSRAM)
FI (1) FI932323L (OSRAM)
HU (1) HUT68277A (OSRAM)
IE (1) IE914044A1 (OSRAM)
IL (1) IL100120A0 (OSRAM)
MX (1) MX9102127A (OSRAM)
NZ (1) NZ240630A (OSRAM)
PT (1) PT99572A (OSRAM)
TW (1) TW264466B (OSRAM)
WO (1) WO1992009571A1 (OSRAM)
ZA (1) ZA919206B (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491170A (en) * 1994-12-19 1996-02-13 Warner-Lambert Company β-carboxy sulfonamide ACAT inhibitors
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3737316A (en) * 1971-08-31 1973-06-05 Eastman Kodak Co Two-equivalent sulfonamido couplers
US3801321A (en) * 1972-07-18 1974-04-02 Eastman Kodak Co Photothermographic element,composition and process
US4013621A (en) * 1975-04-29 1977-03-22 Ciba-Geigy Corporation Substituted sulfonamide derivatives of hindered phenols and stabilized compositions
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
IL83230A (en) * 1986-08-06 1992-06-21 Tanabe Seiyaku Co Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them
DE68909958D1 (de) * 1988-01-19 1993-11-25 Tanabe Seiyaku Co Phenoxyessigsäure-Derivate, ihre Herstellung, pharmazeutische Zusammensetzungen, die sie enthalten, und deren Verwendung.

Also Published As

Publication number Publication date
TW264466B (OSRAM) 1995-12-01
CA2096847A1 (en) 1992-05-23
AU659421B2 (en) 1995-05-18
NZ240630A (en) 1994-12-22
EP0558569B1 (de) 1995-01-25
PT99572A (pt) 1992-10-30
EP0558569A1 (de) 1993-09-08
WO1992009571A1 (de) 1992-06-11
IL100120A0 (en) 1992-08-18
ATE117674T1 (de) 1995-02-15
HUT68277A (en) 1995-06-28
IE914044A1 (en) 1992-06-03
JPH06502632A (ja) 1994-03-24
AU8905791A (en) 1992-06-25
ZA919206B (en) 1992-08-26
FI932323A0 (fi) 1993-05-21
FI932323A7 (fi) 1993-05-21
DE59104443D1 (de) 1995-03-09
FI932323L (fi) 1993-05-21
MX9102127A (es) 1992-07-08
HU9301498D0 (en) 1993-09-28

Similar Documents

Publication Publication Date Title
EP0600949B1 (de) Neue 3,5-di-tert.butyl-4-hydroxyphenyl-derivate, verfahren zu ihrer herstellung und arzneimittel
EP1194403B1 (de) Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen
DE69417885T2 (de) N-acylsulfaminsäureester (oder thioester), n-acylsulfonamide, und n-sulfonylcarbamidsäureester (oder thioester) als hypercholesterolemische mittel
EP0404039B1 (de) Arzneimittel, enthaltend Di-tert.-Butylhydroxyphenyl-Derivate sowie neue Derivate
DE10121003A1 (de) Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE69629390T2 (de) Indandimerverbindungen mit relaxierender wirkung auf die glatten muskeln und/oder mit mastzellen stabilisiernder und/oder entzuendungshemmender wirkung
WO2002024637A1 (de) Substituierte zimtsäureguanidide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE3525284A1 (de) Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten
EP0384279B1 (de) Benzolsulfonamide und Verfahren zu ihrer Herstellung
EP0111746B1 (de) Neue Sulfonsäureester von Hydroxycumarinen, ihre Herstellung und sie enthaltende Arzneimittel
EP1286957B1 (de) Diphenylmethanderivate
DE69120287T2 (de) Aminosulfonylharnstoff-acat-inhibitoren
DE3411993A1 (de) Substituierte benzopyrane, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimittel
EP1812412B1 (de) Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
EP0913396B1 (de) Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
EP0906911A1 (de) Sulfonamid-substituierte Chromane (K+Kanal-Blocker), Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE4037174A1 (de) Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
EP0564499B1 (de) Neue amine, verfahren zu ihrer herstellung, sowie diese verbindungen enthaltende arzneimittel
EP1658266B1 (de) Pentafluorosulfanylphenyl-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
EP0588799B1 (de) Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
EP0371342B1 (de) 2-Halogensubstituierte N-Indolylethyl-sulfonsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE3613623A1 (de) N-dihydroindolylethyl-sulfonamide
EP1791813B1 (de) Pentafluorsulfanylphenyl-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
DE60216967T2 (de) Substituierte cyclohexanderivate
CH502318A (de) Verfahren zur Herstellung von Benzolsulfonylharnstoffen

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee