DE3935132A1 - Antitumormittel, mittel zum unterdruecken von tumorzellmetastasen und verfahren zum behandeln von krebs und zum kontrollieren von tumorzellmetastasen - Google Patents
Antitumormittel, mittel zum unterdruecken von tumorzellmetastasen und verfahren zum behandeln von krebs und zum kontrollieren von tumorzellmetastasenInfo
- Publication number
- DE3935132A1 DE3935132A1 DE3935132A DE3935132A DE3935132A1 DE 3935132 A1 DE3935132 A1 DE 3935132A1 DE 3935132 A DE3935132 A DE 3935132A DE 3935132 A DE3935132 A DE 3935132A DE 3935132 A1 DE3935132 A1 DE 3935132A1
- Authority
- DE
- Germany
- Prior art keywords
- cancer
- metastases
- tumor
- treating cancer
- ribonuclease inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 63
- 210000004881 tumor cell Anatomy 0.000 title claims description 35
- 206010027476 Metastases Diseases 0.000 title claims description 23
- 201000011510 cancer Diseases 0.000 title claims description 20
- 238000000034 method Methods 0.000 title claims description 17
- 239000003161 ribonuclease inhibitor Substances 0.000 claims description 65
- 101710141795 Ribonuclease inhibitor Proteins 0.000 claims description 45
- 229940122208 Ribonuclease inhibitor Drugs 0.000 claims description 45
- 102100037968 Ribonuclease inhibitor Human genes 0.000 claims description 45
- 239000002246 antineoplastic agent Substances 0.000 claims description 17
- 210000004027 cell Anatomy 0.000 claims description 17
- 206010006187 Breast cancer Diseases 0.000 claims description 15
- 208000026310 Breast neoplasm Diseases 0.000 claims description 15
- 210000004072 lung Anatomy 0.000 claims description 12
- 208000029742 colonic neoplasm Diseases 0.000 claims description 11
- 208000020816 lung neoplasm Diseases 0.000 claims description 8
- 210000001165 lymph node Anatomy 0.000 claims description 8
- 239000002257 antimetastatic agent Substances 0.000 claims description 7
- 201000001441 melanoma Diseases 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 201000007270 liver cancer Diseases 0.000 claims description 4
- 208000014018 liver neoplasm Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000003747 lymphoid leukemia Diseases 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 34
- 230000000694 effects Effects 0.000 description 26
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- 238000011282 treatment Methods 0.000 description 17
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- 239000000126 substance Substances 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 10
- 230000003327 cancerostatic effect Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 8
- 229960002949 fluorouracil Drugs 0.000 description 8
- 238000007912 intraperitoneal administration Methods 0.000 description 8
- VFEDRRNHLBGPNN-UHFFFAOYSA-N nimustine Chemical compound CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 VFEDRRNHLBGPNN-UHFFFAOYSA-N 0.000 description 8
- ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 description 7
- 229960003290 cortisone acetate Drugs 0.000 description 7
- 229960001420 nimustine Drugs 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 7
- 238000002054 transplantation Methods 0.000 description 7
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 6
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 6
- 102100035695 Gamma-aminobutyric acid receptor-associated protein Human genes 0.000 description 5
- 101001001372 Homo sapiens Gamma-aminobutyric acid receptor-associated protein Proteins 0.000 description 5
- 238000002512 chemotherapy Methods 0.000 description 5
- 229960004316 cisplatin Drugs 0.000 description 5
- 206010027458 Metastases to lung Diseases 0.000 description 4
- 241000699660 Mus musculus Species 0.000 description 4
- 102000006382 Ribonucleases Human genes 0.000 description 4
- 108010083644 Ribonucleases Proteins 0.000 description 4
- 206010039491 Sarcoma Diseases 0.000 description 4
- 230000002001 anti-metastasis Effects 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- 208000037841 lung tumor Diseases 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 238000011580 nude mouse model Methods 0.000 description 4
- 210000002826 placenta Anatomy 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 208000001382 Experimental Melanoma Diseases 0.000 description 3
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 3
- 206010029113 Neovascularisation Diseases 0.000 description 3
- 229940009456 adriamycin Drugs 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000002648 combination therapy Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000002601 intratumoral effect Effects 0.000 description 3
- 231100000053 low toxicity Toxicity 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 102100022987 Angiogenin Human genes 0.000 description 2
- 108010024636 Glutathione Proteins 0.000 description 2
- 206010053759 Growth retardation Diseases 0.000 description 2
- 229920001491 Lentinan Polymers 0.000 description 2
- 208000007433 Lymphatic Metastasis Diseases 0.000 description 2
- 206010027459 Metastases to lymph nodes Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000001042 affinity chromatography Methods 0.000 description 2
- 108010072788 angiogenin Proteins 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 229940115286 lentinan Drugs 0.000 description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
- 229960004857 mitomycin Drugs 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 229930192392 Mitomycin Natural products 0.000 description 1
- 101100060131 Mus musculus Cdk5rap2 gene Proteins 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940034982 antineoplastic agent Drugs 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000035777 life prolongation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000005476 size effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
- Y10S530/851—Placenta; amniotic fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1126387A JP2842888B2 (ja) | 1989-05-19 | 1989-05-19 | リボヌクレアーゼインヒビターを有効成分とする癌細胞転移抑制剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3935132A1 true DE3935132A1 (de) | 1990-11-22 |
Family
ID=14933885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3935132A Withdrawn DE3935132A1 (de) | 1989-05-19 | 1989-10-18 | Antitumormittel, mittel zum unterdruecken von tumorzellmetastasen und verfahren zum behandeln von krebs und zum kontrollieren von tumorzellmetastasen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5175005A (https=) |
| JP (1) | JP2842888B2 (https=) |
| DE (1) | DE3935132A1 (https=) |
| FR (1) | FR2647017A1 (https=) |
| GB (1) | GB2231793B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5529775A (en) * | 1988-04-06 | 1996-06-25 | Alfacell Corporation | Compositions comprising ONCONASE(™) and cisplatin, melphalan, or doxorubicin HCl |
| EP0651746B1 (en) * | 1992-07-24 | 2002-03-27 | The Regents of the University of California | Drugs that enhance synaptic responses mediated by ampa receptors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0291686A2 (en) * | 1987-04-14 | 1988-11-23 | The President And Fellows Of Harvard College | Inhibitors of angiogenin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4552888A (en) * | 1982-01-15 | 1985-11-12 | Eli Lilly And Company | Ascorbic acid ethers in angiogene |
| US4599331A (en) * | 1984-12-24 | 1986-07-08 | Syntex (U.S.A.) Inc. | Etianic acids as antiangiogenics |
| US4966964A (en) * | 1987-04-14 | 1990-10-30 | President And Fellows Of Harvard College | Inhibitors of angiogenin |
| US5019556A (en) * | 1987-04-14 | 1991-05-28 | President And Fellows Of Harvard College | Inhibitors of angiogenin |
-
1989
- 1989-05-19 JP JP1126387A patent/JP2842888B2/ja not_active Expired - Fee Related
- 1989-10-02 US US07/416,066 patent/US5175005A/en not_active Expired - Fee Related
- 1989-10-18 DE DE3935132A patent/DE3935132A1/de not_active Withdrawn
- 1989-10-30 FR FR8914226A patent/FR2647017A1/fr active Granted
- 1989-10-31 GB GB8924450A patent/GB2231793B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0291686A2 (en) * | 1987-04-14 | 1988-11-23 | The President And Fellows Of Harvard College | Inhibitors of angiogenin |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2647017A1 (fr) | 1990-11-23 |
| GB2231793A (en) | 1990-11-28 |
| JPH02306922A (ja) | 1990-12-20 |
| GB8924450D0 (en) | 1989-12-20 |
| FR2647017B1 (https=) | 1994-08-19 |
| GB2231793B (en) | 1993-10-06 |
| US5175005A (en) | 1992-12-29 |
| JP2842888B2 (ja) | 1999-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: MORINAGA & CO., LTD., TOKIO/TOKYO, JP |
|
| 8128 | New person/name/address of the agent |
Representative=s name: BOEHMERT, A., DIPL.-ING. HOORMANN, W., DIPL.-ING. |
|
| 8110 | Request for examination paragraph 44 | ||
| 8130 | Withdrawal |